SIMILAR PATTERNS OF AMINO ACIDS FOR 3MTE_A_SAMA220

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A 534
GLY A 565
VAL A 531
ALA A 538
SER A 596
 NAP  A 752 (-3.3A)
NAP  A 752 ( 4.9A)
None
FAD  A 750 (-3.7A)
NAP  A 752 (-2.7A)
 1.21A 3mteA-1amoA:
2.3		 3mteA-1amoA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1502 (-3.5A)
None
None
FAD  A1501 ( 3.7A)
NAP  A1502 (-2.6A)
 1.05A 3mteA-1f20A:
4.1		 3mteA-1f20A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 GLY A 324
GLY A 409
ASN A  20
ALA A 326
THR A 393
 None
 1.19A 3mteA-1kfwA:
undetectable		 3mteA-1kfwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		5 GLY B  60
GLY B 144
ALA B 104
ALA B 107
LEU B  64
 None
 1.19A 3mteA-1r4nB:
4.2		 3mteA-1r4nB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjl DNAK SUPPRESSOR
PROTEIN

(Escherichia
coli) 		PF01258
(zf-dskA_traR) 		5 GLY A 112
VAL A 119
ALA A 132
LEU A  37
LEU A 126
 None
 0.94A 3mteA-1tjlA:
undetectable		 3mteA-1tjlA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1453 (-3.6A)
None
None
FAD  A1452 (-3.6A)
NAP  A1453 (-2.3A)
 1.11A 3mteA-1tllA:
2.5		 3mteA-1tllA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		5 GLY A 500
GLY A 502
VAL A 511
LEU A 605
SER A 504
 None
 1.25A 3mteA-1um2A:
undetectable		 3mteA-1um2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 GLY A 268
ALA A 276
ALA A 325
LEU A 307
LEU A 314
 None
 1.09A 3mteA-1vcgA:
undetectable		 3mteA-1vcgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 GLY A 104
GLY A 108
ASN A 109
ALA A 137
LEU A 466
 None
 1.23A 3mteA-1vcjA:
undetectable		 3mteA-1vcjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 160
GLY A 323
ALA A 165
ALA A 136
SER A 301
 NAP  A 801 ( 3.9A)
None
None
None
GOL  A 820 (-2.8A)
 1.16A 3mteA-1yb5A:
4.2		 3mteA-1yb5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 GLY B 233
GLY B 273
ALA B 177
LEU B 268
LEU B 207
 None
 1.18A 3mteA-2akaB:
undetectable		 3mteA-2akaB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
PRO A  72
ALA A  93
LEU A 109
 SAI  A1300 (-3.5A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.2A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.7A)
 0.58A 3mteA-2avnA:
10.2		 3mteA-2avnA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 VAL A 157
ALA A 234
LEU A 272
THR A 249
LEU A 252
 None
 1.19A 3mteA-2b6nA:
undetectable		 3mteA-2b6nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		5 VAL A 253
ALA A 248
ALA A 245
THR A 166
LEU A 164
 None
 1.02A 3mteA-2cygA:
undetectable		 3mteA-2cygA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		5 GLY C 139
VAL C  18
ASN C 135
ALA C  29
LEU C 120
 None
 1.25A 3mteA-2f9zC:
undetectable		 3mteA-2f9zC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9w U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF16842
(RRM_occluded) 		5 GLY A 354
PRO A 318
ASN A 353
LEU A 347
LEU A 332
 None
 1.08A 3mteA-2l9wA:
undetectable		 3mteA-2l9wA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A  75
VAL A  12
ALA A 425
ALA A 428
LEU A 151
 None
 1.08A 3mteA-2nlxA:
undetectable		 3mteA-2nlxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 GLY B2060
GLY B2144
ALA B2104
ALA B2107
LEU B2064
 None
 1.13A 3mteA-2nvuB:
5.3		 3mteA-2nvuB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 GLY A 546
GLY A 579
VAL A 543
ALA A 550
SER A 610
 NAP  A 701 ( 3.9A)
None
None
FAD  A 700 ( 4.7A)
NAP  A 701 (-2.7A)
 1.13A 3mteA-2qtzA:
