SIMILAR PATTERNS OF AMINO ACIDS FOR 3MSS_D_STID1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.53A 3mssD-1k9aA:
27.2		 3mssD-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
MET A 629
GLY A 660
LEU A 731
ALA A 741
ASP A 742
 None
 1.10A 3mssD-1lufA:
35.0		 3mssD-1lufA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
ALA A 288
GLU A 305
MET A 309
ILE A 312
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.79A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
TYR A 272
ALA A 288
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.84A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 None
 0.76A 3mssD-1rjbA:
33.5		 3mssD-1rjbA:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
ALA A 621
GLU A 640
THR A 670
GLY A 676
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.65A 3mssD-1t46A:
34.1		 3mssD-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.57A 3mssD-1u59A:
30.3		 3mssD-1u59A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
ALA A  47
GLU A  65
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.76A 3mssD-2bujA:
22.7		 3mssD-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
ALA X  37
GLU X  54
MET X  58
THR X  82
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.76A 3mssD-2dq7X:
31.9		 3mssD-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
ALA A 184
GLU A 201
GLY A 240
LEU A 290
ALA A 319
 None
 1.06A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
ALA A 184
GLU A 201
ILE A 208
LEU A 290
ALA A 319
 None
 0.77A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.71A 3mssD-2h8hA:
30.5		 3mssD-2h8hA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.87A 3mssD-2henA:
26.5		 3mssD-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
ALA A 271
GLU A 288
MET A 292
THR A 316
PHE A 318
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 0.98A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.95A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
MET A 292
THR A 316
PHE A 318
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
MET A 290
ILE A 293
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.76A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
GLU A 286
MET A 290
ILE A 293
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.67A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
GLU A 288
MET A 292
THR A 316
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.63A 3mssD-2og8A:
32.1		 3mssD-2og8A:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
ASP A 796
 None
 0.94A 3mssD-2ogvA:
32.1		 3mssD-2ogvA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
MET A 637
THR A 663
GLY A 669
LEU A 785
 None
 0.87A 3mssD-2ogvA:
32.1		 3mssD-2ogvA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.74A 3mssD-2psqA:
32.0		 3mssD-2psqA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
ILE A 233
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 1.07A 3mssD-2qluA:
24.3		 3mssD-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 103
ILE A 127
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.13A 3mssD-2v55A:
17.6		 3mssD-2v55A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
ALA A 273
GLU A 290
MET A 294
THR A 319
PHE A 321
ASP A 385
 None
 1.16A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
ALA A 273
MET A 294
THR A 319
PHE A 321
ALA A 384
ASP A 385
 None
 1.15A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
ALA A 273
MET A 294
THR A 319
PHE A 321
GLY A 325
LEU A 374
ALA A 384
 None
 1.18A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.70A 3mssD-3b2tA:
25.7		 3mssD-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.91A 3mssD-3c1xA:
26.5		 3mssD-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.76A 3mssD-3c4fA:
31.2		 3mssD-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.53A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.89A 3mssD-3hngA:
33.1		 3mssD-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.56A 3mssD-3kulA:
31.7		 3mssD-3kulA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.67A 3mssD-3mdyA:
24.8		 3mssD-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
ILE A 247
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.11A 3mssD-3mdyA:
24.8		 3mssD-3mdyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
THR A 277
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.72A 3mssD-3my0A:
24.9		 3mssD-3my0A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
ALA A 109
GLU A 130
MET A 134
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
 0.60A 3mssD-3nuuA:
22.6		 3mssD-3nuuA:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.48A 3mssD-3ppzA:
28.7		 3mssD-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.36A 3mssD-3q4tA:
