SIMILAR PATTERNS OF AMINO ACIDS FOR 3MEC_A_65BA561

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase) 		5 LEU A  83
VAL A  97
TYR A  10
PHE A  11
PRO A  44
 None
 1.29A 3mecA-1bplA:
undetectable		 3mecA-1bplA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 LEU A 183
VAL A 172
VAL A 166
TYR A 261
PHE A 226
 None
 1.21A 3mecA-1cptA:
undetectable		 3mecA-1cptA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		5 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.13A 3mecA-1f2pA:
undetectable		 3mecA-1f2pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		5 LEU A  60
VAL A  34
GLY A   9
PHE A  67
LEU A  68
 None
 1.16A 3mecA-1fueA:
undetectable		 3mecA-1fueA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 LEU A 159
VAL A  78
GLY A  46
LEU A  83
PRO A  81
 None
 1.29A 3mecA-1fztA:
undetectable		 3mecA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 VAL A 410
TYR A 429
GLY A 381
PHE A 202
TYR A 138
 None
 1.30A 3mecA-1gjuA:
undetectable		 3mecA-1gjuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU A1058
VAL A1103
TYR A1100
GLY A1102
PRO A1029
 None
 1.20A 3mecA-1ha5A:
undetectable		 3mecA-1ha5A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.68A 3mecA-1harA:
13.0		 3mecA-1harA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.07A 3mecA-1mu2A:
29.8		 3mecA-1mu2A:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
TRP A 229
LEU A 234
PRO A 236
TYR A 318
 None
 0.80A 3mecA-1mu2A:
29.8		 3mecA-1mu2A:
61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 VAL A  40
VAL A  98
GLY A 120
PHE A  68
PRO A 117
 None
 1.28A 3mecA-1nqzA:
undetectable		 3mecA-1nqzA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.95A 3mecA-1oypA:
undetectable		 3mecA-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 LEU A 307
GLY A 285
TRP A 277
LEU A 311
PRO A 313
 None
 1.11A 3mecA-1pxyA:
undetectable		 3mecA-1pxyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		5 VAL A   6
VAL A  24
TYR A  64
GLY A   5
PHE A  88
 None
 1.20A 3mecA-1uaxA:
3.8		 3mecA-1uaxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.01A 3mecA-1udqA:
undetectable		 3mecA-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A  83
VAL A  97
TYR A  10
PHE A  11
PRO A  44
 None
 1.27A 3mecA-1vjsA:
undetectable		 3mecA-1vjsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		5 LEU A 157
VAL A 140
TYR A 165
GLY A 141
TRP A 167
 None
 1.26A 3mecA-1wscA:
undetectable		 3mecA-1wscA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 348
VAL A 319
VAL A 293
GLY A 335
PRO A 307
 LEU  A 348 ( 0.6A)
VAL  A 319 ( 0.6A)
VAL  A 293 ( 0.6A)
GLY  A 335 ( 0.0A)
PRO  A 307 ( 1.1A)
 1.22A 3mecA-1wsvA:
2.1		 3mecA-1wsvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		5 VAL A  20
TYR A 114
GLY A 109
LEU A 117
TYR A  75
 None
 1.30A 3mecA-1xcoA:
undetectable		 3mecA-1xcoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk5 SNURPORTIN-1

(Homo sapiens) 		no annotation 5 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.27A 3mecA-1xk5A:
undetectable		 3mecA-1xk5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A 879
VAL A 871
TYR A 838
GLY A 833
PRO A 795
 None
 1.25A 3mecA-1yguA:
undetectable		 3mecA-1yguA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		5 LEU A  62
VAL A  36
GLY A   8
PHE A  77
LEU A  78
 None
 1.17A 3mecA-1yobA:
undetectable		 3mecA-1yobA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 VAL A  39
VAL A 232
GLY A   8
PHE A  23
LEU A  26
 None
 1.18A 3mecA-1yyaA:
undetectable		 3mecA-1yyaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 LEU A  40
VAL A  48
TYR A  87
GLY A  91
LEU A 226
 None
 1.28A 3mecA-2a4mA:
undetectable		 3mecA-2a4mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01218
(Coprogen_oxidas) 		5 LEU A 288
GLY A 333
PHE A 296
TRP A 452