4.2		 3mteA-2qtzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 GLY A 168
PRO A  73
ALA A  90
ALA A  91
LEU A 129
 None
 1.26A 3mteA-2rafA:
2.9		 3mteA-2rafA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		5 GLY A 184
VAL A 190
ASN A 189
THR A 229
LEU A 181
 None
 1.23A 3mteA-2rdlA:
undetectable		 3mteA-2rdlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		5 GLY A 513
GLY A 673
ALA A 418
THR A 413
LEU A 515
 None
 1.20A 3mteA-2wsuA:
undetectable		 3mteA-2wsuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 GLY A 211
GLY A 389
ASN A 391
ALA A 134
LEU A 213
 None
 1.06A 3mteA-2zukA:
undetectable		 3mteA-2zukA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 GLY A 231
GLY A 229
THR A 392
LEU A 391
SER A 223
 None
LLP  A 226 ( 3.7A)
None
EDO  A 418 (-3.9A)
LLP  A 226 ( 3.7A)
 1.24A 3mteA-3fd0A:
undetectable		 3mteA-3fd0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY P 274
VAL P 290
ASN P 295
ALA P 255
LEU P 104
 FAD  P 449 (-3.5A)
None
None
None
None
 1.11A 3mteA-3fg2P:
3.4		 3mteA-3fg2P:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A 514
GLY A 545
VAL A 511
ALA A 518
SER A 576
 None
None
None
FAD  A 750 ( 4.2A)
None
 1.20A 3mteA-3fjoA:
undetectable		 3mteA-3fjoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		5 GLY A 238
GLY A 236
THR A 399
LEU A 398
SER A 230
 None
 1.25A 3mteA-3ht4A:
undetectable		 3mteA-3ht4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 GLY A 248
GLY A 246
THR A 409
LEU A 408
SER A 240
 None
LLP  A 243 ( 4.0A)
None
None
LLP  A 243 ( 3.8A)
 1.20A 3mteA-3hvyA:
2.1		 3mteA-3hvyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 VAL A 357
ASN A 304
ALA A 213
LEU A 237
SER A 232
 None
 1.24A 3mteA-3lkdA:
8.5		 3mteA-3lkdA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 0.98A 3mteA-3ltjA:
undetectable		 3mteA-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 0.99A 3mteA-3ltjA:
undetectable		 3mteA-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
12P  A1002 (-3.8A)
 1.06A 3mteA-3ltmA:
undetectable		 3mteA-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 0.99A 3mteA-3ltmA:
undetectable		 3mteA-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 GLY A 150
ALA A 120
LEU A 389
THR A  38
LEU A  39
 None
 1.10A 3mteA-3m6xA:
8.6		 3mteA-3m6xA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 GLY A  32
GLY A  34
ALA A  87
LEU A 102
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
SAH  A 216 (-3.5A)
SAH  A 216 (-4.6A)
SAH  A 216 (-4.0A)
 0.39A 3mteA-3mq2A:
29.1		 3mteA-3mq2A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 GLY A  32
GLY A  34
ALA A  87
LEU A 108
SER A 192
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
SAH  A 216 (-3.5A)
SAH  A 216 (-4.0A)
SAH  A 216 (-3.3A)
 0.78A 3mteA-3mq2A:
29.1		 3mteA-3mq2A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 5 GLY A 788
GLY A 786
VAL A 781
ALA A 790
LEU A 757
 GOL  A 101 ( 3.8A)
GOL  A 101 (-4.4A)
GOL  A 103 (-3.7A)
None
None
 1.06A 3mteA-3p06A:
undetectable		 3mteA-3p06A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 GLY A 210
PRO A 213
VAL A 212
ALA A  91
LEU A 194
 None
 1.27A 3mteA-3p9tA:
undetectable		 3mteA-3p9tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 GLY A 537
GLY A 568
VAL A 534
ALA A 541
SER A 599
 NAP  A 753 (-3.5A)
NAP  A 753 ( 4.7A)
None
FAD  A 752 ( 3.7A)
NAP  A 753 (-2.7A)
 1.23A 3mteA-3qfsA:
2.3		 3mteA-3qfsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7

