SIMILAR PATTERNS OF AMINO ACIDS FOR 3MJR_A_AC2A301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c1k | BPT4 GENE 59HELICASE ASSEMBLYPROTEIN (Escherichiavirus T4) |
PF08993(T4_Gp59_N)PF08994(T4_Gp59_C) | 5 | ILE A 74ARG A 53ASP A 55PHE A 58LEU A 96 | None | 1.10A | 3mjrA-1c1kA:undetectable | 3mjrA-1c1kA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f4h | BETA-GALACTOSIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | ILE A 793GLU A 797ARG A 599ASP A 598PHE A 601 | None | 1.36A | 3mjrA-1f4hA:0.0 | 3mjrA-1f4hA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihp | PHYTASE (Aspergillusficuum) |
PF00328(His_Phos_2) | 5 | GLU A 299GLN A 54ARG A 136ASP A 335LEU A 349 | None | 1.41A | 3mjrA-1ihpA:0.0 | 3mjrA-1ihpA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp3 | RNA POLYMERASE SIGMAFACTOR SIGMA-28(FLIA) (Aquifexaeolicus) |
PF04539(Sigma70_r3)PF04542(Sigma70_r2)PF04545(Sigma70_r4) | 5 | ILE A 29GLU A 145ARG A 82PHE A 138LEU A 33 | None | 1.47A | 3mjrA-1rp3A:0.0 | 3mjrA-1rp3A:25.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w2d | INOSITOL-TRISPHOSPHATE 3-KINASE A (Homo sapiens) |
PF03770(IPK) | 5 | ILE A 380GLU A 385ARG A 432ASP A 449LEU A 400 | None | 1.31A | 3mjrA-1w2dA:undetectable | 3mjrA-1w2dA:22.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2a30 | DEOXYCYTIDINE KINASE (Homo sapiens) |
PF01712(dNK) | 9 | ILE A 30GLU A 53GLN A 97ARG A 104ARG A 128ASP A 133PHE A 137TYR A 204LEU A 208 | DCZ A 302 ( 4.3A)DCZ A 302 (-3.0A)DCZ A 302 (-3.2A)NoneDCZ A 302 (-4.1A)DCZ A 302 (-3.2A)DCZ A 302 (-3.8A)NoneNone | 0.81A | 3mjrA-2a30A:32.5 | 3mjrA-2a30A:92.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a74 | COMPLEMENT COMPONENTC3C (Homo sapiens) |
PF00207(A2M) | 5 | ILE B 866GLN B 805ASP B 901PHE B 807LEU B 838 | None | 1.28A | 3mjrA-2a74B:undetectable | 3mjrA-2a74B:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9g | MITOGEN-ACTIVATEDPROTEIN KINASE FUS3 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | ILE A 251GLU A 192ARG A 297PHE A 292LEU A 248 | None | 1.08A | 3mjrA-2f9gA:undetectable | 3mjrA-2f9gA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) |
PF00343(Phosphorylase) | 5 | ILE A 507GLU A 505ASP A 533PHE A 530LEU A 521 | None | 1.43A | 3mjrA-2gj4A:0.0 | 3mjrA-2gj4A:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jaq | DEOXYGUANOSINEKINASE (Mycoplasmamycoides) |
PF01712(dNK) | 7 | GLN A 54ARG A 61ARG A 78ASP A 83PHE A 86TYR A 157LEU A 161 | DCP A1202 (-2.9A)NoneDCP A1202 (-2.8A)DCP A1202 (-3.6A)DCP A1202 (-3.6A)NoneNone | 0.88A | 3mjrA-2jaqA:21.0 | 3mjrA-2jaqA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jcs | DEOXYNUCLEOSIDEKINASE (Drosophilamelanogaster) |
PF01712(dNK) | 6 | ILE A 29GLN A 81ARG A 105PHE A 114TYR A 179LEU A 183 | TTP A1210 (-3.9A)TTP A1210 (-3.0A)TTP A1210 (-3.7A)TTP A1210 (-3.5A)NoneNone | 0.88A | 3mjrA-2jcsA:23.7 | 3mjrA-2jcsA:28.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocp | DEOXYGUANOSINEKINASE (Homo sapiens) |
PF01712(dNK) | 6 | ILE A 47GLN A 111ASP A 147PHE A 151TYR A 218LEU A 222 | DTP A 301 (-3.8A)DTP A 301 (-2.9A)DTP A 301 (-4.1A)DTP A 301 (-3.3A)NoneNone | 0.96A | 3mjrA-2ocpA:29.9 | 3mjrA-2ocpA:44.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocp | DEOXYGUANOSINEKINASE (Homo sapiens) |
