SIMILAR PATTERNS OF AMINO ACIDS FOR 3MSS_C_STIC1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exz STEM CELL FACTOR

(Homo sapiens) 		PF02404
(SCF) 		4 VAL A  15
VAL A  83
ILE A  76
ARG A 117
 None
 0.92A 3mssC-1exzA:
undetectable		 3mssC-1exzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		4 VAL A  35
VAL A  92
ILE A  74
ARG A  10
 None
None
None
UDP  A1377 (-4.4A)
 0.96A 3mssC-1f6dA:
undetectable		 3mssC-1f6dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxt HYDROGENASE
MATURATION PROTEIN
HYPF

(Escherichia
coli) 		PF00708
(Acylphosphatase) 		4 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 1.02A 3mssC-1gxtA:
undetectable		 3mssC-1gxtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 323
VAL A  66
ILE A 300
MET A  82
 None
 1.13A 3mssC-1jr1A:
undetectable		 3mssC-1jr1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		4 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 1.04A 3mssC-1k1eA:
undetectable		 3mssC-1k1eA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.64A 3mssC-1k9aA:
30.9		 3mssC-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 608
VAL A 638
MET A 657
ARG A 723
 None
 0.81A 3mssC-1lufA:
35.0		 3mssC-1lufA:
37.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 VAL A 479
VAL A 358
ILE A 353
ARG A 459
 None
 0.96A 3mssC-1lw3A:
undetectable		 3mssC-1lw3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  93
VAL A 118
ILE A 136
ARG A 185
 STU  A 401 ( 4.5A)
None
None
None
 0.97A 3mssC-1nxkA:
19.3		 3mssC-1nxkA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.48A 3mssC-1opkA:
34.5		 3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
VAL A 318
ILE A 332
ARG A 381
 P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 1.00A 3mssC-1opkA:
34.5		 3mssC-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 308
VAL A 318
ILE A 332
MET A 337
 None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 0.48A 3mssC-1opkA:
34.5		 3mssC-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 VAL A 394
VAL A 288
ILE A 200
ARG A 307
 None
 1.10A 3mssC-1pvjA:
undetectable		 3mssC-1pvjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 296
VAL A 242
ILE A 288
ARG A 261
 None
 0.97A 3mssC-1rcqA:
undetectable		 3mssC-1rcqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010

(Pyrococcus
horikoshii) 		PF01871
(AMMECR1) 		4 LYS A 203
VAL A  14
ILE A 190
ARG A  53
 None
 0.82A 3mssC-1vajA:
undetectable		 3mssC-1vajA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yww HYPOTHETICAL PROTEIN
PA4738

(Pseudomonas
aeruginosa) 		PF05532
(CsbD) 		4 VAL A  40
ILE A   6
MET A   1
ARG A  53
 None
 1.14A 3mssC-1ywwA:
undetectable		 3mssC-1ywwA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.14A 3mssC-2csdA:
undetectable		 3mssC-2csdA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 0.98A 3mssC-2dq7X:
31.9		 3mssC-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 VAL A  90
VAL A 101
ILE A  85
MET A  76
 None
 1.08A 3mssC-2euhA:
undetectable		 3mssC-2euhA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcf MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LYS A1203
VAL A1209
VAL A1152
ILE A1187
 None
 1.15A 3mssC-2fcfA:
undetectable		 3mssC-2fcfA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
VAL A 323
ILE A 336
MET A 341
 None
 0.89A 3mssC-2hckA:
29.8		 3mssC-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.64A 3mssC-2hk5A:
27.5		 3mssC-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 289
VAL A 299
ILE A 313
MET A 318
ARG A 362
 None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
None
 0.85A 3mssC-2hz0A:
34.6		 3mssC-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		4 VAL G 341
VAL G 296
ILE G 360
ARG G 367
 None
 1.06A 3mssC-2iouG:
undetectable		 3mssC-2iouG:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 3mssC-2iyoA:
undetectable		 3mssC-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.67A 3mssC-2j0jA:
32.1		 3mssC-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lx3 TYPE III ANTIFREEZE
PROTEIN NFEAFP11

