SIMILAR PATTERNS OF AMINO ACIDS FOR 3MS9_B_STIB1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 TYR A  39
VAL A  43
ILE A  91
ARG A 191
 None
 1.14A 3ms9B-1a3qA:
undetectable		 3ms9B-1a3qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		4 VAL A  25
VAL A 269
ILE A 211
ARG A 293
 None
 1.22A 3ms9B-1b5tA:
undetectable		 3ms9B-1b5tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exz STEM CELL FACTOR

(Homo sapiens) 		PF02404
(SCF) 		4 VAL A  15
VAL A  83
ILE A  76
ARG A 117
 None
 0.91A 3ms9B-1exzA:
undetectable		 3ms9B-1exzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 VAL A  82
ILE A  46
MET A  92
ARG A  28
 None
 1.06A 3ms9B-1gpmA:
undetectable		 3ms9B-1gpmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 TYR A 187
VAL A 145
ILE A 152
ARG A 142
 None
 1.27A 3ms9B-1hl2A:
undetectable		 3ms9B-1hl2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A  88
VAL A 185
VAL A 125
ILE A 219
 None
 1.35A 3ms9B-1i4gA:
undetectable		 3ms9B-1i4gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A   6
VAL A  27
ILE A  48
ARG A  78
 None
 1.34A 3ms9B-1j6uA:
undetectable		 3ms9B-1j6uA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 VAL A 210
VAL A  46
ILE A 185
MET A  35
 None
 1.24A 3ms9B-1k1xA:
undetectable		 3ms9B-1k1xA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		4 VAL F 199
VAL F 159
ILE F 130
ARG F 189
 None
 1.34A 3ms9B-1ka9F:
undetectable		 3ms9B-1ka9F:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		4 VAL A 130
ILE A 140
MET A   1
ARG A 126
 None
 1.15A 3ms9B-1kzlA:
undetectable		 3ms9B-1kzlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  93
VAL A 118
ILE A 136
ARG A 185
 STU  A 401 ( 4.5A)
None
None
None
 1.01A 3ms9B-1nxkA:
19.0		 3ms9B-1nxkA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.54A 3ms9B-1opkA:
34.5		 3ms9B-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 TYR A 272
VAL A 308
VAL A 318
ILE A 332
MET A 337
 P16  A   2 (-3.6A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 0.70A 3ms9B-1opkA:
34.5		 3ms9B-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A  67
LYS A 185
VAL A  95
ILE A 189
 None
 1.19A 3ms9B-1oseA:
undetectable		 3ms9B-1oseA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A  10
VAL A  96
VAL A 152
ILE A  99
 None
 1.28A 3ms9B-1ovmA:
undetectable		 3ms9B-1ovmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		4 VAL A 116
VAL A  97
ILE A 123
ARG A  14
 None
 1.28A 3ms9B-1sjiA:
undetectable		 3ms9B-1sjiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		4 VAL B 155
VAL B 278
ILE B 344
ARG B 294
 None
 1.19A 3ms9B-1u2vB:
undetectable		 3ms9B-1u2vB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 TYR A 319
VAL A 188
VAL A 242
ILE A 337
 None
 1.01A 3ms9B-1w5eA:
undetectable		 3ms9B-1w5eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 TYR A 152
VAL A 180
ILE A 129
ARG A 203
 None
 1.22A 3ms9B-1wczA:
undetectable		 3ms9B-1wczA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		4 VAL A 329
VAL A 368
ILE A 336
ARG A 508
 None
 1.33A 3ms9B-1xnyA:
undetectable		 3ms9B-1xnyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		4 VAL A 138
VAL A  88
ILE A 167
ARG A 100
 None
 1.23A 3ms9B-1xovA:
undetectable		 3ms9B-1xovA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 VAL A 178
VAL A 170
ILE A 262
ARG A  26
 None
 0.81A 3ms9B-1ywfA:
undetectable		 3ms9B-1ywfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		4 TYR A  59
VAL A 356
VAL A 325
ILE A  78
 None
 1.23A 3ms9B-1yxaA:
undetectable		 3ms9B-1yxaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1b CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		4 VAL A  16
VAL A  57
ILE A  45
ARG A  11
 None
 1.22A 3ms9B-2a1bA:
undetectable		 3ms9B-2a1bA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		4 TYR P 109
VAL P  86
ILE P 175
MET P  49
 None
 1.30A 3ms9B-2aieP:
undetectable		 3ms9B-2aieP:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 TYR A 429
VAL A  36
ILE A  50
ARG A 213
 None
 1.22A 3ms9B-2cu0A:
undetectable		 3ms9B-2cu0A:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS X  39
VAL X  67
ILE X  80
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 1.07A 3ms9B-2dq7X:
31.9		 3ms9B-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
VAL A 291
VAL A 301
ILE A 314
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
 0.61A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
VAL A 301
ILE A 314
MET A 319
 None
None
1BM  A 499 (-3.9A)
None
 0.60A 3ms9B-2hk5A:
27.6		 3ms9B-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 289
VAL A 299
ILE A 313
MET A 318
 None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 0.27A 3ms9B-2hz0A:
34.9		 3ms9B-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.11A 3ms9B-2iyoA:
undetectable		 3ms9B-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0s RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1) 		4 TYR D  96
VAL D  77
ILE D 102
ARG D  68
 None
 1.34A 3ms9B-2j0sD:
undetectable		 3ms9B-2j0sD:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
ILE A 314
MET A 319
ARG A 363
 None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
None
 1.10A 3ms9B-2og8A:
32.0		 3ms9B-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 4 VAL G  56
VAL G 160
ILE G  35
ARG G 287
 None
 1.26A 3ms9B-2ooxG:
undetectable		 3ms9B-2ooxG:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		4 TYR A 111
VAL A  87
ILE A 176
MET A  50
 None
 1.25A 3ms9B-2os3A:
undetectable		 3ms9B-2os3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.12A 3ms9B-2p3gX:
17.3		 3ms9B-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 0.98A 3ms9B-2q27A:
undetectable		 3ms9B-2q27A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A   7
VAL A  93
VAL A 149
ILE A  96
 TYR  A   7 ( 1.3A)
VAL  A  93 ( 0.6A)
VAL  A 149 ( 0.6A)
ILE  A  96 ( 0.6A)
 1.31A 3ms9B-2vbfA:
undetectable		 3ms9B-2vbfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 377
VAL A  38
ILE A 372
MET A 170
 None
 1.11A 3ms9B-2yfkA:
undetectable		 3ms9B-2yfkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE

(Japanese
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 VAL A 221
ILE A 301
MET A 495
ARG A 242
 None
 1.30A 3ms9B-2z83A:
undetectable		 3ms9B-2z83A:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1050
VAL A1060
MET A1079
ARG A1131
 None
None
None
PTR  A1163 ( 3.6A)
 0.77A 3ms9B-2z8cA:
28.7		 3ms9B-2z8cA:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		4 TYR A  30
VAL A 117
ILE A   4
ARG A 107
 None
None
None
CDP  A 209 (-2.9A)
 1.12A 3ms9B-3akcA:
undetectable		 3ms9B-3akcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 4 TYR A 276
VAL A 326
ILE A 281
ARG A 318
 None
 1.08A 3ms9B-3c2qA:
undetectable		 3ms9B-3c2qA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
VAL A 695
ILE A 709
MET A 714
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
None
 0.63A 3ms9B-3dkoA:
27.7		 3ms9B-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.33A 3ms9B-3dwlF:
undetectable		 3ms9B-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  82
VAL A 113
ILE A 127
MET A 132
 STU  A   1 ( 4.2A)
None
None
None
 0.64A 3ms9B-3fmeA:
17.7		 3ms9B-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		4 TYR A 215
VAL A 316
VAL A 349
ARG A 325
 None
 1.22A 3ms9B-3hoaA:
undetectable		 3ms9B-3hoaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpm PRKCA-BINDING
PROTEIN,9-MER
PEPTIDE OF THE GLUR2
SUBUNIT

(Rattus
norvegicus;
synthetic
construct) 		PF00595
(PDZ) 		4 TYR A  48
VAL A  97
ILE A  35
ARG A  76
 None
 1.16A 3ms9B-3hpmA:
undetectable		 3ms9B-3hpmA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 VAL A 112
VAL A  67
ILE A  39
ARG A 135
 None
 1.14A 3ms9B-3hvuA:
undetectable		 3ms9B-3hvuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 379
VAL A 343
ILE A 382
ARG A 366
 None
 1.06A 3ms9B-3mogA:
undetectable		 3ms9B-3mogA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A   6
VAL A  86
ILE A 114
MET A 279
 None
 1.07A 3ms9B-3my9A:
undetectable		 3ms9B-3my9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5u ACTINIDIN

