SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8X_A_NIMA701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 VAL A 215
SER A 141
LEU A 190
 None
 0.65A 3n8xA-1a2vA:
0.0		 3n8xA-1a2vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)

(Spinacia
oleracea) 		PF00885
(DMRL_synthase) 		3 VAL A  76
SER A 139
LEU A  78
 None
 0.70A 3n8xA-1c2yA:
undetectable		 3n8xA-1c2yA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		3 VAL A 340
SER A 344
LEU A 356
 None
 0.76A 3n8xA-1cemA:
0.0		 3n8xA-1cemA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dee IGM RF 2A2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B 691
SER B 672
LEU B 693
 None
 0.77A 3n8xA-1deeB:
0.0		 3n8xA-1deeB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl3 PROTEIN
(PHOSPHORIBOSYLANTRA
NILATE ISOMERASE)

(Thermotoga
maritima) 		PF00697
(PRAI) 		3 VAL A  75
SER A  47
LEU A  77
 None
 0.74A 3n8xA-1dl3A:
0.0		 3n8xA-1dl3A:
15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 VAL A 349
SER A 353
LEU A 359
 SCL  A 700 ( 4.6A)
None
None
 0.25A 3n8xA-1ebvA:
61.6		 3n8xA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		3 VAL A  20
SER A  22
LEU A  36
 None
 0.76A 3n8xA-1ekqA:
0.0		 3n8xA-1ekqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 VAL A 123
SER A 127
LEU A 159
 None
 0.40A 3n8xA-1h74A:
0.0		 3n8xA-1h74A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbg TRANSCRIPTION
ACTIVATOR OF
MULTIDRUG-EFFLUX
TRANSPORTER GENES
MTA

(Bacillus
subtilis) 		PF13411
(MerR_1) 		3 VAL A   8
SER A  12
LEU A  19
 None
 0.73A 3n8xA-1jbgA:
undetectable		 3n8xA-1jbgA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		3 VAL A  21
SER A  25
LEU A 106
 None
 0.68A 3n8xA-1ll2A:
0.0		 3n8xA-1ll2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 VAL A 456
SER A 459
LEU A 453
 None
 0.74A 3n8xA-1loxA:
0.0		 3n8xA-1loxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5e SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF09272
(Hepsin-SRCR) 		3 VAL L  40
SER L  44
LEU L  31
 None
 0.76A 3n8xA-1o5eL:
undetectable		 3n8xA-1o5eL:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o91 COLLAGEN ALPHA
1(VIII) CHAIN

(Mus musculus) 		PF00386
(C1q) 		3 VAL A 666
SER A 733
LEU A 725
 None
 0.71A 3n8xA-1o91A:
undetectable		 3n8xA-1o91A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 VAL A 871
SER A 873
LEU A 865
 None
 0.71A 3n8xA-1p2zA:
undetectable		 3n8xA-1p2zA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvm CONSERVED
HYPOTHETICAL PROTEIN
TA0289

(Thermoplasma
acidophilum) 		PF00571
(CBS)
PF09151
(DUF1936) 		3 VAL A  74
SER A  54
LEU A  50
 None
 0.75A 3n8xA-1pvmA:
undetectable		 3n8xA-1pvmA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		3 VAL A 588
SER A 549
LEU A 592
 None
 0.72A 3n8xA-1qsaA:
1.7		 3n8xA-1qsaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 VAL A 169
SER A 246
LEU A 173
 None
 0.73A 3n8xA-1re5A:
undetectable		 3n8xA-1re5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrc POLYNUCLEOTIDE
KINASE

(Escherichia
virus T4) 		PF13671
(AAA_33) 		3 VAL A 193
SER A 197
LEU A 170
 None
 0.67A 3n8xA-1rrcA:
undetectable		 3n8xA-1rrcA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF08542
(Rep_fac_C) 		3 VAL A 650
SER A 654
LEU B 286
 None
 0.54A 3n8xA-1sxjA:
undetectable		 3n8xA-1sxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1v SH3 DOMAIN-BINDING
GLUTAMIC ACID-RICH
PROTEIN-LIKE 3

