SIMILAR PATTERNS OF AMINO ACIDS FOR 3MZE_A_CFXA364_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cic PROTEIN (IG HEAVY
CHAIN V REGIONS)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 165
SER B 164
HIS B 168
 None
 0.79A 3mzeA-1cicB:
0.0		 3mzeA-1cicB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		3 SER A  30
SER A  13
HIS A  64
 None
VO3  A1001 ( 4.1A)
None
 0.76A 3mzeA-1e59A:
0.0		 3mzeA-1e59A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 SER C 359
SER C 360
HIS C 332
 None
 0.85A 3mzeA-1ea9C:
0.1		 3mzeA-1ea9C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 SER A 340
SER A 366
HIS A 335
 None
None
FE2  A1001 (-3.4A)
 0.85A 3mzeA-1ey2A:
0.1		 3mzeA-1ey2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fig IGG1-KAPPA 1F7 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 168
SER H 167
HIS H 172
 None
 0.68A 3mzeA-1figH:
0.0		 3mzeA-1figH:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 SER A 924
SER A 922
HIS A 434
 None
 0.59A 3mzeA-1hwwA:
0.0		 3mzeA-1hwwA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 SER A   6
SER A   5
HIS A 356
 None
 0.70A 3mzeA-1ms8A:
2.2		 3mzeA-1ms8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 SER A   6
SER A   5
HIS A 357
 None
 0.68A 3mzeA-1mz5A:
2.4		 3mzeA-1mz5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rso PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Rattus
norvegicus) 		PF02828
(L27) 		3 SER B 106
SER B 105
HIS B 114
 None
 0.84A 3mzeA-1rsoB:
undetectable		 3mzeA-1rsoB:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s05 CYTOCHROME C-556

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		3 SER A  71
SER A  72
HIS A 121
 HEM  A 130 (-4.3A)
None
HEM  A 130 (-3.6A)
 0.79A 3mzeA-1s05A:
0.0		 3mzeA-1s05A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		3 SER A  42
SER A  43
HIS A  38
 None
 0.80A 3mzeA-1sjiA:
undetectable		 3mzeA-1sjiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		3 SER A 338
SER A 337
HIS A 323
 None
 0.85A 3mzeA-1sujA:
undetectable		 3mzeA-1sujA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wig KIAA1808 PROTEIN

(Homo sapiens) 		PF00412
(LIM) 		3 SER A   5
SER A   6
HIS A  28
 None
None
ZN  A 201 (-3.2A)
 0.85A 3mzeA-1wigA:
undetectable		 3mzeA-1wigA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 SER A 585
SER A 584
HIS A 221
 None
 0.85A 3mzeA-2e8yA:
undetectable		 3mzeA-2e8yA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 SER A 651
SER A 643
HIS A 583
 None
 0.53A 3mzeA-2f3oA:
undetectable		 3mzeA-2f3oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		3 SER A  59
SER A  60
HIS A  66
 None
 0.82A 3mzeA-2im9A:
undetectable		 3mzeA-2im9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'

(Homo sapiens) 		PF03095
(PTPA) 		3 SER A 224
SER A 225
HIS A 230
 None
 0.75A 3mzeA-2ixmA:
undetectable		 3mzeA-2ixmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 171
SER A 170
HIS A 175
 None
 0.66A 3mzeA-2jbrA:
0.9		 3mzeA-2jbrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 220
SER A 170
HIS A 175
 None
 0.73A 3mzeA-2jbrA:
0.9		 3mzeA-2jbrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kw7 CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		PF04536
(TPM_phosphatase) 		3 SER A  45
SER A  46
HIS A 155
 None
 0.66A 3mzeA-2kw7A:
undetectable		 3mzeA-2kw7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8e SLEEPING BEAUTY
TRANSPOSASE

(synthetic
construct) 		PF13384
(HTH_23) 		3 SER A  26
SER A  25
HIS A  21
 None
 0.63A 3mzeA-2m8eA:
undetectable		 3mzeA-2m8eA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		3 SER A 135
SER A 134
HIS A 139
 None
 0.69A 3mzeA-2or0A:
undetectable		 3mzeA-2or0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		3 SER A 188
SER A 134
HIS A 139
 None
 0.77A 3mzeA-2or0A:
undetectable		 3mzeA-2or0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 140
SER A 139
HIS A 144
 None
 0.69A 3mzeA-2rfqA:
undetectable		 3mzeA-2rfqA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 189
SER A 139
HIS A 144
 None
 0.80A 3mzeA-2rfqA:
undetectable		 3mzeA-2rfqA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsy PHOSPHOPROTEIN
ASSOCIATED WITH
GLYCOSPHINGOLIPID-EN
RICHED MICRODOMAINS
1
TYROSINE-PROTEIN
KINASE CSK

