SIMILAR PATTERNS OF AMINO ACIDS FOR 3MIY_A_B49A1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  31
LYS A  33
VAL A  64
PHE A  80
LEU A 133
ASP A 144
None
0.74A 3miyA-1h4lA:
20.5
3miyA-1h4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  10
ALA A  31
LYS A  33
VAL A  64
PHE A  80
PHE A  82
LEU A 133
None
0.66A 3miyA-1h4lA:
20.5
3miyA-1h4lA:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
ASP A 539
None
0.76A 3miyA-1k2pA:
26.8
3miyA-1k2pA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 428
VAL A 458
MET A 477
GLY A 480
LEU A 528
SER A 538
ASP A 539
None
0.83A 3miyA-1k2pA:
26.8
3miyA-1k2pA:
57.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
ASP A 332
None
0.81A 3miyA-1k9aA:
32.6
3miyA-1k9aA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 220
LYS A 222
VAL A 249
MET A 269
GLY A 272
LEU A 321
None
0.70A 3miyA-1k9aA:
32.6
3miyA-1k9aA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 220
VAL A 249
MET A 269
GLY A 272
LEU A 321
SER A 331
None
0.77A 3miyA-1k9aA:
32.6
3miyA-1k9aA:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
6 ALA A 606
VAL A 638
PHE A 654
MET A 657
GLY A 660
LEU A 731
None
0.72A 3miyA-1lufA:
32.5
3miyA-1lufA:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ALA A 288
VAL A 318
PHE A 336
MET A 337
GLY A 340
LEU A 389
P16  A   2 (-3.4A)
P16  A   2 ( 4.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.74A 3miyA-1opkA:
30.8
3miyA-1opkA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  99
VAL A 131
MET A 150
GLY A 153
LEU A 201
ASP A 212
ATP  A 535 (-3.6A)
5EA  A1001 (-4.5A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
0.72A 3miyA-1s9iA:
10.2
3miyA-1s9iA:
26.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 389
VAL A 419
PHE A 435
MET A 438
GLY A 441
LEU A 489
SER A 499
ASP A 500
None
0.80A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A 369
ALA A 389
LYS A 391
PHE A 437
MET A 438
GLY A 441
LEU A 489
None
0.85A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ILE A 369
ALA A 389
VAL A 419
PHE A 435
PHE A 437
MET A 438
GLY A 441
LEU A 489
SER A 499
None
0.73A 3miyA-1snxA:
27.7
3miyA-1snxA:
98.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
LEU A 144
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
ATP  A 381 (-4.1A)
None
None
0.63A 3miyA-1ua2A:
23.3
3miyA-1ua2A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG


(Plasmodium
falciparum)
PF00069
(Pkinase)
6 ILE A  10
ALA A  30
VAL A  63
PHE A  79
LEU A 132
ASP A 143
None
0.61A 3miyA-1v0bA:
23.3
3miyA-1v0bA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 293
VAL A 323
PHE A 340
MET A 341
GLY A 344
LEU A 393
ASP A 404
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
0.55A 3miyA-2hckA:
31.4
3miyA-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
8 ILE A 635
ALA A 659
LYS A 661
PHE A 709
MET A 710
GLY A 713
LEU A 761
SER A 771
ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
0.68A 3miyA-2henA:
31.1
3miyA-2henA:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 271
LYS A 273
VAL A 301
PHE A 318
MET A 319
GLY A 322
LEU A 371
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
0.58A 3miyA-2hk5A:
26.0
3miyA-2hk5A:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 269
LYS A 271
VAL A 299
PHE A 317
MET A 318
GLY A 321
LEU A 370
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
0.57A 3miyA-2hz0A:
31.8
3miyA-2hz0A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  10
ALA A  31
LYS A  33
VAL A  64
PHE A  80
PHE A  82
LEU A 134
None
0.78A 3miyA-2jgzA:
19.6
3miyA-2jgzA:
29.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
6 ILE A 428
ALA A 452
LYS A 454
VAL A 484
GLY A 505
LEU A 553
BII  A1687 (-3.8A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
0.79A 3miyA-2jkmA:
33.1
3miyA-2jkmA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 271
LYS A 273
VAL A 301
MET A 319
GLY A 322
LEU A 371
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
0.75A 3miyA-2og8A:
32.2
3miyA-2og8A:
42.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 ALA A 367
LYS A 369
VAL A 399
GLY A 418
LEU A 468
SER A 478
ASP A 479
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
1.23A 3miyA-2ozoA:
29.4
3miyA-2ozoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
7 ALA A  34
LYS A  36
VAL A  66
PHE A  82
PHE A  84
MET A  85
LEU A 140
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
AGS  A3001 ( 4.5A)
None
None
0.65A 3miyA-2pmiA:
21.8
3miyA-2pmiA:
29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
7 ILE B  47
ALA B  67
LYS B  69
VAL B  98
MET B 117
GLY B 120
LEU B 171
None
0.58A 3miyA-2qkwB:
24.8
3miyA-2qkwB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
6 ILE B  47
LYS B  69
VAL B  98
MET B 117
LEU B 171
ASP B 182
None
0.82A 3miyA-2qkwB:
24.8
3miyA-2qkwB:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
0.52A 3miyA-2qobA:
27.5
3miyA-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ILE A 681
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
SER A 817
None
0.63A 3miyA-2r2pA:
29.6
3miyA-2r2pA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
ASP A 861
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
0.78A 3miyA-2r4bA:
27.0
3miyA-2r4bA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 749
VAL A 781
MET A 799
GLY A 802
LEU A 850
ASP A 861
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
0.69A 3miyA-2r4bA:
27.0
3miyA-2r4bA:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
7 ILE B  75
VAL B 131
PHE B 149
MET B 150
GLY B 153
LEU B 202
SER B 212
ANP  B 432 (-4.4A)
None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
0.89A 3miyA-2wtkB:
24.4
3miyA-2wtkB:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ILE A 627
ALA A 651
MET A 702
GLY A 705
LEU A 753
SER A 763
None
Q9G  A1898 (-3.2A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
0.33A 3miyA-2xyuA:
31.1
3miyA-2xyuA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  30
ALA A  51
MET A 110
GLY A 113
LEU A 160
SER A 170
ASP A 171
B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
0.90A 3miyA-2y7jA:
24.0
3miyA-2y7jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  30
ALA A  51
PHE A 107
MET A 110
GLY A 113
LEU A 160
B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
0.73A 3miyA-2y7jA:
24.0
3miyA-2y7jA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 ALA A 273
LYS A 275
VAL A 303
PHE A 321
MET A 322
GLY A 325
LEU A 374
None
0.57A 3miyA-2zv7A:
32.9
3miyA-2zv7A:
41.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  18
ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
0.81A 3miyA-3c0iA:
24.3
3miyA-3c0iA:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
ASP A 332
None
0.81A 3miyA-3d7uA:
27.4
3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 220
LYS A 222
VAL A 249
MET A 269
GLY A 272
LEU A 321
None
0.70A 3miyA-3d7uA:
27.4
3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 220
VAL A 249
MET A 269
GLY A 272
LEU A 321
SER A 331
None
0.77A 3miyA-3d7uA:
27.4
3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
8 ILE A 639
ALA A 663
VAL A 695
PHE A 713
MET A 714
GLY A 717
LEU A 765
SER A 775
IHZ  A1001 ( 4.8A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
0.80A 3miyA-3dkoA:
33.0
3miyA-3dkoA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ALA A 665
MET A 716
GLY A 719
LEU A 767
SER A 777
ASP A 778
None
None
GOL  A 403 (-3.4A)
None
None
None
0.77A 3miyA-3kulA:
33.9
3miyA-3kulA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  25
ALA A  46
LYS A  48
VAL A  79
PHE A 103
PHE A 105
LEU A 156
None
0.87A 3miyA-3mi9A:
23.3
3miyA-3mi9A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
7 ALA A  49
LYS A  51
VAL A  82
PHE A  98
PHE A 100
MET A 101
LEU A 151
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
0.55A 3miyA-3nizA:
24.8
3miyA-3nizA:
25.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 570
VAL A 601
PHE A 617
MET A 620
GLY A 623
LEU A 686
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0.59A 3miyA-3v5qA:
31.9
3miyA-3v5qA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  96
LYS A  98
VAL A 128
MET A 147
GLY A 150
LEU A 198
ASP A 209
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
0.75A 3miyA-3wigA:
24.2
3miyA-3wigA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
0.65A 3miyA-3wzdA:
31.4
3miyA-3wzdA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  31
LYS A  33
VAL A  63
PHE A  79
PHE A  81
LEU A 132
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
0.64A 3miyA-3zduA:
24.2
3miyA-3zduA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ILE A 625
ALA A 649
LYS A 651
PHE A 699
MET A 700
GLY A 703
LEU A 751
SER A 761
ASP A 762
None
0.59A 3miyA-3zfxA:
34.8
3miyA-3zfxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
0.79A 3miyA-4agdA:
30.2
3miyA-4agdA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 586
VAL A 617
PHE A 633
MET A 636
GLY A 639
LEU A 699
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
0.61A 3miyA-4at3A:
31.6
3miyA-4at3A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A  97
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
LEU A 223
30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
0.58A 3miyA-4aw5A:
30.6
3miyA-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ILE A  97
ALA A 121
PHE A 171
MET A 172
GLY A 175
LEU A 223
SER A 233
ASP A 234
30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
30K  A1365 (-3.3A)
0.83A 3miyA-4aw5A:
30.6
3miyA-4aw5A:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  63
VAL A  94
PHE A 112
GLY A 116
LEU A 164
ASP A 175
XZN  A1317 (-3.5A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
0.59A 3miyA-4bc6A:
22.2
3miyA-4bc6A:
28.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
ASP A 701
GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
GUI  A 901 ( 4.1A)
0.75A 3miyA-4e93A:
35.0
3miyA-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 ILE A 567
ALA A 588
LYS A 590
VAL A 620
GLY A 642
LEU A 690
SER A 700
GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
0.64A 3miyA-4e93A:
35.0
3miyA-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 541
VAL A 572
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.50A 3miyA-4f0iA:
25.2
3miyA-4f0iA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
ASP A 512
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
0SB  A 701 (-3.9A)
0.81A 3miyA-4f4pA:
32.1
3miyA-4f4pA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
SER A 511
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
0.78A 3miyA-4f4pA:
32.1
3miyA-4f4pA:
38.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4


