SIMILAR PATTERNS OF AMINO ACIDS FOR 3MEG_A_T27A561

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 3megA-1axdA:
0.0		 3megA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 LEU A 183
VAL A 172
VAL A 166
TYR A 261
PHE A 226
 None
 1.35A 3megA-1cptA:
0.0		 3megA-1cptA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 LEU A 344
VAL A 337
VAL A 169
PHE A 364
LEU A 361
 None
 1.24A 3megA-1gr0A:
0.0		 3megA-1gr0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 PRO A 484
LEU A 236
ASN A 238
VAL A 181
PHE A 231
 None
 1.46A 3megA-1hcyA:
undetectable		 3megA-1hcyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)

(Trypanosoma
cruzi) 		PF00156
(Pribosyltran) 		5 LEU A  61
VAL A 157
TYR A 155
PHE A  68
LEU A  65
 None
 1.30A 3megA-1tc1A:
0.0		 3megA-1tc1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 PRO A 356
ASN A 319
VAL A 315
TYR A 308
TYR A 311
 None
 1.12A 3megA-1wzaA:
0.4		 3megA-1wzaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 PRO A 200
LEU A 170
TYR A 160
TYR A 158
LEU A 174
 None
 1.40A 3megA-1yaaA:
1.5		 3megA-1yaaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 PRO A 200
LEU A 170
TYR A 160
TYR A 158
PHE A 186
 None
 1.45A 3megA-1yaaA:
1.5		 3megA-1yaaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		5 PRO A 538
LEU A 480
TYR A 381
PHE A 359
LEU A 438
 None
 1.35A 3megA-1yggA:
0.0		 3megA-1yggA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.38A 3megA-2ch6A:
1.3		 3megA-2ch6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekh SH3 AND PX
DOMAIN-CONTAINING
PROTEIN 2A

(Homo sapiens) 		PF00018
(SH3_1) 		5 PRO A  56
LEU A  60
VAL A  31
TYR A  17
PHE A  48
 None
 1.29A 3megA-2ekhA:
undetectable		 3megA-2ekhA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epf PSEUDECIN

(Pseudechis
porphyriacus) 		PF00188
(CAP)
PF08562
(Crisp) 		5 PRO A 149
VAL A  81
TYR A 107
TYR A  85
TYR A 136
 None
 1.48A 3megA-2epfA:
undetectable		 3megA-2epfA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 5 LEU H 399
ASN H 390
VAL H 387
PHE H 423
LEU H 401
 None
 1.45A 3megA-2fhgH:
undetectable		 3megA-2fhgH:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.72A 3megA-2hnzA:
38.1		 3megA-2hnzA:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.69A 3megA-2hnzA:
38.1		 3megA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		5 PRO A  29
ASN A  41
VAL A 234
TYR A 255
PHE A 215
 None
 1.46A 3megA-2pifA:
2.1		 3megA-2pifA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 ASN A  32
VAL A  20
TYR A 147
PHE A 145
LEU A 135
 None
 1.41A 3megA-2po4A:
0.4		 3megA-2po4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LEU A 197
ASN A 230
VAL A 231
VAL A 228
TYR A 169
 None
 1.43A 3megA-2r3aA:
undetectable		 3megA-2r3aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PRO B 452
LEU B 414
VAL B 409
TYR B 319
PHE B 622
 None
 1.39A 3megA-2w55B:
undetectable		 3megA-2w55B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 393
LYS A 394
ASN A 398
VAL A 401
TYR A 361
 EDO  A1523 ( 4.7A)
None
None
None
None
 1.24A 3megA-2yjqA:
undetectable		 3megA-2yjqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx7 GLUTAMATE
TRANSPORTER
ASSOCIATED PROTEIN
48

(Rattus
norvegicus) 		PF09128
(RGS-like) 		5 PRO B 414
LEU B 408
TYR B 366
PHE B 385
LEU B 386
 None
 1.43A 3megA-3cx7B:
undetectable		 3megA-3cx7B:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcz PUTATIVE RNFG
SUBUNIT OF ELECTRON
TRANSPORT COMPLEX

