SIMILAR PATTERNS OF AMINO ACIDS FOR 3N23_C_OBNC1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ASP A 326
LEU A 329
VAL A 313
PHE A 340
THR A 321
 None
 1.13A 3n23C-1bvuA:
undetectable		 3n23C-1bvuA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ASP A 326
VAL A 313
ALA A 314
PHE A 340
THR A 321
 None
 1.23A 3n23C-1bvuA:
undetectable		 3n23C-1bvuA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLN A 229
ASP A 232
LEU A 233
VAL A 237
ALA A 238
 None
 1.37A 3n23C-1c7tA:
0.1		 3n23C-1c7tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		5 PRO A 241
LEU A  26
VAL A 137
ALA A 134
PHE A 264
 None
None
None
None
AKG  A 902 (-4.9A)
 1.30A 3n23C-1e5iA:
undetectable		 3n23C-1e5iA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 ASP A 138
LEU A 136
VAL A  92
ALA A  91
THR A 141
 None
 1.15A 3n23C-1fc9A:
undetectable		 3n23C-1fc9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 PRO A  54
LEU A  51
VAL A  49
ALA A  48
PHE A 208
 None
 1.30A 3n23C-1k4yA:
undetectable		 3n23C-1k4yA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		5 ASP A 451
LEU A 453
VAL A 439
ALA A 483
ARG A 494
 None
 1.37A 3n23C-1lshA:
0.0		 3n23C-1lshA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU A 142
VAL A 133
ALA A 132
PHE A 173
PHE A 210
 None
 1.33A 3n23C-1m72A:
2.3		 3n23C-1m72A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8r GUANYLIN

(Homo sapiens) 		PF02058
(Guanylin) 		5 GLN A  71
PRO A  39
LEU A  12
VAL A   3
ALA A  90
 None
 1.18A 3n23C-1o8rA:
undetectable		 3n23C-1o8rA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 GLN A 157
ASP A 182
LEU A 184
VAL A 173
ALA A 174
 None
 1.09A 3n23C-1sezA:
0.0		 3n23C-1sezA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLN A 674
ASN A 670
VAL A 719
ALA A 718
THR A 321
 None
 1.21A 3n23C-1v7vA:
undetectable		 3n23C-1v7vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9d DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2) 		5 ASP A1120
ASN A1123
LEU A1121
VAL A1027
ALA A1030
 None
 1.41A 3n23C-1v9dA:
undetectable		 3n23C-1v9dA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLN A  83
LEU A 250
VAL A 150
ALA A 153
THR A 254
 None
 1.35A 3n23C-1vdkA:
undetectable		 3n23C-1vdkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 PRO A 158
ASP A 115
LEU A 116
VAL A 141
ALA A 138
 None
 1.33A 3n23C-1ytmA:
undetectable		 3n23C-1ytmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		5 GLN 1 380
PRO 1 141
ASP 1 142
LEU 1 128
ALA 1 146
 None
 1.42A 3n23C-2bpa1:
undetectable		 3n23C-2bpa1:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLN A 276
LEU A 181
ALA A 245
PHE A 252
PHE A 294
 None
 1.43A 3n23C-2btuA:
undetectable		 3n23C-2btuA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP A 148
ASN A 153
LEU A 149
VAL A 224
PHE A 239
 None
 1.29A 3n23C-2bujA:
undetectable		 3n23C-2bujA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ASP A   4
LEU A   5
VAL A 604
ALA A 603
PHE A 324
 None
 1.23A 3n23C-2ddhA:
undetectable		 3n23C-2ddhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 ASP A  74
LEU A  76
ALA A 103
PHE A 108
PHE A  66
 UNL  A 273 (-3.0A)
None
None
UNL  A 273 ( 4.9A)
None
 1.42A 3n23C-2ftzA:
undetectable		 3n23C-2ftzA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gex SNOL

(Streptomyces
nogalater) 		PF07366
(SnoaL) 		5 PRO A 136
ASP A 137
LEU A 141
VAL A 100
THR A  96
 None
 1.32A 3n23C-2gexA:
undetectable		 3n23C-2gexA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrj TALIN-1