(Actinidia
arguta) 		PF00112
(Peptidase_C1) 		4 VAL A 133
VAL A  13
ILE A  40
ARG A 198
 None
 1.19A 3ms9B-3p5uA:
undetectable		 3ms9B-3p5uA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.73A 3ms9B-3ppzA:
28.6		 3ms9B-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 TYR E  63
VAL E  47
VAL E 229
ILE E  67
 None
 1.19A 3ms9B-3sdiE:
undetectable		 3ms9B-3sdiE:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 VAL A  82
ILE A  46
MET A  92
ARG A  28
 None
 1.20A 3ms9B-3tqiA:
undetectable		 3ms9B-3tqiA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  55
VAL A 108
ILE A  36
ARG A  89
 None
 1.22A 3ms9B-3ugvA:
undetectable		 3ms9B-3ugvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		4 TYR A  60
VAL A  42
VAL A  76
ILE A 154
 None
 1.33A 3ms9B-3ussA:
undetectable		 3ms9B-3ussA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		4 VAL A 193
VAL A  57
ILE A 216
MET A 230
 None
 1.34A 3ms9B-3wgcA:
undetectable		 3ms9B-3wgcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 TYR A1516
VAL A1529
ILE A1606
ARG A 960
 None
 1.24A 3ms9B-4amcA:
undetectable		 3ms9B-4amcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 TYR A 390
VAL A 334
VAL A 294
ILE A 365
 None
 1.20A 3ms9B-4ay2A:
undetectable		 3ms9B-4ay2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A 388
VAL A 413
ILE A 447
ARG A 365
 None
 1.03A 3ms9B-4g9iA:
undetectable		 3ms9B-4g9iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 317
VAL A 303
ILE A 328
ARG A 262
 None
None
None
NAP  A 502 (-3.3A)
 0.87A 3ms9B-4gi2A:
undetectable		 3ms9B-4gi2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		4 VAL A 261
VAL A 279
ILE A 111
ARG A  42
 None
None
None
CIT  A 302 (-3.1A)
 1.27A 3ms9B-4h1xA:
undetectable		 3ms9B-4h1xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 450
VAL A 507
ILE A 512
ARG A 492
 None
 1.02A 3ms9B-4isbA:
undetectable		 3ms9B-4isbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 TYR A  87
VAL A 413
VAL A 400
ILE A 424
 TYR  A  87 ( 1.3A)
VAL  A 413 ( 0.6A)
VAL  A 400 ( 0.6A)
ILE  A 424 ( 0.4A)
 1.30A 3ms9B-4mwtA:
undetectable		 3ms9B-4mwtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 TYR A 294
VAL A 376
VAL A 347
ILE A 327
 None
 1.18A 3ms9B-4nk6A:
undetectable		 3ms9B-4nk6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4o PHYCOCYANOBILIN
LYASE CPCT

(Nostoc sp. PCC
7120) 		PF06206
(CpeT) 		4 VAL A  49
VAL A  53
ILE A  81
ARG A  12
 None
 0.91A 3ms9B-4o4oA:
undetectable		 3ms9B-4o4oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A6126
VAL A6298
ILE A6123
ARG A6219
 None
 1.18A 3ms9B-4opfA:
undetectable		 3ms9B-4opfA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 TYR A 294
VAL A 376
VAL A 347
ILE A 327
 None
 1.18A 3ms9B-4ozyA:
undetectable		 3ms9B-4ozyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt4 PEPTIDYL-TRNA
HYDROLASE

(Streptococcus
pyogenes) 		PF01195
(Pept_tRNA_hydro) 		4 TYR A  92
VAL A  31
VAL A 167
ILE A   5
 None
 1.29A 3ms9B-4qt4A:
undetectable		 3ms9B-4qt4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgz XAA-PRO
AMINOPEPTIDASE

(Thermococcus
sibiricus) 		no annotation 4 TYR A 164
VAL A 196
VAL A 241
ILE A 183
 None
 1.32A 3ms9B-4rgzA:
undetectable		 3ms9B-4rgzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 TYR A  70
VAL A 114
VAL A 119
ILE A 100
 None
 1.23A 3ms9B-4rweA:
undetectable		 3ms9B-4rweA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 VAL A 409
VAL A 439
ILE A 576
ARG A 354
 None
 1.11A 3ms9B-4tweA:
undetectable		 3ms9B-4tweA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		4 TYR A 209
VAL A 262
MET A 178
ARG A  13
 None
 1.08A 3ms9B-4uq9A:
undetectable		 3ms9B-4uq9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 543
VAL A 598
ILE A 514
ARG A 530
 None
 1.16A 3ms9B-4w8jA:
undetectable		 3ms9B-4w8jA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 TYR A 586
VAL A 668
MET A 652
ARG A 559
 None
 1.27A 3ms9B-4wrnA:
undetectable		 3ms9B-4wrnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		4 VAL A 100
VAL A 241
ILE A 235
ARG A  65
 None
 1.01A 3ms9B-4y7dA:
undetectable		 3ms9B-4y7dA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		4 VAL A  41
VAL A  24
ILE A  38
ARG A  55
 None
 1.24A 3ms9B-4yamA:
undetectable		 3ms9B-4yamA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab8 GROUP 1 TRUNCATED
HEMOGLOBIN GLBN

