SIMILAR PATTERNS OF AMINO ACIDS FOR 3MTE_B_SAMB220_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		5 ALA A 209
ALA A 206
LEU A 223
THR A 251
LEU A 250
 None
 1.04A 3mteB-1a80A:
undetectable		 3mteB-1a80A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
 None
 1.03A 3mteB-1c7tA:
undetectable		 3mteB-1c7tA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 ASN A 119
ALA A 267
ALA A 263
THR A 103
LEU A 102
 None
HEM  A 430 (-3.5A)
HEM  A 430 ( 4.9A)
HEM  A 430 (-4.3A)
HEM  A 430 (-3.6A)
 1.01A 3mteB-1cptA:
undetectable		 3mteB-1cptA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.00A 3mteB-1cu1A:
undetectable		 3mteB-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		5 GLY A 324
GLY A 329
ALA A 255
PHE A 333
LEU A 339
 None
 1.06A 3mteB-1ehkA:
undetectable		 3mteB-1ehkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.93A 3mteB-1epxA:
undetectable		 3mteB-1epxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.97A 3mteB-1f2jA:
undetectable		 3mteB-1f2jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 GLY A 363
GLY A 212
PRO A 207
ALA A 241
ALA A 242
 None
 1.05A 3mteB-1iayA:
undetectable		 3mteB-1iayA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 GLY A 105
GLY A  61
ALA A 102
ALA A  99
LEU A  63
 None
 1.04A 3mteB-1icpA:
undetectable		 3mteB-1icpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ASN A 351
PRO A 525
ALA A 519
ALA A 520
LEU A 136
 None
 0.98A 3mteB-1iq0A:
undetectable		 3mteB-1iq0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		6 GLY A  42
VAL A 110
ALA A 107
ALA A 104
LEU A  39
LEU A 164
 None
 1.17A 3mteB-1j0nA:
undetectable		 3mteB-1j0nA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		6 GLY A  43
VAL A 110
ALA A 107
ALA A 104
LEU A  39
LEU A 164
 None
 1.42A 3mteB-1j0nA:
undetectable		 3mteB-1j0nA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 GLY A  63
VAL A  60
ALA A  56
ALA A 426
GLU A 424
 None
 0.95A 3mteB-1js4A:
undetectable		 3mteB-1js4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		5 GLY A  62
VAL A  59
ALA A  55
ALA A 414
GLU A 412
 None
 0.93A 3mteB-1ks8A:
undetectable		 3mteB-1ks8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.01A 3mteB-1ns3A:
undetectable		 3mteB-1ns3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 GLY B 258
GLY B 237
ALA B 262
GLU B 193
LEU B 235
 None
 1.03A 3mteB-1sb3B:
undetectable		 3mteB-1sb3B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjl DNAK SUPPRESSOR
PROTEIN

(Escherichia
coli) 		PF01258
(zf-dskA_traR) 		5 GLY A 112
VAL A 119
ALA A 132
LEU A  37
LEU A 126
 None
 0.93A 3mteB-1tjlA:
undetectable		 3mteB-1tjlA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN
EMS16 B CHAIN

(Echis
multisquamatus;
Echis
multisquamatus) 		PF00059
(Lectin_C)
PF00059
(Lectin_C) 		5 GLY A  71
ALA B  88
PHE A 127
THR A 108
LEU A 107
 None
 0.96A 3mteB-1ukmA:
undetectable		 3mteB-1ukmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 GLY A 268
ALA A 276
ALA A 325
LEU A 307
LEU A 314
 None
 1.06A 3mteB-1vcgA:
undetectable		 3mteB-1vcgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		6 GLY A  43
GLY A  45
PRO A  61
ALA A  81
GLU A  82
PHE A  49
 NA  A 300 (-4.1A)
None
None
None
None
None
 1.16A 3mteB-1vlmA:
9.9		 3mteB-1vlmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 241
GLU A 337
LEU A 239
THR A 246
LEU A 245
 None
 1.05A 3mteB-1xapA:
undetectable		 3mteB-1xapA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		5 ASN A 288
