SIMILAR PATTERNS OF AMINO ACIDS FOR 3MIH_A_CUA358

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A 118
HIS A  46
MET A 116
 CU  A 502 (-3.1A)
CU  A 502 (-3.2A)
None
 1.00A 3mihA-1eqwA:
undetectable		 3mihA-1eqwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A 118
HIS A  46
MET A 116
 CU  A 150 ( 3.2A)
CU  A 150 ( 3.3A)
None
 1.04A 3mihA-1esoA:
0.0		 3mihA-1esoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 HIS A 385
HIS A 511
MET A 509
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
 0.93A 3mihA-1evlA:
undetectable		 3mihA-1evlA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  69
HIS A  93
MET A  71
 None
 0.64A 3mihA-1h1yA:
undetectable		 3mihA-1h1yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 HIS A 480
HIS A 469
MET A 478
 None
 0.95A 3mihA-1h54A:
0.0		 3mihA-1h54A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 HIS A  74
HIS A 181
MET A  73
 ZN  A 999 ( 3.1A)
ZN  A 999 ( 3.1A)
None
 0.90A 3mihA-1h8lA:
0.0		 3mihA-1h8lA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joi AZURIN

(Pseudomonas
fluorescens) 		PF00127
(Copper-bind) 		3 HIS A 117
HIS A  46
MET A  44
 HIS  A 117 (-0.9A)
HIS  A  46 (-0.9A)
MET  A  44 ( 0.0A)
 0.98A 3mihA-1joiA:
undetectable		 3mihA-1joiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 HIS A 504
HIS A 365
MET A 375
 FUM  A3001 ( 4.1A)
FUM  A3001 (-4.2A)
FAD  A3000 ( 3.5A)
 1.03A 3mihA-1m64A:
0.0		 3mihA-1m64A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		3 HIS A 125
HIS A  47
MET A 123
 CU  A 153 (-3.2A)
CU  A 153 (-3.1A)
None
 1.00A 3mihA-1oalA:
0.0		 3mihA-1oalA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		3 HIS A  89
HIS A 115
MET A  33
 None
 0.80A 3mihA-1pxzA:
undetectable		 3mihA-1pxzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 HIS A 385
HIS A 511
MET A 509
 ZN  A1001 (-3.3A)
ZN  A1001 (-3.4A)
None
 0.84A 3mihA-1qf6A:
undetectable		 3mihA-1qf6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		3 HIS A 117
HIS A  46
MET A  44
 CU  A 200 (-3.0A)
CU  A 200 (-3.1A)
None
 0.96A 3mihA-1rkrA:
undetectable		 3mihA-1rkrA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  74
HIS A  98
MET A  76
 None
 0.66A 3mihA-1rpxA:
undetectable		 3mihA-1rpxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  68
HIS A  92
MET A  70
 None
 0.73A 3mihA-1tqjA:
undetectable		 3mihA-1tqjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  70
HIS A  92
MET A  72
 ZN  A 900 (-3.3A)
None
None
 0.67A 3mihA-1tqxA:
undetectable		 3mihA-1tqxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uri AZURIN