(Homo sapiens)
PF00069
(Pkinase)
PF00786
(PBD)
7 ILE A 327
ALA A 348
LYS A 350
VAL A 379
PHE A 397
LEU A 447
SER A 457
None
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
0.80A 3miyA-4fieA:
23.1
3miyA-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4


(Homo sapiens)
PF00069
(Pkinase)
PF00786
(PBD)
7 ILE A 327
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
SER A 457
None
ANP  A1001 (-3.0A)
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
0.79A 3miyA-4fieA:
23.1
3miyA-4fieA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
SER A 511
ASP A 512
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
1.00A 3miyA-4fl3A:
31.3
3miyA-4fl3A:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1148
LYS A1150
VAL A1180
MET A1199
GLY A1202
LEU A1256
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0.61A 3miyA-4fodA:
31.5
3miyA-4fodA:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 293
LYS A 295
VAL A 323
MET A 341
GLY A 344
LEU A 393
ASP A 404
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
0.71A 3miyA-4k11A:
31.6
3miyA-4k11A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
8 ILE A 413
ALA A 434
LYS A 436
VAL A 465
PHE A 483
GLY A 487
LEU A 533
SER A 543
B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
0.65A 3miyA-4ks8A:
24.9
3miyA-4ks8A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
8 ILE A 413
ALA A 434
VAL A 465
PHE A 483
GLY A 487
LEU A 533
SER A 543
ASP A 544
B49  A 701 (-4.2A)
B49  A 701 (-3.2A)
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
0.73A 3miyA-4ks8A:
24.9
3miyA-4ks8A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l01 TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LYS A 622
VAL A 651
PHE A 669
GLY A 673
LEU A 721
SER A 738
None
0.75A 3miyA-4l01A:
28.9
3miyA-4l01A:
28.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
7 ALA A 293
LYS A 295
VAL A 323
MET A 341
GLY A 344
LEU A 393
ASP A 404
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
0.75A 3miyA-4lggA:
31.9
3miyA-4lggA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS)
7 ALA A 218
LYS A 220
VAL A 255
MET A 274
LEU A 324
SER A 334
ASP A 335
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
0.93A 3miyA-4mk0A:
15.9
3miyA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS)
7 LYS A 220
VAL A 255
MET A 274
GLY A 277
LEU A 324
SER A 334
ASP A 335
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
0.89A 3miyA-4mk0A:
15.9
3miyA-4mk0A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ILE A 619
ALA A 644
MET A 695
GLY A 698
LEU A 746
SER A 756
None
0.69A 3miyA-4p2kA:
34.0
3miyA-4p2kA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 ALA A  35
LYS A  37
VAL A  65
MET A  84
GLY A  87
LEU A 136
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
0.61A 3miyA-4ueuA:
33.1
3miyA-4ueuA:
48.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4


