SIMILAR PATTERNS OF AMINO ACIDS FOR 3MJR_A_AC2A301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN


(Escherichia
virus T4)
PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C)
5 ILE A  74
ARG A  53
ASP A  55
PHE A  58
LEU A  96
None
1.10A 3mjrA-1c1kA:
undetectable
3mjrA-1c1kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
5 ILE A 793
GLU A 797
ARG A 599
ASP A 598
PHE A 601
None
1.36A 3mjrA-1f4hA:
0.0
3mjrA-1f4hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum)
PF00328
(His_Phos_2)
5 GLU A 299
GLN A  54
ARG A 136
ASP A 335
LEU A 349
None
1.41A 3mjrA-1ihpA:
0.0
3mjrA-1ihpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)


(Aquifex
aeolicus)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
5 ILE A  29
GLU A 145
ARG A  82
PHE A 138
LEU A  33
None
1.47A 3mjrA-1rp3A:
0.0
3mjrA-1rp3A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A


(Homo sapiens)
PF03770
(IPK)
5 ILE A 380
GLU A 385
ARG A 432
ASP A 449
LEU A 400
None
1.31A 3mjrA-1w2dA:
undetectable
3mjrA-1w2dA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens)
PF01712
(dNK)
9 ILE A  30
GLU A  53
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
TYR A 204
LEU A 208
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
None
None
0.81A 3mjrA-2a30A:
32.5
3mjrA-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a74 COMPLEMENT COMPONENT
C3C


(Homo sapiens)
PF00207
(A2M)
5 ILE B 866
GLN B 805
ASP B 901
PHE B 807
LEU B 838
None
1.28A 3mjrA-2a74B:
undetectable
3mjrA-2a74B:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 ILE A 251
GLU A 192
ARG A 297
PHE A 292
LEU A 248
None
1.08A 3mjrA-2f9gA:
undetectable
3mjrA-2f9gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM


(Oryctolagus
cuniculus)
PF00343
(Phosphorylase)
5 ILE A 507
GLU A 505
ASP A 533
PHE A 530
LEU A 521
None
1.43A 3mjrA-2gj4A:
0.0
3mjrA-2gj4A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE


(Mycoplasma
mycoides)
PF01712
(dNK)
7 GLN A  54
ARG A  61
ARG A  78
ASP A  83
PHE A  86
TYR A 157
LEU A 161
DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.6A)
None
None
0.88A 3mjrA-2jaqA:
21.0
3mjrA-2jaqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE


(Drosophila
melanogaster)
PF01712
(dNK)
6 ILE A  29
GLN A  81
ARG A 105
PHE A 114
TYR A 179
LEU A 183
TTP  A1210 (-3.9A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
None
None
0.88A 3mjrA-2jcsA:
23.7
3mjrA-2jcsA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE


(Homo sapiens)
PF01712
(dNK)
6 ILE A  47
GLN A 111
ASP A 147
PHE A 151
TYR A 218
LEU A 222
DTP  A 301 (-3.8A)
DTP  A 301 (-2.9A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
None
None
0.96A 3mjrA-2ocpA:
29.9
3mjrA-2ocpA:
44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE


(Homo sapiens)
PF01712
(dNK)
7 ILE A  47
GLU A  70
GLN A 111
ARG A 142
PHE A 151
TYR A 218
LEU A 222
DTP  A 301 (-3.8A)
None
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
None
None
0.72A 3mjrA-2ocpA:
29.9
3mjrA-2ocpA:
44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00027
(cNMP_binding)
5 ILE A  78
ARG A  89
ASP A  42
PHE A  38
LEU A  57
None
1.50A 3mjrA-2pqqA:
undetectable
3mjrA-2pqqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron)
PF01966
(HD)
5 ILE A  80
GLN A 153
ASP A 195
PHE A 150
LEU A  73
None
1.13A 3mjrA-2q14A:
undetectable
3mjrA-2q14A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
5 ILE A 864
GLU A 546
ARG A 938
ASP A 939
LEU A 868
None
1.36A 3mjrA-2r6fA:
undetectable
3mjrA-2r6fA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN


(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
5 ILE B 866
GLN B 805
ASP B 901
PHE B 807
LEU B 838
None
1.22A 3mjrA-2xwbB:
undetectable
3mjrA-2xwbB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C


(Homo sapiens)
PF00225
(Kinesin)
5 ILE A  32
GLU A  24
GLN A  98
ARG A  18
LEU A  44
None
1.16A 3mjrA-3b6vA:
undetectable
3mjrA-3b6vA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16


(Saccharomyces
cerevisiae)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
5 ILE A 422
GLU A 174
ARG A 386
PHE A 394
LEU A 332
None
1.45A 3mjrA-3bitA:
undetectable
3mjrA-3bitA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa)
PF01867
(Cas_Cas1)
5 ILE A 275
ARG A 285
ASP A 287
PHE A 292
LEU A 232
None
1.28A 3mjrA-3godA:
undetectable
3mjrA-3godA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1