(Achromobacter
denitrificans) 		PF00127
(Copper-bind) 		3 HIS A 117
HIS A  46
MET A  44
 CU  A 200 (-3.1A)
CU  A 200 (-3.0A)
None
 0.98A 3mihA-1uriA:
undetectable		 3mihA-1uriA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 HIS A  66
HIS A 173
MET A  65
 ZN  A1405 (-3.2A)
ZN  A1405 (-3.1A)
None
 1.00A 3mihA-1uwyA:
undetectable		 3mihA-1uwyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		3 HIS A 238
HIS A  80
MET A 239
 SAL  A 501 (-3.9A)
None
None
 0.85A 3mihA-1y7iA:
undetectable		 3mihA-1y7iA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu GIANT HEMOGLOBINS B
CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		3 HIS B  36
HIS B 111
MET B 115
 ZN  B 191 (-3.3A)
ZN  B 191 (-3.4A)
ZN  B 191 ( 4.8A)
 0.83A 3mihA-1yhuB:
undetectable		 3mihA-1yhuB:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 HIS A 242
HIS A 244
MET A 314
 CU  A 358 (-3.2A)
CU  A 358 (-3.2A)
CU  A 358 (-2.2A)
 0.14A 3mihA-1yjkA:
45.0		 3mihA-1yjkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A 151
HIS A  72
MET A 149
 CU  A 200 (-3.2A)
CU  A 200 (-3.2A)
None
 0.98A 3mihA-1z9nA:
undetectable		 3mihA-1z9nA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A 151
HIS A  72
MET A 149
 CU  A 200 (-3.2A)
CU  A 200 (-3.2A)
None
 0.97A 3mihA-1z9pA:
undetectable		 3mihA-1z9pA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 HIS A  -3
HIS A   0
MET A   1
 GOL  A 223 ( 4.6A)
None
GOL  A 223 (-4.9A)
 0.76A 3mihA-1zybA:
undetectable		 3mihA-1zybA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 HIS A 141
HIS A  62
MET A 139
 CU  A 402 ( 3.1A)
CU  A 402 ( 3.4A)
None
 0.99A 3mihA-2apsA:
undetectable		 3mihA-2apsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 3 HIS C 160
HIS C  81
MET C 158
 CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
None
 1.00A 3mihA-2aqtC:
undetectable		 3mihA-2aqtC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djr ZINC FINGER BED
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02892
(zf-BED) 		3 HIS A  59
HIS A  54
MET A  58
 ZN  A 201 (-3.5A)
ZN  A 201 (-3.4A)
ZN  A 201 (-3.4A)
 0.92A 3mihA-2djrA:
undetectable		 3mihA-2djrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  67
HIS A  91
MET A  69
 ZN  A1981 ( 3.3A)
None
DX5  A1901 (-3.4A)
 0.64A 3mihA-2fliA:
undetectable		 3mihA-2fliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A 128
HIS A  50
MET A 126
 CU1  A 155 (-3.0A)
CU1  A 155 (-3.3A)
CU1  A 155 ( 4.2A)
 1.01A 3mihA-2k4wA:
undetectable		 3mihA-2k4wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		3 HIS A 118
HIS A  49
MET A  47
 CU1  A 201 (-3.1A)
CU1  A 201 (-3.2A)
None
 1.01A 3mihA-2n0mA:
undetectable		 3mihA-2n0mA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		3 HIS A 242
HIS A 147
MET A 246
 None
 0.98A 3mihA-2p90A:
undetectable		 3mihA-2p90A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkw CARBOXYLESTERASE

(Alcaligenes sp.) 		no annotation 3 HIS A 298
HIS A 205
MET A 299
 W22  A 577 (-4.4A)
None
None
 1.00A 3mihA-2wkwA:
undetectable		 3mihA-2wkwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A 135
HIS A  56
MET A 133
 ZN  A1165 (-3.3A)
ZN  A1165 (-3.4A)
None
 1.02A 3mihA-2wwoA:
undetectable		 3mihA-2wwoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 HIS A 643
HIS A 673
MET A 641
 None
 0.70A 3mihA-2xt6A:
undetectable		 3mihA-2xt6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		3 HIS A 144
HIS A 108
MET A 142
 None
 0.48A 3mihA-2zbmA:
undetectable		 3mihA-2zbmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 456
HIS A 403
MET A 454
 CU  A 701 (-3.3A)
CU  A 701 ( 3.1A)
None
 0.78A 3mihA-3abgA:
undetectable		 3mihA-3abgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		3 HIS A 171
HIS A 102
MET A 100
 ZN  A1001 (-3.2A)
ZN  A1001 (-3.0A)
None
 1.04A 3mihA-3ay2A:
undetectable		 3mihA-3ay2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		3 HIS A 134
HIS A 135
MET A 131
 None
 0.74A 3mihA-3bt5A:
undetectable		 3mihA-3bt5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 HIS A 107
HIS A 109
MET A   5
 None
 0.90A 3mihA-3c4qA:
undetectable		 3mihA-3c4qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct7 D-ALLULOSE-6-PHOSPHA
TE 3-EPIMERASE

(Escherichia
coli) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  63
HIS A  87
MET A  65
 MG  A 232 (-3.3A)
None
MG  A 232 ( 4.8A)
 0.67A 3mihA-3ct7A:
undetectable		 3mihA-3ct7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		3 HIS A  27
HIS A  28
MET A  24
 None
 0.83A 3mihA-3dt8A:
undetectable		 3mihA-3dt8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 280
HIS A 235
MET A 278
 CU  A 304 (-3.1A)
CU  A 304 ( 3.1A)
CU  A 304 ( 3.9A)
 0.51A 3mihA-3gdcA:
undetectable		 3mihA-3gdcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz7 PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Bordetella
bronchiseptica) 		PF03992
(ABM) 		3 HIS A  91
HIS A  62
MET A  63
 None
CIT  A  97 (-3.6A)
None
 0.82A 3mihA-3gz7A:
2.4		 3mihA-3gz7A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE

(Francisella
tularensis) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  68
HIS A  92
MET A  70
 None
 0.72A 3mihA-3inpA:
undetectable		 3mihA-3inpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		3 HIS A 104
HIS A 158
MET A 106
 None
None
Z97  A 767 ( 4.1A)
 0.82A 3mihA-3koyA:
undetectable		 3mihA-3koyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 287
HIS A 236
MET A 285
 CU  A 403 (-3.5A)
CU  A 403 ( 3.2A)
CU  A 403 ( 4.6A)
 0.60A 3mihA-3kw8A:
undetectable		 3mihA-3kw8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 HIS A 101
HIS A 217
MET A 100
 ZN  A 999 ( 3.0A)
ZN  A 999 ( 3.2A)
None
 0.95A 3mihA-3mn8A:
undetectable		 3mihA-3mn8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1l FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00551
(Formyl_trans_N) 		3 HIS A  36
HIS A  49
MET A  47
 None
 0.95A 3mihA-3o1lA:
undetectable		 3mihA-3o1lA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc3 D-RIBULOSE-5-PHOSPHA
TE-3-EPIMERASE

(Homo sapiens) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  70
HIS A  94
MET A  72
 FE  A 231 ( 3.0A)
None
GOL  A 232 (-4.0A)
 0.66A 3mihA-3qc3A:
undetectable		 3mihA-3qc3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		3 HIS A  29
HIS A  43
MET A  45
 None
 1.00A 3mihA-3qy2A:
undetectable		 3mihA-3qy2A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 HIS X  57
HIS X  76
MET X  55
 None
 0.76A 3mihA-3rj2X:
4.0		 3mihA-3rj2X:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 275
HIS A 224
MET A 273
 CU  A 310 ( 3.3A)
CU  A 310 ( 3.3A)
CU  A 310 ( 4.4A)
 0.59A 3mihA-3t9wA:
undetectable		 3mihA-3t9wA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 282
HIS A 231
MET A 280
 CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
CU  A   8 ( 4.6A)
 0.68A 3mihA-3tbbA:
undetectable		 3mihA-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 134
HIS A 100
MET A 132
 CU  A 402 ( 3.2A)
CU  A 402 (-3.2A)
None
 0.66A 3mihA-3wiaA:
undetectable		 3mihA-3wiaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 134
HIS A 100
MET A 132
 CU  A 402 ( 3.2A)
CU  A 402 (-3.2A)
None
 0.67A 3mihA-3wkqA:
undetectable		 3mihA-3wkqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo5 AP-4-A PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01230
(HIT) 		3 HIS A  91
HIS A 155
MET A  93
 None
PO4  A 301 (-3.9A)
PG4  A 302 (-4.9A)
 0.79A 3mihA-3wo5A:
undetectable		 3mihA-3wo5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo5 AP-4-A PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01230
(HIT) 		3 HIS A 155
HIS A 153
MET A  93
 PO4  A 301 (-3.9A)
PO4  A 301 (-3.9A)
PG4  A 302 (-4.9A)
 0.93A 3mihA-3wo5A:
undetectable		 3mihA-3wo5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wup DNA POLYMERASE ETA

(Homo sapiens) 		no annotation 3 HIS A 650
HIS A 654
MET A 651
 ZN  A 701 (-3.2A)
ZN  A 701 (-3.2A)
ZN  A 701 ( 4.9A)
 0.97A 3mihA-3wupA:
undetectable		 3mihA-3wupA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		3 HIS B 111
HIS B 115
MET B 112
 ZN  B1339 ( 3.2A)
ZN  B1339 ( 3.3A)
AGS  B1342 (-3.2A)
 1.00A 3mihA-3zeuB:
undetectable		 3mihA-3zeuB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 HIS A 643
HIS A 673
MET A 641
 None
 0.73A 3mihA-3zhrA:
undetectable		 3mihA-3zhrA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zja SL3965