(Zoarces
elongatus) 		no annotation 4 VAL A   5
VAL A  20
ILE A  11
ARG A  39
 None
 1.13A 3mssC-2lx3A:
undetectable		 3mssC-2lx3A:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
ILE A 314
MET A 319
ARG A 363
 None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
None
 0.79A 3mssC-2og8A:
32.0		 3mssC-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.08A 3mssC-2p3gX:
17.7		 3mssC-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.96A 3mssC-2q27A:
undetectable		 3mssC-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 VAL A 196
VAL A 188
ILE A 211
ARG A 268
 None
None
None
GOL  A1441 ( 4.1A)
 1.08A 3mssC-2w38A:
undetectable		 3mssC-2w38A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  65
ILE A  71
MET A 146
ARG A   5
 None
None
ADP  A1303 (-4.2A)
None
 1.05A 3mssC-2w4kA:
22.4		 3mssC-2w4kA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp4 MOLYBDOPTERIN-CONVER
TING FACTOR SUBUNIT
2 1

(Mycobacterium
tuberculosis) 		PF02391
(MoaE) 		4 LYS A 125
VAL A  87
ILE A 121
MET A  70
 None
 1.10A 3mssC-2wp4A:
undetectable		 3mssC-2wp4A:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 303
ILE A 317
MET A 322
ARG A 366
 None
 1.08A 3mssC-2zv7A:
31.3		 3mssC-2zv7A:
46.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 VAL A 531
ILE A 298
MET A 569
ARG A 435
 None
None
None
SO4  A 654 (-3.7A)
 1.07A 3mssC-3af5A:
undetectable		 3mssC-3af5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjz PHOSPHOHEPTOSE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13580
(SIS_2) 		4 VAL A  37
VAL A 142
ILE A  46
ARG A 190
 None
 1.12A 3mssC-3bjzA:
undetectable		 3mssC-3bjzA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.64A 3mssC-3d7uA:
26.9		 3mssC-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.66A 3mssC-3dkoA:
30.7		 3mssC-3dkoA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 695
ILE A 709
MET A 714
ARG A 757
 IHZ  A1001 ( 4.9A)
None
None
None
 0.89A 3mssC-3dkoA:
30.7		 3mssC-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		4 VAL A   9
VAL A 168
ILE A   5
ARG A  21
 None
 1.00A 3mssC-3dmeA:
undetectable		 3mssC-3dmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 VAL C1602
VAL C1647
ILE C1582
ARG C1632
 None
 1.04A 3mssC-3dqvC:
undetectable		 3mssC-3dqvC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.12A 3mssC-3dwlF:
undetectable		 3mssC-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4

(Rattus
norvegicus) 		PF13848
(Thioredoxin_6) 		4 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.06A 3mssC-3ec3A:
undetectable		 3mssC-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 308
VAL A 125
ILE A 275
ARG A  39
 None
 1.15A 3mssC-3fcpA:
undetectable		 3mssC-3fcpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 LYS A 180
VAL A 161
VAL A 153
ILE A 179
 None
 1.01A 3mssC-3ffsA:
undetectable		 3mssC-3ffsA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  82
VAL A 113
ILE A 127
MET A 132
 STU  A   1 ( 4.2A)
None
None
None
 0.65A 3mssC-3fmeA:
17.7		 3mssC-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.10A 3mssC-3geiA:
undetectable		 3mssC-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN

([Clostridium]
symbiosum) 		PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N) 		4 VAL A 201
VAL A 188
ILE A 154
ARG A 176
 None
 0.99A 3mssC-3gkuA:
undetectable		 3mssC-3gkuA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 4 VAL A 277
VAL A 109
ILE A 311
ARG A 233
 None
 1.02A 3mssC-3j0hA:
undetectable		 3mssC-3j0hA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.05A 3mssC-3j8gX:
undetectable		 3mssC-3j8gX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 LYS A 180
VAL A 161
VAL A 153
ILE A 179
 None
 0.99A 3mssC-3khjA:
undetectable		 3mssC-3khjA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A   6
VAL A  86
ILE A 114
MET A 279
 None
 1.06A 3mssC-3my9A:
undetectable		 3mssC-3my9A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.75A 3mssC-3ppzA:
28.6		 3mssC-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  73
VAL A  98
ILE A 116
ARG A 165
 I85  A 350 (-2.8A)
None
None
None
 0.82A 3mssC-3sheA:
18.5		 3mssC-3sheA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Toxoplasma
gondii) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A  75
VAL A  91
ILE A  84
ARG A  15
 None
 1.13A 3mssC-3sthA:
undetectable		 3mssC-3sthA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  82
VAL A 113
ILE A 127
MET A 132
 ANK  A 401 (-2.4A)
None
None
None
 1.07A 3mssC-3vn9A:
21.9		 3mssC-3vn9A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		4 VAL A 110
VAL A 250
ILE A 125
ARG A 299
 None
 1.05A 3mssC-4b43A:
undetectable		 3mssC-4b43A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LYS A 532
VAL A 569
VAL A 592
ARG A 562
 None
 1.15A 3mssC-4bp8A:
undetectable		 3mssC-4bp8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 317
VAL A 303
ILE A 328
ARG A 262
 None
None
None
NAP  A 502 (-3.3A)
 0.99A 3mssC-4gi2A:
undetectable		 3mssC-4gi2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 VAL A 162
VAL A 196
ILE A 125
ARG A 170
 None
None
NAI  A 502 (-3.7A)
None
 1.11A 3mssC-4im7A:
undetectable		 3mssC-4im7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 VAL A  72
VAL A  68
ILE A  98
ARG A  57
 None
 1.05A 3mssC-4irxA:
undetectable		 3mssC-4irxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 450
VAL A 507
ILE A 512
ARG A 492
 None
 1.03A 3mssC-4isbA:
undetectable		 3mssC-4isbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		4 VAL A 225
VAL A 194
ILE A 271
ARG A 117
 None
 1.03A 3mssC-4jduA:
undetectable		 3mssC-4jduA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 VAL A 169
VAL A 139
ILE A 221
ARG A 157
 None
SO4  A 503 (-4.8A)
None
NK  A 501 ( 4.9A)
 1.02A 3mssC-4jz6A:
undetectable		 3mssC-4jz6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis) 		PF14011
(ESX-1_EspG) 		4 VAL A 115
VAL A 106
ILE A  72
ARG A  95
 None
 1.14A 3mssC-4l4wA:
undetectable		 3mssC-4l4wA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 313
VAL A 323
ILE A 336
MET A 341
ARG A 385
 None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
None
 1.03A 3mssC-4lggA:
29.5		 3mssC-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.78A 3mssC-4lwoB:
undetectable		 3mssC-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		4 LYS A 261
VAL A 242
VAL A 234
ILE A 260
 None
 0.98A 3mssC-4mz1A:
undetectable		 3mssC-4mz1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		4 VAL A  93
VAL A 128
ILE A 119
ARG A  13
 None
 1.13A 3mssC-4oecA:
undetectable		 3mssC-4oecA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
VAL A  65
ILE A  79
ARG A 128
 None
 1.13A 3mssC-4ueuA:
32.4		 3mssC-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 VAL A  65
ILE A  79
MET A  84
ARG A 128
 None
 0.98A 3mssC-4ueuA:
32.4		 3mssC-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0j ACYL-[ACYL-CARRIER-P
ROTEIN] DESATURASE,
CHLOROPLASTIC

(Ricinus
communis) 		PF03405
(FA_desaturase_2) 		4 VAL A 305
ILE A 190
MET A 265
ARG A 329
 None
 0.96A 3mssC-4v0jA:
undetectable		 3mssC-4v0jA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LYS B 290
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 (-4.6A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.74A 3mssC-4xeyB:
35.3		 3mssC-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 VAL B 308
VAL B 318
ILE B 332
MET B 337
 None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
None
 0.57A 3mssC-4xeyB:
35.3		 3mssC-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 VAL A 296
VAL A  45
ILE A 273
MET A  61
 None
 1.06A 3mssC-5ahmA:
undetectable		 3mssC-5ahmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 296
VAL A  45
ILE A 273
MET A  61
 None
 1.08A 3mssC-5ahnA:
undetectable		 3mssC-5ahnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L3

