SIMILAR PATTERNS OF AMINO ACIDS FOR 3MSS_D_STID1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 487
VAL A 452
ILE A 474
MET A 558
 None
 0.79A 3mssD-1bhyA:
undetectable		 3mssD-1bhyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 322
VAL A 289
ILE A 309
MET A 395
 None
 0.97A 3mssD-1euzA:
undetectable		 3mssD-1euzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuz PLASTOCYANIN

(Ulva pertusa) 		PF00127
(Copper-bind) 		4 VAL A  70
VAL A  98
VAL A  82
ILE A  27
 None
 0.94A 3mssD-1iuzA:
undetectable		 3mssD-1iuzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jif BLEOMYCIN-BINDING
PROTEIN

(Streptomyces
verticillus) 		no annotation 4 VAL A  41
VAL A  68
VAL A 116
ILE A  46
 None
 0.96A 3mssD-1jifA:
undetectable		 3mssD-1jifA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 416
LYS A 430
VAL A 458
ILE A 472
 None
 0.78A 3mssD-1k2pA:
28.9		 3mssD-1k2pA:
44.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.58A 3mssD-1k9aA:
27.2		 3mssD-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 209
VAL A 239
ILE A 264
MET A 269
 None
 0.81A 3mssD-1k9aA:
27.2		 3mssD-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 588
LYS A 608
VAL A 638
MET A 657
 None
 0.75A 3mssD-1lufA:
35.0		 3mssD-1lufA:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
 0.50A 3mssD-1nxkA:
19.3		 3mssD-1nxkA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 275
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.52A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 275
VAL A 308
VAL A 318
ILE A 332
MET A 337
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 0.50A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A 381
VAL A 430
VAL A 408
ILE A 351
 None
 0.00A 3mssD-1q5aA:
undetectable		 3mssD-1q5aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  86
LYS A 101
VAL A 215
VAL A 131
ILE A 145
 ATP  A 535 (-4.1A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-3.9A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
 1.19A 3mssD-1s9iA:
21.4		 3mssD-1s9iA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 129
VAL A  66
VAL A  88
ILE A  38
 None
 0.77A 3mssD-1upxA:
undetectable		 3mssD-1upxA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
GOL  A 998 (-4.9A)
None
 0.80A 3mssD-1zy4A:
19.7		 3mssD-1zy4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 281
LYS B 296
VAL B 321
ILE B 364
 None
 0.64A 3mssD-2a1aB:
21.2		 3mssD-2a1aB:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  25
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
 0.54A 3mssD-2dq7X:
32.0		 3mssD-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  25
VAL X  67
ILE X  80
MET X  85
 STU  X 902 ( 4.8A)
None
None
None
 0.61A 3mssD-2dq7X:
32.0		 3mssD-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 150
VAL A 196
ILE A 210
MET A 215
 None
 0.67A 3mssD-2dylA:
21.6		 3mssD-2dylA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 170
LYS A 186
VAL A 204
ILE A 234
 None
 0.62A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 170
VAL A 204
VAL A 220
ILE A 234
 None
 0.54A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.67A 3mssD-2h8hA:
30.5		 3mssD-2h8hA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 ( 4.8A)
None
None
None
None
 0.90A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.60A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
VAL A 291
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 4.8A)
None
None
1BM  A 499 (-3.9A)
None
 0.76A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 256
LYS A 271
VAL A 289
ILE A 313
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
 0.61A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 256
VAL A 289
VAL A 299
ILE A 313
MET A 318
 GIN  A 600 ( 4.7A)
None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.42A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  34
LYS A  49
VAL A  78
ILE A 106
 None
 0.65A 3mssD-2i6lA:
23.0		 3mssD-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		4 VAL A   3
VAL A  45
ILE A  31
MET A  77
 None
 0.99A 3mssD-2i9xA:
undetectable		 3mssD-2i9xA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9z PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		4 VAL A   3
VAL A  45
ILE A  31
MET A  77
 None
 0.88A 3mssD-2i9zA:
undetectable		 3mssD-2i9zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
VAL A 484
ILE A 497
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.40A 3mssD-2j0jA:
32.2		 3mssD-2j0jA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
VAL A 484
ILE A 497
 BII  A1687 ( 4.7A)
BII  A1687 (-2.9A)
None
None