(Gallus gallus) 		PF00373
(FERM_M) 		5 ASN A  25
LEU A  24
VAL A 111
ALA A 114
PHE A  77
 None
 1.26A 3n23C-2hrjA:
undetectable		 3n23C-2hrjA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU C 142
VAL C 133
ALA C 132
PHE C 173
PHE C 210
 None
 1.38A 3n23C-2nn3C:
2.2		 3n23C-2nn3C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ASP A  88
ASN A  86
LEU A  89
VAL A  77
ALA A  76
 ASP  A  88 ( 0.5A)
ASN  A  86 ( 0.6A)
LEU  A  89 ( 0.6A)
VAL  A  77 ( 0.6A)
ALA  A  76 ( 0.0A)
 1.24A 3n23C-2nvvA:
undetectable		 3n23C-2nvvA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 PRO A 108
ASP A 109
ASN A 107
VAL A  14
ALA A  13
 None
None
None
EDO  A 225 (-4.9A)
EDO  A 225 (-3.7A)
 1.41A 3n23C-2o2gA:
3.8		 3n23C-2o2gA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjz HYPOTHETICAL PROTEIN
ST1066

(Sulfurisphaera
tokodaii) 		PF00005
(ABC_tran) 		5 PRO A 155
ASP A 153
ASN A  79
ALA A  49
THR A  44
 None
None
None
None
SO4  A 502 (-3.7A)
 1.28A 3n23C-2pjzA:
undetectable		 3n23C-2pjzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 GLN A 641
PRO A 665
ASN A 664
LEU A 661
ALA A 649
 None
 1.42A 3n23C-2v70A:
undetectable		 3n23C-2v70A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 PRO A 600
ASP A 599
ASN A 500
VAL A 474
ALA A 473
 None
 1.28A 3n23C-2vsqA:
undetectable		 3n23C-2vsqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Pisum sativum) 		PF01652
(IF4E) 		5 ASP A 142
VAL A 170
ALA A 108
PHE A 110
PHE A  61
 None
 1.35A 3n23C-2wmcA:
undetectable		 3n23C-2wmcA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfb METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER

(Pseudomonas
putida) 		PF16591
(HBM) 		5 GLN A 218
ASP A 213
LEU A 209
VAL A 233
ALA A 232
 None
 1.30A 3n23C-2yfbA:
undetectable		 3n23C-2yfbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		5 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
 EMT  A3503 (-4.8A)
None
None
None
None
 1.33A 3n23C-2ypdA:
undetectable		 3n23C-2ypdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 PRO A 115
ASP A 114
LEU A 111
VAL A 328
ALA A 329
 None
 1.11A 3n23C-2zq5A:
undetectable		 3n23C-2zq5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Aeropyrum
pernix) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 GLN A 258
PRO A 227
LEU A 252
VAL A 235
PHE A 199
 None
 1.43A 3n23C-3agkA:
undetectable		 3n23C-3agkA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B 212
VAL B 278
ALA B 243
PHE B 160
THR B 237
 None
 1.29A 3n23C-3aqcB:
undetectable		 3n23C-3aqcB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA
HEMOGLOBIN BETA