(Dictyostelium
discoideum) 		PF00297
(Ribosomal_L3) 		4 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 0.85A 3mssC-5an9A:
undetectable		 3mssC-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 LYS I 315
VAL I 345
ILE I 313
ARG I 323
 None
 0.91A 3mssC-5b04I:
undetectable		 3mssC-5b04I:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 VAL A  70
VAL A  28
ILE A 123
ARG A  41
 None
 0.89A 3mssC-5by3A:
undetectable		 3mssC-5by3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		4 VAL A 375
VAL A 390
ILE A 381
ARG A 409
 None
 0.87A 3mssC-5c7rA:
undetectable		 3mssC-5c7rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 VAL A 862
VAL A 801
ILE A 859
ARG A 456
 None
 1.11A 3mssC-5hy7A:
undetectable		 3mssC-5hy7A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A  78
VAL A  95
ILE A  87
ARG A  15
 None
 1.10A 3mssC-5j9gA:
undetectable		 3mssC-5j9gA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 VAL A 457
VAL A 442
ILE A 548
ARG A 486
 None
 1.03A 3mssC-5jrlA:
undetectable		 3mssC-5jrlA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.88A 3mssC-5k5tA:
undetectable		 3mssC-5k5tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Chaetomium
thermophilum) 		PF01912
(eIF-6) 		4 VAL A 199
VAL A 109
ILE A 193
ARG A 223
 None
 1.15A 3mssC-5m3qA:
undetectable		 3mssC-5m3qA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1h OUTER MEMBRANE PORIN
F

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 VAL A 111
VAL A  85
ILE A  29
ARG A  65
 None
 1.13A 3mssC-5u1hA:
undetectable		 3mssC-5u1hA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		4 VAL A 139
VAL A 341
ILE A  95
ARG A 126
 None
 1.11A 3mssC-5u7sA:
undetectable		 3mssC-5u7sA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LYS A  40
VAL A  72
ILE A  90
ARG A 137
 G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
 0.96A 3mssC-5u94A:
18.9		 3mssC-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 VAL A 146
ILE A 214
MET A 238
ARG A 540
 None
 1.11A 3mssC-5w25A:
undetectable		 3mssC-5w25A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.88A 3mssC-5wlhA:
undetectable		 3mssC-5wlhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Caldanaerobacter
subterraneus) 		no annotation 4 VAL A 203
VAL A 176
ILE A 159
ARG A 186
 None
 1.10A 3mssC-5woyA:
undetectable		 3mssC-5woyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 4 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.74A 3mssC-5xw6C:
undetectable		 3mssC-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
agalactiae) 		no annotation 4 VAL A  78
VAL A  94
ILE A  87
ARG A  19
 None
 1.14A 3mssC-5y37A:
undetectable		 3mssC-5y37A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5s PHOTOSYNTHETIC
REACTION CENTER H
SUBUNIT

(Thermochromatium
tepidum) 		no annotation 4 VAL H 239
VAL H 184
ILE H 214
ARG H 180
 None
 1.14A 3mssC-5y5sH:
undetectable		 3mssC-5y5sH:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.11A 3mssC-5zzkA:
undetectable		 3mssC-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10

(Homo sapiens) 		no annotation 4 VAL B  53
VAL B  56
ILE B   3
ARG B  82
 None
 1.14A 3mssC-6c9mB:
undetectable		 3mssC-6c9mB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 LYS A 213
VAL A 246
MET A 265
ARG A 310
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.12A 3mssC-6f3dA:
23.2		 3mssC-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL A 236
VAL A 246
MET A 265
ARG A 310
 None
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.08A 3mssC-6f3dA:
23.2		 3mssC-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 0.99A 3mssC-6fkhg:
undetectable		 3mssC-6fkhg:
11.97