SIMILAR PATTERNS OF AMINO ACIDS FOR 3MG0_N_BO2N1404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
NAD  A 352 (-3.5A)
None
None
None
 1.19A 3mg0N-1a5zA:
undetectable		 3mg0N-1a5zA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 THR A 227
THR A 191
ALA A 195
GLY A 221
ALA A 295
 None
SO4  A 602 (-2.8A)
None
None
None
 1.07A 3mg0N-1euzA:
undetectable		 3mg0N-1euzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		5 THR A 258
THR A 256
ALA A 260
GLY A 212
ALA A 207
 None
 1.07A 3mg0N-1f7cA:
undetectable		 3mg0N-1f7cA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		5 THR H   1
THR H  21
ALA H  27
LYS H  33
GLY H  47
 CIB  H1001 (-1.9A)
CIB  H1001 (-4.5A)
CIB  H1001 (-3.5A)
CIB  H1001 (-4.0A)
CIB  H1001 (-4.4A)
 0.34A 3mg0N-1j2qH:
28.9		 3mg0N-1j2qH:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 334
THR A 333
THR A 332
GLY A 309
ALA A 375
 FAD  A 701 (-2.8A)
None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.8A)
 1.15A 3mg0N-1jscA:
undetectable		 3mg0N-1jscA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 582
THR A 583
THR A 394
ALA A 584
GLY A 398
 None
 1.18A 3mg0N-1kcwA:
undetectable		 3mg0N-1kcwA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 THR A 403
THR A 404
THR A 405
ALA A 223
GLY A 433
 None
 0.95A 3mg0N-1kqfA:
undetectable		 3mg0N-1kqfA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.10A 3mg0N-1l2qA:
undetectable		 3mg0N-1l2qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		5 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.20A 3mg0N-1m6sA:
undetectable		 3mg0N-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		5 THR A  14
THR A  13
SER A  31
GLY A  32
ALA A  52
 None
 1.16A 3mg0N-1nbwA:
undetectable		 3mg0N-1nbwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 THR X 240
THR X 239
ARG X 346
ALA X 246
SER X 310
 None
 1.17A 3mg0N-1pp1X:
undetectable		 3mg0N-1pp1X:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		6 THR H   1
THR H  21
ALA H  27
LYS H  33
GLY H  47
ALA H  49
 None
 0.51A 3mg0N-1q5qH:
27.0		 3mg0N-1q5qH:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 474
THR A 472
ALA A 473
SER A 440
GLY A 441
 None
2MD  A 799 (-4.0A)
None
2MD  A 799 ( 4.4A)
2MD  A 799 (-3.7A)
 1.16A 3mg0N-1tmoA:
undetectable		 3mg0N-1tmoA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
 None
 1.22A 3mg0N-1xkwA:
undetectable		 3mg0N-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.14A 3mg0N-2cfzA:
undetectable		 3mg0N-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 THR A 139
THR A 159
GLY A 211
ALA A 200
SER A 190
 None
CL  A 408 (-4.9A)
None
None
None
 1.12A 3mg0N-2f91A:
undetectable		 3mg0N-2f91A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 5 THR H 301
THR H 321
LYS H 333
GLY H 347
ALA H 349
 None
 0.58A 3mg0N-2fhgH:
25.8		 3mg0N-2fhgH:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		5 THR A 168
THR A  11
ARG A 281
SER A 174
GLY A 178
 CA  A1503 (-3.8A)
None
None
CA  A1503 (-2.6A)
None
 1.19A 3mg0N-2gjmA:
undetectable		 3mg0N-2gjmA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 THR A 407
ALA A 411
GLY A 164
ALA A 162
SER A 403
 None
None
FAD  A 501 (-3.3A)
None
None
 1.20A 3mg0N-2i0zA:
undetectable		 3mg0N-2i0zA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 THR A1028
THR A1027
THR A1056
GLY A1155
ALA A1170
 None
 1.20A 3mg0N-2iphA:
undetectable		 3mg0N-2iphA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 THR A 126
THR A 125
SER A 377
GLY A 376
ALA A 380
 None
None
SCY  A 129 ( 3.6A)
SCY  A 129 ( 3.5A)
None
 0.86A 3mg0N-2p8uA:
undetectable		 3mg0N-2p8uA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 THR A 275
ARG A  12
GLY A 160
ALA A 162
SER A 276
 None
None
None
None
DFD  A 760 (-3.2A)
 1.21A 3mg0N-2qnyA:
undetectable		 3mg0N-2qnyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		5 THR A 610
ALA A 606
SER A 377
GLY A 378
ALA A 380
 None
 1.14A 3mg0N-2vobA:
undetectable		 3mg0N-2vobA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv)
no annotation 		5 THR 1 235
ALA 3  83
SER 3 180
GLY 3 181
SER 3 171
 None
 1.21A 3mg0N-2ws91:
undetectable		 3mg0N-2ws91:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 THR A 163
THR A 162
SER A 414
GLY A 413
ALA A 417
 None
None
HMG  A1509 (-3.4A)
HMG  A1509 (-3.5A)
None
 0.84A 3mg0N-2wyaA:
undetectable		 3mg0N-2wyaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 THR A 244
THR A 266
SER A 237
GLY A 238
ALA A 172
 None
 1.21A 3mg0N-2wyxA:
undetectable		 3mg0N-2wyxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 THR A 155
THR A 154
ALA A 156
GLY A 240
ALA A 238
 None
 0.90A 3mg0N-2xtsA:
undetectable		 3mg0N-2xtsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01128
(IspD) 		5 THR A  58
SER A  74
GLY A  75
ALA A  86
SER A  61
 None
 1.18A 3mg0N-2xwlA:
undetectable		 3mg0N-2xwlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		5 THR A 100
THR A  28
THR A  29
ALA A  32
SER A  95
 None
 1.05A 3mg0N-2z0jA:
undetectable		 3mg0N-2z0jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 THR B 230
THR B 195
ALA A  84
GLY A  10
SER B 228
 ASP  B 501 ( 3.8A)
None
None
None
None
 1.18A 3mg0N-2zalB:
5.2		 3mg0N-2zalB:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 THR A 197
THR A 195
ALA A 199
GLY A 220
ALA A 175
 None
 1.07A 3mg0N-3anvA:
undetectable		 3mg0N-3anvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 THR A 235
THR A 236
SER A 268
GLY A 267
ALA A 145
 None
 0.82A 3mg0N-3bjeA:
undetectable		 3mg0N-3bjeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 THR A 230
THR A 195
ALA A  84
GLY A  10
SER A 228
 None
 1.16A 3mg0N-3c17A:
2.9		 3mg0N-3c17A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eex OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		6 THR A 241
THR A 245
THR A 246
SER A 224
GLY A 225
ALA A 227
 None
 1.45A 3mg0N-3eexA:
undetectable		 3mg0N-3eexA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 THR A 263
ALA A 267
SER A 232
GLY A 233
SER A 259
 None
 1.10A 3mg0N-3etvA:
undetectable		 3mg0N-3etvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggn UNCHARACTERIZED
PROTEIN DR_A0006