VAL A  36
ALA A  41
ALA A  44
LEU A  20
 None
 0.93A 3mteB-1xknA:
undetectable		 3mteB-1xknA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 GLY A 101
GLY A 103
PRO A 124
VAL A 125
GLU A 150
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
 0.33A 3mteB-1xtpA:
9.9		 3mteB-1xtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 254
GLY A 260
ASN A 262
ALA A 286
LEU A 293
 None
 0.86A 3mteB-1yfmA:
undetectable		 3mteB-1yfmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		6 GLY A  50
GLY A  52
PRO A  72
ALA A  93
GLU A  94
LEU A 109
 SAI  A1300 (-3.5A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.2A)
SAI  A1300 (-3.5A)
SAI  A1300 (-3.0A)
SAI  A1300 (-4.7A)
 0.70A 3mteB-2avnA:
10.5		 3mteB-2avnA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 GLY A 326
GLY A 331
ASN A 309
ALA A   9
THR A 152
 None
None
None
None
PLP  A1361 (-2.7A)
 1.05A 3mteB-2bi3A:
undetectable		 3mteB-2bi3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 GLY A1094
VAL A1107
ALA A1197
ALA A1196
LEU A1042
 None
 0.98A 3mteB-2bjiA:
undetectable		 3mteB-2bjiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A   8
GLY A  13
PHE A  60
THR A  65
LEU A  63
 NDP  A1302 (-3.4A)
None
None
None
NDP  A1302 (-4.2A)
 1.05A 3mteB-2cvzA:
3.1		 3mteB-2cvzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		5 VAL A 253
ALA A 248
ALA A 245
THR A 166
LEU A 164
 None
 1.03A 3mteB-2cygA:
undetectable		 3mteB-2cygA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		6 GLY X 115
ALA X  82
ALA X 397
LEU X 111
PHE X 119
LEU X  87
 None
SO4  X 740 ( 4.0A)
None
None
None
None
 1.36A 3mteB-2epkX:
undetectable		 3mteB-2epkX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fus FUMARASE C

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 229
GLY A 235
ASN A 237
ALA A 261
LEU A 268
 None
 1.03A 3mteB-2fusA:
undetectable		 3mteB-2fusA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 GLY A  45
GLY A  47
PRO A  65
GLU A  88
PHE A 103
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-4.5A)
 0.85A 3mteB-2gs9A:
9.1		 3mteB-2gs9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 157
GLY A 283
ALA A 162
LEU A 134
THR A 226
 None
 1.05A 3mteB-2hjrA:
4.5		 3mteB-2hjrA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hn1 MAGNESIUM AND COBALT
TRANSPORTER

(Archaeoglobus
fulgidus) 		PF01544
(CorA) 		5 GLY A  49
GLU A 142
LEU A  51
PHE A  84
THR A 140
 None
 1.00A 3mteB-2hn1A:
undetectable		 3mteB-2hn1A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.02A 3mteB-2i7nA:
undetectable		 3mteB-2i7nA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		6 GLY A 113
VAL A  65
ALA A 121
ALA A 122
LEU A  14
LEU A 119
 None
 1.50A 3mteB-2o3iA:
undetectable		 3mteB-2o3iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 GLY A  79
GLY A  47
ALA A  84
ALA A 105
LEU A  77
 ATP  A 281 (-3.2A)
ATP  A 281 (-3.1A)
None
None
None
 0.94A 3mteB-2ogxA:
2.7		 3mteB-2ogxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 GLY A 311
GLY A 313
ALA A 291
LEU A 344
THR A 338
 None
 1.06A 3mteB-2qneA:
undetectable		 3mteB-2qneA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 GLY A 178
GLY A 124
ALA A 310
THR A 241
LEU A 240
 None
 0.93A 3mteB-2x4gA:
4.1		 3mteB-2x4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.00A 3mteB-2yneA:
undetectable		 3mteB-2yneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 ALA A 249
LEU A 236
PHE A 237
THR A 245