(Mus musculus) 		PF04908
(SH3BGR) 		3 VAL A   6
SER A   8
LEU A  37
 None
 0.72A 3n8xA-1t1vA:
undetectable		 3n8xA-1t1vA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		3 VAL A 178
SER A 142
LEU A 182
 None
 0.67A 3n8xA-1tqjA:
undetectable		 3n8xA-1tqjA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		3 VAL A 159
SER A 129
LEU A 161
 None
 0.73A 3n8xA-1tz6A:
undetectable		 3n8xA-1tz6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 VAL A 251
SER A 253
LEU A 212
 None
 0.76A 3n8xA-1uz5A:
undetectable		 3n8xA-1uz5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		3 VAL A  95
SER A 261
LEU A 107
 None
 0.71A 3n8xA-1w9zA:
undetectable		 3n8xA-1w9zA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		3 VAL A 120
SER A  66
LEU A 128
 None
 0.74A 3n8xA-1wl1A:
undetectable		 3n8xA-1wl1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xty PEPTIDYL-TRNA
HYDROLASE

(Sulfolobus
solfataricus) 		PF01981
(PTH2) 		3 VAL A   8
SER A  10
LEU A 120
 None
 0.53A 3n8xA-1xtyA:
undetectable		 3n8xA-1xtyA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj5 5' POLYNUCLEOTIDE
KINASE-3'
PHOSPHATASE FHA
DOMAIN

(Mus musculus) 		no annotation 3 VAL C  74
SER C  72
LEU C  93
 None
 0.72A 3n8xA-1yj5C:
undetectable		 3n8xA-1yj5C:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		3 VAL A 129
SER A 133
LEU A 109
 None
 0.62A 3n8xA-1yjgA:
undetectable		 3n8xA-1yjgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A  65
SER A  69
LEU A 107
 None
 0.74A 3n8xA-1zd1A:
undetectable		 3n8xA-1zd1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 VAL A 190
SER A 194
LEU A 186
 None
 0.75A 3n8xA-2f1nA:
undetectable		 3n8xA-2f1nA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		3 VAL A 175
SER A 173
LEU A 198
 None
 0.72A 3n8xA-2f28A:
undetectable		 3n8xA-2f28A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		3 VAL A 268
SER A 272
LEU A 244
 None
 0.57A 3n8xA-2f6iA:
undetectable		 3n8xA-2f6iA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 3 VAL A 164
SER A  98
LEU A  88
 None
 0.58A 3n8xA-2fnoA:
undetectable		 3n8xA-2fnoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		3 VAL A 243
SER A 245
LEU A 192
 None
 0.71A 3n8xA-2frxA:
undetectable		 3n8xA-2frxA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		3 VAL A 129
SER A 133
LEU A 109
 None
 0.65A 3n8xA-2ga0A:
undetectable		 3n8xA-2ga0A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 VAL A  35
SER A  39
LEU A  46
 None
 0.68A 3n8xA-2gfnA:
0.9		 3n8xA-2gfnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		3 VAL A 148
SER A 150
LEU A 146
 None
 0.75A 3n8xA-2gfqA:
1.6		 3n8xA-2gfqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		3 VAL A 188
SER A 190
LEU A  64
 None
 0.73A 3n8xA-2gy5A:
3.1		 3n8xA-2gy5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h32 IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 190
SER H 171
LEU H 192
 None
 0.47A 3n8xA-2h32H:
undetectable		 3n8xA-2h32H:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 VAL A 667
SER A 825
LEU A 670
 None
 0.59A 3n8xA-2hpiA:
0.2		 3n8xA-2hpiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqd ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Mus musculus) 		PF14580
(LRR_9) 		3 VAL A  52
SER A  29
LEU A  54
 None
 0.70A 3n8xA-2jqdA:
undetectable		 3n8xA-2jqdA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF09649
(CHZ)
PF16211
(Histone_H2A_C) 		3 VAL A  86
SER A  90
LEU B  29
 None
 0.68A 3n8xA-2jssA:
undetectable		 3n8xA-2jssA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n67 HEMOLYSIN II

(Bacillus cereus) 		no annotation 3 VAL B  72
SER B  76
LEU B  27
 None
 0.72A 3n8xA-2n67B:
undetectable		 3n8xA-2n67B:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 VAL A 836
SER A 838
LEU A 830
 None
 0.67A 3n8xA-2obeA:
undetectable		 3n8xA-2obeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		3 VAL A 257
SER A 200
LEU A 261
 None
 0.75A 3n8xA-2pbeA:
undetectable		 3n8xA-2pbeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		3 VAL X 169
SER X 164
LEU X 155
 None
 0.72A 3n8xA-2uydX:
undetectable		 3n8xA-2uydX:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 VAL J 805
SER J 809
LEU J 790
 None
 0.55A 3n8xA-2wp8J:
undetectable		 3n8xA-2wp8J:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3