PRO A 255
 None
 1.19A 3mecA-2aexA:
undetectable		 3mecA-2aexA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		5 LEU A 230
TYR A 350
TYR A 356
LEU A 237
PRO A 235
 None
 0.96A 3mecA-2am4A:
undetectable		 3mecA-2am4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		5 VAL A 231
TYR A 205
TYR A 229
GLY A 208
PRO A 234
 None
 1.22A 3mecA-2amyA:
2.7		 3mecA-2amyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 VAL A 147
TYR A 179
TYR A 144
GLY A 148
LEU A  59
 None
 1.29A 3mecA-2c6rA:
undetectable		 3mecA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		5 LEU A 273
GLY A 244
PHE A  13
LEU A  12
TYR A 274
 None
 0.83A 3mecA-2ebnA:
undetectable		 3mecA-2ebnA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
TYR A 181
GLY A 190
TRP A 229
LEU A 234
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.82A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
TYR A 181
TYR A 188
GLY A 190
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.69A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
GLY A 190
LEU A 234
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.68A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.54A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LYS A 103
VAL A 106
VAL A 179
GLY A 190
PHE A 227
LEU A 234
PRO A 236
TYR A 318
 None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 0.93A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LYS A 103
VAL A 179
TYR A 181
GLY A 190
PRO A 236
TYR A 318
 None
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 1.22A 3mecA-2hnzA:
38.1		 3mecA-2hnzA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 5 LEU A 343
VAL A 272
TYR A 278
GLY A 273
LEU A 301
 None
 1.26A 3mecA-2p9wA:
undetectable		 3mecA-2p9wA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A  23
TYR A 160
GLY A  10
PHE A   5
LEU A   6
 None
 1.18A 3mecA-2qp4A:
undetectable		 3mecA-2qp4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  74
GLY A 173
LEU A  40
PRO A  43
TYR A  20
 None
 1.13A 3mecA-2qpsA:
undetectable		 3mecA-2qpsA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00651
(BTB) 		5 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.18A 3mecA-2vkpA:
undetectable		 3mecA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		5 LEU A  63
VAL A  37
GLY A   9
PHE A  78
LEU A  79
 None
 1.19A 3mecA-2wc1A:
undetectable		 3mecA-2wc1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		5 LEU A 344
VAL A 333
VAL A 305
GLY A 317
PRO A 341
 None
 1.19A 3mecA-2xhcA:
3.6		 3mecA-2xhcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.29A 3mecA-2ybqA:
undetectable		 3mecA-2ybqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.09A 3mecA-2znsA:
undetectable		 3mecA-2znsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.14A 3mecA-3anyA:
undetectable		 3mecA-3anyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.93A 3mecA-3b4tA:
undetectable		 3mecA-3b4tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		5 LEU A 309
VAL A 326
GLY A 275
LEU A 307
PRO A 306
 None
 1.28A 3mecA-3cdxA:
undetectable		 3mecA-3cdxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.93A 3mecA-3dd6A:
undetectable		 3mecA-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		5 VAL A  80
VAL A  54
TYR A  50
GLY A  56
PHE A  95
 None
 1.21A 3mecA-3dh1A:
undetectable		 3mecA-3dh1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 TYR A 319
GLY A 164
TRP A 327
LEU A 263
PRO A 191
 None
 1.26A 3mecA-3ib3A:
undetectable		 3mecA-3ib3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL

(Bos taurus) 		PF00318
(Ribosomal_S2) 		5 LEU B 114
VAL B 211
VAL B  78
GLY B 227
PRO B 224
 None
 1.26A 3mecA-3jd5B:
undetectable		 3mecA-3jd5B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		5 LEU A 160
VAL A 196
GLY A 194
LEU A 151