LEU A 242
 None
 1.02A 3mteB-2zq5A:
undetectable		 3mteB-2zq5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.03A 3mteB-3b40A:
undetectable		 3mteB-3b40A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		5 GLY A  54
GLY A  56
ALA A 111
LEU A 130
PHE A 131
 GOL  A 302 ( 3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.8A)
SAM  A 301 (-4.8A)
 0.77A 3mteB-3ckkA:
13.6		 3mteB-3ckkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		5 GLY A 165
VAL A 115
ALA A 143
GLU A 146
LEU A 155
 None
None
None
CIT  A 302 (-3.4A)
None
 1.06A 3mteB-3cswA:
undetectable		 3mteB-3cswA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		5 GLY A 227
PRO A 237
PHE A 258
THR A 270
LEU A 271
 None
 1.06A 3mteB-3cx3A:
undetectable		 3mteB-3cx3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 5 ALA O 216
LEU O 312
PHE O 297
THR O 156
LEU O 159
 None
None
None
SO4  O6921 (-4.8A)
None
 1.05A 3mteB-3e6aO:
undetectable		 3mteB-3e6aO:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 GLY A  41
GLY A  43
PRO A  63
ALA A  84
GLU A  85
 EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
EDO  A 261 ( 4.9A)
None
None
 0.75A 3mteB-3egeA:
10.3		 3mteB-3egeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etn PUTATIVE
PHOSPHOSUGAR
ISOMERASE INVOLVED
IN CAPSULE FORMATION

(Bacteroides
fragilis) 		PF01380
(SIS) 		5 GLY A 124
PRO A 143
ALA A  15
LEU A 138
THR A 158
 None
 1.06A 3mteB-3etnA:
undetectable		 3mteB-3etnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 GLY C 284
ALA C 263
ALA C 245
THR C 393
LEU C 392
 GLY  C 284 ( 0.0A)
ALA  C 263 ( 0.0A)
ALA  C 245 ( 0.0A)
THR  C 393 ( 0.8A)
LEU  C 392 ( 0.5A)
 1.02A 3mteB-3ghgC:
undetectable		 3mteB-3ghgC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		6 GLY A 236
PRO A 198
VAL A 199
ALA A 230
ALA A 257
LEU A 244
 None
 1.20A 3mteB-3i4jA:
undetectable		 3mteB-3i4jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		5 GLY A 225
GLY A 252
VAL A 228
ALA A 318
PHE A 424
 None
 0.95A 3mteB-3ij3A:
undetectable		 3mteB-3ij3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
MYA  A1001 (-4.1A)
None
None
 1.04A 3mteB-3iu1A:
undetectable		 3mteB-3iu1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 GLY A 105
ALA A 113
ALA A 114
THR A 124
LEU A 111
 None
None
None
EDO  A  17 (-3.8A)
None
 1.04A 3mteB-3k11A:
undetectable		 3mteB-3k11A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 5 GLY B 362
PRO B 365
PHE B 356
THR B 349
LEU B 350
 None
None
None
AU  B 391 (-4.4A)
None
 1.04A 3mteB-3k1lB:
undetectable		 3mteB-3k1lB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 1.01A 3mteB-3ltjA:
undetectable		 3mteB-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 1.03A 3mteB-3ltjA:
undetectable		 3mteB-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 1.03A 3mteB-3ltmA:
undetectable		 3mteB-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 VAL A  33
ALA A 301
LEU A 347
THR A 326
LEU A 327
 None
 0.98A 3mteB-3mpnA:
undetectable		 3mteB-3mpnA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
ALA A  87
GLU A  88
LEU A 102
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
SAH  A 216 (-3.5A)
SAH  A 216 (-2.9A)
SAH  A 216 (-4.6A)
SAH  A 216 (-4.0A)
 0.37A 3mteB-3mq2A:
28.5		 3mteB-3mq2A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		5 GLY A 326
GLY A 305
LEU A 307
THR A 249
LEU A 250
 None
 0.99A 3mteB-3na6A:
undetectable		 3mteB-3na6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 5 GLY A 788