(Deinococcus
radiodurans) 		PF03364
(Polyketide_cyc) 		5 THR A  10
THR A 101
ALA A  95
ARG A 133
ALA A   8
 None
 1.20A 3mg0N-3ggnA:
undetectable		 3mg0N-3ggnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7r ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 THR A  12
ALA A 173
SER A 145
GLY A 146
ALA A 148
 None
None
EDO  A 508 ( 4.7A)
None
None
 1.20A 3mg0N-3h7rA:
undetectable		 3mg0N-3h7rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		5 THR A 109
THR A 108
ALA A 128
SER A  56
GLY A  55
 None
 1.12A 3mg0N-3hj6A:
undetectable		 3mg0N-3hj6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 THR A 292
ALA A 295
SER A 286
GLY A  27
SER A 103
 None
 1.21A 3mg0N-3i45A:
undetectable		 3mg0N-3i45A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  79
SER A 311
GLY A 310
ALA A 302
SER A 120
 None
None
None
SCY  A 112 ( 3.8A)
None
 1.11A 3mg0N-3il3A:
undetectable		 3mg0N-3il3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 THR A 282
ALA A 281
SER A 296
GLY A 312
SER A 318
 None
 1.17A 3mg0N-3kw3A:
undetectable		 3mg0N-3kw3A:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 6 THR N   1
THR N  20
ARG N  45
SER N  46
ALA N  49
SER N 169
 None
 1.46A 3mg0N-3mg6N:
38.5		 3mg0N-3mg6N:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 11 THR N   1
THR N  20
THR N  21
THR N  22
ALA N  27
LYS N  33
ARG N  45
SER N  46
GLY N  47
ALA N  49
SER N 168
 None
 0.50A 3mg0N-3mg6N:
38.5		 3mg0N-3mg6N:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 251
THR A 190
ALA A 192
SER A 248
GLY A 247
 None
 1.11A 3mg0N-3oibA:
undetectable		 3mg0N-3oibA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.20A 3mg0N-3pbiA:
undetectable		 3mg0N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 THR A  21
ALA A  23
SER A 210
GLY A 211
SER A 133
 None
 1.10A 3mg0N-3q9tA:
undetectable		 3mg0N-3q9tA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 THR A 228
THR A 488
ALA A 489
SER A 222
SER A 230
 None
 1.22A 3mg0N-3texA:
undetectable		 3mg0N-3texA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unf PROTEASOME SUBUNIT
BETA TYPE-10