(Sphingopyxis
macrogoltabida) 		PF00067
(p450) 		5 GLY A 247
ASN A 248
ALA A 103
ALA A  77
LEU A  96
 None
 1.25A 3mteA-3rwlA:
undetectable		 3mteA-3rwlA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 GLY A 233
GLY A 273
ALA A 177
LEU A 268
LEU A 207
 None
 1.08A 3mteA-3snhA:
undetectable		 3mteA-3snhA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.06A 3mteA-3srzA:
undetectable		 3mteA-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 254
ASN A 253
ALA A 294
LEU A 263
LEU A 288
 None
 1.03A 3mteA-3tqpA:
undetectable		 3mteA-3tqpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trd ALPHA/BETA HYDROLASE

(Coxiella
burnetii) 		PF00561
(Abhydrolase_1) 		5 GLY A 108
GLY A 112
LEU A 106
THR A  51
LEU A  52
 None
 1.14A 3mteA-3trdA:
2.4		 3mteA-3trdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.97A 3mteA-3u5tA:
5.6		 3mteA-3u5tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 GLY A 577
GLY A 579
ASN A  14
LEU A  33
SER A 805
 None
 1.23A 3mteA-3zqjA:
undetectable		 3mteA-3zqjA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 GLY A  79
ALA A  60
ALA A  70
THR A 408
LEU A 407
 None
GOL  A1436 ( 3.7A)
GOL  A1436 (-3.8A)
GOL  A1436 ( 4.8A)
None
 0.98A 3mteA-4aoaA:
undetectable		 3mteA-4aoaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		5 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.97A 3mteA-4as5A:
undetectable		 3mteA-4as5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 GLY A 905
GLY A 936
VAL A 902
ALA A 909
SER A 966
 SO4  A1104 ( 4.2A)
None
None
FAD  A1101 ( 4.1A)
SO4  A1103 (-2.8A)
 1.07A 3mteA-4dqkA:
2.6		 3mteA-4dqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 265
ALA A 342
ALA A 339
LEU A 331
SER A 111
 None
 1.11A 3mteA-4hr3A:
undetectable		 3mteA-4hr3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 GLY B 270
GLY B 266
VAL B 413
ALA B  77
SER B 363
 None
 1.24A 3mteA-4iu9B:
undetectable		 3mteA-4iu9B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		5 GLY A  91
VAL A  96
ALA A  74
LEU A  85
THR A 118
 None
None
None
PYC  A 402 ( 4.8A)
None
 1.11A 3mteA-4j9wA:
undetectable		 3mteA-4j9wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 202
GLY A 180
VAL A 363
ALA A  93
ALA A  94
 None
 1.20A 3mteA-4jgaA:
undetectable		 3mteA-4jgaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw2 A3 ARTIFICIAL
PROTEIN

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A  39
GLY A  42
VAL A  47
ALA A  65
ALA A  64
 None
 0.98A 3mteA-4jw2A:
undetectable		 3mteA-4jw2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw3 ALPHA-HELICAL
ARTIFICIAL PROTEINS

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C  70
GLY C  73
VAL C  78
ALA C  96
ALA C  95
 None
 1.08A 3mteA-4jw3C:
undetectable		 3mteA-4jw3C:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpk ENOYL-COA
HYDRATASE/ISOMERASE

(Shewanella
pealeana) 		PF00378
(ECH_1) 		5 GLY A 126
GLY A 129
VAL A 158
ALA A  78
SER A 134
 None
 1.15A 3mteA-4kpkA:
undetectable		 3mteA-4kpkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 GLY A 396
VAL A 424
ALA A 415
ALA A 417
SER A 182
 None
 1.19A 3mteA-4mnrA:
undetectable		 3mteA-4mnrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		5 GLY A  47
GLY A  45
ALA A 269
ALA A 272
LEU A  51
 None
SO4  A 302 (-3.2A)
None
None
None
 1.07A 3mteA-4ns1A:
undetectable		 3mteA-4ns1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 116
GLY A  93
VAL A  86
ALA A  71
LEU A 358
 None
 1.11A 3mteA-4nzsA:
undetectable		 3mteA-4nzsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 GLY A 233
GLY A  68
ALA A 239
LEU A  93
THR A  72
 None
 1.07A 3mteA-4o5pA:
undetectable		 3mteA-4o5pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omu SHIKIMATE
DEHYDROGENASE

