SIMILAR PATTERNS OF AMINO ACIDS FOR 3MIH_A_CUA357_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 506
HIS A 448
HIS A 450
 CU  A 555 (-3.1A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
 0.81A 3mihA-1asoA:
0.0		 3mihA-1asoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A1500 ( 3.2A)
CU  A1500 (-3.3A)
CU  A1502 (-3.1A)
 0.82A 3mihA-1gycA:
0.6		 3mihA-1gycA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 452
HIS A 398
HIS A 400
 CU  A1501 (-3.3A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
 0.80A 3mihA-1gycA:
0.6		 3mihA-1gycA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
CU  A 703 (-4.7A)
 0.81A 3mihA-1hfuA:
0.3		 3mihA-1hfuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 HIS A   1
HIS A  -3
HIS A   0
 None
SO4  A2002 ( 4.7A)
SO4  A2002 (-3.5A)
 0.84A 3mihA-1im4A:
0.0		 3mihA-1im4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 161
HIS A 101
HIS A 103
 CU  A1051 (-3.3A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 0.84A 3mihA-1kcwA:
undetectable		 3mihA-1kcwA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		3 HIS A  97
HIS A  64
HIS A  63
 None
FE  A 301 (-3.3A)
FE  A 302 (-3.7A)
 0.67A 3mihA-1nmoA:
undetectable		 3mihA-1nmoA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A  99
HIS A  97
HIS A 120
 None
MN  A 503 (-3.6A)
MN  A 503 (-3.6A)
 0.60A 3mihA-1s3nA:
0.0		 3mihA-1s3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A 120
HIS A  99
HIS A  97
 MN  A 503 (-3.6A)
None
MN  A 503 (-3.6A)
 0.67A 3mihA-1s3nA:
0.0		 3mihA-1s3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		3 HIS A 517
HIS A 534
HIS A 536
 None
 0.77A 3mihA-1s58A:
0.0		 3mihA-1s58A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		3 HIS A 105
HIS A 127
HIS A 107
 ZN  A 301 (-3.4A)
ZN  A 301 ( 3.3A)
None
 0.79A 3mihA-1su1A:
undetectable		 3mihA-1su1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		3 HIS A 107
HIS A 105
HIS A 127
 None
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.3A)
 0.78A 3mihA-1su1A:
undetectable		 3mihA-1su1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		3 HIS A 127
HIS A 107
HIS A 105
 ZN  A 301 ( 3.3A)
None
ZN  A 301 (-3.4A)
 0.35A 3mihA-1su1A:
undetectable		 3mihA-1su1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6t SH3 DOMAIN-BINDING
GLUTAMIC
ACID-RICH-LIKE
PROTEIN

(Homo sapiens) 		PF04908
(SH3BGR) 		3 HIS A 120
HIS A 117
HIS A 116
 None
 0.78A 3mihA-1u6tA:
undetectable		 3mihA-1u6tA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 HIS A 107
HIS A 108
HIS A 172
 CU  A 357 (-3.0A)
CU  A 357 (-3.0A)
CU  A 357 (-3.1A)
 0.25A 3mihA-1yjkA:
45.0		 3mihA-1yjkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  83
HIS A 126
HIS A  81
 CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.3A)
 0.86A 3mihA-1zpuA:
undetectable		 3mihA-1zpuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A  97
HIS A 120
HIS A  99
 None
 0.81A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A  99
HIS A  97
HIS A 120
 None
 0.70A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahd PHOSPHODIESTERASE
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A 120
HIS A  99
HIS A  97
 None
 0.43A 3mihA-2ahdA:
undetectable		 3mihA-2ahdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 499
HIS A 446
HIS A 448
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.78A 3mihA-2fqdA:
undetectable		 3mihA-2fqdA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		3 HIS A  69
HIS A  68
HIS A 103
 ZN  A 374 (-3.4A)
ZN  A 375 (-3.3A)
ZN  A 375 (-4.8A)
 0.65A 3mihA-2gx8A:
undetectable		 3mihA-2gx8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		3 HIS A 103
HIS A  69
HIS A  68
 ZN  A 375 (-4.8A)
ZN  A 374 (-3.4A)
ZN  A 375 (-3.3A)
 0.64A 3mihA-2gx8A:
undetectable		 3mihA-2gx8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		3 HIS A 170
HIS A 169
HIS A 207
 None
MN  A 555 (-3.3A)
MN  A 555 ( 3.3A)
 0.63A 3mihA-2hypA:
undetectable		 3mihA-2hypA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 603 ( 3.1A)
CU  A 603 (-3.4A)
CU  A 604 ( 3.1A)
 0.86A 3mihA-2hzhA:
undetectable		 3mihA-2hzhA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 452
HIS A 398
HIS A 400
