SIMILAR PATTERNS OF AMINO ACIDS FOR 3MIY_B_B49B2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
LYS A  33
PHE A  80
PHE A  82
LEU A 133
 None
 0.67A 3miyB-1h4lA:
24.9		 3miyB-1h4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
 None
 0.68A 3miyB-1k9aA:
28.2		 3miyB-1k9aA:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
PHE A 654
MET A 657
GLY A 660
LEU A 731
 None
 0.68A 3miyB-1lufA:
32.5		 3miyB-1lufA:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 288
PHE A 336
MET A 337
GLY A 340
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.59A 3miyB-1opkA:
31.0		 3miyB-1opkA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ILE A 211
ALA A 230
LYS A 232
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.71A 3miyB-1py5A:
26.3		 3miyB-1py5A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  99
LYS A 101
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.62A 3miyB-1s9iA:
23.4		 3miyB-1s9iA:
26.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 369
ALA A 389
LYS A 391
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
 None
 0.75A 3miyB-1snxA:
25.9		 3miyB-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 369
ALA A 389
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
SER A 499
 None
 0.67A 3miyB-1snxA:
25.9		 3miyB-1snxA:
98.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
LEU A 144
 ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
ATP  A 381 (-4.1A)
None
None
 0.59A 3miyB-1ua2A:
23.0		 3miyB-1ua2A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 111
PHE A 159
MET A 162
GLY A 165
LEU A 212
 None
 0.62A 3miyB-2ac5A:
20.6		 3miyB-2ac5A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.52A 3miyB-2h8hA:
31.3		 3miyB-2h8hA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.35A 3miyB-2hckA:
31.4		 3miyB-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 635
ALA A 659
LYS A 661
PHE A 709
MET A 710
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.59A 3miyB-2henA:
34.3		 3miyB-2henA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.58A 3miyB-2hk5A:
32.7		 3miyB-2hk5A:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
LYS A 271
PHE A 317
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
 0.64A 3miyB-2hz0A:
31.6		 3miyB-2hz0A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
ALA A  31
LYS A  33
PHE A  80
PHE A  82
LEU A 134
 None
 0.78A 3miyB-2jgzA:
24.0		 3miyB-2jgzA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 ALA A  46
PHE A 103
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
 0.59A 3miyB-2phkA:
23.1		 3miyB-2phkA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A  34
LYS A  36
PHE A  82
PHE A  84
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 ( 4.5A)
None
None
 0.53A 3miyB-2pmiA:
21.7		 3miyB-2pmiA:
29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
ALA B  67
LYS B  69
MET B 117
GLY B 120
LEU B 171
 None
 0.56A 3miyB-2qkwB:
24.5		 3miyB-2qkwB:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
LYS A 217
PHE A 267
GLY A 271
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.66A 3miyB-2qluA:
25.6		 3miyB-2qluA:
25.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.51A 3miyB-2qobA:
33.0		 3miyB-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.68A 3miyB-2r2pA:
27.3		 3miyB-2r2pA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.59A 3miyB-2r4bA:
30.9		 3miyB-2r4bA:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 ILE A 490
ALA A 509
LYS A 511
PHE A 605
PHE A 607
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.3A)
 0.58A 3miyB-2vuwA:
12.4		 3miyB-2vuwA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE B  75
PHE B 149
MET B 150
GLY B 153
LEU B 202
SER B 212
 ANP  B 432 (-4.4A)
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
 0.88A 3miyB-2wtkB:
24.3		 3miyB-2wtkB:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
ALA A 651
MET A 702
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 (-3.2A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.30A 3miyB-2xyuA:
34.2		 3miyB-2xyuA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
MET A 110
GLY A 113
LEU A 160
SER A 170
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
 0.81A 3miyB-2y7jA:
24.0		 3miyB-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
