SIMILAR PATTERNS OF AMINO ACIDS FOR 3MJR_D_AC2D601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 GLU A  76
GLN A 112
ARG A  74
ASP A  65
 None
 1.12A 3mjrD-1gkrA:
1.3		 3mjrD-1gkrA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A  80
PHE A 128
ARG A 354
ASP A  57
 None
OCA  A1360 (-4.5A)
NAJ  A1361 (-3.1A)
None
 1.10A 3mjrD-1h2bA:
undetectable		 3mjrD-1h2bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 GLU A 145
TYR A 211
PHE A 271
ARG A 142
 None
 0.99A 3mjrD-1nnhA:
undetectable		 3mjrD-1nnhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 PHE A  63
ARG A  98
ARG A  95
ASP A  99
 None
 1.17A 3mjrD-1o12A:
undetectable		 3mjrD-1o12A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 GLU A1295
GLN A1001
ARG A1257
PHE A1014
 None
 0.97A 3mjrD-1tllA:
3.3		 3mjrD-1tllA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A  12
TYR A 357
PHE A 375
ASP A 382
 None
 1.13A 3mjrD-1ulzA:
undetectable		 3mjrD-1ulzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpm ACYL-COA HYDROLASE

(Bacillus
halodurans) 		PF03061
(4HBT) 		4 GLU A  89
ARG A 150
ARG A 146
ASP A  60
 None
 0.94A 3mjrD-1vpmA:
undetectable		 3mjrD-1vpmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 GLU A 289
TYR A 532
ARG A 268
PHE A 388
 None
 1.07A 3mjrD-1yi7A:
undetectable		 3mjrD-1yi7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		4 GLU A1281
TYR A1523
ARG A1269
PHE A1381
 None
 1.07A 3mjrD-1yrzA:
undetectable		 3mjrD-1yrzA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		6 GLU A  53
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
 DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
 0.78A 3mjrD-2a30A:
30.4		 3mjrD-2a30A:
92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		6 GLU A  53
TYR A  86
GLN A  97
ARG A 104
ARG A 128
ASP A 133
 DCZ  A 302 (-3.0A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
 0.86A 3mjrD-2a30A:
30.4		 3mjrD-2a30A:
92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 PHE A  96
GLN A  97
ARG A 128
ASP A 133
PHE A 137
 DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
 0.89A 3mjrD-2a30A:
30.4		 3mjrD-2a30A:
92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 TYR A  86
PHE A  96
GLN A  97
ARG A 128
ASP A 133
 DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
 0.92A 3mjrD-2a30A:
30.4		 3mjrD-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 GLU A 458
PHE A 431
ARG A 454
PHE A 471
 None
 1.13A 3mjrD-2ehqA:
undetectable		 3mjrD-2ehqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 GLU A 289
TYR A 532
ARG A 268
PHE A 388
 None
 1.04A 3mjrD-2exhA:
undetectable		 3mjrD-2exhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0v RAC-LIKE GTP-BINDING
PROTEIN ARAC7

(Arabidopsis
thaliana) 		PF00071
(Ras) 		4 GLU A 155
GLN A 162
ARG A 123
ASP A 124
 None
 1.19A 3mjrD-2j0vA:
4.8		 3mjrD-2j0vA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		5 GLU A 218
ARG A 366
ARG A 368
ASP A 422
PHE A 401
 None
 1.44A 3mjrD-2j3zA:
undetectable		 3mjrD-2j3zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		5 GLN A  54
ARG A  61
ARG A  78
ASP A  83
PHE A  86
 DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.6A)
 0.85A 3mjrD-2jaqA:
20.0		 3mjrD-2jaqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		4 TYR A  43
GLN A  54
ARG A  61
ASP A  83
 None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-3.6A)
 0.86A 3mjrD-2jaqA:
20.0		 3mjrD-2jaqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		4 PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 1.19A 3mjrD-2jcsA:
21.7		 3mjrD-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		4 TYR A  70
PHE A  80
GLN A  81
ARG A 105
 TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
 0.92A 3mjrD-2jcsA:
21.7		 3mjrD-2jcsA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLU A  70
TYR A 100
PHE A 110
GLN A 111
ASP A 147
 None
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-4.1A)
 1.41A 3mjrD-2ocpA:
28.4		 3mjrD-2ocpA:
44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfx UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Ruegeria sp.
TM1040) 		PF02627
(CMD) 		4 GLU A 141
ARG A 148
ARG A 144
ASP A 154
 None
 0.86A 3mjrD-2pfxA:
undetectable		 3mjrD-2pfxA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wex APOLIPOPROTEIN M