GLY A 786
VAL A 781
ALA A 790
LEU A 757
 GOL  A 101 ( 3.8A)
GOL  A 101 (-4.4A)
GOL  A 103 (-3.7A)
None
None
 1.05A 3mteB-3p06A:
undetectable		 3mteB-3p06A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 GLY A 168
ALA A 105
ALA A 106
LEU A 172
LEU A 128
 None
 1.06A 3mteB-3peaA:
undetectable		 3mteB-3peaA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
 None
 1.00A 3mteB-3pkoA:
undetectable		 3mteB-3pkoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 GLY A1609
ALA A1661
GLU A1660
THR A1656
LEU A1657
 None
 0.95A 3mteB-3ppxA:
undetectable		 3mteB-3ppxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 GLY A1609
GLU A1660
PHE A1514
THR A1656
LEU A1657
 None
 0.96A 3mteB-3ppxA:
undetectable		 3mteB-3ppxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		5 GLY A 111
GLY A  95
ALA A  59
ALA A  60
LEU A 116
 None
 1.03A 3mteB-3qbwA:
undetectable		 3mteB-3qbwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.93A 3mteB-3srzA:
undetectable		 3mteB-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		5 VAL A  30
ALA A 245
ALA A 246
THR A   8
LEU A   9
 None
 0.89A 3mteB-3u0hA:
undetectable		 3mteB-3u0hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.97A 3mteB-3u5tA:
5.9		 3mteB-3u5tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		6 GLY A 823
GLY A 820
ALA A 794
ALA A 797
LEU A 855
LEU A 826
 None
 1.35A 3mteB-3un9A:
undetectable		 3mteB-3un9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		5 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 1.01A 3mteB-3uoeA:
undetectable		 3mteB-3uoeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 GLY A 672
ALA A 597
LEU A 669
PHE A 636
LEU A 676
 None
 1.06A 3mteB-3ut2A:
undetectable		 3mteB-3ut2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 GLY A 257
ALA A 190
ALA A 191
LEU A 252
LEU A 215
 BTB  A 401 ( 4.9A)
None
None
None
None
 1.06A 3mteB-3uwdA:
2.2		 3mteB-3uwdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 GLY A  82
VAL A  79
ALA A  75
ALA A 433
GLU A 431
 None
None
TRS  A 503 ( 4.7A)
None
GOL  A 505 ( 3.1A)
 0.98A 3mteB-3wc3A:
undetectable		 3mteB-3wc3A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis) 		PF01758
(SBF) 		5 GLY A  73
ALA A 243
ALA A 244
THR A 258
LEU A 257
 None
None
None
PTY  A1319 (-4.0A)
None
 1.03A 3mteB-3zuyA:
undetectable		 3mteB-3zuyA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 GLY A  79
ALA A  60
ALA A  70
THR A 408
LEU A 407
 None
GOL  A1436 ( 3.7A)
GOL  A1436 (-3.8A)
GOL  A1436 ( 4.8A)
None
 1.06A 3mteB-4aoaA:
undetectable		 3mteB-4aoaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		5 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.97A 3mteB-4as5A:
undetectable		 3mteB-4as5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.03A 3mteB-4c2xA:
undetectable		 3mteB-4c2xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 GLY A 618
VAL A 545
ALA A 666
ALA A 667
PHE A 623
 None
None
None
NAG  A1542 (-3.6A)
None
 1.06A 3mteB-4ccdA:
undetectable		 3mteB-4ccdA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
GLY A 121
VAL A 151
ALA A 159
ALA A 138
 None
 1.02A 3mteB-4d9iA:
undetectable		 3mteB-4d9iA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		5 GLY A  49
GLY A  57
LEU A  51
PHE A 183
LEU A 107
 None
 1.00A 3mteB-4dveA:
undetectable		 3mteB-4dveA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 ALA A 102
ALA A  99
PHE A   6
THR A 229
LEU A 228
 None