PF01712(dNK) | 7 | ILE A 47GLU A 70GLN A 111ARG A 142PHE A 151TYR A 218LEU A 222 | DTP A 301 (-3.8A)NoneDTP A 301 (-2.9A)DTP A 301 (-3.2A)DTP A 301 (-3.3A)NoneNone | 0.72A | 3mjrA-2ocpA:29.9 | 3mjrA-2ocpA:44.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqq | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00027(cNMP_binding) | 5 | ILE A 78ARG A 89ASP A 42PHE A 38LEU A 57 | None | 1.50A | 3mjrA-2pqqA:undetectable | 3mjrA-2pqqA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q14 | PHOSPHOHYDROLASE (Bacteroidesthetaiotaomicron) |
PF01966(HD) | 5 | ILE A 80GLN A 153ASP A 195PHE A 150LEU A 73 | None | 1.13A | 3mjrA-2q14A:undetectable | 3mjrA-2q14A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6f | EXCINUCLEASE ABCSUBUNIT A (Geobacillusstearothermophilus) |
PF00005(ABC_tran) | 5 | ILE A 864GLU A 546ARG A 938ASP A 939LEU A 868 | None | 1.36A | 3mjrA-2r6fA:undetectable | 3mjrA-2r6fA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwb | COMPLEMENT C3BALPHA' CHAIN (Homo sapiens) |
PF00207(A2M)PF01759(NTR)PF07677(A2M_recep)PF07678(A2M_comp)PF10569(Thiol-ester_cl) | 5 | ILE B 866GLN B 805ASP B 901PHE B 807LEU B 838 | None | 1.22A | 3mjrA-2xwbB:undetectable | 3mjrA-2xwbB:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b6v | KINESIN-LIKE PROTEINKIF3C (Homo sapiens) |
PF00225(Kinesin) | 5 | ILE A 32GLU A 24GLN A 98ARG A 18LEU A 44 | None | 1.16A | 3mjrA-3b6vA:undetectable | 3mjrA-3b6vA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bit | FACT COMPLEX SUBUNITSPT16 (Saccharomycescerevisiae) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | ILE A 422GLU A 174ARG A 386PHE A 394LEU A 332 | None | 1.45A | 3mjrA-3bitA:undetectable | 3mjrA-3bitA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3god | CAS1 (Pseudomonasaeruginosa) |
PF01867(Cas_Cas1) | 5 | ILE A 275ARG A 285ASP A 287PHE A 292LEU A 232 | None | 1.28A | 3mjrA-3godA:undetectable | 3mjrA-3godA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwt | PHOSPHOINOSITIDEPHOSPHATASE SAC1 (Saccharomycescerevisiae) |
PF02383(Syja_N) | 5 | ILE X 204GLU X 232ARG X 154ARG X 206ASP X 152 | None | 1.35A | 3mjrA-3lwtX:undetectable | 3mjrA-3lwtX:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxq | UNCHARACTERIZEDPROTEIN VP1736 (Vibrioparahaemolyticus) |
PF00884(Sulfatase) | 5 | ILE A 539ASP A 608PHE A 609TYR A 326LEU A 588 | None | 1.49A | 3mjrA-3lxqA:1.6 | 3mjrA-3lxqA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1m | ORF904 (Sulfolobusislandicus) |
PF09250(Prim-Pol)PF13010(pRN1_helical) | 5 | ILE A 317GLN A 350ARG A 264PHE A 353LEU A 335 | None | 1.34A | 3mjrA-3m1mA:undetectable | 3mjrA-3m1mA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6n | RNA-DEPENDENT RNAPOLYMERASE (Enterovirus A) |
PF00680(RdRP_1) | 5 | ARG A 49ASP A 47PHE A 54TYR A 276LEU A 58 | None | 1.17A | 3mjrA-3n6nA:undetectable | 3mjrA-3n6nA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n9x | PHOSPHOTRANSFERASE (Plasmodiumberghei) |
PF00069(Pkinase) | 5 | ILE A 307GLU A 221ARG A 353PHE A 348LEU A 304 | None | 1.16A | 3mjrA-3n9xA:undetectable | 3mjrA-3n9xA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nie | MAP2 KINASE (Plasmodiumfalciparum) |
PF00069(Pkinase) | 5 | ILE A 312GLU A 226ARG A 358PHE A 353LEU A 309 | None | 1.01A | 3mjrA-3nieA:undetectable | 3mjrA-3nieA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xrl | MITOGEN-ACTIVATEDPROTEIN KINASE 1 (Rattusnorvegicus) |