(Homo sapiens) 		PF11032
(ApoM) 		4 GLU A 136
PHE A  71
ARG A 143
PHE A  63
 GYM  A1186 (-3.1A)
GYM  A1186 (-3.8A)
None
GYM  A1186 (-4.6A)
 1.07A 3mjrD-2wexA:
undetectable		 3mjrD-2wexA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 TYR A 502
PHE A 507
GLN A 476
ASP A 473
 None
 1.12A 3mjrD-2xa7A:
undetectable		 3mjrD-2xa7A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 GLU A 134
PHE A 257
ARG A 142
PHE A 143
 None
 0.91A 3mjrD-2yn0A:
undetectable		 3mjrD-2yn0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		4 GLU A 338
ARG A 340
ASP A 329
PHE A 332
 None
 1.07A 3mjrD-3btpA:
undetectable		 3mjrD-3btpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		4 GLU A 138
ARG A 145
ARG A 141
ASP A 151
 None
 0.95A 3mjrD-3c1lA:
undetectable		 3mjrD-3c1lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 GLU A 291
TYR A 534
ARG A 267
PHE A 390
 None
 1.02A 3mjrD-3c2uA:
undetectable		 3mjrD-3c2uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		4 GLU A 381
PHE A  23
ARG A 474
ASP A 472
 None
 1.07A 3mjrD-3c3vA:
undetectable		 3mjrD-3c3vA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Cytophaga
hutchinsonii) 		PF03009
(GDPD) 		4 GLU A  62
GLN A 106
ARG A 102
PHE A 103
 EDO  A 273 (-3.0A)
None
GOL  A 289 (-2.7A)
None
 0.84A 3mjrD-3ch0A:
undetectable		 3mjrD-3ch0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		4 PHE A 395
ARG A  57
ASP A 391
PHE A 393
 None
 1.07A 3mjrD-3e0jA:
undetectable		 3mjrD-3e0jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 GLU A 369
TYR A 495
ARG A 246
PHE A 247
 None
 1.20A 3mjrD-3gzsA:
undetectable		 3mjrD-3gzsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		4 GLU A  23
PHE A  -2
GLN A  -1
ARG A 215
 None
None
None
EDO  A 236 (-2.9A)
 0.99A 3mjrD-3h1nA:
undetectable		 3mjrD-3h1nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 GLU A 185
PHE A 171
ARG A 236
PHE A 240
 None
 0.85A 3mjrD-3h39A:
undetectable		 3mjrD-3h39A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 440
ARG A 341
ARG A 443
ASP A 339
 None
 1.18A 3mjrD-3iv0A:
undetectable		 3mjrD-3iv0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 GLU A  26
TYR A   4
ARG A  55
PHE A  56
 None
 1.15A 3mjrD-3lf2A:
undetectable		 3mjrD-3lf2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mda DNA POLYMERASE
LAMBDA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLU A 315
TYR A 279
ARG A 323
ASP A 326
 None
 1.18A 3mjrD-3mdaA:
undetectable		 3mjrD-3mdaA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 GLU A 235
TYR A  86
GLN A  61
ASP A 320
 NGQ  A 455 (-2.9A)
None
NGQ  A 455 (-3.4A)
ZN  A 454 (-2.9A)
 1.00A 3mjrD-3mduA:
undetectable		 3mjrD-3mduA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		4 TYR A 227
PHE A 302
ARG A 299
ARG A 251
 None
 1.17A 3mjrD-3npfA:
undetectable		 3mjrD-3npfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6f HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 GLU B  43
GLN B  39
ARG B  58
PHE B  60
 None
 0.95A 3mjrD-3o6fB:
undetectable		 3mjrD-3o6fB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 GLU A 145
TYR A 211
PHE A 271
ARG A 142
 None
 0.99A 3mjrD-3p8tA:
undetectable		 3mjrD-3p8tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL

(Saccharophagus
degradans) 		PF04616
(Glyco_hydro_43) 		4 TYR A 148
PHE A 126
GLN A 142
ASP A 207
 None
 0.89A 3mjrD-3r4zA:
undetectable		 3mjrD-3r4zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 407
ARG A 321
ARG A 410
ASP A 319
 None
 0.83A 3mjrD-3snxA:
undetectable		 3mjrD-3snxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v 26S PROTEASOME
COMPLEX SUBUNIT SEM1
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05160
(DSS1_SEM1) 		4 GLU C  36
ARG B 266
ARG B 262
ASP C  32
 None
 1.12A 3mjrD-3t5vC:
undetectable		 3mjrD-3t5vC:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 GLU A 976
PHE A 899
ARG A 963
ASP A 962
 None
 1.03A 3mjrD-3ummA:
undetectable		 3mjrD-3ummA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 PHE A 172
ARG A 123
ASP A  51
PHE A  41
 None
 1.17A 3mjrD-4aodA:
undetectable		 3mjrD-4aodA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLU A1000
PHE A1191
ARG A1141
PHE A1143
 None
 1.20A 3mjrD-4bedA:
undetectable		 3mjrD-4bedA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 GLU A 651
GLN A 629
ARG A 680
ASP A 446
 None
 1.16A 3mjrD-4bzkA:
undetectable		 3mjrD-4bzkA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8

(Homo sapiens) 		PF10075
(CSN8_PSD8_EIF3K) 		4 GLU H 107
PHE H  13
ARG H 110
ASP H 111
 None
 1.08A 3mjrD-4d10H:
undetectable		 3mjrD-4d10H:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 GLU A  50
TYR A 303
PHE A  27
ARG A  90
 None
 1.15A 3mjrD-4e8dA:
undetectable		 3mjrD-4e8dA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		4 GLU A 570
PHE A 518
ARG A 574
PHE A 703
 None
 1.17A 3mjrD-4ernA:
undetectable		 3mjrD-4ernA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		4 GLU A 240
TYR A  91
GLN A  66
ASP A 325
 None
None
None
FE  A 501 (-2.8A)
 1.19A 3mjrD-4f0lA:
undetectable		 3mjrD-4f0lA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 145
PHE A 121
ARG A 207
ASP A 256
 None
 1.11A 3mjrD-4f7kA:
undetectable		 3mjrD-4f7kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 GLU A 255
ARG A 316
ARG A 312
ASP A  36
 None
 0.85A 3mjrD-4f9uA:
1.7		 3mjrD-4f9uA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 PHE C  71
GLN C  75
ARG C  77
PHE C  78
 None
 1.17A 3mjrD-4g59C:
undetectable		 3mjrD-4g59C:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		4 GLU A 291
TYR A 304
ARG A  33
ASP A  30
 None
 1.16A 3mjrD-4gklA:
undetectable		 3mjrD-4gklA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw3 ALPHA-HELICAL
ARTIFICIAL PROTEINS

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 PHE C  29
ARG C  59
ASP C  58
PHE C  60
 None
 1.20A 3mjrD-4jw3C:
undetectable		 3mjrD-4jw3C:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		4 GLU A 106
TYR A 137
ARG A  70
PHE A  68
 None
 1.08A 3mjrD-4kruA:
undetectable		 3mjrD-4kruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 459
PHE A 423
ARG A 339
ASP A 337
 None
 1.12A 3mjrD-4l7tA:
undetectable		 3mjrD-4l7tA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		4 GLU A  86
ARG A 147
ARG A 143
ASP A  57
 None
 0.98A 3mjrD-4mobA:
undetectable		 3mjrD-4mobA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLN A 376
ARG A 269
ASP A 302
PHE A 304
 None
 1.10A 3mjrD-4nnzA:
undetectable		 3mjrD-4nnzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oby ARGININE--TRNA
LIGASE