(Mus musculus) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
THR H  21
ALA H  27
LYS H  33
GLY H  47
ALA H  49
 04C  H 301 (-2.5A)
04C  H 301 (-3.9A)
None
04C  H 301 (-3.5A)
04C  H 301 (-3.7A)
04C  H 301 (-3.6A)
 0.59A 3mg0N-3unfH:
30.9		 3mg0N-3unfH:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 THR A 294
ALA A 291
SER A 304
GLY A 303
ALA A 346
 None
 1.19A 3mg0N-3wkhA:
undetectable		 3mg0N-3wkhA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 5 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.18A 3mg0N-3wlxB:
undetectable		 3mg0N-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 THR L   1
THR L  21
ALA L  27
LYS L  33
GLY L  47
ALA L  49
 None
 0.78A 3mg0N-3wxrL:
28.6		 3mg0N-3wxrL:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR L   2
THR L   1
SER L 174
GLY L 173
ALA L 165
 None
 0.89A 3mg0N-3wxrL:
28.6		 3mg0N-3wxrL:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
 1.08A 3mg0N-4a73A:
undetectable		 3mg0N-4a73A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 THR A 150
ALA A 122
GLY A 184
ALA A 169
SER A 222
 None
 1.03A 3mg0N-4cakA:
undetectable		 3mg0N-4cakA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 THR A  33
THR A 158
THR A 159
ALA A 200
GLY A 135
 None
 0.80A 3mg0N-4dqxA:
undetectable		 3mg0N-4dqxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		5 THR A 162
ALA A 148
SER A 124
GLY A 123
ALA A 121
 None
 1.16A 3mg0N-4g4eA:
20.3		 3mg0N-4g4eA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho7 HSLVU COMPLEX
PROTEOLYTIC SUBUNIT,
PUTATIVE

(Trypanosoma
brucei) 		PF00227
(Proteasome) 		5 THR A   1
THR A  21
ALA A  28
LYS A  34
GLY A  48
 None
 0.63A 3mg0N-4ho7A:
20.3		 3mg0N-4ho7A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)

(Homo sapiens) 		PF07686
(V-set) 		5 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.19A 3mg0N-4k3gA:
undetectable		 3mg0N-4k3gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 THR A 262
ALA A 176
ARG A 131
GLY A 127
SER A 260
 EDO  A 814 (-4.2A)
None
None
None
None
 1.08A 3mg0N-4lgnA:
undetectable		 3mg0N-4lgnA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 THR A  87
THR A  89
ALA A  85
ARG A 175
GLY A  79
 None
 1.19A 3mg0N-4ng3A:
undetectable		 3mg0N-4ng3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE

(Homo sapiens) 		PF01112
(Asparaginase_2) 		5 THR A 219
THR A 184
ALA A  79
GLY A   9
SER A 217
 None
 1.18A 3mg0N-4o0eA:
3.1		 3mg0N-4o0eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		5 THR A 219
THR A 184
ALA A  79
GLY A   9
SER A 217
 ASP  A 402 (-3.7A)
None
None
None
None
 1.20A 3mg0N-4o48A:
2.1		 3mg0N-4o48A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		5 THR B 246
THR B 212
ALA A  82
GLY A  10
SER B 244
 ASP  B 501 (-3.6A)
None
None
None
None
 1.14A 3mg0N-4pu6B:
5.3		 3mg0N-4pu6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 THR K   1
THR K  21
ALA K  27
LYS K  33
GLY K  47
ALA K  49
 None
 0.62A 3mg0N-4qv9K:
28.8		 3mg0N-4qv9K:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 174
GLY K 173
ALA K 165
 None
 0.92A 3mg0N-4qv9K:
28.8		 3mg0N-4qv9K:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsk KETOL-ACID
REDUCTOISOMERASE

(Alicyclobacillus
acidocaldarius) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 3mg0N-4tskA:
undetectable		 3mg0N-4tskA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 THR A  67
ALA A  70
GLY A  84
ALA A  50
SER A  98
 None
 1.06A 3mg0N-4ur8A:
undetectable		 3mg0N-4ur8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 THR A 233
ALA A  47
SER A 252
GLY A 251
SER A 235
 PLP  A1380 (-3.6A)
None
PLP  A1381 (-2.6A)
PLP  A1381 (-3.5A)
None
 0.87A 3mg0N-4v15A:
undetectable		 3mg0N-4v15A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 THR A 417
THR A 416
THR A 415
ALA A 399
GLY A 145
 NA  A 601 ( 4.7A)
None
None
None
None
 1.21A 3mg0N-4y23A:
undetectable		 3mg0N-4y23A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		5 THR A  27
THR A 210
THR A 208
ALA A 212
ALA A 279
 None
None
None
None
MG  A 502 (-4.8A)
 1.16A 3mg0N-5dqlA:
undetectable		 3mg0N-5dqlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 THR A 188
THR A  66
THR A  65
ALA A  92
ALA A  68
 None
 1.01A 3mg0N-5e7pA:
undetectable		 3mg0N-5e7pA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 THR A 135
THR A 134
THR A 133
ALA A 138
ALA A 161
 None
 1.17A 3mg0N-5ey8A:
undetectable		 3mg0N-5ey8A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		6 THR H   1
THR H  21
ALA H  27
LYS H  33
GLY H  47
ALA H  49
 None
 0.46A 3mg0N-5fg9H:
27.9		 3mg0N-5fg9H:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 THR I   1
THR I  21
ALA I  27
GLY I  47
ALA I  49
 7F1  I 300 (-2.7A)
None
7F1  I 300 ( 3.8A)
7F1  I 300 (-3.8A)
7F1  I 300 (-3.5A)
 0.53A 3mg0N-5fmgI:
28.1		 3mg0N-5fmgI:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 THR I  21
ALA I  27
LYS I  33
GLY I  47
ALA I  49
 None
7F1  I 300 ( 3.8A)
7F1  I 300 (-4.7A)
7F1  I 300 (-3.8A)
7F1  I 300 (-3.5A)
 0.86A 3mg0N-5fmgI:
28.1		 3mg0N-5fmgI:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 THR A 298
THR A 261
THR A 285
ALA A 260
ALA A 281
 None
 1.17A 3mg0N-5hd2A:
undetectable		 3mg0N-5hd2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hso UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		5 THR A  96
ALA A  78
GLY A  49
ALA A  93
SER A  45
 None
 1.19A 3mg0N-5hsoA:
undetectable		 3mg0N-5hsoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 THR A  31
THR A  86
SER A 116
GLY A 117
ALA A  94
 None
 1.13A 3mg0N-5jxlA:
undetectable		 3mg0N-5jxlA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 THR A 468
THR A 436
THR A 437
THR A 438
GLY A 465
 None
 0.97A 3mg0N-5l46A:
undetectable		 3mg0N-5l46A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
THR K  21
ALA K  27
LYS K  33
GLY K  47
 None
 0.59A 3mg0N-5l5wK:
28.7		 3mg0N-5l5wK:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
THR K  21
LYS K  33
GLY K  47
ALA K  49
 None
 0.78A 3mg0N-5l5wK:
28.7		 3mg0N-5l5wK:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
 None
 0.87A 3mg0N-5l5wK:
28.7		 3mg0N-5l5wK:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 ALA K  28
SER K  46
GLY K  47
ALA K  49
SER K 170
 7DX  K 301 ( 4.6A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
None
 1.08A 3mg0N-5m2bK:
28.9		 3mg0N-5m2bK:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
ALA K  28
SER K  46
GLY K  47
ALA K  49
 7DX  K 301 (-3.3A)
7DX  K 301 ( 4.6A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
 0.87A 3mg0N-5m2bK:
28.9		 3mg0N-5m2bK:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   1
LYS K  33
SER K  46
GLY K  47
ALA K  49
 7DX  K 301 (-3.3A)
7DX  K 301 (-4.2A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
 0.39A 3mg0N-5m2bK:
28.9		 3mg0N-5m2bK:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
 None
7DX  K 301 (-3.3A)
None
None
MG  K 302 (-4.8A)
 0.91A 3mg0N-5m2bK:
28.9		 3mg0N-5m2bK:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		6 THR A   1
THR A  20
ALA A  28
LYS A  32
GLY A  50
SER A 190
 None
 1.30A 3mg0N-5nyjA:
21.4		 3mg0N-5nyjA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovt BPH