 0.85A 3mssD-2jkmA:
32.0		 3mssD-2jkmA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 259
VAL A 301
ILE A 314
MET A 319
 None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.59A 3mssD-2og8A:
32.1		 3mssD-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  78
LYS X  93
VAL X 118
ILE X 136
 None
F10  X 401 (-4.3A)
None
None
 0.70A 3mssD-2p3gX:
17.6		 3mssD-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  85
VAL B 121
VAL B 131
MET B 150
 ANP  B 432 (-4.6A)
None
None
None
 0.95A 3mssD-2wtkB:
22.1		 3mssD-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 VAL A  77
VAL A 155
ILE A 147
MET A 183
 None
 0.86A 3mssD-2x2iA:
undetectable		 3mssD-2x2iA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 635
LYS A 653
ILE A 697
MET A 702
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
 0.50A 3mssD-2xyuA:
27.5		 3mssD-2xyuA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 313
LYS A 328
VAL A 360
ILE A 374
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.78A 3mssD-2z2wA:
22.6		 3mssD-2z2wA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1010
VAL A1050
VAL A1060
MET A1079
 S91  A   1 ( 4.9A)
None
None
None
 0.73A 3mssD-2z8cA:
23.4		 3mssD-2z8cA:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.79A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 261
VAL A 303
ILE A 317
MET A 322
 None
 0.78A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.58A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 209
VAL A 239
ILE A 264
MET A 269
 None
 0.81A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 647
LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.64A 3mssD-3dkoA:
30.9		 3mssD-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 None
STU  A   1 ( 4.2A)
None
None
None
 0.65A 3mssD-3fmeA:
17.9		 3mssD-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 363
LYS A 375
VAL A 396
ILE A 419
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
 0.73A 3mssD-3omvA:
26.6		 3mssD-3omvA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  25
LYS A  40
VAL A  72
MET A  93
 None
 0.81A 3mssD-3oz6A:
21.0		 3mssD-3oz6A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 VAL A 565
LYS A 578
VAL A 609
ILE A 623
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
 0.62A 3mssD-3ppzA:
28.7		 3mssD-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL B 603
LYS B 618
VAL B 648
ILE B 884
 None
 0.70A 3mssD-3qd2B:
21.3		 3mssD-3qd2B:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  58
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
 0.56A 3mssD-3sheA:
18.5		 3mssD-3sheA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 552
LYS A 572
VAL A 601
MET A 620
 None
0F4  A 902 (-4.0A)
None
None
 0.84A 3mssD-3v5qA:
33.4		 3mssD-3v5qA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
None
 1.14A 3mssD-3vn9A:
22.0		 3mssD-3vn9A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  83
LYS A  98
VAL A 212
VAL A 128
ILE A 142
 ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 1.14A 3mssD-3wigA:
22.1		 3mssD-3wigA:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 568
LYS A 588
VAL A 617
MET A 636
 None
 0.69A 3mssD-4at3A:
33.8		 3mssD-4at3A:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  50
LYS A  65
VAL A  94
ILE A 108
 XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
 0.89A 3mssD-4bc6A:
21.5		 3mssD-4bc6A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  25
LYS A  40
VAL A  72
ILE A  86
 None
 0.57A 3mssD-4d28A:
20.9		 3mssD-4d28A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
None
 0.65A 3mssD-4eutA:
10.4		 3mssD-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.62A 3mssD-4euuA:
21.3		 3mssD-4euuA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 523
LYS A 543
VAL A 572
MET A 591
 None
 0.74A 3mssD-4f0iA:
27.6		 3mssD-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 385
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
None
 0.73A 3mssD-4f4pA:
26.0		 3mssD-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1130
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
 0.87A 3mssD-4fodA:
25.5		 3mssD-4fodA:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 None
 0.76A 3mssD-4fzdB:
18.5		 3mssD-4fzdB:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 606
LYS A 621
VAL A 651
ILE A 885
 924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
 0.39A 3mssD-4g34A:
20.3		 3mssD-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.78A 3mssD-4idtA:
21.6		 3mssD-4idtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmn PROBABLE
L,D-TRANSPEPTIDASE
LDTA