(Rattus
norvegicus) 		PF00017
(SH2)
PF15347
(PAG) 		3 SER B 293
SER B 292
HIS A 128
 None
 0.71A 3mzeA-2rsyB:
undetectable		 3mzeA-2rsyB:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		3 SER A 735
SER A 734
HIS A 729
 None
 0.79A 3mzeA-2vdwA:
undetectable		 3mzeA-2vdwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		3 SER A 203
SER A 202
HIS A 193
 None
None
FE  A 402 (-2.9A)
 0.65A 3mzeA-2vunA:
undetectable		 3mzeA-2vunA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wx3 MRNA-DECAPPING
ENZYME 1A

(Homo sapiens) 		PF16741
(mRNA_decap_C) 		3 SER A 559
SER A 560
HIS A 566
 None
 0.71A 3mzeA-2wx3A:
undetectable		 3mzeA-2wx3A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		3 SER A 309
SER A 310
HIS A 386
 None
 0.74A 3mzeA-2xfbA:
undetectable		 3mzeA-2xfbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		3 SER A 994
SER A 993
HIS A 594
 None
 0.81A 3mzeA-2ya1A:
undetectable		 3mzeA-2ya1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 SER A 539
SER A 538
HIS A 139
 None
 0.80A 3mzeA-2ya2A:
undetectable		 3mzeA-2ya2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		3 SER A 227
SER A 228
HIS A 371
 None
 0.82A 3mzeA-2z23A:
undetectable		 3mzeA-2z23A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 143
SER A 142
HIS A 147
 None
 0.70A 3mzeA-3afeA:
undetectable		 3mzeA-3afeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 SER A 192
SER A 142
HIS A 147
 None
 0.71A 3mzeA-3afeA:
undetectable		 3mzeA-3afeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al5 JMJC
DOMAIN-CONTAINING
PROTEIN C2ORF60

(Homo sapiens) 		PF13621
(Cupin_8) 		3 SER A 151
SER A 152
HIS A  61
 None
 0.84A 3mzeA-3al5A:
undetectable		 3mzeA-3al5A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		3 SER A 356
SER A 357
HIS A 128
 None
 0.64A 3mzeA-3e0jA:
undetectable		 3mzeA-3e0jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 SER A 238
SER A 237
HIS A  44
 None
 0.69A 3mzeA-3e77A:
undetectable		 3mzeA-3e77A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 SER A  84
SER A  83
HIS A 113
 None
 0.82A 3mzeA-3egoA:
undetectable		 3mzeA-3egoA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1r FIBROBLAST GROWTH
FACTOR 20

(Homo sapiens) 		PF00167
(FGF) 		3 SER A 152
SER A 153
HIS A 158
 None
 0.85A 3mzeA-3f1rA:
undetectable		 3mzeA-3f1rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 SER P 187
SER P 188
HIS P 194
 None
 0.72A 3mzeA-3fg2P:
undetectable		 3mzeA-3fg2P:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1

(Escherichia
coli) 		PF13246
(Cation_ATPase) 		3 SER A 432
SER A 429
HIS A 408
 None
 0.70A 3mzeA-3gwiA:
undetectable		 3mzeA-3gwiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		3 SER A1527
SER A1583
HIS A1538
 None
 0.74A 3mzeA-3hrrA:
0.9		 3mzeA-3hrrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		3 SER L 111
SER L 112
HIS L 131
 None
 0.73A 3mzeA-3jb9L:
undetectable		 3mzeA-3jb9L:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		3 SER A 531
SER A 532
HIS A 201
 None
None
FAD  A 541 (-4.2A)
 0.82A 3mzeA-3js8A:
undetectable		 3mzeA-3js8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 SER A 327
SER A 328
HIS A 334
 None
 0.55A 3mzeA-3lg5A:
undetectable		 3mzeA-3lg5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln6 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Streptococcus
agalactiae) 		PF01071
(GARS_A)
PF04262
(Glu_cys_ligase) 		3 SER A 141
SER A 102
HIS A 144
 None
 0.84A 3mzeA-3ln6A:
undetectable		 3mzeA-3ln6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1i EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		3 SER A 146
SER A 145
HIS A  57
 None
 0.60A 3mzeA-3p1iA:
undetectable		 3mzeA-3p1iA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		3 SER A 130
SER A 131
HIS A 137
 None
 0.80A 3mzeA-3qa8A:
undetectable		 3mzeA-3qa8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum FAB 5D5A5 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 162
SER B 161
HIS B 165
 None
 0.52A 3mzeA-3qumB:
1.9		 3mzeA-3qumB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sog AMPHIPHYSIN