(Thermotoga
maritima) 		PF04205
(FMN_bind) 		5 PRO A 162
LEU A 166
ASN A 213
VAL A 209
PHE A 158
 None
 1.39A 3megA-3dczA:
undetectable		 3megA-3dczA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2

(Homo sapiens) 		PF04042
(DNA_pol_E_B) 		5 LEU A  97
VAL A  93
TYR A 176
PHE A 171
LEU A 144
 None
 1.30A 3megA-3e0jA:
undetectable		 3megA-3e0jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		5 LEU A 340
LYS A 338
VAL A 326
PHE A 322
LEU A 198
 None
 1.17A 3megA-3f0nA:
3.8		 3megA-3f0nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		5 LEU A 338
VAL A 299
VAL A 288
LEU A 310
TYR A 321
 None
 1.46A 3megA-3g8rA:
undetectable		 3megA-3g8rA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.25A 3megA-3l2eA:
undetectable		 3megA-3l2eA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 430
LYS A 153
VAL A 451
PHE A 395
LEU A 396
 None
 1.50A 3megA-3oeeA:
undetectable		 3megA-3oeeA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		5 ASN A 484
VAL A 364
TYR A 366
TYR A 553
PHE A 491
 None
 1.38A 3megA-3q7zA:
undetectable		 3megA-3q7zA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 PRO A 310
LEU A 329
VAL A 379
VAL A 306
TYR A 377
 None
 1.40A 3megA-3v8vA:
undetectable		 3megA-3v8vA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.46A 3megA-4aejA:
undetectable		 3megA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 PRO A 218
ASN A 210
VAL A 209
TYR A 226
LEU A 192
 None
None
None
None
CL  A 303 ( 4.8A)
 1.39A 3megA-4mg4A:
1.5		 3megA-4mg4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzd INTERLEUKIN-21
RECEPTOR

(Homo sapiens) 		PF09238
(IL4Ra_N) 		5 LEU A 139
VAL A 109
VAL A 107
LEU A 166
TYR A 141
 None
 1.19A 3megA-4nzdA:
undetectable		 3megA-4nzdA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2) 		5 PRO C 161
LEU C 175
ASN C 152
PHE C 132
LEU C 156
 None
 1.50A 3megA-4z61C:
undetectable		 3megA-4z61C:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 207
ASN A 205
VAL A  71
TYR A  72
LEU A 210
 None
 1.50A 3megA-5bt1A:
undetectable		 3megA-5bt1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
TYR H 124
LEU H 146
 None
 1.02A 3megA-5fg9H:
undetectable		 3megA-5fg9H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 582
VAL A 414
VAL A 541
PHE A 473
TYR A 583
 None
 1.49A 3megA-5ju6A:
undetectable		 3megA-5ju6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR

(Yersinia
enterocolitica) 		PF03472
(Autoind_bind) 		5 ASN A 125
VAL A  69
TYR A  63
PHE A  98
TYR A  50
 482  A 201 (-3.7A)
482  A 201 (-4.6A)
None
482  A 201 (-3.5A)
482  A 201 (-4.5A)
 1.50A 3megA-5l09A:
undetectable		 3megA-5l09A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 ASN J 101
VAL J  47
TYR J   3
PHE J 137
TYR J 117
 None
 1.24A 3megA-5m32J:
undetectable		 3megA-5m32J:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 5 ASN A 131
VAL A 132
TYR A 156
PHE A 154
LEU A 155
 None
 1.50A 3megA-5n2pA:
1.5		 3megA-5n2pA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2u NUCLEOPROTEIN

(Influenza D
virus) 		no annotation 5 PRO A 266
LEU A 162
ASN A 155
VAL A 186
LEU A 262
 None
 1.49A 3megA-5n2uA:
undetectable		 3megA-5n2uA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 PRO A  90
LEU A  79
VAL A 189
PHE A 100
LEU A  97
 None
 1.48A 3megA-5o1mA:
undetectable		 3megA-5o1mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 5 PRO B  79
LEU B 164
PHE B 174
LEU B 171
TYR B  71
 None
 1.33A 3megA-6dexB:
undetectable		 3megA-6dexB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.40A 3megA-6fzwA:
undetectable		 3megA-6fzwA:
8.36