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 GLY A 104
GLY A 102
ALA A 246
ALA A 243
LEU A 109
 None
 1.22A 3mteA-4omuA:
3.3		 3mteA-4omuA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 GLY Y  32
GLY Y  34
PRO Y  56
ALA Y  85
LEU Y 104
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
None
SFG  Y 301 (-4.6A)
 1.26A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		9 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ALA Y  86
ALA Y  87
LEU Y 104
THR Y 109
LEU Y 110
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
 0.45A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		7 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ASN Y  60
LEU Y 104
THR Y 109
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
G  A1486 ( 3.9A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
 0.58A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		7 GLY Y  32
PRO Y  56
ALA Y  86
ALA Y  87
THR Y 109
LEU Y 110
SER Y 195
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-4.4A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
SFG  Y 301 ( 3.7A)
 0.63A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 190
GLY A 168
VAL A 348
ALA A  81
ALA A  82
 None
 1.16A 3mteA-4qavA:
undetectable		 3mteA-4qavA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
 1.25A 3mteA-4r04A:
2.3		 3mteA-4r04A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 295
PRO A 299
ALA A 171
ALA A 170
SER A 324
 None
None
None
None
MPD  A1339 (-3.3A)
 1.23A 3mteA-4v2pA:
undetectable		 3mteA-4v2pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 GLY A 105
GLY A 367
LEU A 448
THR A 432
LEU A 433
 None
 1.00A 3mteA-4wgxA:
undetectable		 3mteA-4wgxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C  39
GLY C  42
VAL C  47
ALA C  65
ALA C  64
 None
 1.03A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C  70
GLY C  73
VAL C  78
ALA C  96
ALA C  95
 None
 1.01A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C 163
GLY C 166
VAL C 171
ALA C 189
ALA C 188
 None
 0.98A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		5 GLY A 140
PRO A 191
ALA A 168
ALA A 169
THR A 131
 TYL  A 502 ( 4.9A)
None
None
None
None
 1.02A 3mteA-4yjiA:
undetectable		 3mteA-4yjiA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  13
ALA A 213
ALA A 214
LEU A  35
LEU A  86
 FAD  A 601 ( 4.6A)
None
None
None
None
 1.19A 3mteA-4ynuA:
6.5		 3mteA-4ynuA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		6 GLY A 691
GLY A 693
PRO A 401
ASN A 684
ALA A 770
SER A 680
 None
 1.33A 3mteA-4yu5A:
undetectable		 3mteA-4yu5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 295
PRO A 299
ALA A 171
ALA A 170
SER A 324
 None
 1.25A 3mteA-4yufA:
undetectable		 3mteA-4yufA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 284
GLY A 257
ALA A 480
ALA A 464
LEU A 260
 None
None
None
None
ZN  A 501 ( 4.8A)
 1.26A 3mteA-4zi6A:
undetectable		 3mteA-4zi6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A 132
GLY A 135
VAL A 140
ALA A 158
ALA A 157
 None
 1.03A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A 163
GLY A 166
VAL A 171
ALA A 189
ALA A 188
 None
 1.00A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A 194
GLY A 197
VAL A 202
ALA A 220
ALA A 219
 None
 0.93A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		5 GLY A 109
GLY A 133
VAL A 104
LEU A 150
SER A 136
 None
 0.90A 3mteA-4zv9A:
2.9		 3mteA-4zv9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 6 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.48A 3mteA-5bw4A:
26.9		 3mteA-5bw4A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 GLY A 233
GLY A 273
ALA A 177
LEU A 268
LEU A 207
 None
 1.15A 3mteA-5d3qA:
undetectable		 3mteA-5d3qA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A  69
GLY A  72
VAL A  77
ALA A  95
ALA A  94
 None
 1.01A 3mteA-5dcqA:
undetectable		 3mteA-5dcqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 GLY A 507
GLY A 505
ALA A 535
LEU A 524
LEU A 533
 None
 1.22A 3mteA-5e02A:
undetectable		 3mteA-5e02A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.78A 3mteA-5e26A:
2.4		 3mteA-5e26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 GLY A1103
PRO A1015
ALA A1016
LEU A1109
SER A 999
 None
 1.20A 3mteA-5ehkA:
undetectable		 3mteA-5ehkA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 GLY A  33
ALA A 242
ALA A 245
LEU A  29
LEU A  45
 NAP  A 301 ( 4.6A)
None
None
None
None
 1.18A 3mteA-5feuA:
4.9		 3mteA-5feuA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLY A 612
PRO A 615
VAL A 614
ASN A 569
LEU A 675
 None
 1.25A 3mteA-5hy7A:
undetectable		 3mteA-5hy7A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		5 GLY A  78
ALA A 129
ALA A 130
LEU A 138
SER A  83
 None
 1.24A 3mteA-5iqkA:
undetectable		 3mteA-5iqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 GLY A 786
GLY A 783
ALA A 757
ALA A 760
SER A 808
 None
 0.99A 3mteA-5irmA:
undetectable		 3mteA-5irmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT BETA