23.9		 3mssD-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.88A 3mssD-3q5iA:
20.0		 3mssD-3q5iA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 345
GLU A 384
MET A 388
THR A 413
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.8A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 1.09A 3mssD-3s95A:
23.8		 3mssD-3s95A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.78A 3mssD-3sxsA:
31.8		 3mssD-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.70A 3mssD-3tt0A:
30.5		 3mssD-3tt0A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
ALA A 382
GLU A 403
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.88A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.99A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
ALA A 382
ILE A 406
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.99A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.98A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.75A 3mssD-3vidA:
30.2		 3mssD-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.77A 3mssD-3wzdA:
31.2		 3mssD-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
ILE A 888
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.9A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 1.06A 3mssD-3wzdA:
31.2		 3mssD-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.80A 3mssD-4agdA:
32.7		 3mssD-4agdA:
35.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
ALA A  63
GLU A  81
PHE A 112
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.75A 3mssD-4bc6A:
21.5		 3mssD-4bc6A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
ALA A  63
ILE A  84
PHE A 112
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.92A 3mssD-4bc6A:
21.5		 3mssD-4bc6A:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
ALA A 653
GLU A 672
MET A 676
THR A 701
GLY A 707
LEU A 773
ALA A 783
ASP A 784
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.70A 3mssD-4ckrA:
32.1		 3mssD-4ckrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
ALA A 684
GLU A 705
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
ALA A 684
ILE A 708
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.88A 3mssD-4crsA:
20.5		 3mssD-4crsA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 ALA A1053
GLU A1078
MET A1082
PHE A1107
GLY A1111
ALA A1176
 None
 1.05A 3mssD-4f0gA:
26.3		 3mssD-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
ALA A 400
GLU A 420
MET A 424
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 1.02A 3mssD-4f4pA:
26.0		 3mssD-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 514
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.83A 3mssD-4feqA:
23.0		 3mssD-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
GLU A 871
GLY A 908
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.55A 3mssD-4hviA:
29.7		 3mssD-4hviA:
35.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
ALA A 506
GLU A 525
MET A 529
ILE A 532
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.90A 3mssD-4k33A:
26.4		 3mssD-4k33A:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 434
GLU A 452
ILE A 455
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.88A 3mssD-4ks8A:
23.1		 3mssD-4ks8A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  54
GLU A  70
MET A  74
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.1A)
None
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.11A 3mssD-4lg4A:
17.8		 3mssD-4lg4A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
MET A 314
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.01A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.69A 3mssD-4m69A:
18.6		 3mssD-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
ALA A  99
GLU A 117
MET A 121
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.90A 3mssD-4mvfA:
19.0		 3mssD-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
None
 0.95A 3mssD-4o38A:
19.1		 3mssD-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
ALA A  67
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.84A 3mssD-4o38A:
19.1		 3mssD-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.87A 3mssD-4q9zA:
15.6		 3mssD-4q9zA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.60A 3mssD-4rt7A:
29.2		 3mssD-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
ALA A  35
GLU A  52
MET A  56
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
None
 1.16A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
ASP A 173
 6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 0.91A 3mssD-4usfA:
19.0		 3mssD-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  40
ALA A  61
PHE A 110
GLY A 114
LEU A 162
ALA A 172
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
 0.92A 3mssD-4usfA:
19.0		 3mssD-4usfA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.90A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