 CU  A 602 (-3.1A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
 0.82A 3mihA-2hzhA:
undetectable		 3mihA-2hzhA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 500 (-3.1A)
 0.85A 3mihA-2qt6A:
undetectable		 3mihA-2qt6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 451
HIS A 397
HIS A 399
 CU  A 501 (-3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.83A 3mihA-2qt6A:
undetectable		 3mihA-2qt6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		3 HIS A  78
HIS A  76
HIS A 219
 NI  A1234 (-3.1A)
NI  A1234 (-3.3A)
NI  A1234 (-3.3A)
 0.81A 3mihA-2v24A:
3.6		 3mihA-2v24A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		3 HIS A 244
HIS A 243
HIS A 281
 None
FE  A 556 (-3.4A)
FE  A 556 ( 3.3A)
 0.63A 3mihA-2xmoA:
undetectable		 3mihA-2xmoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 503 (-3.1A)
CU  A 503 ( 3.2A)
CU  A 504 ( 3.1A)
 0.87A 3mihA-2xybA:
undetectable		 3mihA-2xybA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		3 HIS A  64
HIS A  97
HIS A  65
 None
 0.86A 3mihA-2yybA:
undetectable		 3mihA-2yybA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		3 HIS A  97
HIS A  65
HIS A  64
 None
 0.73A 3mihA-2yybA:
undetectable		 3mihA-2yybA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		3 HIS A 156
HIS A 195
HIS A 157
 FE2  A 276 (-3.6A)
FE2  A 276 ( 3.5A)
None
 0.76A 3mihA-2zoaA:
undetectable		 3mihA-2zoaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		3 HIS A 157
HIS A 156
HIS A 195
 None
FE2  A 276 (-3.6A)
FE2  A 276 ( 3.5A)
 0.57A 3mihA-2zoaA:
undetectable		 3mihA-2zoaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 459
HIS A 394
HIS A 396
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.77A 3mihA-3aw5A:
undetectable		 3mihA-3aw5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 HIS A 311
HIS A 308
HIS A  20
 None
 0.85A 3mihA-3b9nA:
undetectable		 3mihA-3b9nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		3 HIS A 146
HIS A  40
HIS A 144
 CU  A 711 ( 3.5A)
CU  A 712 ( 3.4A)
CU  A 711 (-3.7A)
 0.67A 3mihA-3chxA:
undetectable		 3mihA-3chxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		3 HIS A  81
HIS A 110
HIS A  83
 MN  A 202 (-3.3A)
MN  A 202 ( 3.5A)
None
 0.69A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		3 HIS A  83
HIS A  81
HIS A 110
 None
MN  A 202 (-3.3A)
MN  A 202 ( 3.5A)
 0.72A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		3 HIS A 110
HIS A  83
HIS A  81
 MN  A 202 ( 3.5A)
None
MN  A 202 (-3.3A)
 0.41A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  95
HIS A 138
HIS A  93
 CU  A 603 ( 3.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.1A)
 0.85A 3mihA-3dkhA:
undetectable		 3mihA-3dkhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 502
HIS A 434
HIS A 436
 CU  A 602 ( 3.2A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
 0.76A 3mihA-3dkhA:
undetectable		 3mihA-3dkhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 294
HIS A 246
HIS A 248
 None
C1O  A   2 ( 3.1A)
C1O  A   2 ( 3.5A)
 0.80A 3mihA-3g5wA:
undetectable		 3mihA-3g5wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 280
HIS A 233
HIS A 235
 CU  A 304 (-3.1A)
CU  A 302 (-3.0A)
CU  A 304 ( 3.1A)
 0.79A 3mihA-3gdcA:
undetectable		 3mihA-3gdcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 602
HIS A 527
HIS A 529
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.77A 3mihA-3gyrA:
undetectable		 3mihA-3gyrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		3 HIS A 118
HIS A 120
HIS A 199
 None
 0.64A 3mihA-3hjwA:
undetectable		 3mihA-3hjwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		3 HIS A 170
HIS A 169
HIS A 207
 None
MN  A 555 (-3.4A)
MN  A 555 ( 3.3A)
 0.58A 3mihA-3ib7A:
undetectable		 3mihA-3ib7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 604 ( 2.9A)
CU  A 604 (-3.2A)
CU  A 602 (-3.1A)
 0.85A 3mihA-3kw7A:
undetectable		 3mihA-3kw7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 455
HIS A 403
HIS A 405
 CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
 0.82A 3mihA-3kw7A:
undetectable		 3mihA-3kw7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 287
HIS A 234
HIS A 236
 CU  A 403 (-3.5A)
CU  A 404 (-3.1A)
CU  A 403 ( 3.2A)
 0.80A 3mihA-3kw8A:
undetectable		 3mihA-3kw8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388

(Staphylococcus
aureus) 		PF01784
(NIF3) 		3 HIS A  69
HIS A  68
HIS A 102
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
B3P  A 371 ( 4.8A)
 0.57A 3mihA-3lnlA:
undetectable		 3mihA-3lnlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388

(Staphylococcus
aureus) 		PF01784
(NIF3) 		3 HIS A 102
HIS A  69
HIS A  68
 B3P  A 371 ( 4.8A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
 0.64A 3mihA-3lnlA:
undetectable		 3mihA-3lnlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 503
HIS A 435
HIS A 437
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
 0.78A 3mihA-3ppsA:
undetectable		 3mihA-3ppsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A1501 ( 3.0A)
CU  A1501 (-3.2A)
CU  A1502 ( 3.0A)
 0.83A 3mihA-3pxlA:
undetectable		 3mihA-3pxlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 452
HIS A 398
HIS A 400
 CU  A1500 (-3.1A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
 0.84A 3mihA-3pxlA:
undetectable		 3mihA-3pxlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 HIS A 242
HIS A 246
HIS A 247
 AMP  A 482 (-4.2A)
ZN  A 481 (-3.3A)
None
 0.80A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 HIS A 246
HIS A 247
HIS A 242
 ZN  A 481 (-3.3A)
None
AMP  A 482 (-4.2A)
 0.45A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 HIS A 247
HIS A 242
HIS A 246
 None
AMP  A 482 (-4.2A)
ZN  A 481 (-3.3A)
 0.84A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  67
HIS A 110
HIS A  65
 CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
CU  A 504 (-3.1A)
 0.86A 3mihA-3t6wA:
undetectable		 3mihA-3t6wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 452
HIS A 400
HIS A 402
 CU  A 503 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
 0.76A 3mihA-3t6wA:
undetectable		 3mihA-3t6wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 275
HIS A 222
HIS A 224
 CU  A 310 ( 3.3A)
CU  A 308 ( 3.4A)
CU  A 310 ( 3.3A)
 0.77A 3mihA-3t9wA:
undetectable		 3mihA-3t9wA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 282
HIS A 229
HIS A 231
 CU  A   8 ( 3.3A)
CU  A   7 ( 3.2A)
CU  A   8 (-3.3A)
 0.83A 3mihA-3tbbA:
undetectable		 3mihA-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 HIS A 479
HIS A 476
HIS A 475
 ZN  A   3 ( 3.4A)
None
ZN  A   3 (-3.5A)
 0.79A 3mihA-3ttfA:
undetectable		 3mihA-3ttfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 HIS A 487
HIS A 484
HIS A 483
 FE  A 807 ( 3.4A)
None
FE  A 807 ( 3.4A)
 0.77A 3mihA-3vthA:
undetectable		 3mihA-3vthA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 474
HIS A 420
HIS A 422
 CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
 0.80A 3mihA-3x1bA:
undetectable		 3mihA-3x1bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 494
HIS A 442
HIS A 444
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
 0.85A 3mihA-3zx1A:
undetectable		 3mihA-3zx1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 491
HIS A 422
HIS A 424
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 0.81A 3mihA-4akoA:
undetectable		 3mihA-4akoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A1252
HIS A1204
HIS A1206
 CU  A1403 ( 3.2A)
CU  A1404 ( 3.0A)
CU  A1403 (-3.1A)
 0.78A 3mihA-4e9xA:
undetectable		 3mihA-4e9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		3 HIS A1068
HIS A1027
HIS A1134
 None
MN  A1502 (-3.5A)
None
 0.76A 3mihA-4fbqA:
undetectable		 3mihA-4fbqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 3 HIS B  68
HIS B  27
HIS B 134
 None
MN  B 501 (-3.7A)
None
 0.74A 3mihA-4fcxB:
undetectable		 3mihA-4fcxB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 287
HIS A 234
HIS A 236
 CU  A 403 (-3.4A)
CU  A 404 (-3.1A)
CU  A 403 ( 3.2A)
 0.83A 3mihA-4gybA:
undetectable		 3mihA-4gybA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		3 HIS A  70
HIS A 103
HIS A  71
 None
 0.66A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		3 HIS A  71
HIS A  70
HIS A 103
 None
 0.63A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		3 HIS A 103
HIS A  71
HIS A  70
 None
 0.58A 3mihA-4iwmA:
undetectable		 3mihA-4iwmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 504 ( 2.8A)