(Perca
flavescens) 		PF00042
(Globin) 		5 GLN B 127
LEU B  18
VAL B  23
ALA B  26
PHE A 118
 None
 1.26A 3n23C-3bj1B:
undetectable		 3n23C-3bj1B:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek3 NITROREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		5 GLN A 135
LEU A  59
VAL A  53
ALA A  52
PHE A 120
 FMN  A 200 (-3.0A)
None
None
None
None
 1.19A 3n23C-3ek3A:
undetectable		 3n23C-3ek3A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ASP A 786
ASN A 782
LEU A 785
VAL A 800
ALA A 740
 None
 1.43A 3n23C-3f2bA:
undetectable		 3n23C-3f2bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 PRO A 289
LEU A 259
VAL A 218
ALA A 221
ARG A 102
 None
 1.31A 3n23C-3gkaA:
undetectable		 3n23C-3gkaA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 LEU A  76
VAL A  39
ALA A  38
PHE A 267
ARG A 244
 None
 1.30A 3n23C-3h7uA:
undetectable		 3n23C-3h7uA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		5 PRO A 132
ASP A 131
LEU A 127
VAL A 150
ALA A 149
 None
 0.87A 3n23C-3hwkA:
undetectable		 3n23C-3hwkA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Schistosoma
mansoni) 		PF01652
(IF4E) 		5 PRO A  69
LEU A  34
VAL A  50
PHE A  59
THR A  66
 None
 1.39A 3n23C-3hxgA:
undetectable		 3n23C-3hxgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 PRO A 166
ASP A 165
ALA A 263
PHE A 260
ARG A 227
 None
ATP  A 900 ( 4.3A)
None
ATP  A 900 (-4.2A)
None
 1.29A 3n23C-3iq0A:
3.8		 3n23C-3iq0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 GLN A 472
LEU A 482
VAL A 114
ALA A 401
PHE A 405
 None
 1.37A 3n23C-3izkA:
undetectable		 3n23C-3izkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 ASP A 470
LEU A 472
ALA A 171
PHE A 118
PHE A 114
 None
 1.30A 3n23C-3jz4A:
3.1		 3n23C-3jz4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A  83
VAL A  90
ALA A  91
PHE A  40
ARG A  58
 None
 1.40A 3n23C-3k0sA:
undetectable		 3n23C-3k0sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 LEU A 190
VAL A 405
ALA A 404
PHE A 391
ARG A 387
 None
 1.29A 3n23C-3koyA:
0.8		 3n23C-3koyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		5 ASP A 118
ASN A 325
LEU A 324
VAL A 345
ALA A 360
 None
None
GOL  A 499 ( 4.9A)
None
None
 1.27A 3n23C-3kscA:
undetectable		 3n23C-3kscA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 GLN A 184
LEU A  80
VAL A  65
PHE A 126
PHE A 156
 None
 1.40A 3n23C-3njpA:
undetectable		 3n23C-3njpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1

(Homo sapiens) 		PF03031
(NIF) 		5 PRO A 209
ASP A 206
LEU A 205
PHE A 226
THR A 100
 None
MG  A   1 ( 4.4A)
None
None
None
 1.42A 3n23C-3pglA:
8.2		 3n23C-3pglA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PRO A 155
ASN A 152
LEU A 149
VAL A  17
ALA A  20
 None
 1.36A 3n23C-3plrA:
undetectable		 3n23C-3plrA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD

(Pseudomonas
aeruginosa) 		PF14467
(DUF4426) 		5 PRO A  63
ASN A 101
LEU A 102
VAL A  48
ALA A  47
 None
 1.35A 3n23C-3uc2A:
undetectable		 3n23C-3uc2A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		5 PRO A  33
LEU A  28
VAL A  23
ALA A  22
THR A  38
 None
 1.19A 3n23C-3w25A:
undetectable		 3n23C-3w25A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 195
VAL A 225
ALA A 224
PHE A 128
PHE A 118
 None
 1.34A 3n23C-4awnA:
undetectable		 3n23C-4awnA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ASP A 171
LEU A 174
VAL A 136
ALA A 132
PHE A 165
 None
None
None
None
MLA  A1415 (-4.3A)
 1.14A 3n23C-4b0nA:
undetectable		 3n23C-4b0nA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		5 ASP A 156
ASN A 155
LEU A 154
VAL A  59
ALA A  58
 None
 1.16A 3n23C-4bz7A:
undetectable		 3n23C-4bz7A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU L 193
VAL L 235
ALA L 236
PHE L 243
PHE L 245
 None
 1.32A 3n23C-4cr4L:
undetectable		 3n23C-4cr4L:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 325
VAL A 367
ALA A 366
PHE A 183
THR A 344
 None
 1.16A 3n23C-4dhgA:
undetectable		 3n23C-4dhgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 GLN A 196
LEU A 512
VAL A 277
ALA A 274
PHE A 272
 None
 1.43A 3n23C-4di5A:
undetectable		 3n23C-4di5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF

(Escherichia
coli) 		PF01656
(CbiA) 		5 PRO A  40
ASP A  39
LEU A  44
VAL A  19
ALA A  18
 None
ACP  A 301 (-3.9A)
None
None
None
 1.31A 3n23C-4e09A:
undetectable		 3n23C-4e09A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 CULLIN-1
E3 UBIQUITIN-PROTEIN
LIGASE RBX1