ALA A  72
GLU A  90
MET A  94
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.75A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.70A 3mssD-4xcuA:
30.9		 3mssD-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 ALA B 288
MET B 309
ILE B 312
THR B 334
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.74A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
MET B 309
ILE B 312
THR B 334
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.7A)
None
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.91A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.70A 3mssD-4xufA:
33.4		 3mssD-4xufA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
GLU A 509
THR A 539
GLY A 545
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.68A 3mssD-4yffA:
19.8		 3mssD-4yffA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 1.07A 3mssD-4ysjA:
22.8		 3mssD-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.80A 3mssD-4ysjA:
22.8		 3mssD-4ysjA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.76A 3mssD-5a46A:
30.4		 3mssD-5a46A:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
GLU A 290
THR A 325
PHE A 327
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.70A 3mssD-5e8yA:
18.9		 3mssD-5e8yA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 275
ILE A 293
THR A 325
PHE A 327
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.91A 3mssD-5e8yA:
18.9		 3mssD-5e8yA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.94A 3mssD-5eykA:
17.7		 3mssD-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 3mssD-5grnA:
29.6		 3mssD-5grnA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
ALA A  41
GLU A  61
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.79A 3mssD-5hu3A:
17.1		 3mssD-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
GLU A  61
MET A  65
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.61A 3mssD-5j5tA:
21.3		 3mssD-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLU A 315
MET A 319
GLY A 350
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
None
 0.89A 3mssD-5kbrA:
22.0		 3mssD-5kbrA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 663
MET A 686
THR A 711
PHE A 713
LEU A 765
ASP A 776
 6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-4.5A)
None
 0.72A 3mssD-5l6oA:
33.0		 3mssD-5l6oA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 593
ALA A 617
MET A 641
PHE A 673
ALA A 740
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 1.00A 3mssD-5td2A:
29.3		 3mssD-5td2A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 593
ALA A 617
MET A 641
PHE A 673
GLY A 677
ALA A 740
 7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
 0.84A 3mssD-5td2A:
29.3		 3mssD-5td2A:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
ALA A  45
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.51A 3mssD-5w5jA:
19.4		 3mssD-5w5jA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
ALA A 906
GLU A 925
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.78A 3mssD-6c7yA:
20.8		 3mssD-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
ALA A 906
ILE A 928
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.88A 3mssD-6c7yA:
20.8		 3mssD-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
 None
 1.00A 3mssD-6c9dA:
21.0		 3mssD-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.86A 3mssD-6fdyU:
21.8		 3mssD-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.76A 3mssD-6fdyU:
21.8		 3mssD-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 487
VAL A 452
ILE A 474
MET A 558
 None
 0.79A 3mssD-1bhyA:
undetectable		 3mssD-1bhyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 322
VAL A 289
ILE A 309
MET A 395
 None
 0.97A 3mssD-1euzA:
undetectable		 3mssD-1euzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuz PLASTOCYANIN

(Ulva pertusa) 		PF00127
(Copper-bind) 		4 VAL A  70
VAL A  98
VAL A  82
ILE A  27
 None
 0.94A 3mssD-1iuzA:
undetectable		 3mssD-1iuzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jif BLEOMYCIN-BINDING
PROTEIN

(Streptomyces
verticillus) 		no annotation 4 VAL A  41
VAL A  68
VAL A 116
ILE A  46
 None
 0.96A 3mssD-1jifA:
undetectable		 3mssD-1jifA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 416
LYS A 430
VAL A 458
ILE A 472
 None
 0.78A 3mssD-1k2pA:
28.9		 3mssD-1k2pA:
44.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 209
LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.58A 3mssD-1k9aA:
27.2		 3mssD-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 209
VAL A 239
ILE A 264
MET A 269
 None
 0.81A 3mssD-1k9aA:
27.2		 3mssD-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 588
LYS A 608
VAL A 638
MET A 657
 None
 0.75A 3mssD-1lufA:
35.0		 3mssD-1lufA:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
LYS A  93
VAL A 118
ILE A 136
 STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
None
 0.50A 3mssD-1nxkA:
19.3		 3mssD-1nxkA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 275
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.52A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 275
VAL A 308
VAL A 318
ILE A 332
MET A 337
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 0.50A 3mssD-1opkA:
34.6		 3mssD-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 VAL A 381
VAL A 430
VAL A 408
ILE A 351
 None
 0.00A 3mssD-1q5aA:
undetectable		 3mssD-1q5aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  86
LYS A 101
VAL A 215
VAL A 131
ILE A 145
 ATP  A 535 (-4.1A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-3.9A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
 1.19A 3mssD-1s9iA:
21.4		 3mssD-1s9iA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 129
VAL A  66
VAL A  88
ILE A  38
 None
 0.77A 3mssD-1upxA:
undetectable		 3mssD-1upxA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
GOL  A 998 (-4.9A)
None
 0.80A 3mssD-1zy4A:
19.7		 3mssD-1zy4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 281
LYS B 296
VAL B 321
ILE B 364
 None
 0.64A 3mssD-2a1aB:
21.2		 3mssD-2a1aB:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  25
LYS X  39
VAL X  67
ILE X  80
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
 0.54A 3mssD-2dq7X:
32.0		 3mssD-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  25
VAL X  67
ILE X  80
MET X  85
 STU  X 902 ( 4.8A)
None
None
None
 0.61A 3mssD-2dq7X:
32.0		 3mssD-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 150
VAL A 196
ILE A 210
MET A 215
 None
 0.67A 3mssD-2dylA:
21.6		 3mssD-2dylA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 170
LYS A 186
VAL A 204
ILE A 234
 None
 0.62A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 170
VAL A 204
VAL A 220
ILE A 234
 None
 0.54A 3mssD-2eu9A:
21.4		 3mssD-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.67A 3mssD-2h8hA:
30.5		 3mssD-2h8hA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 ( 4.8A)
None
None
None
None
 0.90A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.60A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
VAL A 291
VAL A 301
ILE A 314
MET A 319
 1BM  A 499 ( 4.8A)
None
None
1BM  A 499 (-3.9A)
None
 0.76A 3mssD-2hk5A:
27.8		 3mssD-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 256
LYS A 271
VAL A 289
ILE A 313
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
 0.61A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 256
VAL A 289
VAL A 299
ILE A 313
MET A 318
 GIN  A 600 ( 4.7A)
None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.42A 3mssD-2hz0A:
34.7		 3mssD-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  34
LYS A  49
VAL A  78
ILE A 106
 None
 0.65A 3mssD-2i6lA:
23.0		 3mssD-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		4 VAL A   3
VAL A  45
ILE A  31
MET A  77
 None
 0.99A 3mssD-2i9xA:
undetectable		 3mssD-2i9xA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9z PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		4 VAL A   3
VAL A  45
ILE A  31
MET A  77
 None
 0.88A 3mssD-2i9zA:
undetectable		 3mssD-2i9zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
VAL A 484
ILE A 497
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.40A 3mssD-2j0jA:
32.2		 3mssD-2j0jA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
VAL A 484
ILE A 497
 BII  A1687 ( 4.7A)
BII  A1687 (-2.9A)
None
None
 0.85A 3mssD-2jkmA:
32.0		 3mssD-2jkmA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 259
VAL A 301
ILE A 314
MET A 319
 None
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
 0.59A 3mssD-2og8A:
32.1		 3mssD-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  78
LYS X  93
VAL X 118
ILE X 136
 None
F10  X 401 (-4.3A)
None
None
 0.70A 3mssD-2p3gX:
17.6		 3mssD-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  85
VAL B 121
VAL B 131
MET B 150
 ANP  B 432 (-4.6A)
None
None
None
 0.95A 3mssD-2wtkB:
22.1		 3mssD-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 VAL A  77
VAL A 155
ILE A 147
MET A 183
 None
 0.86A 3mssD-2x2iA:
undetectable		 3mssD-2x2iA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 635
LYS A 653
ILE A 697
MET A 702
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
 0.50A 3mssD-2xyuA:
27.5		 3mssD-2xyuA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 313
LYS A 328
VAL A 360
ILE A 374
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.78A 3mssD-2z2wA:
22.6		 3mssD-2z2wA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1010
VAL A1050
VAL A1060
MET A1079
 S91  A   1 ( 4.9A)
None
None
None
 0.73A 3mssD-2z8cA:
23.4		 3mssD-2z8cA:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 261
LYS A 275
VAL A 303
ILE A 317
 None
 0.79A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 261
VAL A 303
ILE A 317
MET A 322
 None
 0.78A 3mssD-2zv7A:
26.3		 3mssD-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 209
LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.58A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 209
VAL A 239
ILE A 264
MET A 269
 None
 0.81A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 647
LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.64A 3mssD-3dkoA:
30.9		 3mssD-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 None
STU  A   1 ( 4.2A)
None
None
None
 0.65A 3mssD-3fmeA:
17.9		 3mssD-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 363
LYS A 375
VAL A 396
ILE A 419
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.5A)
None
SM5  A   1 ( 4.3A)
 0.73A 3mssD-3omvA:
26.6		 3mssD-3omvA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  25
LYS A  40
VAL A  72
MET A  93
 None
 0.81A 3mssD-3oz6A:
21.0		 3mssD-3oz6A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 VAL A 565
LYS A 578
VAL A 609
ILE A 623
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
 0.62A 3mssD-3ppzA:
28.7		 3mssD-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL B 603
LYS B 618
VAL B 648
ILE B 884
 None
 0.70A 3mssD-3qd2B:
21.3		 3mssD-3qd2B:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  58
LYS A  73
VAL A  98
ILE A 116
 I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
None
 0.56A 3mssD-3sheA:
18.5		 3mssD-3sheA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 552
LYS A 572
VAL A 601
MET A 620
 None
0F4  A 902 (-4.0A)
None
None
 0.84A 3mssD-3v5qA:
33.4		 3mssD-3v5qA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
LYS A  82
VAL A 113
ILE A 127
MET A 132
 ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
None
None
None
 1.14A 3mssD-3vn9A:
22.0		 3mssD-3vn9A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  83
LYS A  98
VAL A 212
VAL A 128
ILE A 142
 ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 1.14A 3mssD-3wigA:
22.1		 3mssD-3wigA:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 568
LYS A 588
VAL A 617
MET A 636
 None
 0.69A 3mssD-4at3A:
33.8		 3mssD-4at3A:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  50
LYS A  65
VAL A  94
ILE A 108
 XZN  A1317 ( 4.7A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
 0.89A 3mssD-4bc6A:
21.5		 3mssD-4bc6A:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  25
LYS A  40
VAL A  72
ILE A  86
 None
 0.57A 3mssD-4d28A:
20.9		 3mssD-4d28A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
None
 0.65A 3mssD-4eutA:
10.4		 3mssD-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.62A 3mssD-4euuA:
21.3		 3mssD-4euuA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 523
LYS A 543
VAL A 572
MET A 591
 None
 0.74A 3mssD-4f0iA:
27.6		 3mssD-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 385
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
None
 0.73A 3mssD-4f4pA:
26.0		 3mssD-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1130
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
 0.87A 3mssD-4fodA:
25.5		 3mssD-4fodA:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 None
 0.76A 3mssD-4fzdB:
18.5		 3mssD-4fzdB:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 606
LYS A 621
VAL A 651
ILE A 885
 924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
 0.39A 3mssD-4g34A:
20.3		 3mssD-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 414
LYS A 429
VAL A 453
ILE A 467
 T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
None
 0.78A 3mssD-4idtA:
21.6		 3mssD-4idtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmn PROBABLE
L,D-TRANSPEPTIDASE
LDTA

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		4 VAL A 198
VAL A 250
VAL A 138
ILE A 227
 None
 0.98A 3mssD-4jmnA:
undetectable		 3mssD-4jmnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 360
VAL A 325
ILE A 347
MET A 431
 None
 0.86A 3mssD-4jq9A:
undetectable		 3mssD-4jq9A:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
LYS A 295
VAL A 323
ILE A 336
 0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
 0.49A 3mssD-4k11A:
30.3		 3mssD-4k11A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 281
VAL A 323
ILE A 336
MET A 341
 0J9  A 601 (-4.4A)
None
0J9  A 601 (-4.4A)
None
 0.82A 3mssD-4k11A:
30.3		 3mssD-4k11A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  41
LYS A  56
VAL A  83
ILE A  97
 GOL  A 404 (-4.5A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
None
 0.79A 3mssD-4lg4A:
17.8		 3mssD-4lg4A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 281
LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.83A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 281
VAL A 313
VAL A 323
ILE A 336
MET A 341
 VGG  A 601 ( 3.5A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
 0.93A 3mssD-4lggA:
29.7		 3mssD-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.76A 3mssD-4lwoB:
undetectable		 3mssD-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.1A)
None
None
 0.65A 3mssD-4o27B:
18.4		 3mssD-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		4 VAL A  30
VAL A   9
VAL A  93
ILE A  56
 None
 0.99A 3mssD-4r86A:
undetectable		 3mssD-4r86A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 VAL A 180
VAL A 232
VAL A 240
ILE A 182
 None
 0.89A 3mssD-4twiA:
undetectable		 3mssD-4twiA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  22
LYS A  37
VAL A  65
ILE A  79
 ACP  A1264 (-4.7A)
None
None
None
 0.67A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  22
VAL A  65
ILE A  79
MET A  84
 ACP  A1264 (-4.7A)
None
None
None
 0.66A 3mssD-4ueuA:
32.5		 3mssD-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  60
LYS A  74
VAL A 104
ILE A 124
 KSA  A 405 ( 4.9A)
None
None
None
 0.66A 3mssD-4wsqA:
22.4		 3mssD-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
LYS B 290
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.75A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 VAL B 275
VAL B 308
VAL B 318
ILE B 332
MET B 337
 1N1  B 601 ( 4.9A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.60A 3mssD-4xeyB:
35.4		 3mssD-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 VAL A  80
LYS A 176
VAL A 230
ILE A 199
 None
 0.92A 3mssD-4y67A:
undetectable		 3mssD-4y67A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00497
(SBP_bac_3) 		4 VAL A 218
VAL A 131
VAL A 151
ILE A 215
 None
 0.98A 3mssD-4ymxA:
undetectable		 3mssD-4ymxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  77
VAL A 123
ILE A 142
MET A 147
 None
 0.80A 3mssD-5ci6A:
20.9		 3mssD-5ci6A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fis EXD1

(Bombyx mori) 		PF01612
(DNA_pol_A_exo1) 		4 VAL B 192
LYS B 169
VAL B 106
ILE B 115
 None
 0.98A 3mssD-5fisB:
undetectable		 3mssD-5fisB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 4 VAL B1287
VAL B1315
VAL B1258
ILE B1279
 None
 0.91A 3mssD-5hb0B:
undetectable		 3mssD-5hb0B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF03177
(Nucleoporin_C) 		4 VAL A1287
VAL A1315
VAL A1258
ILE A1279
 None
 0.97A 3mssD-5hb1A:
undetectable		 3mssD-5hb1A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  65
LYS A  79
VAL A 109
ILE A 128
 IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
None
 0.39A 3mssD-5i3oA:
22.1		 3mssD-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  30
LYS A  45
VAL A  74
ILE A  88
 6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
 0.47A 3mssD-5j5tA:
21.3		 3mssD-5j5tA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 647
LYS A 665
ILE A 709
MET A 714
 None
None
6P6  A1001 ( 4.5A)
None
 0.69A 3mssD-5l6oA:
33.0		 3mssD-5l6oA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  25
LYS A  40
VAL A  72
ILE A  90
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
 0.69A 3mssD-5u94A:
23.5		 3mssD-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 226
LYS A 241
VAL A 273
ILE A 287
 8X7  A 501 ( 4.5A)
PO4  A 502 (-3.6A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
 0.65A 3mssD-5vdkA:
12.2		 3mssD-5vdkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 212
LYS A 227
VAL A 247
VAL A 257
 None
 0.75A 3mssD-5xzwA:
18.9		 3mssD-5xzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 VAL A  41
LYS A  56
VAL A  83
ILE A  97
 ANP  A 501 (-4.4A)
ANP  A 501 (-2.4A)
None
None
 0.84A 3mssD-6ao5A:
22.1		 3mssD-6ao5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL A 200
LYS A 213
VAL A 246
MET A 265
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
 0.73A 3mssD-6f3dA:
23.5		 3mssD-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 VAL A 177
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
None
None
 0.55A 3mssD-6fylA:
21.7		 3mssD-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 VAL A 177
VAL A 211
VAL A 227
ILE A 241
 3NG  A 501 ( 4.4A)
None
None
None
 0.75A 3mssD-6fylA:
21.7		 3mssD-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 VAL A 175
LYS A 191
VAL A 209
VAL A 225
ILE A 239
 None
EAQ  A 501 (-3.2A)
None
None
None
 0.76A 3mssD-6fyoA:
21.4		 3mssD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
 0.53A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 ( 4.3A)
None
None
None
 0.67A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7pcy PLASTOCYANIN

(Ulva prolifera) 		PF00127
(Copper-bind) 		4 VAL A  70
VAL A  98
VAL A  82
ILE A  27
 None
 0.92A 3mssD-7pcyA:
undetectable		 3mssD-7pcyA:
15.70