(Saccharomyces
cerevisiae)
PF02383
(Syja_N)
5 ILE X 204
GLU X 232
ARG X 154
ARG X 206
ASP X 152
None
1.35A 3mjrA-3lwtX:
undetectable
3mjrA-3lwtX:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736


(Vibrio
parahaemolyticus)
PF00884
(Sulfatase)
5 ILE A 539
ASP A 608
PHE A 609
TYR A 326
LEU A 588
None
1.49A 3mjrA-3lxqA:
1.6
3mjrA-3lxqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus)
PF09250
(Prim-Pol)
PF13010
(pRN1_helical)
5 ILE A 317
GLN A 350
ARG A 264
PHE A 353
LEU A 335
None
1.34A 3mjrA-3m1mA:
undetectable
3mjrA-3m1mA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE


(Enterovirus A)
PF00680
(RdRP_1)
5 ARG A  49
ASP A  47
PHE A  54
TYR A 276
LEU A  58
None
1.17A 3mjrA-3n6nA:
undetectable
3mjrA-3n6nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei)
PF00069
(Pkinase)
5 ILE A 307
GLU A 221
ARG A 353
PHE A 348
LEU A 304
None
1.16A 3mjrA-3n9xA:
undetectable
3mjrA-3n9xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum)
PF00069
(Pkinase)
5 ILE A 312
GLU A 226
ARG A 358
PHE A 353
LEU A 309
None
1.01A 3mjrA-3nieA:
undetectable
3mjrA-3nieA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
5 ILE A 253
GLU A 195
ARG A 299
PHE A 294
LEU A 250
None
1.15A 3mjrA-4xrlA:
undetectable
3mjrA-4xrlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
5 ILE A 458
GLU A 472
ARG A 137
ASP A 138
LEU A 455
ILE  A 458 ( 0.6A)
GLU  A 472 ( 0.6A)
ARG  A 137 ( 0.6A)
ASP  A 138 ( 0.6A)
LEU  A 455 ( 0.6A)
1.44A 3mjrA-5cdnA:
undetectable
3mjrA-5cdnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA


(Moorella
thermoacetica)
PF01855
(POR_N)
PF17147
(PFOR_II)
5 ILE A 149
GLU A 142
ARG A 294
ASP A 255
LEU A 235
None
1.46A 3mjrA-5exeA:
undetectable
3mjrA-5exeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA


(Moorella
thermoacetica)
PF01855
(POR_N)
PF17147
(PFOR_II)
5 ILE A 327
GLU A 337
GLN A 269
ARG A 299
ARG A 128
None
1.20A 3mjrA-5exeA:
undetectable
3mjrA-5exeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE


(Myxococcus
xanthus)
PF01596
(Methyltransf_3)
5 ILE A 141
GLU A 153
ARG A 202
ASP A 200
LEU A 167
None
1.48A 3mjrA-5logA:
undetectable
3mjrA-5logA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1


(Homo sapiens)
no annotation 5 GLU A  75
GLN A  32
ARG A  72
PHE A  78
LEU A  62
None
1.43A 3mjrA-5onsA:
undetectable
3mjrA-5onsA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982)
5 ILE A 103
GLU A 100
GLN A  96
PHE A 143
LEU A 141
None
1.34A 3mjrA-5uj6A:
undetectable
3mjrA-5uj6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA


(Bdellovibrio
bacteriovorus)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 ILE A 679
GLU A 681
ARG A 568
ASP A 569
LEU A 675
None
1.45A 3mjrA-5ur2A:
undetectable
3mjrA-5ur2A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE


(Zymomonas
mobilis)
no annotation 5 ILE A 276
GLU A 273
GLN A 237
ARG A 378
ASP A 266
None
1.33A 3mjrA-5utiA:
0.9
3mjrA-5utiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL


(Homo sapiens)
PF06212
(GRIM-19)
5 ILE w  66
GLN w 132
ARG w 161
ASP w 166
TYR w 233
None
1.02A 3mjrA-5xtdw:
17.0
3mjrA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL


(Homo sapiens)
PF06212
(GRIM-19)
5 ILE w  66
GLU w 160
ARG w 161
ASP w 166
TYR w 233
None
1.35A 3mjrA-5xtdw:
17.0
3mjrA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila)
no annotation 5 ILE A 184
GLN A  89
ASP A 225
PHE A 221
LEU A 187
None
1.43A 3mjrA-6b7pA:
undetectable
3mjrA-6b7pA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE BETA
SUBUNIT


(Rhodococcus
jostii)
no annotation 5 ILE B  39
GLU B 233
ARG B 227
ASP B  20
LEU B  36
None
1.45A 3mjrA-6co9B:
undetectable
3mjrA-6co9B:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL


(Mus musculus)
no annotation 6 ILE O  31
GLU O  53
GLN O  97
ARG O 126
PHE O 134
TYR O 198
ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-3.5A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
None
0.88A 3mjrA-6g2jO:
undetectable
3mjrA-6g2jO:
13.98