PRO A 154
 None
 1.27A 3mecA-3jx8A:
undetectable		 3mecA-3jx8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF04777
(Evr1_Alr) 		5 LEU A 308
VAL A 347
GLY A 343
PHE A 413
LEU A 410
 None
 1.25A 3mecA-3llkA:
undetectable		 3mecA-3llkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 LEU A 520
VAL A 562
TYR A 593
LEU A 374
PRO A 376
 None
 1.17A 3mecA-3ozxA:
undetectable		 3mecA-3ozxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 435
VAL A 735
GLY A 734
LEU A 760
TYR A 431
 None
 1.08A 3mecA-3qxmA:
undetectable		 3mecA-3qxmA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1395
GLY A1357
PHE A1365
LEU A1366
TYR A1401
 None
 1.22A 3mecA-3rytA:
undetectable		 3mecA-3rytA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1833
PHE A1443
LEU A1446
PRO A1710
TYR A1832
 None
 1.23A 3mecA-3rytA:
undetectable		 3mecA-3rytA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 LEU A 311
VAL A 350
GLY A 346
PHE A 416
LEU A 413
 None
 1.25A 3mecA-3t58A:
undetectable		 3mecA-3t58A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 VAL A 229
VAL A 223
GLY A 224
PRO A 231
TYR A 217
 None
 1.30A 3mecA-3tfjA:
2.9		 3mecA-3tfjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 190
VAL A 150
TYR A 165
GLY A 162
PRO A 179
 None
 1.17A 3mecA-3thzA:
2.3		 3mecA-3thzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 113
GLY A 460
LEU A 134
PRO A 133
TYR A 117
 None
 1.28A 3mecA-3wkyA:
undetectable		 3mecA-3wkyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A  98
GLY A 196
LEU A  64
PRO A  67
TYR A  44
 None
 1.21A 3mecA-3wn6A:
undetectable		 3mecA-3wn6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 LEU A 347
VAL A 198
GLY A 194
PRO A 214
TYR A 234
 None
 1.21A 3mecA-4ddqA:
4.6		 3mecA-4ddqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 530
VAL A 482
VAL A 495
LEU A 526
PRO A 524
 None
 1.12A 3mecA-4e93A:
2.0		 3mecA-4e93A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Bordetella
bronchiseptica) 		PF02962
(CHMI) 		5 LEU A 107
VAL A 116
TYR A   8
GLY A 117
LEU A  79
 None
 1.13A 3mecA-4jj9A:
undetectable		 3mecA-4jj9A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.30A 3mecA-4m5pA:
undetectable		 3mecA-4m5pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 VAL A 453
VAL A  94
TYR A 451
GLY A  96
PRO A  99
 None
 1.25A 3mecA-4mjuA:
undetectable		 3mecA-4mjuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		5 VAL A 277
TYR A 358
GLY A 278
PHE A 324
PRO A 327
 None
None
SO4  A 507 (-3.5A)
None
None
 1.23A 3mecA-4nxkA:
undetectable		 3mecA-4nxkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 LEU A 314
VAL A 234
VAL A 328
TYR A 232
PHE A 368
 None
 1.12A 3mecA-4nz0A:
2.9		 3mecA-4nz0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2l SULFHYDRYL OXIDASE 1

(Rattus
norvegicus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 LEU A 311
VAL A 350
GLY A 346
PHE A 416
LEU A 413
 None
 1.21A 3mecA-4p2lA:
undetectable		 3mecA-4p2lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		5 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.20A 3mecA-4rmlA:
undetectable		 3mecA-4rmlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 LEU A 621
TYR A 555
TRP A 556
LEU A 617
PRO A 615
 None
 1.11A 3mecA-4s3pA:
undetectable		 3mecA-4s3pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 TYR B 332
GLY B 334
TRP B 384
LEU B 361
PRO B 356
 None
 1.20A 3mecA-4tqoB:
undetectable		 3mecA-4tqoB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		5 TYR A 447
GLY A 449
LEU A 463
PRO A 377
TYR A 485
 None
 1.24A 3mecA-4uf7A:
undetectable		 3mecA-4uf7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		5 LEU A 315
VAL A 324
TYR A 239
TRP A 223
LEU A 220
 None
 1.27A 3mecA-4y4vA:
2.0		 3mecA-4y4vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 LEU A1162