(Streptomyces
lividans) 		PF04314
(PCuAC) 		3 HIS A 127
HIS A  98
MET A 105
 CU  A 999 (-3.3A)
CU  A 999 (-3.2A)
CU  A 999 (-2.2A)
 1.00A 3mihA-3zjaA:
undetectable		 3mihA-3zjaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 HIS A 274
HIS A 106
MET A 275
 SO4  A1308 ( 3.8A)
None
None
 0.80A 3mihA-4b9aA:
undetectable		 3mihA-4b9aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		3 HIS A 385
HIS A 414
MET A 418
 None
 0.79A 3mihA-4ecnA:
undetectable		 3mihA-4ecnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 HIS A 184
HIS A 319
MET A 317
 ZN  A1003 (-3.6A)
ZN  A1003 ( 3.5A)
None
 0.88A 3mihA-4eo4A:
undetectable		 3mihA-4eo4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 HIS A 164
HIS A 361
MET A 166
 MN  A 402 (-3.5A)
None
None
 1.01A 3mihA-4ewtA:
undetectable		 3mihA-4ewtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 287
HIS A 236
MET A 285
 CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
CU  A 403 ( 4.6A)
 0.64A 3mihA-4gybA:
undetectable		 3mihA-4gybA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		3 HIS A  86
HIS A 222
MET A  84
 None
 0.84A 3mihA-4j34A:
undetectable		 3mihA-4j34A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		3 HIS A 128
HIS A  50
MET A 126
 CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.2A)
None
 0.97A 3mihA-4l05A:
undetectable		 3mihA-4l05A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		3 HIS A 238
HIS A  93
MET A 239
 None
None
ACY  A 301 (-3.3A)
 0.82A 3mihA-4l0cA:
undetectable		 3mihA-4l0cA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m16 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella sp.
AR 15-3) 		PF02661
(Fic) 		3 HIS A   6
HIS A   7
MET A   8
 None
 0.76A 3mihA-4m16A:
undetectable		 3mihA-4m16A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  71
HIS A  95
MET A  73
 ZN  A 303 (-3.2A)
None
None
 0.67A 3mihA-4nu7A:
undetectable		 3mihA-4nu7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 HIS A 891
HIS A 846
MET A 850
 None
 1.02A 3mihA-4q73A:
undetectable		 3mihA-4q73A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 284
HIS A 233
MET A 282
 CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
CU  A 403 ( 4.8A)
 0.56A 3mihA-4w1tA:
undetectable		 3mihA-4w1tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		3 HIS A 152
HIS A 201
MET A 205
 None
 0.83A 3mihA-4yraA:
undetectable		 3mihA-4yraA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		3 HIS A 412
HIS A 414
MET A 487
 CU  A 701 (-3.3A)
CU  A 701 (-4.2A)
CU  A 701 (-2.7A)
 0.38A 3mihA-4zelA:
24.9		 3mihA-4zelA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 3 HIS A 426
HIS A 181
MET A 427
 None
 1.01A 3mihA-5ah1A:
undetectable		 3mihA-5ah1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		3 HIS A 310
HIS A 314
MET A 311
 None
 0.99A 3mihA-5c6uA:
undetectable		 3mihA-5c6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5duy GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 3 HIS A  37
HIS A  16
MET A  40
 GOL  A 201 (-4.1A)
GOL  A 201 (-3.8A)
None
 0.89A 3mihA-5duyA:
undetectable		 3mihA-5duyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5duy GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 3 HIS A 129
HIS A 108
MET A 132
 GOL  A 203 (-4.2A)
GOL  A 203 (-3.8A)
None
 0.93A 3mihA-5duyA:
undetectable		 3mihA-5duyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8y GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 3 HIS A  37
HIS A  16
MET A  40
 X6X  A 203 (-4.0A)
X6X  A 203 (-3.7A)
None
 0.91A 3mihA-5f8yA:
undetectable		 3mihA-5f8yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8y GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 3 HIS A 129
HIS A 108
MET A 132
 X6X  A 202 (-3.9A)
X6X  A 202 (-3.8A)
None
 0.92A 3mihA-5f8yA:
undetectable		 3mihA-5f8yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fej COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		3 HIS A  56
HIS A  57
MET A  53
 CU1  A 201 (-2.9A)
CU1  A 201 (-2.9A)
CU1  A 201 (-3.0A)
 0.90A 3mihA-5fejA:
undetectable		 3mihA-5fejA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fej COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		3 HIS A 148
HIS A 149
MET A 145
 CU1  A 202 (-2.8A)
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 0.85A 3mihA-5fejA:
undetectable		 3mihA-5fejA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		3 HIS A 228
HIS A  88
MET A 229
 None
 0.89A 3mihA-5frdA:
undetectable		 3mihA-5frdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		3 HIS C 148
HIS C 232
MET C 152
 NA  C 302 (-3.4A)
NA  C 302 (-3.4A)
NA  C 302 ( 3.9A)
 0.83A 3mihA-5iy5C:
undetectable		 3mihA-5iy5C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlt MIDDLE TRANSCRIPTION
REGULATORY PROTEIN
MOTA