 0.96A 3mteB-4eelA:
undetectable		 3mteB-4eelA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 GLY A  79
GLY A  47
ALA A  84
ALA A 105
LEU A  77
 ATP  A 301 (-3.2A)
ATP  A 301 (-3.1A)
None
None
None
 0.96A 3mteB-4f6tA:
2.6		 3mteB-4f6tA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		6 GLY A 272
GLY A 274
ALA A 267
LEU A 244
PHE A 279
LEU A 362
 None
 1.32A 3mteB-4fgwA:
3.6		 3mteB-4fgwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 GLY A 203
VAL A 234
LEU A 509
THR A 211
LEU A 212
 None
 1.05A 3mteB-4fj6A:
undetectable		 3mteB-4fj6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF00361
(Proton_antipo_M) 		5 ALA M 395
ALA M 392
PHE L 169
THR M 380
LEU M 381
 None
 0.96A 3mteB-4heaM:
undetectable		 3mteB-4heaM:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 239
GLY A 245
ASN A 247
ALA A 271
LEU A 278
 None
 1.03A 3mteB-4hgvA:
undetectable		 3mteB-4hgvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 GLY A 171
GLY A 199
ALA A 280
LEU A 173
LEU A 203
 None
 0.98A 3mteB-4jn6A:
undetectable		 3mteB-4jn6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw2 A3 ARTIFICIAL
PROTEIN

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A  39
GLY A  42
VAL A  47
ALA A  65
ALA A  64
 None
 1.01A 3mteB-4jw2A:
undetectable		 3mteB-4jw2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 GLY A 148
GLY A 144
ALA A 191
ALA A 192
LEU A 189
 None
 1.05A 3mteB-4kzkA:
2.5		 3mteB-4kzkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf0 ALIPHATIC AMIDASE

(Bacillus sp.
(in: Bacteria)) 		PF00795
(CN_hydrolase) 		5 GLY A  64
ALA A  76
ALA A  77
PHE A  57
LEU A 102
 None
 0.98A 3mteB-4lf0A:
undetectable		 3mteB-4lf0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		5 GLY A 243
GLY A 247
ALA A 241
PHE A 270
LEU A 272
 None
 1.04A 3mteB-4lg9A:
undetectable		 3mteB-4lg9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 GLY A 194
GLY A 217
ASN A 222
VAL A 191
LEU A 236
 ADP  A 402 (-2.9A)
None
ADP  A 402 (-3.9A)
None
ADP  A 402 ( 4.2A)
 1.04A 3mteB-4ng4A:
3.2		 3mteB-4ng4A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		8 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  85
LEU Y 104
PHE Y 105
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
None
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
 1.49A 3mteB-4ox9Y:
34.2		 3mteB-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		12 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  86
ALA Y  87
GLU Y  88
LEU Y 104
PHE Y 105
THR Y 109
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
 0.65A 3mteB-4ox9Y:
34.2		 3mteB-4ox9Y:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLY A 101
GLY A  97
ASN A  95
ALA A 233
ALA A 236
 None
 1.00A 3mteB-4psdA:
undetectable		 3mteB-4psdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLY A 278
GLY A 276
ALA A 232
THR A 239
LEU A 237
 None
 1.04A 3mteB-4pzcA:
5.1		 3mteB-4pzcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.01A 3mteB-4r04A:
undetectable		 3mteB-4r04A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes) 		no annotation 5 GLY A 277
ASN A 240
LEU A 282
THR A 268
LEU A 269
 None
 1.00A 3mteB-4rkmA:
undetectable		 3mteB-4rkmA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx1 PUTATIVE RRNA
METHYLTRANSFERASE

(Sorangium
cellulosum) 		no annotation 5 GLY A  32
GLY A  34
PRO A  56
PHE A 105
LEU A 110
 GOL  A 303 (-3.7A)
None
None
None
None
 0.75A 3mteB-4rx1A:
25.4		 3mteB-4rx1A:
29.82