PHE A 107
MET A 110
GLY A 113
LEU A 160
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.68A 3miyB-2y7jA:
24.0		 3miyB-2y7jA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
LYS A 275
PHE A 321
MET A 322
GLY A 325
LEU A 374
 None
 0.41A 3miyB-2zv7A:
32.8		 3miyB-2zv7A:
41.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  18
ALA A  39
PHE A  91
PHE A  93
MET A  94
 3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
 0.58A 3miyB-3c0iA:
24.0		 3miyB-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  18
ALA A  39
PHE A  93
MET A  94
GLY A  96
LEU A 148
 3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
 1.26A 3miyB-3c0iA:
24.0		 3miyB-3c0iA:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
 None
 0.68A 3miyB-3d7uA:
33.5		 3miyB-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 639
ALA A 663
PHE A 713
MET A 714
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.78A 3miyB-3dkoA:
32.8		 3miyB-3dkoA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 150
ALA A 169
PHE A 222
GLY A 226
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
 0.43A 3miyB-3dtcA:
29.0		 3miyB-3dtcA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 209
ALA A 228
LYS A 230
GLY A 285
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.63A 3miyB-3g2fA:
19.5		 3miyB-3g2fA:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
MET A 716
GLY A 719
LEU A 767
SER A 777
 None
None
GOL  A 403 (-3.4A)
None
None
 0.59A 3miyB-3kulA:
28.6		 3miyB-3kulA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  25
ALA A  46
LYS A  48
PHE A 103
PHE A 105
LEU A 156
 None
 0.83A 3miyB-3mi9A:
23.2		 3miyB-3mi9A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
PHE A  98
PHE A 100
MET A 101
LEU A 151
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
 0.46A 3miyB-3nizA:
24.5		 3miyB-3nizA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 213
LYS A 215
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.71A 3miyB-3nyoA:
22.2		 3miyB-3nyoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.71A 3miyB-3q4tA:
25.1		 3miyB-3q4tA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.57A 3miyB-3v5qA:
31.9		 3miyB-3v5qA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.45A 3miyB-3wigA:
24.0		 3miyB-3wigA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1978
LYS A1980
MET A2029
GLY A2032
LEU A2086
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.55A 3miyB-3zbfA:
32.8		 3miyB-3zbfA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 625
ALA A 649
LYS A 651
PHE A 699
MET A 700
GLY A 703
LEU A 751
SER A 761
 None
 0.39A 3miyB-3zfxA:
34.6		 3miyB-3zfxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
LYS A 868
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.71A 3miyB-4agdA:
30.1		 3miyB-4agdA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 586
PHE A 633
MET A 636
GLY A 639
LEU A 699
 LTI  A1839 (-3.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.53A 3miyB-4at3A:
31.7		 3miyB-4at3A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A  97
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.50A 3miyB-4aw5A:
34.3		 3miyB-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A  97
ALA A 121
PHE A 171
MET A 172
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.66A 3miyB-4aw5A:
34.3		 3miyB-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.64A 3miyB-4e93A:
34.8		 3miyB-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
 None
 0.34A 3miyB-4f0iA:
31.8		 3miyB-4f0iA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.72A 3miyB-4f4pA:
26.8		 3miyB-4f4pA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
 0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
 0.72A 3miyB-4feqA:
24.8		 3miyB-4feqA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 ILE A 327
ALA A 348
LYS A 350
PHE A 397
LEU A 447
SER A 457
 None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.77A 3miyB-4fieA:
22.9		 3miyB-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 ILE A 327
LYS A 350
PHE A 397
GLY A 401
LEU A 447
SER A 457
 None
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
 0.77A 3miyB-4fieA:
22.9		 3miyB-4fieA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1148
LYS A1150