(Homo sapiens) 		PF03114
(BAR) 		3 SER A 210
SER A 211
HIS A 217
 None
 0.66A 3mzeA-3sogA:
undetectable		 3mzeA-3sogA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 SER A 265
SER A 266
HIS A 343
 None
 0.63A 3mzeA-3t5oA:
undetectable		 3mzeA-3t5oA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		3 SER A 219
SER A 213
HIS A 246
 None
 0.81A 3mzeA-3ti7A:
undetectable		 3mzeA-3ti7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		3 SER A  80
SER A  81
HIS A 378
 None
 0.81A 3mzeA-3zdnA:
undetectable		 3mzeA-3zdnA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 SER A 180
SER A 205
HIS A 183
 None
 0.79A 3mzeA-4b3gA:
undetectable		 3mzeA-4b3gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		3 SER A  52
SER A  19
HIS A  56
 None
 0.65A 3mzeA-4b3kA:
undetectable		 3mzeA-4b3kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		3 SER A 257
SER A 258
HIS A 163
 None
 0.84A 3mzeA-4c4aA:
undetectable		 3mzeA-4c4aA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		3 SER A 401
SER A 399
HIS A 242
 None
 0.77A 3mzeA-4cylA:
undetectable		 3mzeA-4cylA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 154
SER A  72
HIS A  40
 None
 0.81A 3mzeA-4d9rA:
undetectable		 3mzeA-4d9rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 SER A 634
SER A 632
HIS A 597
 None
 0.81A 3mzeA-4fyeA:
2.3		 3mzeA-4fyeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		3 SER A 225
SER A 226
HIS A  37
 10D  A 402 (-2.4A)
10D  A 402 (-4.3A)
None
 0.70A 3mzeA-4h4cA:
undetectable		 3mzeA-4h4cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3y RAB GTPASE-BINDING
EFFECTOR PROTEIN 1

(Homo sapiens) 		PF09311
(Rab5-bind) 		3 SER B 588
SER B 589
HIS B 594
 None
 0.79A 3mzeA-4n3yB:
undetectable		 3mzeA-4n3yB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb9 AB64 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 161
SER H 160
HIS H 164
 None
 0.83A 3mzeA-4pb9H:
undetectable		 3mzeA-4pb9H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 160
SER H 159
HIS H 163
 None
 0.82A 3mzeA-4qexH:
undetectable		 3mzeA-4qexH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		3 SER A 198
SER A 199
HIS A 117
 None
 0.79A 3mzeA-4r7bA:
undetectable		 3mzeA-4r7bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		3 SER A  58
SER A 105
HIS A 219
 None
 0.81A 3mzeA-4r9zA:
2.2		 3mzeA-4r9zA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvc ABC TRANSPORTER
ATP-BINDING PROTEIN

(Geobacillus
kaustophilus) 		PF00005
(ABC_tran) 		3 SER A 130
SER A 129
HIS A  96
 None
 0.59A 3mzeA-4rvcA:
undetectable		 3mzeA-4rvcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 SER A 481
SER A 482
HIS A 400
 None
 0.76A 3mzeA-4txgA:
undetectable		 3mzeA-4txgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 170
SER B 169
HIS B 173
 None
 0.80A 3mzeA-4u1gB:
1.3		 3mzeA-4u1gB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 SER A 272
SER A 270
HIS A 218
 None
 0.84A 3mzeA-4uwaA:
undetectable		 3mzeA-4uwaA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 SER A 348
SER A 570
HIS A 194
 None
None
ZN  A 801 ( 3.3A)
 0.83A 3mzeA-4wgkA:
undetectable		 3mzeA-4wgkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		3 SER A 547
SER A 546
HIS A 153
 None
 0.81A 3mzeA-4wisA:
undetectable		 3mzeA-4wisA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 SER A 160
SER A 159
HIS A 140
 None
 0.84A 3mzeA-4wjsA:
undetectable		 3mzeA-4wjsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 3 SER A 569
SER A1018
HIS A 593
 None
 0.69A 3mzeA-4yhcA:
undetectable		 3mzeA-4yhcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Myxococcus
xanthus) 		PF00753
(Lactamase_B) 		3 SER A  12
SER A   9
HIS A  62
 None
 0.79A 3mzeA-4ysbA:
undetectable		 3mzeA-4ysbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 3 SER D 349
SER D 346
HIS D  29
 None
 0.73A 3mzeA-4zhsD:
undetectable		 3mzeA-4zhsD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		3 SER A 309
SER A 310
HIS A 386
 None
 0.78A 3mzeA-5anyA:
undetectable		 3mzeA-5anyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		3 SER A 114
SER A  91
HIS A  38
 SAH  A 303 ( 4.6A)
None
None
 0.78A 3mzeA-5bp9A:
undetectable		 3mzeA-5bp9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clr LEGK4