(Homo sapiens) 		PF00888
(Cullin)
PF12678
(zf-rbx1) 		5 LEU A 540
VAL B  30
ALA B  29
PHE A 566
PHE A 569
 None
 1.43A 3n23C-4f52A:
undetectable		 3n23C-4f52A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE

(Actinobacillus
succinogenes) 		PF13378
(MR_MLE_C) 		5 LEU A 344
VAL A 386
PHE A 197
PHE A 200
THR A 363
 None
 1.43A 3n23C-4g8tA:
undetectable		 3n23C-4g8tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 PRO A 220
LEU A 167
VAL A 200
PHE A 252
PHE A 206
 None
 0.93A 3n23C-4iv9A:
undetectable		 3n23C-4iv9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		5 PRO A 146
LEU A 203
VAL A 229
ALA A 228
ARG A 220
 None
 1.30A 3n23C-4lylA:
undetectable		 3n23C-4lylA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PRO A 244
LEU A 225
VAL A 306
THR A 300
ARG A 401
 None
 1.37A 3n23C-4mv3A:
1.8		 3n23C-4mv3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		5 LEU A 316
VAL A  16
ALA A  39
THR A  28
ARG A  80
 None
 1.42A 3n23C-4ntcA:
undetectable		 3n23C-4ntcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		5 PRO A 105
LEU A 138
ALA A 327
PHE A 323
PHE A 319
 None
 1.25A 3n23C-4p9kA:
undetectable		 3n23C-4p9kA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 GLN A 127
ASP A 149
PHE A 298
PHE A 282
THR A 179
 None
 1.41A 3n23C-4pdxA:
undetectable		 3n23C-4pdxA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP A  81
LEU A 103
VAL A  12
ALA A  13
THR A  77
 None
 1.38A 3n23C-4qciA:
undetectable		 3n23C-4qciA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 ASP A  23
ASN A 167
LEU A  24
VAL A 159
ALA A 160
 None
None
None
EDO  A 309 (-3.5A)
None
 1.20A 3n23C-4r3fA:
undetectable		 3n23C-4r3fA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		5 PRO A  60
LEU A  39
VAL A  90
ALA A  91
PHE A  87
 None
 1.38A 3n23C-4rheA:
3.5		 3n23C-4rheA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1

(Saccharomyces
cerevisiae) 		PF02383
(Syja_N) 		5 ASN X 299
LEU X 301
VAL X 259
PHE X 230
PHE X 155
 None
 1.29A 3n23C-4tu3X:
undetectable		 3n23C-4tu3X:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 ASP A  74
LEU A  76
ALA A 103
PHE A 108
PHE A  66
 None
 1.39A 3n23C-4wk5A:
undetectable		 3n23C-4wk5A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 GLN A 583
PRO A 584
ASP A 587
LEU A 588
ALA A 542
 None
 1.43A 3n23C-4y9lA:
undetectable		 3n23C-4y9lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PRO A 662
ASP A 381
VAL A 378
THR A 566
ARG A 485
 None
 1.35A 3n23C-4zohA:
undetectable		 3n23C-4zohA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		5 PRO A 382
ASN A  33
LEU A  32
VAL A  76
ALA A  77
 None
 1.37A 3n23C-5a2rA:
undetectable		 3n23C-5a2rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 GLN A 181
PRO A 139
VAL A 221
ALA A 222
ARG A 314
 None
None
None
None
ACT  A 406 (-3.8A)
 1.18A 3n23C-5az0A:
undetectable		 3n23C-5az0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)