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 VAL A 198
VAL A 250
VAL A 138
ILE A 227
 None
 0.98A 3mssD-4jmnA:
undetectable		 3mssD-4jmnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 360
VAL A 325
ILE A 347
MET A 431
 None
 0.86A 3mssD-4jq9A:
undetectable		 3mssD-4jq9A:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.49A 3mssD-4k11A:
30.3		 3mssD-4k11A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
VAL A 323
ILE A 336
MET A 341
 0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
None
 0.82A 3mssD-4k11A:
30.3		 3mssD-4k11A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  41
LYS A  56
VAL A  83
ILE A  97
 GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
None
 0.79A 3mssD-4lg4A:
17.8		 3mssD-4lg4A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 281
LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.83A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 281
VAL A 313
VAL A 323
ILE A 336
MET A 341
 VGG  A 601 ( 3.5A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.93A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.76A 3mssD-4lwoB:
undetectable		 3mssD-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
 0.65A 3mssD-4o27B:
18.4		 3mssD-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		4 VAL A  30
VAL A   9
VAL A  93
ILE A  56
 None
 0.99A 3mssD-4r86A:
undetectable		 3mssD-4r86A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 VAL A 180
VAL A 232
VAL A 240
ILE A 182
 None
 0.89A 3mssD-4twiA:
undetectable		 3mssD-4twiA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  22
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 (-4.7A)
None
None
None
 0.67A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  22
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 (-4.7A)
None
None
None
 0.66A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  60
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.9A)
None
None
None
 0.66A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
LYS B 290
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.75A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
VAL B 308
VAL B 318
ILE B 332
MET B 337
 1N1  B 601 ( 4.9A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.60A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 VAL A  80
LYS A 176
VAL A 230
ILE A 199
 None
 0.92A 3mssD-4y67A:
undetectable		 3mssD-4y67A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00497
(SBP_bac_3) 		4 VAL A 218
VAL A 131
VAL A 151
ILE A 215
 None
 0.98A 3mssD-4ymxA:
undetectable		 3mssD-4ymxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  77
VAL A 123
ILE A 142
MET A 147
 None
 0.80A 3mssD-5ci6A:
20.9		 3mssD-5ci6A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fis EXD1

(Bombyx mori) 		PF01612
(DNA_pol_A_exo1) 		4 VAL B 192
LYS B 169
VAL B 106
ILE B 115
 None
 0.98A 3mssD-5fisB:
undetectable		 3mssD-5fisB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 4 VAL B1287
VAL B1315
VAL B1258
ILE B1279
 None
 0.91A 3mssD-5hb0B:
undetectable		 3mssD-5hb0B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF03177
(Nucleoporin_C) 		4 VAL A1287
VAL A1315
VAL A1258
ILE A1279
 None
 0.97A 3mssD-5hb1A:
undetectable		 3mssD-5hb1A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.39A 3mssD-5i3oA:
22.1		 3mssD-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  30
LYS A  45
VAL A  74
ILE A  88
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
 0.47A 3mssD-5j5tA:
21.3		 3mssD-5j5tA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 647
LYS A 665
ILE A 709
MET A 714
 None
None
6P6  A1001 ( 4.5A)
None
 0.69A 3mssD-5l6oA:
33.0		 3mssD-5l6oA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.69A 3mssD-5u94A:
23.5		 3mssD-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 226
LYS A 241
VAL A 273
ILE A 287
 8X7  A 501 ( 4.5A)
PO4  A 502 (-3.6A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
 0.65A 3mssD-5vdkA:
12.2		 3mssD-5vdkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 212
LYS A 227
VAL A 247
VAL A 257
 None
 0.75A 3mssD-5xzwA:
18.9		 3mssD-5xzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.84A 3mssD-6ao5A:
22.1		 3mssD-6ao5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL A 200
LYS A 213
VAL A 246
MET A 265
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
 0.73A 3mssD-6f3dA:
23.5		 3mssD-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 VAL A 177
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
None
None
 0.55A 3mssD-6fylA:
21.7		 3mssD-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 VAL A 177
VAL A 211
VAL A 227
ILE A 241
 3NG  A 501 ( 4.4A)
None
None
None
 0.75A 3mssD-6fylA:
21.7		 3mssD-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 VAL A 175
LYS A 191
VAL A 209
VAL A 225
ILE A 239
 None
EAQ  A 501 (-3.2A)
None
None
None
 0.76A 3mssD-6fyoA:
21.4		 3mssD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
 0.53A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 ( 4.3A)
None
None
None
 0.67A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7pcy PLASTOCYANIN

(Ulva prolifera) 		PF00127
(Copper-bind) 		4 VAL A  70
VAL A  98
VAL A  82
ILE A  27
 None
 0.92A 3mssD-7pcyA:
undetectable		 3mssD-7pcyA:
15.70