(Thiobacillus
denitrificans) 		no annotation 5 THR A   1
THR A  20
LYS A  37
GLY A  50
ALA A  52
 PO4  A 301 ( 4.5A)
None
None
PO4  A 301 (-4.1A)
None
 0.45A 3mg0N-5ovtA:
5.7		 3mg0N-5ovtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		no annotation 6 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.68A 3mg0N-5vfrR:
27.8		 3mg0N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
BETA TYPE-5

(Homo sapiens) 		no annotation 5 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.83A 3mg0N-5vfrR:
27.8		 3mg0N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 5 THR A  14
THR A  13
ALA A  25
SER A   2
GLY A   3
 None
 1.07A 3mg0N-5z9aA:
undetectable		 3mg0N-5z9aA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 5 THR B   1
THR B  21
ALA B  27
LYS B  33
GLY B  47
 None
 0.76A 3mg0N-6avoB:
21.3		 3mg0N-6avoB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 5 THR B  21
ALA B  27
LYS B  33
GLY B  47
ALA B  49
 None
 0.69A 3mg0N-6avoB:
21.3		 3mg0N-6avoB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 5 THR C   1
ALA C  28
SER C  46
GLY C  47
ALA C  49
 BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.4A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
 1.03A 3mg0N-6avoC:
29.3		 3mg0N-6avoC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-8

(Homo sapiens) 		no annotation 5 THR C   1
LYS C  33
SER C  46
GLY C  47
ALA C  49
 BZ7  C 301 (-4.0A)
BZ7  C 301 ( 4.8A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
 0.62A 3mg0N-6avoC:
29.3		 3mg0N-6avoC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-9

(Homo sapiens) 		no annotation 6 THR A   1
LYS A  33
SER A  46
GLY A  47
ALA A  49
SER A 168
 None
 0.59A 3mg0N-6avoA:
25.7		 3mg0N-6avoA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 5 THR A 154
ALA A 100
SER A  88
GLY A  89
ALA A  85
 None
 1.21A 3mg0N-6cv0A:
undetectable		 3mg0N-6cv0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 THR A 276
THR A  49
GLY A  58
ALA A  54
SER A 272
 None
 1.09A 3mg0N-6f34A:
undetectable		 3mg0N-6f34A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY

(Brevundimonas
sp. BAL3) 		no annotation 5 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.20A 3mg0N-6frlA:
undetectable		 3mg0N-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwv -

(-) 		no annotation 5 THR A 238
THR A 237
ALA A  38
ARG A 243
GLY A  57
 None
 1.12A 3mg0N-6fwvA:
undetectable		 3mg0N-6fwvA:
undetectable