SIMILAR PATTERNS OF AMINO ACIDS FOR 3ME6_D_CGED501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE B 287
PHE B 356
THR B 349
VAL B 547
VAL B 545
 None
 1.15A 3me6D-1e9yB:
0.0		 3me6D-1e9yB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		5 ILE A 313
PHE A 309
ALA A 306
VAL A 341
VAL A 316
 None
 1.16A 3me6D-1ei6A:
0.0		 3me6D-1ei6A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL A 105
PHE A  39
ILE A  75
ALA A 127
VAL A  35
 None
 0.87A 3me6D-1ethA:
0.0		 3me6D-1ethA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		5 VAL A 130
ILE A 128
ALA A 137
VAL A  65
VAL A  47
 None
 1.12A 3me6D-1fjjA:
undetectable		 3me6D-1fjjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 VAL A 366
PHE A 429
ILE A 407
VAL A 375
VAL A 353
 None
 1.10A 3me6D-1g7rA:
undetectable		 3me6D-1g7rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 VAL A 443
ILE A 480
ALA A 399
VAL A 403
VAL A 466
 None
 1.15A 3me6D-1hp1A:
undetectable		 3me6D-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 VAL A  41
ILE A  72
PHE A  98
ALA A 101
VAL A  74
 None
 1.27A 3me6D-1kbvA:
0.0		 3me6D-1kbvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 465
PHE A 467
PHE A 330
ILE A 339
THR A 428
 None
 1.23A 3me6D-1kyaA:
undetectable		 3me6D-1kyaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C

(Enterovirus C) 		PF00548
(Peptidase_C3) 		5 VAL A  30
ILE A  90
ALA A 172
VAL A 150
VAL A 157
 None
 1.27A 3me6D-1l1nA:
undetectable		 3me6D-1l1nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 VAL A  34
ILE A 355
PHE A  17
ALA A  20
VAL A  69
 None
 1.15A 3me6D-1musA:
undetectable		 3me6D-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 VAL A  34
ILE A 355
PHE A  17
ALA A  77
VAL A  69
 None
 1.26A 3me6D-1musA:
undetectable		 3me6D-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 PHE A 274
ILE A 214
ALA A  62
THR A  64
VAL A 179
 None
 1.13A 3me6D-1n7jA:
undetectable		 3me6D-1n7jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 VAL A 372
PHE A 426
ALA A 396
VAL A 410
VAL A 388
 None
 1.27A 3me6D-1q5nA:
1.5		 3me6D-1q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ANP  A 901 (-3.2A)
None
 1.03A 3me6D-1qvrA:
1.3		 3me6D-1qvrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		5 PHE A 138
ILE A 179
ALA A 159
THR A 182
VAL A 155
 None
 1.04A 3me6D-1t71A:
undetectable		 3me6D-1t71A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 VAL A 268
ILE A 213
ALA A 306
THR A 310
VAL A 211
 None
 1.14A 3me6D-1w61A:
undetectable		 3me6D-1w61A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 VAL A 320
PHE A 322
ILE A 285
ALA A 290
VAL A 296
 None
 1.28A 3me6D-1x9jA:
undetectable		 3me6D-1x9jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 122
ILE A 238
ALA A  23
THR A  25
VAL A 246
 None
 1.17A 3me6D-1y6jA:
undetectable		 3me6D-1y6jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 VAL A  48
PHE A  79
ILE A  31
ALA A 125
VAL A  75
 None
 1.03A 3me6D-1zchA:
undetectable		 3me6D-1zchA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdr UREIDOGLYCOLATE
HYDROLASE

(Pseudomonas
putida) 		PF04115
(Ureidogly_lyase) 		5 PHE A 110
ILE A  93
ALA A  15
VAL A 124
VAL A  95
 None
 1.23A 3me6D-2bdrA:
undetectable		 3me6D-2bdrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 VAL A 151
ILE A 174
ALA A 195
VAL A 189
VAL A 176
 None
 1.15A 3me6D-2bejA:
undetectable		 3me6D-2bejA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		5 VAL A 111
ILE A  19
ALA A  25
VAL A 126
VAL A 124
 None
 1.26A 3me6D-2cu5A:
undetectable		 3me6D-2cu5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 ILE A   6
ALA A  20
THR A  16
VAL A 241
VAL A 106
 None
None
GDP  A 501 (-3.9A)
None
None
 1.17A 3me6D-2dbyA:
undetectable		 3me6D-2dbyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 VAL A 328
PHE A 181
ILE A 339
ALA A 345
VAL A 309
 None
 1.26A 3me6D-2dpyA:
undetectable		 3me6D-2dpyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Streptococcus
pyogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A 225
PHE A 222
ILE A  16
ALA A 170
VAL A 150
 None
 1.02A 3me6D-2gs8A:
undetectable		 3me6D-2gs8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 PHE B  64
PHE B 298
ALA B 248
VAL B 241
VAL B 300
 None
 1.21A 3me6D-2odrB:
undetectable		 3me6D-2odrB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE

(Avian
coronavirus) 		PF05409
(Peptidase_C30) 		5 VAL A 146
PHE A 157
ILE A  17
ALA A  12
VAL A 120
 None
 1.18A 3me6D-2q6dA:
undetectable		 3me6D-2q6dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		5 VAL A  84
PHE A 129
ILE A 132
PHE A 162
ALA A 163
 None
 1.02A 3me6D-2qm0A:
undetectable		 3me6D-2qm0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re2 UNCHARACTERIZED
PROTEIN TA1041

(Thermoplasma
acidophilum) 		PF02579
(Nitro_FeMo-Co) 		5 ILE A  98
PHE A   3
ALA A   4
VAL A  12
VAL A  86
 None
 1.12A 3me6D-2re2A:
undetectable		 3me6D-2re2A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 5 VAL A 243
PHE A 239
PHE A 191
PHE A 106
VAL A  10
 None
 1.26A 3me6D-2w3yA:
undetectable		 3me6D-2w3yA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		5 VAL A 144
PHE A 174
ILE A 158
ALA A 182
VAL A 150
 None
 1.18A 3me6D-2wlcA:
undetectable		 3me6D-2wlcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 VAL 3 204
PHE 3  81
ALA 3  80
VAL 3 185
VAL 3 160
 None
 0.87A 3me6D-2wzr3:
undetectable		 3me6D-2wzr3:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  35
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.04A 3me6D-2y3sA:
undetectable		 3me6D-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  76
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.21A 3me6D-2y3sA:
undetectable		 3me6D-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
 None
 0.90A 3me6D-2zghA:
undetectable		 3me6D-2zghA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 VAL A 179
ILE A 197
ALA A 170
VAL A 154
VAL A 163
 None
 1.11A 3me6D-3a9xA:
undetectable		 3me6D-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 VAL A 585
PHE A 589
ILE A 635
THR A 672
VAL A 716
 None
 1.08A 3me6D-3aqpA:
1.0		 3me6D-3aqpA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 116
PHE A 207
PHE A 298
ALA A 299
VAL A 364
 None
None
None
HEM  A 500 ( 3.3A)
HEM  A 500 ( 4.4A)
 1.14A 3me6D-3e4eA:
54.2		 3me6D-3e4eA:
49.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		5 VAL A 191
ILE A 139
ALA A 202
THR A 204
VAL A 185
 None
 1.03A 3me6D-3gocA:
undetectable		 3me6D-3gocA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 VAL B 558
PHE B 756
ILE B 738
ALA B 570
THR B 572
 None
 1.06A 3me6D-3k70B:
undetectable		 3me6D-3k70B:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		5 VAL A 103
PHE A 105
ILE A 135
ALA A 126
VAL A 163
 None
 1.16A 3me6D-3krvA:
undetectable		 3me6D-3krvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 VAL A 292
PHE A 454
ILE A 302
VAL A 271
VAL A 273
 None
 1.26A 3me6D-3kveA:
undetectable		 3me6D-3kveA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llq AQUAPORIN Z 2

(Agrobacterium
fabrum) 		PF00230
(MIP) 		5 VAL A  24
PHE A  25
PHE A 194
ALA A  98
VAL A  16
 None
 1.25A 3me6D-3llqA:
undetectable		 3me6D-3llqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 PHE A 392
ILE A 369
PHE A  22
ALA A 399
VAL A 432
 None
 1.28A 3me6D-3lmlA:
undetectable		 3me6D-3lmlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lno PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacillus
anthracis) 		PF01883
(FeS_assembly_P) 		5 VAL A  64
ILE A  26
ALA A  12
VAL A  35
VAL A  32
 None
 1.09A 3me6D-3lnoA:
undetectable		 3me6D-3lnoA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 PHE A 146
ALA A 163
THR A 443
VAL A 430
VAL A 428
 None
 1.16A 3me6D-3lnpA:
undetectable		 3me6D-3lnpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjz FG41 MALONATE
SEMIALDEHYDE
DECARBOXYLASE

