SIMILAR PATTERNS OF AMINO ACIDS FOR 3MEE_A_T27A561_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 3meeA-1axdA:
undetectable		 3meeA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 LEU A 183
VAL A 172
VAL A 166
TYR A 261
PHE A 226
 None
 1.26A 3meeA-1cptA:
undetectable		 3meeA-1cptA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 PRO A 151
LYS A  47
VAL A 134
TYR A 139
PHE A 161
 None
A3P  A 701 (-2.7A)
None
None
None
 1.39A 3meeA-1g3mA:
undetectable		 3meeA-1g3mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 LEU A 344
VAL A 337
VAL A 169
PHE A 364
LEU A 361
 None
 1.21A 3meeA-1gr0A:
0.0		 3meeA-1gr0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.23A 3meeA-1j2bA:
0.0		 3meeA-1j2bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)

(Trypanosoma
cruzi) 		PF00156
(Pribosyltran) 		5 LEU A  61
VAL A 157
TYR A 155
PHE A  68
LEU A  65
 None
 1.27A 3meeA-1tc1A:
0.0		 3meeA-1tc1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A  32
VAL A 361
TYR A 367
TYR A 363
LEU A  25
 None
 1.49A 3meeA-1vjsA:
0.1		 3meeA-1vjsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 PRO A 200
LEU A 170
TYR A 160
TYR A 158
LEU A 174
 None
 1.43A 3meeA-1yaaA:
1.5		 3meeA-1yaaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekh SH3 AND PX
DOMAIN-CONTAINING
PROTEIN 2A

(Homo sapiens) 		PF00018
(SH3_1) 		5 PRO A  56
LEU A  60
VAL A  31
TYR A  17
PHE A  48
 None
 1.26A 3meeA-2ekhA:
undetectable		 3meeA-2ekhA:
9.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
VAL A 179
TYR A 181
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.3A)
 1.34A 3meeA-2hnzA:
38.2		 3meeA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		10 PRO A  95
LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.67A 3meeA-2hnzA:
38.2		 3meeA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		10 PRO A  95
LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.65A 3meeA-2hnzA:
38.2		 3meeA-2hnzA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkn UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF12850
(Metallophos_2) 		5 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.36A 3meeA-2kknA:
undetectable		 3meeA-2kknA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgy RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 PRO A  46
LEU A  81
VAL A  20
TYR A  43
LEU A  79
 None
 1.50A 3meeA-2lgyA:
undetectable		 3meeA-2lgyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
 None
 1.45A 3meeA-2vdaA:
undetectable		 3meeA-2vdaA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PRO B 452
LEU B 414
VAL B 409
TYR B 319
PHE B 622
 None
 1.40A 3meeA-2w55B:
undetectable		 3meeA-2w55B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE

(Clostridium
acetobutylicum) 		PF06314
(ADC) 		5 PRO A  50
LEU A  51
TYR A 240
LEU A 168
TYR A  92
 None
 1.47A 3meeA-3bh2A:
undetectable		 3meeA-3bh2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		5 LEU A 340
LYS A 338
VAL A 326
PHE A 322
LEU A 198
 None
 1.18A 3meeA-3f0nA:
3.8		 3meeA-3f0nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.27A 3meeA-3l2eA:
3.3		 3meeA-3l2eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 LEU A  28
VAL A  42
TYR A 189
PHE A  52
LEU A  55
 None
 1.49A 3meeA-3nwpA:
undetectable		 3meeA-3nwpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.42A 3meeA-4aejA:
undetectable		 3meeA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		5 PRO A 154
LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.32A 3meeA-4cg1A:
1.5		 3meeA-4cg1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		5 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.31A 3meeA-4gdlB:
undetectable		 3meeA-4gdlB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 PRO A 479
LEU A 450
VAL A 418
VAL A 429
TYR A 485
 None
None
None
TRS  A 618 (-3.9A)
None
 1.46A 3meeA-4pspA:
undetectable		 3meeA-4pspA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.50A 3meeA-5amqA:
6.1		 3meeA-5amqA:
13.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
 None
 0.98A 3meeA-5c24B:
14.1		 3meeA-5c24B:
96.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
TYR H 124
LEU H 146
 None
 0.99A 3meeA-5fg9H:
undetectable		 3meeA-5fg9H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 582
VAL A 414
VAL A 541
PHE A 473
TYR A 583
 None
 1.49A 3meeA-5ju6A:
0.4		 3meeA-5ju6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 PRO A  90
LEU A  79
VAL A 189
PHE A 100
LEU A  97
 None
 1.40A 3meeA-5o1mA:
undetectable		 3meeA-5o1mA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A  99
LYS A 102
VAL A 105
LEU A 233
TYR A 317
 None
 0.83A 3meeA-5ovnA:
26.9		 3meeA-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PRO A  94
LEU A  99
VAL A 105
LEU A 233
TYR A 317
 None
 1.00A 3meeA-5ovnA:
26.9		 3meeA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.01A 3meeA-5u8sE:
2.3		 3meeA-5u8sE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.38A 3meeA-6fzwA:
undetectable		 3meeA-6fzwA:
8.36