(Homo sapiens)
PF00069
(Pkinase)
PF15342
(FAM212)
8 ILE A 327
ALA A 348
LYS A 350
VAL A 379
PHE A 397
LEU A 447
SER A 457
ASP A 458
None
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
ATP  A 601 (-4.6A)
None
ATP  A 601 ( 4.6A)
ATP  A 601 ( 2.5A)
0.84A 3miyA-4xbrA:
19.4
3miyA-4xbrA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4


(Homo sapiens)
PF00069
(Pkinase)
PF15342
(FAM212)
7 LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
SER A 457
ASP A 458
ATP  A 601 (-2.8A)
None
ATP  A 601 (-4.6A)
None
None
ATP  A 601 ( 4.6A)
ATP  A 601 ( 2.5A)
0.85A 3miyA-4xbrA:
19.4
3miyA-4xbrA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 7 ALA B 288
LYS B 290
VAL B 318
PHE B 336
MET B 337
GLY B 340
LEU B 389
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.3A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
0.79A 3miyA-4xeyB:
26.2
3miyA-4xeyB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 428
VAL A 458
MET A 477
GLY A 480
LEU A 528
SER A 538
ASP A 539
None
0.67A 3miyA-4xi2A:
29.4
3miyA-4xi2A:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
8 ALA A 428
LYS A 430
VAL A 458
MET A 477
GLY A 480
LEU A 528
SER A 538
ASP A 539
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
746  A 702 (-3.7A)
0.65A 3miyA-4y93A:
33.1
3miyA-4y93A:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  10
ALA A  31
LYS A  33
VAL A  64
PHE A  80
LEU A 135
ASP A 146
None
0.74A 3miyA-4yc6A:
23.5
3miyA-4yc6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 ILE A  10
ALA A  31
VAL A  64
PHE A  80
PHE A  82
LEU A 135
ASP A 146
None
0.66A 3miyA-4yc6A:
23.5
3miyA-4yc6A:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
6 ALA A 214
LYS A 216
VAL A 248
MET A 267
LEU A 319
SER A 329
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
AN2  A 601 ( 4.5A)
0.80A 3miyA-4yhjA:
20.3
3miyA-4yhjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
6 ILE A  69
ALA A  90
LYS A  92
VAL A 123
MET A 147
LEU A 196
None
0.54A 3miyA-5ci6A:
22.0
3miyA-5ci6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A 396
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
0.80A 3miyA-5jznA:
23.3
3miyA-5jznA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 639
ALA A 663
PHE A 713
MET A 714
LEU A 765
SER A 775
6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.5A)
None
6P6  A1001 (-4.5A)
6P6  A1001 ( 3.7A)
0.45A 3miyA-5l6oA:
32.6
3miyA-5l6oA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
9 ILE A 889
ALA A 909
LYS A 911
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
ASP A1027
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.65A 3miyA-5lpyA:
24.6
3miyA-5lpyA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
9 ILE A 889
ALA A 909
LYS A 911
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.49A 3miyA-5lpyA:
24.6
3miyA-5lpyA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
9 ILE A 889
ALA A 909
LYS A 911
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
ASP A1027
ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
0.66A 3miyA-5lpzA:
24.5
3miyA-5lpzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
8 ILE A 889
ALA A 909
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
None
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
0.64A 3miyA-5lpzA:
24.5
3miyA-5lpzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1