(Legionella
pneumophila) 		PF00069
(Pkinase) 		3 SER A 217
SER A 218
HIS A 187
 None
 0.76A 3mzeA-5clrA:
undetectable		 3mzeA-5clrA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 SER A  63
SER A  62
HIS A 118
 None
 0.74A 3mzeA-5demA:
undetectable		 3mzeA-5demA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		3 SER A 259
SER A 250
HIS A 262
 None
 0.84A 3mzeA-5dm3A:
undetectable		 3mzeA-5dm3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 SER A 201
SER A 200
HIS A 246
 None
 0.77A 3mzeA-5dqfA:
undetectable		 3mzeA-5dqfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		3 SER A 131
SER A 132
HIS A 234
 None
 0.72A 3mzeA-5f1yA:
undetectable		 3mzeA-5f1yA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		3 SER A  89
SER A  88
HIS A  93
 SO4  A 401 (-3.4A)
SO4  A 401 (-4.6A)
None
 0.81A 3mzeA-5lt1A:
undetectable		 3mzeA-5lt1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		3 SER A  78
SER A  77
HIS A  54
 None
 0.80A 3mzeA-5m0tA:
undetectable		 3mzeA-5m0tA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A 599
SER A 604
HIS A 612
 SO4  A 705 (-3.0A)
None
None
 0.62A 3mzeA-5myvA:
undetectable		 3mzeA-5myvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 3 SER A 254
SER A 252
HIS A 198
 None
 0.85A 3mzeA-5nfnA:
undetectable		 3mzeA-5nfnA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2d POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		no annotation 3 SER A1048
SER A1042
HIS A1091
 None
 0.85A 3mzeA-5o2dA:
undetectable		 3mzeA-5o2dA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v FAB 19/1786 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 168
SER H 167
HIS H 171
 None
 0.78A 3mzeA-5o6vH:
undetectable		 3mzeA-5o6vH:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v FAB 19/1786 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 185
SER H 186
HIS H 206
 None
 0.81A 3mzeA-5o6vH:
undetectable		 3mzeA-5o6vH:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 SER A 403
SER A 404
HIS A 355
 MAN  A 619 (-1.4A)
None
None
 0.82A 3mzeA-5t9tA:
undetectable		 3mzeA-5t9tA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 SER A 105
SER A 106
HIS A 235
 None
 0.72A 3mzeA-5tr7A:
41.3		 3mzeA-5tr7A:
58.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 SER A 689
SER A 688
HIS A 693
 None
 0.72A 3mzeA-5vocA:
undetectable		 3mzeA-5vocA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 3 SER A 349
SER A 348
HIS A 123
 None
 0.83A 3mzeA-5xncA:
undetectable		 3mzeA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0u -

(-) 		no annotation 3 SER A 275
SER A 274
HIS A 281
 None
None
ZN  A 401 (-3.2A)
 0.84A 3mzeA-5y0uA:
undetectable		 3mzeA-5y0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 3 SER A 856
SER A 857
HIS A 863
 None
 0.65A 3mzeA-5yudA:
undetectable		 3mzeA-5yudA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 SER 2 630
SER 2 648
HIS 2 656
 None
 0.85A 3mzeA-5zvs2:
undetectable		 3mzeA-5zvs2:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME BIOGENESIS
PROTEIN BRX1

(Saccharomyces
cerevisiae) 		no annotation 3 SER b  38
SER b  37
HIS b  94
 None
None
U  1 286 ( 4.0A)
 0.78A 3mzeA-6c0fb:
undetectable		 3mzeA-6c0fb:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 SER A 303
SER A 302
HIS A 110
 None
 0.57A 3mzeA-6czxA:
undetectable		 3mzeA-6czxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 SER D  99
SER D 130
HIS D 133
 None
 0.80A 3mzeA-6fkhD:
undetectable		 3mzeA-6fkhD:
18.65