(Homo sapiens) 		PF01026
(TatD_DNase) 		3 VAL A 146
SER A 148
LEU A 169
 None
 0.60A 3n8xA-2y1hA:
undetectable		 3n8xA-2y1hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		3 VAL A  43
SER A  45
LEU A  39
 None
 0.73A 3n8xA-2zm2A:
undetectable		 3n8xA-2zm2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 VAL A 592
SER A 596
LEU A 559
 None
 0.60A 3n8xA-2zxhA:
undetectable		 3n8xA-2zxhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		3 VAL A  46
SER A 114
LEU A 121
 None
 0.72A 3n8xA-3aeuA:
undetectable		 3n8xA-3aeuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 VAL A 578
SER A 580
LEU A 565
 None
 0.73A 3n8xA-3aibA:
undetectable		 3n8xA-3aibA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		3 VAL A 117
SER A 121
LEU A  80
 None
 0.64A 3n8xA-3ajbA:
undetectable		 3n8xA-3ajbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoh ANTI-CLEAVAGE
ANTI-GREA
TRANSCRIPTION FACTOR
GFH1

(Thermus
thermophilus) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		3 VAL X   5
SER X 106
LEU X   7
 None
 0.71A 3n8xA-3aohX:
undetectable		 3n8xA-3aohX:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		3 VAL A 118
SER A 122
LEU A 243
 None
 0.53A 3n8xA-3b6uA:
undetectable		 3n8xA-3b6uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c90 PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		no annotation 3 VAL X  77
SER X  81
LEU X  41
 None
 0.73A 3n8xA-3c90X:
undetectable		 3n8xA-3c90X:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		3 VAL A 445
SER A 329
LEU A 429
 None
 0.69A 3n8xA-3cvrA:
0.8		 3n8xA-3cvrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 118
SER A 306
LEU A 351
 None
 0.71A 3n8xA-3dg7A:
undetectable		 3n8xA-3dg7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		3 VAL A 161
SER A 132
LEU A 163
 None
 0.66A 3n8xA-3ewmA:
0.9		 3n8xA-3ewmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc3 RESTRICTION
ENDONUCLEASE HPY99I

(Helicobacter
pylori) 		PF02945
(Endonuclease_7) 		3 VAL A 139
SER A 137
LEU A 145
 None
 0.76A 3n8xA-3fc3A:
undetectable		 3n8xA-3fc3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		3 VAL A 152
SER A 118
LEU A 169
 None
 0.76A 3n8xA-3fhcA:
undetectable		 3n8xA-3fhcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 VAL A  85
SER A  48
LEU A  87
 None
 0.76A 3n8xA-3gg4A:
undetectable		 3n8xA-3gg4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 VAL B  72
SER B  65
LEU B 101
 None
 0.69A 3n8xA-3h0rB:
undetectable		 3n8xA-3h0rB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		3 VAL A 265
SER A 269
LEU A 251
 None
 0.47A 3n8xA-3hh8A:
undetectable		 3n8xA-3hh8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		no annotation 3 VAL B  97
SER B  99
LEU B 108
 None
 0.65A 3n8xA-3hhfB:
undetectable		 3n8xA-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		3 VAL A1051
SER A1063
LEU A1055
 None
 0.65A 3n8xA-3i5pA:
undetectable		 3n8xA-3i5pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		3 VAL A  30
SER A 127
LEU A  20
 None
 0.75A 3n8xA-3iclA:
undetectable		 3n8xA-3iclA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in6 FMN-BINDING PROTEIN

(Syntrophomonas
wolfei) 		no annotation 3 VAL A  83
SER A  31
LEU A  85
 None
 0.59A 3n8xA-3in6A:
undetectable		 3n8xA-3in6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 VAL A 277
SER A 283
LEU A 270
 None
 0.70A 3n8xA-3iv0A:
undetectable		 3n8xA-3iv0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 3 VAL B 964
SER B 961
LEU B1059
 None
 0.71A 3n8xA-3iz3B:
undetectable		 3n8xA-3iz3B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		3 VAL p 270
SER p 264
LEU p 275
 None
 0.62A 3n8xA-3japp:
undetectable		 3n8xA-3japp:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		3 VAL A 138
SER A 133
LEU A 116
 None
 0.53A 3n8xA-3jy6A:
undetectable		 3n8xA-3jy6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		3 VAL A 368
SER A 372
LEU A 362
 None
 0.77A 3n8xA-3lggA:
undetectable		 3n8xA-3lggA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA

(Histophilus
somni) 		PF02661
(Fic) 		3 VAL A3771
SER A3767
LEU A3708
 None
 0.73A 3n8xA-3n3uA:
undetectable		 3n8xA-3n3uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		3 VAL A 134
SER A 131
LEU A  93
 None
 0.60A 3n8xA-3nfqA:
undetectable		 3n8xA-3nfqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		3 VAL A 129
SER A 127
LEU A  59
 None
 0.72A 3n8xA-3npfA:
undetectable		 3n8xA-3npfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		3 VAL A 193
SER A 195
LEU A 180
 None
 0.64A 3n8xA-3ntxA:
undetectable		 3n8xA-3ntxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 VAL A 315
SER A 319
LEU A 326
 None
 0.66A 3n8xA-3o5aA:
undetectable		 3n8xA-3o5aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa3 ALDOLASE

(Coccidioides
immitis) 		PF01791
(DeoC) 		3 VAL A 184
SER A 176
LEU A 159
 None
 0.65A 3n8xA-3oa3A:
undetectable		 3n8xA-3oa3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		3 VAL A 274
SER A 271
LEU A 233
 None
 0.72A 3n8xA-3oakA:
undetectable		 3n8xA-3oakA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 VAL A 139
SER A 137
LEU A 126
 None
 0.73A 3n8xA-3oflA:
undetectable		 3n8xA-3oflA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		3 VAL A  23
SER A  18
LEU A  36
 None
 0.62A 3n8xA-3oheA:
undetectable		 3n8xA-3oheA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 VAL A 222
SER A 224
LEU A 181
 None
 0.67A 3n8xA-3p1vA:
undetectable		 3n8xA-3p1vA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 VAL A 187
SER A 185
LEU A 201
 None
 0.74A 3n8xA-3p6lA:
undetectable		 3n8xA-3p6lA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		3 VAL A 396
SER A 398
LEU A 105
 None
 0.70A 3n8xA-3penA:
undetectable		 3n8xA-3penA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 VAL A 304
SER A 219
LEU A 276
 None
 0.74A 3n8xA-3psgA:
undetectable		 3n8xA-3psgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 VAL N  23
SER N  27
LEU N  40
 None
 0.72A 3n8xA-3rkoN:
undetectable		 3n8xA-3rkoN:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		3 VAL A  21
SER A  25
LEU A 106
 None
 0.63A 3n8xA-3rmvA:
undetectable		 3n8xA-3rmvA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7x MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 4) 		PF00718
(Polyoma_coat) 		3 VAL A 100
SER A  98
LEU A  54
 None
 0.72A 3n8xA-3s7xA:
undetectable		 3n8xA-3s7xA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		3 VAL A  85
SER A  89
LEU A  76
 None
 0.69A 3n8xA-3t2nA:
undetectable		 3n8xA-3t2nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		3 VAL A 402
SER A 332
LEU A 406
 None
 0.69A 3n8xA-3u0kA:
undetectable		 3n8xA-3u0kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A1815
SER A1819
LEU A1878
 None
 0.69A 3n8xA-3vkgA:
undetectable		 3n8xA-3vkgA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		3 VAL A  91
SER A  93
LEU A  50
 None
 0.66A 3n8xA-3vvlA:
undetectable		 3n8xA-3vvlA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 VAL A 642
SER A 632
LEU A 661
 None
 0.74A 3n8xA-3wnpA:
undetectable		 3n8xA-3wnpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 VAL A  68
SER A  83
LEU A 112
 None
 0.71A 3n8xA-3zxlA:
undetectable		 3n8xA-3zxlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		3 VAL A 107
SER A 111
LEU A  71
 None
 0.62A 3n8xA-4bz7A:
undetectable		 3n8xA-4bz7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		3 VAL A 223
SER A 221
LEU A 147
 None
 0.66A 3n8xA-4c8yA:
undetectable		 3n8xA-4c8yA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c98 CAS6B

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		3 VAL A 250
SER A 248
LEU A 168
 None
 0.66A 3n8xA-4c98A:
undetectable		 3n8xA-4c98A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		3 VAL A 164
SER A 157
LEU A 162
 None
 0.76A 3n8xA-4d6vA:
undetectable		 3n8xA-4d6vA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 VAL A 100
SER A 104
LEU A 392
 None
 0.67A 3n8xA-4dd5A:
undetectable		 3n8xA-4dd5A:
19.61