(Arabidopsis
thaliana)
no annotation 7 ALA A 103
VAL A 134
PHE A 152
MET A 153
GLY A 156
LEU A 209
SER A 219
None
0.98A 3miyA-5tosA:
22.9
3miyA-5tosA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 565
LYS A 567
PHE A 622
MET A 623
GLY A 626
ASP A 690
7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
0.81A 3miyA-5u6bA:
32.2
3miyA-5u6bA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  98
ALA A 119
LYS A 121
VAL A 153
MET A 172
LEU A 221
None
0.78A 3miyA-5u7qA:
19.6
3miyA-5u7qA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
7 ALA A 218
LYS A 220
VAL A 255
MET A 274
LEU A 324
SER A 334
ASP A 335
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 ( 3.7A)
QRW  A 601 (-3.7A)
0.95A 3miyA-5uuuA:
22.1
3miyA-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
7 LYS A 220
VAL A 255
MET A 274
GLY A 277
LEU A 324
SER A 334
ASP A 335
QRW  A 601 (-3.0A)
None
MES  A 604 (-3.9A)
None
None
QRW  A 601 ( 3.7A)
QRW  A 601 (-3.7A)
0.96A 3miyA-5uuuA:
22.1
3miyA-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4


(Homo sapiens)
no annotation 9 ILE A 327
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
SER A 457
ASP A 458
M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
M77  A 601 ( 3.5A)
0.87A 3miyA-5vefA:
24.1
3miyA-5vefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-)
no annotation 6 LYS A 581
VAL A 610
PHE A 628
GLY A 632
LEU A 680
SER A 698
SKE  A 901 ( 4.7A)
SKE  A 901 ( 4.7A)
SKE  A 901 (-3.6A)
SKE  A 901 (-3.1A)
SKE  A 901 (-4.1A)
SKE  A 901 (-3.3A)
0.70A 3miyA-5winA:
29.2
3miyA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12


(Homo sapiens)
no annotation 7 ILE A 733
ALA A 754
LYS A 756
VAL A 787
PHE A 813
MET A 816
LEU A 866
CJM  A1102 (-3.4A)
CJM  A1102 (-3.1A)
None
None
CJM  A1102 ( 4.4A)
None
CJM  A1102 (-4.4A)
0.82A 3miyA-6b3eA:
23.9
3miyA-6b3eA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1


(Homo sapiens)
no annotation 8 ILE A 218
ALA A 237
LYS A 239
VAL A 272
PHE A 290
GLY A 294
LEU A 347
ASP A 358
DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-4.3A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
0.61A 3miyA-6bfnA:
25.0
3miyA-6bfnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 7 ILE A 171
ALA A 192
LYS A 194
VAL A 249
PHE A 267
GLY A 273
LEU A 319
BI9  A 501 (-4.0A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
None
BI9  A 501 ( 4.2A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
0.59A 3miyA-6bqlA:
23.0
3miyA-6bqlA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 6 ALA A 906
LYS A 908
VAL A 938
PHE A 958
GLY A 962
LEU A1010
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
0.62A 3miyA-6c7yA:
29.7
3miyA-6c7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1


(Homo sapiens)
no annotation 7 ILE A 134
ALA A 155
LYS A 157
VAL A 212
PHE A 230
GLY A 236
LEU A 282
H1N  A 501 (-4.3A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.7A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
0.58A 3miyA-6ccfA:
23.4
3miyA-6ccfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 6 ILE A 171
ALA A 192
VAL A 249
PHE A 267
GLY A 273
LEU A 319
F6J  A 501 (-4.3A)
F6J  A 501 (-3.4A)
None
F6J  A 501 (-3.7A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
0.77A 3miyA-6cmjA:
22.9
3miyA-6cmjA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4


(Homo sapiens)
no annotation 6 ALA A 211
VAL A 246
MET A 265
GLY A 268
LEU A 318
SER A 328
CJT  A 502 (-3.4A)
None
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.3A)
0.73A 3miyA-6f3dA:
25.4
3miyA-6f3dA:
13.17