(Nostoc sp. PCC
7120) 		no annotation 5 GLY B 119
ALA B 114
ALA B 115
THR B 141
LEU B 142
 None
 0.91A 3mteA-5n3uB:
undetectable		 3mteA-5n3uB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		5 GLY A 435
GLY A 437
ALA A 416
LEU A 222
LEU A 393
 None
None
None
None
NAD  A 601 (-4.3A)
 1.15A 3mteA-5nnoA:
4.4		 3mteA-5nnoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suh MSM0271 PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  75
GLY A  38
PRO A  41
ALA A  47
LEU A  77
 None
 0.82A 3mteA-5suhA:
undetectable		 3mteA-5suhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 GLY A 366
ALA A 370
ALA A 347
LEU A 343
SER A 364
 None
 1.22A 3mteA-5u0lA:
4.2		 3mteA-5u0lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 GLY A 142
VAL A 139
ALA A  22
ALA A  21
LEU A 174
 None
 1.21A 3mteA-5u3cA:
undetectable		 3mteA-5u3cA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 GLY A 122
VAL A 201
ALA A 217
LEU A 127
THR A  82
 None
None
None
9CM  A 307 (-3.9A)
None
 1.14A 3mteA-5vfdA:
undetectable		 3mteA-5vfdA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 VAL A 277
ASN A 281
ALA A 291
ALA A 290
SER A 223
 None
 1.03A 3mteA-5yfbA:
undetectable		 3mteA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
GOL  A 502 (-3.7A)
 0.95A 3mteA-6ft5A:
undetectable		 3mteA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 1.00A 3mteA-6ft5A:
undetectable		 3mteA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ASN A  99
ASP A 516
GLU A 526
TRP A  93
 None
 1.37A 3mteA-4bc7A:
0.0		 3mteA-4bc7A:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		4 ASN Y  38
ASP Y  55
GLU Y  88
TRP Y 197
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.5A)
 0.83A 3mteA-4ox9Y:
34.9		 3mteA-4ox9Y:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ASN A 294
ASP A 343
GLU A 440
TRP A 285
 None
 1.36A 3mteA-4p08A:
0.0		 3mteA-4p08A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ASN A   8
ASP A  33
GLU A  96
TRP A 223
 None
 0.80A 3mteA-5gjeA:
0.0		 3mteA-5gjeA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		4 ASN A 250
ASP A 210
GLU A  86
TRP A 252
 None
 1.33A 3mteA-5hhaA:
0.0		 3mteA-5hhaA:
23.55