SIMILAR PATTERNS OF AMINO ACIDS FOR 3N65_B_MTLB870

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 SER A 477
ARG A 481
ASN A 498
ASN A 569
TYR A 706
 None
None
None
None
HEM  A 750 (-4.1A)
 1.22A 3n65B-1lzxA:
62.5		 3n65B-1lzxA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		8 SER A 477
ARG A 481
ASN A 498
GLN A 500
PHE A 501
ASN A 569
ASP A 709
TRP A 711
 None
 0.32A 3n65B-1lzxA:
62.5		 3n65B-1lzxA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		6 SER A 246
ARG A 250
ASN A 267
ASN A 338
ASP A 478
TRP A 480
 None
 0.66A 3n65B-1m9qA:
59.2		 3n65B-1m9qA:
64.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 SER A 246
ARG A 250
ASN A 267
ASN A 338
TYR A 475
 None
None
None
None
HEM  A 901 (-4.2A)
 1.16A 3n65B-1m9qA:
59.2		 3n65B-1m9qA:
64.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 SER A 256
ARG A 260
PHE A 280
ASN A 348
TRP A 490
 None
 0.70A 3n65B-1qw5A:
58.2		 3n65B-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 SER A 109
ARG A 112
ASN A 289
PHE A 294
TRP A 239
 None
 1.33A 3n65B-3ix1A:
0.0		 3n65B-3ix1A:
19.91