SIMILAR PATTERNS OF AMINO ACIDS FOR 3N23_A_OBNA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ASP A 326
VAL A 313
ALA A 314
PHE A 340
THR A 321
None
1.23A 3n23A-1bvuA:
0.0
3n23A-1bvuA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckr HEAT SHOCK SUBSTRATE
BINDING DOMAIN OF
HSC-70


(Rattus
norvegicus)
PF00012
(HSP70)
5 ASP A 531
ASN A 537
VAL A 474
THR A 409
ILE A 401
None
1.33A 3n23A-1ckrA:
0.0
3n23A-1ckrA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA


(Homo sapiens)
PF00069
(Pkinase)
5 PRO A 353
ASP A  91
VAL A  53
ALA A  44
ILE A  55
None
1.39A 3n23A-1cm8A:
0.0
3n23A-1cm8A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT


(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1)
5 PRO A 490
ASP A 495
ASN A 489
THR A 248
ILE A 247
None
1.42A 3n23A-1ddgA:
3.0
3n23A-1ddgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE


(Equus caballus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 PRO A 248
VAL A 261
PHE A 197
ILE A 219
ARG A 270
None
None
None
None
NAD  A1100 (-4.4A)
1.41A 3n23A-1ee2A:
5.2
3n23A-1ee2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng FRATTIDE
GLYCOGEN SYNTHASE
KINASE-3 BETA


(Homo sapiens)
PF00069
(Pkinase)
PF05350
(GSK-3_bind)
5 VAL X 217
ALA X 216
PHE A 257
THR A 275
ILE X 213
None
1.27A 3n23A-1gngX:
undetectable
3n23A-1gngX:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  39
PRO A  38
ASP A  32
VAL A 101
ILE A  97
None
None
NAD  A1306 (-3.0A)
None
NAD  A1306 (-3.8A)
1.13A 3n23A-1guzA:
3.6
3n23A-1guzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  39
PRO A  38
ASP A  32
VAL A 101
ILE A  97
None
None
NAD  A1306 (-3.1A)
None
NAD  A1306 (-4.1A)
1.15A 3n23A-1gv0A:
undetectable
3n23A-1gv0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT


(Escherichia
coli)
PF00701
(DHDPS)
5 ASP A 191
VAL A 242
PHE A 252
THR A 209
ILE A 212
None
1.10A 3n23A-1hl2A:
undetectable
3n23A-1hl2A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 ASP A 284
ASN A 288
PHE A 328
PHE A 326
THR A 298
None
1.43A 3n23A-1jaeA:
undetectable
3n23A-1jaeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans)
PF00232
(Glyco_hydro_1)
5 GLN A  20
ASN A 165
THR A 354
ILE A 293
ARG A 375
None
1.37A 3n23A-1qoxA:
undetectable
3n23A-1qoxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B


(Homo sapiens)
PF00233
(PDEase_I)
5 VAL A 685
PHE A 679
THR A 743
ILE A 740
ARG A 755
None
1.36A 3n23A-1sojA:
undetectable
3n23A-1sojA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B


([Haemophilus]
ducreyi)
PF03372
(Exo_endo_phos)
5 ASP B 244
ALA B 240
PHE B  27
ILE B 224
ARG B 126
None
1.25A 3n23A-1sr4B:
undetectable
3n23A-1sr4B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
5 GLN A 395
PRO A 508
ASN A 412
ALA A 499
THR A 502
None
1.28A 3n23A-1uf2A:
undetectable
3n23A-1uf2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  40
PRO A  39
ASP A  33
ALA A 101
ILE A  98
None
None
NAD  A1310 (-3.0A)
NAD  A1310 ( 4.4A)
NAD  A1310 (-4.1A)
1.29A 3n23A-1uxiA:
undetectable
3n23A-1uxiA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 GLN A 674
ASN A 670
VAL A 719
ALA A 718
THR A 321
None
1.20A 3n23A-1v7vA:
undetectable
3n23A-1v7vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR


(Escherichia
coli)
PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N)
5 ASP A 328
ALA A 317
THR A 268
ILE A 267
ARG A 212
None
None
None
None
AGS  A1600 ( 3.2A)
1.42A 3n23A-1xpoA:
2.9
3n23A-1xpoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
5 PRO A 449
VAL A 326
ALA A 327
PHE A 336
ILE A 323
None
1.38A 3n23A-2fknA:
undetectable
3n23A-2fknA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN


(Thermotoga
maritima)
PF13407
(Peripla_BP_4)
5 PRO A 144
ASN A 106
VAL A 273
PHE A  16
ILE A 102
None
1.30A 3n23A-2fn9A:
2.2
3n23A-2fn9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR


(Saccharomyces
cerevisiae)
PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16)
5 ASN A 212
ALA A 569
PHE A 565
THR A 583
ILE A 582
None
1.29A 3n23A-2gw1A:
undetectable
3n23A-2gw1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Elizabethkingia
meningoseptica)
PF01408
(GFO_IDH_MocA)
5 VAL A  48
ALA A  49
PHE A  25
ILE A  92
ARG A  31
None
None
None
None
NAD  A1445 (-3.4A)
1.12A 3n23A-2ixbA:
2.5
3n23A-2ixbA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE


(Trichormus
variabilis)
PF01738
(DLH)
5 PRO A 108
ASP A 109
ASN A 107
VAL A  14
ALA A  13
None
None
None
EDO  A 225 (-4.9A)
EDO  A 225 (-3.7A)
1.41A 3n23A-2o2gA:
undetectable
3n23A-2o2gA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae)
PF00710
(Asparaginase)
5 ASP A  73
ALA A 100
PHE A 105
PHE A 203
ILE A 208
None
1.43A 3n23A-2ocdA:
undetectable
3n23A-2ocdA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjz HYPOTHETICAL PROTEIN
ST1066


(Sulfurisphaera
tokodaii)
PF00005
(ABC_tran)
5 PRO A 155
ASP A 153
ASN A  79
ALA A  49
THR A  44
None
None
None
None
SO4  A 502 (-3.7A)
1.28A 3n23A-2pjzA:
undetectable
3n23A-2pjzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ASN B 191
VAL B 204
PHE B 365
ILE B 206
ARG B 366
SRM  B 503 ( 3.5A)
None
None
None
None
1.22A 3n23A-2v4jB:
undetectable
3n23A-2v4jB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 PRO A 600
ASP A 599
ASN A 500
VAL A 474
ALA A 473
None
1.28A 3n23A-2vsqA:
undetectable
3n23A-2vsqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1


(Avena sativa;
Homo sapiens)
PF00071
(Ras)
PF13426
(PAS_9)
5 ASP A 471
ASN A 472
VAL A 476
PHE A 509
ILE A 466
None
None
None
None
FMN  A1725 (-4.2A)
1.14A 3n23A-2wkpA:
undetectable
3n23A-2wkpA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1


(Avena sativa;
Homo sapiens)
PF00071
(Ras)
PF13426
(PAS_9)
5 ASP A 471
VAL A 476
PHE A 509
ILE A 466
ARG A 421
None
None
None
FMN  A1725 (-4.2A)
None
1.03A 3n23A-2wkpA:
undetectable
3n23A-2wkpA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Pisum sativum)
PF01652
(IF4E)
5 ASP A 142
VAL A 170
ALA A 108
PHE A 110
PHE A  61
None
1.35A 3n23A-2wmcA:
undetectable
3n23A-2wmcA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE


(Burkholderia
cepacia)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 VAL A  84
ALA A  83
PHE A  27
ILE A  82
ARG A  65
None
1.23A 3n23A-2y0eA:
undetectable
3n23A-2y0eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C


(Homo sapiens)
PF02373
(JmjC)
5 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
EMT  A3503 (-4.8A)
None
None
None
None
1.33A 3n23A-2ypdA:
undetectable
3n23A-2ypdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128)
no annotation 5 GLN A 699
PRO A 695
VAL A 739
ALA A 751
ILE A 741
None
1.42A 3n23A-3a0fA:
undetectable
3n23A-3a0fA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
5 ASP B 212
VAL B 278
ALA B 243
PHE B 160
THR B 237
None
1.29A 3n23A-3aqcB:
undetectable
3n23A-3aqcB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346