 0.82A 3mihA-4jhvA:
undetectable		 3mihA-4jhvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 449
HIS A 397
HIS A 399
 CU  A 501 (-3.1A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
 0.86A 3mihA-4jhvA:
undetectable		 3mihA-4jhvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 284
HIS A 231
HIS A 233
 CU  A 403 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.3A)
 0.84A 3mihA-4w1tA:
undetectable		 3mihA-4w1tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		3 HIS A  60
HIS A  19
HIS A 125
 None
MN  A 601 (-3.4A)
None
 0.85A 3mihA-4ykeA:
undetectable		 3mihA-4ykeA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 0.87A 3mihA-4zr1A:
undetectable		 3mihA-4zr1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 HIS A 537
HIS A 538
HIS A 535
 12V  A2060 (-4.1A)
None
None
 0.83A 3mihA-5a01A:
undetectable		 3mihA-5a01A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		3 HIS A 379
HIS A 386
HIS A 381
 None
AMP  A 601 (-4.8A)
AMP  A 601 (-4.2A)
 0.82A 3mihA-5ck7A:
undetectable		 3mihA-5ck7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		3 HIS A 381
HIS A 379
HIS A 386
 AMP  A 601 (-4.2A)
None
AMP  A 601 (-4.8A)
 0.79A 3mihA-5ck7A:
undetectable		 3mihA-5ck7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		3 HIS A 386
HIS A 381
HIS A 379
 AMP  A 601 (-4.8A)
AMP  A 601 (-4.2A)
None
 0.82A 3mihA-5ck7A:
undetectable		 3mihA-5ck7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  66
HIS A 109
HIS A  64
 CU  A 508 ( 3.1A)
CU  A 508 (-3.3A)
CU  A 509 (-3.2A)
 0.85A 3mihA-5ehfA:
undetectable		 3mihA-5ehfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 450
HIS A 398
HIS A 400
 CU  A 507 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
 0.77A 3mihA-5ehfA:
undetectable		 3mihA-5ehfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  97
HIS A 135
HIS A  95
 CU  A1465 (-3.1A)
CU  A1465 (-3.2A)
CU  A1463 (-4.1A)
 0.80A 3mihA-5g3fA:
undetectable		 3mihA-5g3fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 444
HIS A 396
HIS A 398
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
 0.79A 3mihA-5g3fA:
undetectable		 3mihA-5g3fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 HIS A 248
HIS A 247
HIS A 289
 None
 0.85A 3mihA-5im3A:
undetectable		 3mihA-5im3A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 HIS A 289
HIS A 248
HIS A 247
 None
 0.85A 3mihA-5im3A:
undetectable		 3mihA-5im3A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 515
HIS A 451
HIS A 453
 CU  A 602 ( 3.2A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
 0.81A 3mihA-5lm8A:
undetectable		 3mihA-5lm8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  67
HIS A 110
HIS A  65
 CU  A 502 ( 2.9A)
CU  A 502 (-3.1A)
CU  A 503 (-3.1A)
 0.85A 3mihA-5mewA:
undetectable		 3mihA-5mewA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 452
HIS A 400
HIS A 402
 CU  A 501 ( 3.0A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
 0.77A 3mihA-5mewA:
undetectable		 3mihA-5mewA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 3 HIS A 288
HIS A 235
HIS A 237
 None
 0.80A 3mihA-5mkmA:
undetectable		 3mihA-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A1014
HIS A 972
HIS A 974
 CU  A1101 (-3.2A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
 0.82A 3mihA-5n4lA:
undetectable		 3mihA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 3 HIS A  86
HIS A 115
HIS A  88
 None
 0.84A 3mihA-5oshA:
undetectable		 3mihA-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 3 HIS A  88
HIS A  86
HIS A 115
 None
 0.86A 3mihA-5oshA:
undetectable		 3mihA-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 3 HIS A 115
HIS A  88
HIS A  86
 None
 0.43A 3mihA-5oshA:
undetectable		 3mihA-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 HIS A 159
HIS A 143
HIS A 158
 None
EDO  A 509 ( 3.5A)
EDO  A 509 (-2.9A)
 0.75A 3mihA-5uamA:
undetectable		 3mihA-5uamA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 HIS A 108
HIS A 172
HIS A 107
 None
 0.79A 3mihA-5wm0A:
45.2		 3mihA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 3 HIS A 489
HIS A 437
HIS A 439
 None
None
EDO  A 602 (-3.8A)
 0.83A 3mihA-6evgA:
undetectable		 3mihA-6evgA:
undetectable