(Escherichia
coli) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 TYR A 442
PHE A 380
ARG A 383
ASP A 392
 None
 1.06A 3mjrD-4obyA:
undetectable		 3mjrD-4obyA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		4 GLU A 443
GLN A 252
ARG A 176
ASP A 249
 None
 1.01A 3mjrD-4oo3A:
2.2		 3mjrD-4oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 GLU A 111
ARG A 272
ASP A  34
PHE A  35
 None
None
None
PRO  A 303 (-3.5A)
 1.09A 3mjrD-4p7wA:
undetectable		 3mjrD-4p7wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn0 ENDONUCLEASE G,
MITOCHONDRIAL

(Caenorhabditis
elegans) 		PF01223
(Endonuclease_NS) 		4 GLU A  68
TYR A  74
ARG A 108
ASP A  85
 None
 1.14A 3mjrD-4qn0A:
undetectable		 3mjrD-4qn0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 334
TYR A 431
ARG A 336
ASP A 490
 None
 0.92A 3mjrD-4r1dA:
2.4		 3mjrD-4r1dA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		4 PHE A  80
GLN A 296
ARG A 165
ASP A 168
 RIB  A 401 (-3.6A)
RIB  A 401 (-3.4A)
None
None
 1.18A 3mjrD-4rk1A:
undetectable		 3mjrD-4rk1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 GLU A  95
PHE A  34
ARG A  91
ARG A 124
 ACT  A 608 (-3.3A)
None
ACT  A 608 (-2.7A)
ACT  A 608 ( 4.9A)
 1.13A 3mjrD-4tlvA:
undetectable		 3mjrD-4tlvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 GLU A 236
TYR A  55
PHE A  29
GLN A  27
 None
 1.17A 3mjrD-4uzyA:
undetectable		 3mjrD-4uzyA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y19 HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 GLU B  14
GLN B  10
ARG B  29
PHE B  31
 None
 0.96A 3mjrD-4y19B:
undetectable		 3mjrD-4y19B:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a65 THIAMINE
TRIPHOSPHATASE

(Mus musculus) 		PF01928
(CYTH) 		4 TYR A  39
PHE A 121
ARG A 125
PHE A  35
 None
None
PO4  A1001 (-3.0A)
None
 0.84A 3mjrD-5a65A:
undetectable		 3mjrD-5a65A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		4 GLU B 378
GLN B 167
ARG B 192
ASP B 193
 None
 1.13A 3mjrD-5dynB:
undetectable		 3mjrD-5dynB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLU A 303
PHE A 416
GLN A 379
ASP A 382
 None
 1.20A 3mjrD-5eufA:
undetectable		 3mjrD-5eufA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04390
(LptE)
PF04453
(OstA_C) 		4 GLU B 146
GLN A 486
ARG A 515
ASP A 516
 None
 0.96A 3mjrD-5iv9B:
undetectable		 3mjrD-5iv9B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		4 TYR A 261
ARG A 125
ASP A 189
PHE A 193
 None
 1.02A 3mjrD-5iysA:
undetectable		 3mjrD-5iysA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 197
TYR A 138
GLN A 459
ARG A 194
 None
None
None
BGC  A 801 (-2.9A)
 1.00A 3mjrD-5jp0A:
2.6		 3mjrD-5jp0A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLU A 587
GLN A 549
ARG A 582
PHE A 551
 None
 1.17A 3mjrD-5kdxA:
undetectable		 3mjrD-5kdxA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 4 GLU A 202
GLN A  16
ARG A 276
ASP A 112
 None
 0.97A 3mjrD-5m86A:
undetectable		 3mjrD-5m86A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 TYR A 186
PHE A 164
GLN A 180
ASP A 245
 None
None
AAL  A 502 (-3.2A)
AAL  A 502 (-2.7A)
 0.92A 3mjrD-5ta9A:
undetectable		 3mjrD-5ta9A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLU A 422
GLN A 507
ARG A 485
ASP A 489
 MN  A 702 ( 4.5A)
None
LA6  A 704 (-2.9A)
None
 1.19A 3mjrD-5uv2A:
undetectable		 3mjrD-5uv2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v89 DCN1-LIKE PROTEIN 4