(Corynebacterium
diphtheriae)
PF08903
(DUF1846)
5 PRO A 212
ASN A 237
VAL A 333
ALA A 330
ILE A 306
None
1.27A 3n23A-3bh1A:
undetectable
3n23A-3bh1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE


(Trichormus
variabilis)
PF00881
(Nitroreductase)
5 PRO A 100
ASP A 187
VAL A 165
ALA A 232
ILE A 231
FMN  A 700 (-4.1A)
FMN  A 700 (-4.4A)
None
None
None
1.40A 3n23A-3eo7A:
undetectable
3n23A-3eo7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
5 GLN A 162
VAL A 225
PHE A 195
ILE A 184
ARG A 203
None
1.29A 3n23A-3hgoA:
undetectable
3n23A-3hgoA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II


(Escherichia
coli)
PF00294
(PfkB)
5 PRO A 166
ASP A 165
ALA A 263
PHE A 260
ARG A 227
None
ATP  A 900 ( 4.3A)
None
ATP  A 900 (-4.2A)
None
1.29A 3n23A-3iq0A:
3.7
3n23A-3iq0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kln TRANSCRIPTIONAL
REGULATOR, LUXR
FAMILY


(Vibrio cholerae)
PF00196
(GerE)
5 GLN A  92
VAL A  86
ALA A 106
ILE A 125
ARG A 134
None
1.18A 3n23A-3klnA:
undetectable
3n23A-3klnA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION


(Bartonella
henselae)
PF01230
(HIT)
5 PRO A  41
ASN A 132
VAL A  24
ALA A  32
ILE A  73
None
1.40A 3n23A-3lb5A:
undetectable
3n23A-3lb5A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN X  60
PRO X  59
ASP X  53
VAL X 123
ILE X 119
None
1.17A 3n23A-3nepX:
undetectable
3n23A-3nepX:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus)
PF02126
(PTE)
5 ALA A 167
PHE A 109
THR A  96
ILE A 144
ARG A 112
None
None
None
KCX  A 145 ( 4.1A)
None
1.28A 3n23A-3orwA:
undetectable
3n23A-3orwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0t UNCHARACTERIZED
PROTEIN


(Mycobacterium
avium)
PF01230
(HIT)
5 PRO A  32
VAL A  71
ALA A  70
THR A  38
ILE A  67
None
1.29A 3n23A-3p0tA:
undetectable
3n23A-3p0tA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 PRO A  75
ASP A  73
VAL A 270
ALA A 269
ILE A 313
None
1.32A 3n23A-3pocA:
undetectable
3n23A-3pocA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 ASP A 282
VAL A 272
ALA A 271
PHE A 128
PHE A 111
None
1.43A 3n23A-3q3uA:
undetectable
3n23A-3q3uA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)


(Sulfolobus
solfataricus)
PF01156
(IU_nuc_hydro)
5 ASP A   7
ASN A 126
ALA A 171
PHE A 162
ILE A 146
None
None
None
GOL  A 310 (-4.6A)
None
1.42A 3n23A-3t8iA:
4.5
3n23A-3t8iA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Thermotoga
maritima)
PF13458
(Peripla_BP_6)
5 ASP A 306
VAL A 132
ALA A 344
THR A 326
ILE A 338
None
1.34A 3n23A-3td9A:
3.3
3n23A-3td9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN


(Pseudomonas
aeruginosa)
PF13416
(SBP_bac_8)
5 PRO A 162
VAL A 235
ALA A 236
PHE A 175
ILE A 137
None
1.21A 3n23A-3ttlA:
undetectable
3n23A-3ttlA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ASN A  43
VAL A 178
ALA A 179
ILE A 241
ARG A 330
None
1.14A 3n23A-3uogA:
5.3
3n23A-3uogA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT


(Carboxydothermus
hydrogenoformans)
PF03599
(CdhD)
PF04060
(FeS)
5 GLN A 244
PRO A 232
ASP A 231
ALA A 132
ILE A 161
None
1.35A 3n23A-4c1nA:
undetectable
3n23A-4c1nA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 GLN A 588
PRO A 592
ALA A 299
PHE A 327
ILE A 615
None
1.34A 3n23A-4c30A:
undetectable
3n23A-4c30A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djt GTP-BINDING NUCLEAR
PROTEIN GSP1


(Encephalitozoon
cuniculi)
PF00071
(Ras)
5 ALA A 166
PHE A 162
PHE A 158
ILE A  57
ARG A  26
None
1.35A 3n23A-4djtA:
undetectable
3n23A-4djtA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME


(Aquifex
aeolicus;
Escherichia
virus T4)
PF00902
(TatC)
5 PRO A  42
VAL A  71
ALA A  70
PHE A 152
ILE A  67
None
1.28A 3n23A-4httA:
undetectable
3n23A-4httA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN


(Bacteroides
ovatus)
PF01833
(TIG)
5 VAL A 332
ALA A 319
PHE A 391
ILE A 310
ARG A 400
None
1.38A 3n23A-4hw6A:
undetectable
3n23A-4hw6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
5 ASP A 130
ALA A 186
PHE A 230
THR A 148
ILE A 152
None
None
GOL  A 503 ( 4.8A)
None
None
1.28A 3n23A-4maaA:
2.1
3n23A-4maaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  60
PRO A  59
ASP A  53
VAL A 123
ILE A 119
None
None
NAD  A 401 (-2.7A)
None
NAD  A 401 (-3.9A)
1.26A 3n23A-4nd4A:
undetectable
3n23A-4nd4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE


(Coxiella
burnetii)
PF00162
(PGK)
5 PRO A 168
ASP A 142
VAL A  57
ALA A 109
ILE A  59
None
1.24A 3n23A-4ng4A:
5.2
3n23A-4ng4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus)
PF07992
(Pyr_redox_2)
5 VAL A  16
ALA A  39
THR A  28
ILE A  18
ARG A  80
None
1.36A 3n23A-4ntcA:
undetectable
3n23A-4ntcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE


(Nicotiana
tabacum)
PF00145
(DNA_methylase)
5 PRO A 369
ASP A 368
VAL A 393
ALA A 392
ILE A 389
None
0.98A 3n23A-4onqA:
undetectable
3n23A-4onqA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Verminephrobacter
eiseniae)
PF03480
(DctP)
5 PRO A 105
ALA A 327
PHE A 323
PHE A 319
ILE A 331
None
1.34A 3n23A-4p9kA:
undetectable
3n23A-4p9kA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS


(Escherichia
coli)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
5 GLN A 127
ASP A 149
PHE A 298
PHE A 282
THR A 179
None
1.41A 3n23A-4pdxA:
undetectable
3n23A-4pdxA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)


(Streptococcus
parasanguinis)
PF08759
(GT-D)
5 GLN A  57
ASP A 210
ALA A 176
PHE A 177
ILE A 183
None
None
UDP  A 301 (-3.3A)
None
None
1.38A 3n23A-4phsA:
undetectable
3n23A-4phsA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE


(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  46
PRO A  45
ASP A  39
VAL A 113
ILE A 109
None
None
NAI  A 401 (-2.2A)
None
NAI  A 401 (-3.7A)
1.20A 3n23A-4plfA:
undetectable
3n23A-4plfA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  42
PRO A  41
ASP A  35
VAL A 104
ILE A 100
None
None
NAI  A 403 (-2.8A)
None
NAI  A 403 (-3.7A)
1.17A 3n23A-4plhA:
undetectable
3n23A-4plhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Acinetobacter
baumannii)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 GLN A  11
VAL A 158
ALA A 132
THR A  26
ILE A  22
None
1.35A 3n23A-4zn6A:
undetectable
3n23A-4zn6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT


(Sulfurisphaera
tokodaii)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 GLN A 562
PRO A 662
ASP A 381
ILE A 412
ARG A 485
None
1.27A 3n23A-4zohA:
undetectable
3n23A-4zohA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00478
(IMPDH)
5 ASP A 337
ASN A 276
VAL A 245
ILE A  69
ARG A 456
IMP  A 501 (-2.6A)
IMP  A 501 ( 4.3A)
None
None
None
1.21A 3n23A-5ahmA:
undetectable
3n23A-5ahmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN


([Candida]
glabrata)
PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central)
5 GLN A 184
PRO A 182
VAL A 562
ALA A 563
ILE A 586
None
1.41A 3n23A-5d0fA:
undetectable
3n23A-5d0fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN


([Candida]
glabrata)
PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central)
5 VAL A1365
PHE A1360
PHE A1356
ILE A1362
ARG A1337
None
1.41A 3n23A-5d0fA:
undetectable
3n23A-5d0fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dju NPH1-2

(Avena sativa)
PF13426
(PAS_9)
5 ASP A 471
ASN A 472
VAL A 476
PHE A 509
ILE A 466
None
None
None
None
FMN  A 601 ( 4.4A)
1.18A 3n23A-5djuA:
undetectable
3n23A-5djuA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dju NPH1-2

(Avena sativa)
PF13426
(PAS_9)
5 ASP A 471
VAL A 476
PHE A 509
ILE A 466
ARG A 421
None
None
None
FMN  A 601 ( 4.4A)
None
1.13A 3n23A-5djuA:
undetectable
3n23A-5djuA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae)
PF00463
(ICL)
5 ASP A 323
ASN A 326
VAL A 362
ALA A 357
ILE A 365
None
1.25A 3n23A-5e9gA:
undetectable
3n23A-5e9gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
5 VAL L  16
ALA L  15
PHE L 126
THR L  44
ILE L  34
None
1.31A 3n23A-5fmgL:
undetectable
3n23A-5fmgL:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C


(Homo sapiens)
PF02373
(JmjC)
5 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
None
1.36A 3n23A-5fzoA:
undetectable
3n23A-5fzoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli)
PF04055
(Radical_SAM)
5 ASP A  34
VAL A  74
ALA A  75
ILE A  18
ARG A  25
None
1.11A 3n23A-5hr6A:
undetectable
3n23A-5hr6A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
5 PRO A  33
VAL A 260
ALA A 259
ILE A 220
ARG A  56
None
1.27A 3n23A-5hw3A:
undetectable
3n23A-5hw3A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1


(Avena sativa;
Homo sapiens)
PF00071
(Ras)
PF13426
(PAS_9)
5 ASP A 118
ASN A 119
VAL A 123
PHE A 156
ILE A 113
None
None
None
FMN  A 402 (-4.9A)
FMN  A 402 (-4.3A)
1.20A 3n23A-5hzhA:
undetectable
3n23A-5hzhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1


(Avena sativa;
Homo sapiens)
PF00071
(Ras)
PF13426
(PAS_9)
5 ASP A 118
VAL A 123
PHE A 156
ILE A 113
ARG A  68
None
None
FMN  A 402 (-4.9A)
FMN  A 402 (-4.3A)
None
1.35A 3n23A-5hzhA:
undetectable
3n23A-5hzhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1


(Avena sativa;
Homo sapiens)
PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13)
5 ASP B1376
ASN B1377
VAL B1381
PHE B1414
ILE B1371
None
None
None
FMN  B1801 (-4.8A)
FMN  B1801 (-4.1A)
1.25A 3n23A-5hzkB:
undetectable
3n23A-5hzkB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1


(Avena sativa;
Homo sapiens)
PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13)
5 ASP B1376
VAL B1381
PHE B1414
ILE B1371
ARG B1326
None
None
FMN  B1801 (-4.8A)
FMN  B1801 (-4.1A)
None
1.31A 3n23A-5hzkB:
undetectable
3n23A-5hzkB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 GLN A 650
ASP A 526
ASN A 654
PHE A 482
ILE B1011
None
1.14A 3n23A-5ip9A:
undetectable
3n23A-5ip9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
5 ASN A  93
VAL A  82
ALA A  81
THR A  34
ILE A  78
None
1.14A 3n23A-5jh8A:
undetectable
3n23A-5jh8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Vibrio
vulnificus)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 GLN A   2
VAL A 149
ALA A 123
THR A  17
ILE A  13
None
1.26A 3n23A-5ks1A:
undetectable
3n23A-5ks1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 GLN A1620
VAL A1695
ALA A1611
THR A1598
ILE A1602
None
1.42A 3n23A-5m59A:
undetectable
3n23A-5m59A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE


(Nocardia
iowensis)
PF00501
(AMP-binding)
5 GLN A  11
VAL A  24
ALA A  27
THR A 338
ILE A 291
None
1.21A 3n23A-5mscA:
3.3
3n23A-5mscA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN


(Azotobacter
vinelandii)
no annotation 5 GLN E 181
ASP E 244
ASN E 247
ALA E 176
ILE E 173
None
1.40A 3n23A-5n6yE:
undetectable
3n23A-5n6yE:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 5 GLN A 176
ALA A 358
PHE A 320
THR A 390
ILE A 391
None
ANN  A 601 ( 4.9A)
None
None
ANN  A 601 (-3.9A)
1.43A 3n23A-5oc1A:
undetectable
3n23A-5oc1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 GLN A  41
PRO A  40
ASP A  34
VAL A 103
ALA A 102
None
1.03A 3n23A-5ulvA:
undetectable
3n23A-5ulvA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ASP A 158
ASN A 159
ALA A 424
THR A 417
ILE A 415
None
1.41A 3n23A-5wroA:
undetectable
3n23A-5wroA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Acinetobacter
baumannii)
no annotation 5 GLN A 152
PRO A 144
ASN A 108
VAL A 576
ALA A 575
None
1.37A 3n23A-5ws4A:
undetectable
3n23A-5ws4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuf PUTATIVE MEMBRANE
PROTEIN


(Colwellia
psychrerythraea)
PF03458
(UPF0126)
5 VAL A  13
ALA A  42
THR A  72
ILE A  69
ARG A  26
None
1.39A 3n23A-5wufA:
undetectable
3n23A-5wufA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbc NSP1 PROTEIN

(Porcine
epidemic
diarrhea virus)
no annotation 5 ASP A  50
VAL A  44
ALA A  10
THR A  51
ILE A  15
None
1.25A 3n23A-5xbcA:
undetectable
3n23A-5xbcA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe3 ENDORIBONUCLEASE
MAZF4


(Mycobacterium
tuberculosis)
no annotation 5 PRO C  56
ASP C  58
VAL C  64
THR C  88
ILE C  92
None
1.33A 3n23A-5xe3C:
undetectable
3n23A-5xe3C:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICB

(Streptococcus
pneumoniae)
no annotation 5 GLN A  34
ASP A  12
PHE A  86
PHE A  80
THR A  89
None
1.41A 3n23A-5yrzA:
undetectable
3n23A-5yrzA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
no annotation 5 GLN A 789
PRO A 790
ASP A 791
THR A 692
ILE A 691
None
0.93A 3n23A-5ywzA:
undetectable
3n23A-5ywzA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens)
no annotation 5 ASP A 192
ALA A 153
THR A 190
ILE A 177
ARG A 197
None
1.28A 3n23A-6b0tA:
undetectable
3n23A-6b0tA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri)
no annotation 5 ASN A 211
VAL A 205
PHE A 144
THR A 126
ARG A 462
None
1.39A 3n23A-6byiA:
undetectable
3n23A-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT


(Methylomicrobium
alcaliphilum)
no annotation 5 PRO A 280
ALA A 315
PHE A 392
PHE A  50
ILE A 394
None
1.32A 3n23A-6cxhA:
undetectable
3n23A-6cxhA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2


(Danio rerio)
no annotation 5 GLN A  74
ASP A 107
VAL A 104
PHE A 130
ILE A 315
None
1.33A 3n23A-6d21A:
undetectable
3n23A-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 PRO C 159
ASP C 155
VAL C 179
ALA C 180
THR C 149
None
1.37A 3n23A-6fkhC:
undetectable
3n23A-6fkhC:
6.51