PHE A1252
LEU A1249
PRO A1247
TYR A1161
 None
 1.25A 3mecA-5b16A:
undetectable		 3mecA-5b16A:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
GLY B 190
 None
 1.15A 3mecA-5c24B:
12.0		 3mecA-5c24B:
96.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.90A 3mecA-5c24B:
12.0		 3mecA-5c24B:
96.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		5 LEU A  40
TYR A 203
PHE B  89
LEU B  65
TYR A  36
 None
 1.26A 3mecA-5c5bA:
undetectable		 3mecA-5c5bA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
TYR H 124
LEU H 146
 None
 1.16A 3mecA-5fg9H:
undetectable		 3mecA-5fg9H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 VAL H  13
VAL H   4
TYR H 124
PHE H   8
LEU H 146
 None
 1.12A 3mecA-5fg9H:
undetectable		 3mecA-5fg9H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		5 VAL A  71
PHE A  60
LEU A  63
PRO A  65
TYR A  23
 None
 1.25A 3mecA-5i2cA:
undetectable		 3mecA-5i2cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		5 LEU A 264
VAL A 176
VAL A 195
GLY A 177
TRP A 199
 None
 1.28A 3mecA-5jm6A:
undetectable		 3mecA-5jm6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 LEU A 256
VAL A 300
VAL A 215
TRP A 292
PRO A 289
 None
 1.27A 3mecA-5jowA:
undetectable		 3mecA-5jowA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 VAL A  15
GLY A 100
LEU A 121
PRO A 119
TYR A 135
 None
 1.18A 3mecA-5kkgA:
undetectable		 3mecA-5kkgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 435
VAL A 735
GLY A 734
LEU A 760
TYR A 431
 None
 0.92A 3mecA-5kufA:
undetectable		 3mecA-5kufA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		5 LEU A 533
VAL A 516
TYR A 518
LEU A 474
PRO A 545
 None
 1.29A 3mecA-5mzoA:
2.8		 3mecA-5mzoA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 LEU A  99
LYS A 102
VAL A 105
GLY A 189
LEU A 233
TYR A 317
 None
 0.78A 3mecA-5ovnA:
26.9		 3mecA-5ovnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 LEU A  99
VAL A 105
GLY A 189
LEU A 233
PRO A 235
TYR A 317
 None
 0.93A 3mecA-5ovnA:
26.9		 3mecA-5ovnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LYS B 102
VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.78A 3mecA-5ovnB:
10.2		 3mecA-5ovnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		5 LEU A 320
VAL A 308
VAL A 311
GLY A 309
LEU A 325
 None
 1.28A 3mecA-5u7wA:
2.7		 3mecA-5u7wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A  73
GLY A  67
PHE A  45
LEU A  48
PRO A  46
 None
 1.27A 3mecA-5u8qA:
undetectable		 3mecA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.15A 3mecA-5u8sE:
2.7		 3mecA-5u8sE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU D 118
VAL D 135
PHE D 107
LEU D 114
PRO D 122
 None
 1.13A 3mecA-5uheD:
undetectable		 3mecA-5uheD:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 5 VAL A 280
TYR A 284
TRP A 236
LEU A 193
TYR A 221
 None
 1.24A 3mecA-5vanA:
undetectable		 3mecA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 5 VAL A 278
TYR A 282
TRP A 234
LEU A 191
TYR A 219
 None
 1.22A 3mecA-5w21A:
undetectable		 3mecA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 198
VAL A 241
GLY A 201
LEU A 178
PRO A 227
 None
 1.28A 3mecA-5wjcA:
undetectable		 3mecA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 141
VAL A  40
GLY A 144
LEU A  34
TYR A 129
 None
 1.24A 3mecA-5xhxA:
undetectable		 3mecA-5xhxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		5 LEU A  84
VAL A  97
GLY A  94
PHE A  11
PRO A   8
 None
 1.20A 3mecA-5xoyA:
5.1		 3mecA-5xoyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 5 LEU A 385
VAL A 403
TYR A 466
LEU A 345
PRO A 341
 None
 1.10A 3mecA-6eoqA:
undetectable		 3mecA-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 VAL I 236
TYR I 234
TYR I 261
GLY I 279
TYR I   9
 None
 1.18A 3mecA-6esqI:
undetectable		 3mecA-6esqI:
undetectable