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		4 VAL A  94
VAL A  29
ILE A 119
ARG A  84
 HEM  A 144 (-4.2A)
None
HEM  A 144 ( 4.9A)
HEM  A 144 (-3.3A)
 1.17A 3ms9B-5ab8A:
undetectable		 3ms9B-5ab8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		4 TYR A 190
VAL A  12
VAL A 126
ILE A 114
 None
 0.84A 3ms9B-5b6kA:
undetectable		 3ms9B-5b6kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 TYR A 344
VAL A 351
ILE A 159
MET A 155
 None
 1.36A 3ms9B-5fa1A:
undetectable		 3ms9B-5fa1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fka STAPHYLOCOCCAL
ENTEROTOXIN E

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR C  88
VAL C 185
VAL C 125
ILE C 219
 None
 1.30A 3ms9B-5fkaC:
undetectable		 3ms9B-5fkaC:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc) 		4 TYR A 745
VAL A 726
ILE A 805
ARG A 694
 None
 1.11A 3ms9B-5jnbA:
undetectable		 3ms9B-5jnbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 VAL A 452
VAL A 465
ILE A 474
ARG A 585
 None
 1.21A 3ms9B-5k9tA:
undetectable		 3ms9B-5k9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		4 TYR A 235
VAL A 143
VAL A 306
ARG A 359
 None
 1.24A 3ms9B-5m7oA:
undetectable		 3ms9B-5m7oA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h PROTEASOME SUBUNIT
BETA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		4 TYR O 189
VAL O  99
VAL O  13
ILE O  34
 None
 1.14A 3ms9B-5t0hO:
undetectable		 3ms9B-5t0hO:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h PROTEASOME SUBUNIT
BETA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		4 TYR O 189
VAL O  99
VAL O 177
ILE O  34
 None
 1.24A 3ms9B-5t0hO:
undetectable		 3ms9B-5t0hO:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		4 TYR A 617
VAL A 519
VAL A 515
ILE A 532
 None
 1.06A 3ms9B-5tj7A:
undetectable		 3ms9B-5tj7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 VAL A  23
VAL A 267
ILE A 209
ARG A 291
 None
 1.25A 3ms9B-5umeA:
undetectable		 3ms9B-5umeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6y CHORISMATE MUTASE

(Physcomitrella
patens) 		no annotation 4 VAL A 254
VAL A 299
MET A 179
ARG A  82
 None
 1.31A 3ms9B-5w6yA:
undetectable		 3ms9B-5w6yA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 270
VAL A 248
MET A  33
ARG A 198
 None
 1.28A 3ms9B-5welA:
undetectable		 3ms9B-5welA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3t RIBONUCLEASE VAPC26

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		4 TYR B  88
VAL B  39
VAL B 102
ILE B  95
 None
 1.29A 3ms9B-5x3tB:
undetectable		 3ms9B-5x3tB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5

(Mus musculus) 		no annotation 4 TYR B 126
VAL B  39
VAL B  92
ILE B 123
 None
 1.31A 3ms9B-5x6mB:
undetectable		 3ms9B-5x6mB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 4 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.81A 3ms9B-5xw6C:
undetectable		 3ms9B-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 VAL A 223
VAL A 242
ILE A 231
MET A 264
 None
 1.16A 3ms9B-5zzkA:
undetectable		 3ms9B-5zzkA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 393
VAL A 298
ILE A 387
ARG A 153
 None
None
None
C  I  58 ( 4.0A)
 1.05A 3ms9B-6asoA:
undetectable		 3ms9B-6asoA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 VAL M 276
VAL M 248
ILE M 189
MET M 152
 None
 1.19A 3ms9B-6cfwM:
undetectable		 3ms9B-6cfwM:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 869
VAL A 558
ILE A 883
MET A 921
 None
 1.23A 3ms9B-6eojA:
undetectable		 3ms9B-6eojA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewp CENTROSOMAL PROTEIN
OF 120 KDA

(Mus musculus) 		no annotation 4 VAL A 500
ILE A 596
MET A 504
ARG A 480
 None
 1.30A 3ms9B-6ewpA:
undetectable		 3ms9B-6ewpA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 LYS P 283
VAL P 242
ILE P 287
ARG P 186
 None
 1.21A 3ms9B-6g2jP:
undetectable		 3ms9B-6g2jP:
11.19