(Streptococcus
suis) 		no annotation 5 GLN A 215
ASP A 217
ALA A 299
PHE A 199
THR A 219
 None
 1.43A 3n23C-5bobA:
undetectable		 3n23C-5bobA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 LEU A 979
VAL A 798
ALA A 801
PHE A 752
PHE A 749
 None
 1.43A 3n23C-5ffjA:
undetectable		 3n23C-5ffjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 PRO A  37
LEU A  34
VAL A  32
ALA A  31
PHE A 191
 None
 1.37A 3n23C-5fv4A:
1.4		 3n23C-5fv4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		5 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
 None
 1.36A 3n23C-5fzoA:
undetectable		 3n23C-5fzoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 GLN A 419
ASP A 380
LEU A  60
VAL A  66
ALA A  67
 None
 1.26A 3n23C-5kdxA:
undetectable		 3n23C-5kdxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 ASP A 267
ASN A 271
LEU A 268
VAL A  88
ALA A  64
 None
GOL  A 405 (-3.6A)
None
None
None
 1.39A 3n23C-5kwsA:
3.0		 3n23C-5kwsA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2d POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		no annotation 5 LEU A1077
VAL A1069
ALA A1070
THR A1075
ARG A1098
 None
 1.13A 3n23C-5o2dA:
undetectable		 3n23C-5o2dA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A  41
PRO A  40
ASP A  34
VAL A 103
ALA A 102
 None
 1.02A 3n23C-5ulvA:
undetectable		 3n23C-5ulvA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 5 LEU A 244
VAL A 233
ALA A 234
PHE A 257
PHE A 287
 None
 1.41A 3n23C-5vaeA:
6.5		 3n23C-5vaeA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 5 GLN A 152
PRO A 144
ASN A 108
VAL A 576
ALA A 575
 None
 1.38A 3n23C-5ws4A:
undetectable		 3n23C-5ws4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		5 GLN A 796
ASN A1029
LEU A1033
ALA A 901
PHE A 895
 None
 1.41A 3n23C-5x59A:
undetectable		 3n23C-5x59A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 ASN A 169
LEU A 168
VAL A 201
ALA A 198
PHE A 251
 None
None
None
None
GOL  A 502 (-4.8A)
 1.18A 3n23C-5xgzA:
undetectable		 3n23C-5xgzA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN
OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 PRO C  23
LEU C  18
VAL C  75
ALA C  76
ARG A 154
 None
 1.40A 3n23C-5xn6C:
undetectable		 3n23C-5xn6C:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4

(Homo sapiens) 		no annotation 5 PRO A 401
ASP A 392
LEU A 390
VAL A 456
ALA A 455
 None
 1.14A 3n23C-5yc1A:
undetectable		 3n23C-5yc1A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICB

(Streptococcus
pneumoniae) 		no annotation 5 GLN A  34
ASP A  12
PHE A  86
PHE A  80
THR A  89
 None
 1.41A 3n23C-5yrzA:
undetectable		 3n23C-5yrzA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 5 ASP C 371
LEU C  42
VAL C 449
PHE C 374
THR C  39
 None
 1.07A 3n23C-6bspC:
undetectable		 3n23C-6bspC:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 ASN A 211
VAL A 205
PHE A 144
THR A 126
ARG A 462
 None
 1.39A 3n23C-6byiA:
undetectable		 3n23C-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 5 PRO A 362
ASP A 365
LEU A 369
ALA A 258
ARG A 231
 None
 1.34A 3n23C-6c4nA:
undetectable		 3n23C-6c4nA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 5 LEU A 188
VAL A 166
ALA A 165
PHE A 290
THR A 159
 FMT  A 502 (-4.4A)
None
None
None
SAH  A 501 (-3.0A)
 1.14A 3n23C-6c5bA:
undetectable		 3n23C-6c5bA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ

(Pyrococcus
furiosus) 		no annotation 5 PRO M  46
ASP M  49
LEU M  53
ALA J  66
ARG M  38
 None
 1.40A 3n23C-6cfwM:
undetectable		 3n23C-6cfwM:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 5 PRO A  38
LEU A  33
VAL A  28
ALA A  27
THR A  43
 None
 1.25A 3n23C-6fheA:
undetectable		 3n23C-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 PRO C 159
ASP C 155
VAL C 179
ALA C 180
THR C 149
 None
 1.36A 3n23C-6fkhC:
undetectable		 3n23C-6fkhC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 LEU A 431
VAL A 460
ALA A 457
PHE A 455
PHE A 507
 None
 1.26A 3n23C-6fwfA:
undetectable		 3n23C-6fwfA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 ASN A 319
LEU A 316
VAL A 130
ALA A 115
PHE A  28
 None
 1.40A 3n23C-6gh2A:
undetectable		 3n23C-6gh2A:
6.28