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.66A 3miyB-4fodA:
31.6		 3miyB-4fodA:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.59A 3miyB-4k11A:
31.3		 3miyB-4k11A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
ALA A 434
LYS A 436
PHE A 483
GLY A 487
LEU A 533
SER A 543
 B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.63A 3miyB-4ks8A:
24.6		 3miyB-4ks8A:
28.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.42A 3miyB-4lggA:
31.8		 3miyB-4lggA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
PHE A  97
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 1.03A 3miyB-4m69A:
25.3		 3miyB-4m69A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
MET A 274
LEU A 324
SER A 334
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.68A 3miyB-4mk0A:
21.8		 3miyB-4mk0A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 619
ALA A 644
LYS A 646
MET A 695
GLY A 698
LEU A 746
SER A 756
 None
 0.86A 3miyB-4p2kA:
33.9		 3miyB-4p2kA:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ILE A  27
ALA A  49
LYS A  51
MET A 107
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
None
ANP  A 402 (-4.6A)
 0.72A 3miyB-4qnyA:
22.2		 3miyB-4qnyA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 ALA A  35
LYS A  37
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.58A 3miyB-4ueuA:
33.1		 3miyB-4ueuA:
48.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  61
LYS A  63
PHE A 110
GLY A 114
LEU A 162
 6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.69A 3miyB-4usfA:
24.8		 3miyB-4usfA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		6 ILE A 327
ALA A 348
LYS A 350
PHE A 397
LEU A 447
SER A 457
 None
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
ATP  A 601 (-4.6A)
None
ATP  A 601 ( 4.6A)
 0.73A 3miyB-4xbrA:
22.7		 3miyB-4xbrA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
LYS B 290
PHE B 336
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.59A 3miyB-4xeyB:
27.2		 3miyB-4xeyB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
MET A 477
GLY A 480
LEU A 528
SER A 538
 None
 0.57A 3miyB-4xi2A:
32.6		 3miyB-4xi2A:
42.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  29
ALA A  50
LYS A  52
MET A 106
LEU A 154
 42A  A 402 ( 4.7A)
42A  A 402 (-3.2A)
42A  A 402 (-4.1A)
None
42A  A 402 ( 4.9A)
 0.58A 3miyB-4xrlA:
17.2		 3miyB-4xrlA:
26.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
SER A 538
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.64A 3miyB-4y93A:
33.2		 3miyB-4y93A:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  10
ALA A  31
LYS A  33
PHE A  80
LEU A 135
 None
 0.72A 3miyB-4yc6A:
23.4		 3miyB-4yc6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  10
ALA A  31
PHE A  80
PHE A  82
LEU A 135
 None
 0.54A 3miyB-4yc6A:
23.4		 3miyB-4yc6A:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 214
LYS A 216
MET A 267
LEU A 319
SER A 329
 AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
AN2  A 601 ( 4.5A)
 0.71A 3miyB-4yhjA:
20.3		 3miyB-4yhjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A  69
ALA A  90
LYS A  92
MET A 147
LEU A 196
 None
 0.56A 3miyB-5ci6A:
21.9		 3miyB-5ci6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 275
LYS A 277
PHE A 327
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.70A 3miyB-5e8yA:
25.3		 3miyB-5e8yA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.72A 3miyB-5eykA:
18.2		 3miyB-5eykA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
LYS A 758
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.51A 3miyB-5fm2A:
31.7		 3miyB-5fm2A:
32.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  22
ALA A  43
PHE A  92
GLY A  96
LEU A 143
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.55A 3miyB-5j5tA:
22.7		 3miyB-5j5tA:
26.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.50A 3miyB-5j9zA:
26.4		 3miyB-5j9zA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 396
ALA A 417
LYS A 419
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.72A 3miyB-5jznA:
23.2		 3miyB-5jznA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 639
ALA A 663
PHE A 713
MET A 714
LEU A 765
SER A 775
 6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.5A)
None
6P6  A1001 (-4.5A)
6P6  A1001 ( 3.7A)
 0.38A 3miyB-5l6oA:
32.5		 3miyB-5l6oA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 ILE A 889
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
 None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
 0.54A 3miyB-5lpyA:
24.5		 3miyB-5lpyA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.46A 3miyB-5lpzA:
24.5		 3miyB-5lpzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
ALA A 909
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.65A 3miyB-5lpzA:
24.5		 3miyB-5lpzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 ILE A 358
ALA A 379
LYS A 381
PHE A 431
LEU A 482
SER A 492
 ANP  A 801 (-4.2A)
ANP  A 801 ( 3.9A)
ANP  A 801 (-2.6A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.8A)
None
 1.02A 3miyB-5nclA:
19.4		 3miyB-5nclA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 ILE A 358
LYS A 381
PHE A 431
GLY A 435
LEU A 482
SER A 492
 ANP  A 801 (-4.2A)
ANP  A 801 (-2.6A)
ANP  A 801 ( 4.9A)
None
ANP  A 801 (-4.8A)
None
 1.02A 3miyB-5nclA:
19.4		 3miyB-5nclA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 617
LYS A 619
PHE A 673
MET A 674
GLY A 677
 7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
 0.55A 3miyB-5td2A:
31.2		 3miyB-5td2A:
38.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 6 ALA A 103
PHE A 152
MET A 153
GLY A 156
LEU A 209
SER A 219
 None
 0.87A 3miyB-5tosA:
17.3		 3miyB-5tosA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 565
LYS A 567
PHE A 622
MET A 623
GLY A 626
 7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.63A 3miyB-5u6bA:
31.7		 3miyB-5u6bA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
MET A 274
LEU A 324
SER A 334
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
MES  A 604 (-3.9A)
None
QRW  A 601 ( 3.7A)
 0.72A 3miyB-5uuuA:
22.0		 3miyB-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 ILE A 327
ALA A 348
LYS A 350
PHE A 397
GLY A 401
LEU A 447
SER A 457
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.69A 3miyB-5vefA:
23.8		 3miyB-5vefA:
27.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 150
LYS A 152
PHE A 192
GLY A 196
LEU A 243
SER A 253
 9FS  A 501 (-3.4A)
None
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
9FS  A 501 ( 4.3A)
 0.83A 3miyB-5vo1A:
27.9		 3miyB-5vo1A:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 ALA A  45
LYS A  47
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.66A 3miyB-5w5jA:
24.9		 3miyB-5w5jA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 5 LYS A 581
PHE A 628
GLY A 632
LEU A 680
SER A 698
 SKE  A 901 ( 4.7A)
SKE  A 901 (-3.6A)
SKE  A 901 (-3.1A)
SKE  A 901 (-4.1A)
SKE  A 901 (-3.3A)
 0.72A 3miyB-5winA:
29.0		 3miyB-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 ALA A  49
MET A  99
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-3.2A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.58A 3miyB-5wnmA:
28.9		 3miyB-5wnmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 ILE A 733
ALA A 754
LYS A 756
PHE A 813
MET A 816
LEU A 866
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
CJM  A1102 ( 4.4A)
None
CJM  A1102 (-4.4A)
 0.64A 3miyB-6b3eA:
23.7		 3miyB-6b3eA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 218
ALA A 237
LYS A 239
PHE A 290
GLY A 294
LEU A 347
 DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 (-4.3A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.57A 3miyB-6bfnA:
24.8		 3miyB-6bfnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
ALA A 192
LYS A 194
PHE A 267
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
BI9  A 501 ( 4.2A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.58A 3miyB-6bqlA:
23.1		 3miyB-6bqlA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ALA A 906
LYS A 908
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.60A 3miyB-6c7yA:
29.4		 3miyB-6c7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 134
ALA A 155
LYS A 157
PHE A 230
GLY A 236
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-3.7A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.57A 3miyB-6ccfA:
23.2		 3miyB-6ccfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 ALA A 211
MET A 265
GLY A 268
LEU A 318
SER A 328
 CJT  A 502 (-3.4A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.3A)
 0.70A 3miyB-6f3dA:
25.4		 3miyB-6f3dA:
13.17