(Escherichia
virus T4) 		PF09158
(MotCF) 		3 HIS A 170
HIS A 171
MET A 168
 None
 0.78A 3mihA-5jltA:
undetectable		 3mihA-5jltA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlu ADHESIN COMPETENCE
REPRESSOR

(Streptococcus
pyogenes) 		PF01047
(MarR) 		3 HIS A  42
HIS A 108
MET A  45
 ZN  A 201 (-3.3A)
ZN  A 201 (-3.3A)
None
 0.91A 3mihA-5jluA:
undetectable		 3mihA-5jluA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5h TRANSCRIPTIONAL
REPRESSOR CTCF

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13909
(zf-H2C2_5) 		3 HIS A 397
HIS A 401
MET A 398
 ZN  A 502 (-3.0A)
ZN  A 502 (-3.1A)
ZN  A 502 ( 4.8A)
 1.01A 3mihA-5k5hA:
undetectable		 3mihA-5k5hA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl2 WILMS TUMOR PROTEIN

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 HIS A 435
HIS A 431
MET A 434
 ZN  A 507 (-3.1A)
ZN  A 507 (-3.2A)
None
 0.97A 3mihA-5kl2A:
undetectable		 3mihA-5kl2A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 3 HIS A 288
HIS A 237
MET A 286
 None
 0.70A 3mihA-5mkmA:
undetectable		 3mihA-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 HIS A  87
HIS A 214
MET A  85
 None
 0.81A 3mihA-5nagA:
undetectable		 3mihA-5nagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umf RIBULOSE-PHOSPHATE
3-EPIMERASE

(Neisseria
gonorrhoeae) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  67
HIS A  91
MET A  69
 ZN  A 301 (-3.3A)
None
None
 0.66A 3mihA-5umfA:
undetectable		 3mihA-5umfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbk LECTIN

(Mytilus
californianus) 		no annotation 3 HIS A  37
HIS A  16
MET A  40
 GOL  A 201 (-3.9A)
GOL  A 201 (-4.0A)
None
 0.90A 3mihA-5vbkA:
undetectable		 3mihA-5vbkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbk LECTIN

(Mytilus
californianus) 		no annotation 3 HIS A 129
HIS A 108
MET A 132
 GOL  A 202 (-4.1A)
GOL  A 202 (-3.9A)
None
 0.97A 3mihA-5vbkA:
undetectable		 3mihA-5vbkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 HIS A 242
HIS A 244
MET A 314
 None
 0.32A 3mihA-5wm0A:
45.2		 3mihA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		3 HIS A  37
HIS A  16
MET A  40
 A2G  A 201 (-4.0A)
A2G  A 201 (-3.7A)
None
 0.89A 3mihA-5xg5A:
undetectable		 3mihA-5xg5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		3 HIS A  85
HIS A  64
MET A  88
 A2G  A 202 (-4.0A)
A2G  A 202 (-3.7A)
None
 0.89A 3mihA-5xg5A:
undetectable		 3mihA-5xg5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		3 HIS A 133
HIS A 112
MET A 136
 A2G  A 203 (-4.0A)
A2G  A 203 (-3.7A)
None
 0.89A 3mihA-5xg5A:
undetectable		 3mihA-5xg5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yal ESTERASE

(Streptomyces
cinnamoneus) 		no annotation 3 HIS A 268
HIS A 190
MET A 269
 None
 0.84A 3mihA-5yalA:
undetectable		 3mihA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt7 -

(-) 		no annotation 3 HIS A   3
HIS A  65
MET A  63
 CU  A 201 (-3.1A)
CU  A 201 (-3.1A)
None
 1.02A 3mihA-5yt7A:
undetectable		 3mihA-5yt7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 HIS A 526
HIS A 527
MET A 528
 MGD  A 903 ( 4.0A)
MGD  A 903 ( 3.8A)
None
 1.00A 3mihA-6czaA:
undetectable		 3mihA-6czaA:
undetectable