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 GLU A 284
TYR A 244
PHE A 238
GLN A 241
 None
 1.04A 3mjrD-5v89A:
undetectable		 3mjrD-5v89A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 GLU A 811
PHE A 871
ARG A 796
PHE A 797
 None
 1.15A 3mjrD-5wvgA:
undetectable		 3mjrD-5wvgA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 TYR A 314
PHE A 474
ARG A 536
ASP A 537
 None
 1.07A 3mjrD-5xfaA:
undetectable		 3mjrD-5xfaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN
VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
no annotation 		4 GLU A1527
TYR B 110
ARG A1534
ASP A1532
 None
 1.19A 3mjrD-5xsyA:
undetectable		 3mjrD-5xsyA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		4 GLN w 132
ARG w 139
ARG w 161
ASP w 166
 None
 1.20A 3mjrD-5xtdw:
16.5		 3mjrD-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 4 PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.10A 3mjrD-5xykE:
undetectable		 3mjrD-5xykE:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A 202
GLN A 159
ARG A 168
ASP A 164
 None
 1.04A 3mjrD-5yk2A:
undetectable		 3mjrD-5yk2A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 GLU A 862
PHE A 844
ARG A 866
ARG A 897
 None
 1.15A 3mjrD-5yudA:
undetectable		 3mjrD-5yudA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 GLU A 270
TYR A 507
ARG A 257
PHE A 371
 None
None
None
GOL  A 605 (-3.6A)
 1.11A 3mjrD-5z5dA:
undetectable		 3mjrD-5z5dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 GLU A 288
TYR A 530
ARG A 267
PHE A 387
 None
 1.07A 3mjrD-5zqjA:
undetectable		 3mjrD-5zqjA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 GLU A 129
PHE A 122
ARG A 117
ASP A 119
 None
 1.12A 3mjrD-6bmaA:
undetectable		 3mjrD-6bmaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 GLU A 273
TYR A 137
PHE A  45
ASP A  25
 None
 1.14A 3mjrD-6cc4A:
2.3		 3mjrD-6cc4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLU A 471
TYR A 528
ARG A 393
ASP A 475
 None
 1.15A 3mjrD-6cczA:
undetectable		 3mjrD-6cczA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 GLU B 174
ARG B 231
ARG B  48
PHE B 204
 None
 1.08A 3mjrD-6fd2B:
undetectable		 3mjrD-6fd2B:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 GLU A 209
ARG A 271
ARG A 335
ASP A 275
 ACR  A 801 (-3.9A)
None
ACR  A 801 (-2.8A)
None
 1.19A 3mjrD-6fhwA:
undetectable		 3mjrD-6fhwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 GLU O  53
ARG O 126
ASP O 131
PHE O 134
 ADP  O 401 ( 4.7A)
ADP  O 401 ( 4.3A)
None
ADP  O 401 (-3.6A)
 1.09A 3mjrD-6g2jO:
undetectable		 3mjrD-6g2jO:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 GLU O  53
GLN O  97
ASP O 131
PHE O 134
 ADP  O 401 ( 4.7A)
ADP  O 401 (-3.5A)
None
ADP  O 401 (-3.6A)
 1.08A 3mjrD-6g2jO:
undetectable		 3mjrD-6g2jO:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 GLU O  53
TYR O  83
GLN O  97
ASP O 131
 ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 (-3.5A)
None
 1.12A 3mjrD-6g2jO:
undetectable		 3mjrD-6g2jO:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 4 GLU A 125
ARG A 297
ARG A 128
ASP A 301
 None
 1.15A 3mjrD-6h20A:
undetectable		 3mjrD-6h20A:
undetectable