PF00069(Pkinase) | 5 | ILE A 253GLU A 195ARG A 299PHE A 294LEU A 250 | None | 1.15A | 3mjrA-4xrlA:undetectable | 3mjrA-4xrlA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdn | DNA GYRASE SUBUNIT A (Staphylococcusaureus) |
PF00521(DNA_topoisoIV) | 5 | ILE A 458GLU A 472ARG A 137ASP A 138LEU A 455 | ILE A 458 ( 0.6A)GLU A 472 ( 0.6A)ARG A 137 ( 0.6A)ASP A 138 ( 0.6A)LEU A 455 ( 0.6A) | 1.44A | 3mjrA-5cdnA:undetectable | 3mjrA-5cdnA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exe | OXALATEOXIDOREDUCTASESUBUNIT ALPHA (Moorellathermoacetica) |
PF01855(POR_N)PF17147(PFOR_II) | 5 | ILE A 149GLU A 142ARG A 294ASP A 255LEU A 235 | None | 1.46A | 3mjrA-5exeA:undetectable | 3mjrA-5exeA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exe | OXALATEOXIDOREDUCTASESUBUNIT ALPHA (Moorellathermoacetica) |
PF01855(POR_N)PF17147(PFOR_II) | 5 | ILE A 327GLU A 337GLN A 269ARG A 299ARG A 128 | None | 1.20A | 3mjrA-5exeA:undetectable | 3mjrA-5exeA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5log | PUTATIVEO-METHYLTRANSFERASE (Myxococcusxanthus) |
PF01596(Methyltransf_3) | 5 | ILE A 141GLU A 153ARG A 202ASP A 200LEU A 167 | None | 1.48A | 3mjrA-5logA:undetectable | 3mjrA-5logA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ons | MALIGNANTT-CELL-AMPLIFIEDSEQUENCE 1 (Homo sapiens) |
no annotation | 5 | GLU A 75GLN A 32ARG A 72PHE A 78LEU A 62 | None | 1.43A | 3mjrA-5onsA:undetectable | 3mjrA-5onsA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj6 | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF11721(Malectin)PF16355(DUF4982) | 5 | ILE A 103GLU A 100GLN A 96PHE A 143LEU A 141 | None | 1.34A | 3mjrA-5uj6A:undetectable | 3mjrA-5uj6A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur2 | BIFUNCTIONAL PROTEINPUTA (Bdellovibriobacteriovorus) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | ILE A 679GLU A 681ARG A 568ASP A 569LEU A 675 | None | 1.45A | 3mjrA-5ur2A:undetectable | 3mjrA-5ur2A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uti | QUEUINETRNA-RIBOSYLTRANSFERASE (Zymomonasmobilis) |
no annotation | 5 | ILE A 276GLU A 273GLN A 237ARG A 378ASP A 266 | None | 1.33A | 3mjrA-5utiA:0.9 | 3mjrA-5utiA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtd | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT10, MITOCHONDRIAL (Homo sapiens) |
PF06212(GRIM-19) | 5 | ILE w 66GLN w 132ARG w 161ASP w 166TYR w 233 | None | 1.02A | 3mjrA-5xtdw:17.0 | 3mjrA-5xtdw:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtd | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT10, MITOCHONDRIAL (Homo sapiens) |
PF06212(GRIM-19) | 5 | ILE w 66GLU w 160ARG w 161ASP w 166TYR w 233 | None | 1.35A | 3mjrA-5xtdw:17.0 | 3mjrA-5xtdw:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b7p | SDED (Legionellapneumophila) |
no annotation | 5 | ILE A 184GLN A 89ASP A 225PHE A 221LEU A 187 | None | 1.43A | 3mjrA-6b7pA:undetectable | 3mjrA-6b7pA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co9 | PROBABLECOA-TRANSFERASE BETASUBUNIT (Rhodococcusjostii) |
no annotation | 5 | ILE B 39GLU B 233ARG B 227ASP B 20LEU B 36 | None | 1.45A | 3mjrA-6co9B:undetectable | 3mjrA-6co9B:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT10, MITOCHONDRIAL (Mus musculus) |
no annotation | 6 | ILE O 31GLU O 53GLN O 97ARG O 126PHE O 134TYR O 198 | ADP O 401 (-4.0A)ADP O 401 ( 4.7A)ADP O 401 (-3.5A)ADP O 401 ( 4.3A)ADP O 401 (-3.6A)None | 0.88A | 3mjrA-6g2jO:undetectable | 3mjrA-6g2jO:13.98 |