(coryneform
bacterium) 		PF14552
(Tautomerase_2) 		5 VAL A  23
ILE A  68
THR A   8
VAL A  97
VAL A 102
 None
 1.07A 3me6D-3mjzA:
undetectable		 3me6D-3mjzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1

(Mycolicibacterium
smegmatis) 		PF02682
(CT_C_D) 		5 VAL B 168
ILE B  89
ALA B 196
VAL B 123
VAL B 204
 None
 0.99A 3me6D-3mmlB:
undetectable		 3me6D-3mmlB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op3 M-PHASE INDUCER
PHOSPHATASE 3

(Homo sapiens) 		PF00581
(Rhodanese) 		5 VAL A 327
PHE A 325
ILE A 341
ALA A 312
VAL A 305
 None
 1.01A 3me6D-3op3A:
undetectable		 3me6D-3op3A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdy PLECTIN

(Homo sapiens) 		PF00435
(Spectrin) 		5 PHE A 723
PHE A 648
ALA A 651
THR A 653
VAL A 578
 None
 1.12A 3me6D-3pdyA:
undetectable		 3me6D-3pdyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.88A 3me6D-3pxgA:
undetectable		 3me6D-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.88A 3me6D-3pxiA:
undetectable		 3me6D-3pxiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd7 UNCHARACTERIZED
PROTEIN YDAL

(Escherichia
coli) 		PF01713
(Smr) 		5 VAL X 138
PHE X 105
ILE X 119
VAL X 148
VAL X 166
 None
 1.22A 3me6D-3qd7X:
undetectable		 3me6D-3qd7X:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 VAL A   3
PHE A  53
PHE A 199
ILE A 145
ALA A 337
 None
 1.28A 3me6D-3qw2A:
undetectable		 3me6D-3qw2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 VAL A 306
PHE A 301
THR A 341
VAL A 297
VAL A 287
 None
 1.20A 3me6D-3rb9A:
undetectable		 3me6D-3rb9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 VAL A 138
PHE A 256
ILE A 257
ALA A 274
VAL A 184
 None
 1.18A 3me6D-3ry7A:
undetectable		 3me6D-3ry7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sno HYPOTHETICAL
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF01063
(Aminotran_4) 		5 PHE A 250
ILE A 231
ALA A 248
VAL A 279
VAL A 224
 None
 0.96A 3me6D-3snoA:
undetectable		 3me6D-3snoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
 None
 1.22A 3me6D-3t1wA:
undetectable		 3me6D-3t1wA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PHE A 108
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.24A 3me6D-3tk3A:
62.9		 3me6D-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		7 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.38A 3me6D-3tk3A:
62.9		 3me6D-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 VAL A 128
PHE A 245
ILE A 220
ALA A 278
VAL A 109
 None
 1.28A 3me6D-3uqzA:
undetectable		 3me6D-3uqzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urg ALR1010 PROTEIN

(Nostoc sp. PCC
7120) 		PF11535
(Calci_bind_CcbP) 		5 VAL A  65
PHE A  42
ILE A 100
ALA A 112
VAL A 105
 None
NA  A 127 (-4.5A)
None
None
None
 0.89A 3me6D-3urgA:
undetectable		 3me6D-3urgA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 VAL A 369
PHE A 280
ALA A 287
THR A 289
VAL A 330
 None
 1.23A 3me6D-3vz0A:
undetectable		 3me6D-3vz0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 VAL A 369
PHE A 280
ILE A 347
ALA A 287
THR A 289
 None
 1.21A 3me6D-3vz0A:
undetectable		 3me6D-3vz0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAF PROTEIN

(Escherichia
coli) 		PF03743
(TrbI) 		5 VAL A 889
ILE A 820
THR A 816
VAL A 767
VAL A 787
 None
 1.03A 3me6D-3zbiA:
undetectable		 3me6D-3zbiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		5 VAL A 341
ILE A 354
THR A 383
VAL A 347
VAL A 349
 None
 1.21A 3me6D-4ac3A:
undetectable		 3me6D-4ac3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c84 E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Danio rerio) 		no annotation 5 VAL A  97
ILE A  72
ALA A  68
VAL A  35
VAL A  37
 None
 1.24A 3me6D-4c84A:
undetectable		 3me6D-4c84A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8t E3 UBIQUITIN-PROTEIN
LIGASE ZNRF3

(Xenopus
tropicalis) 		no annotation 5 VAL A  96
ILE A  71
ALA A  67
VAL A  34
VAL A  36
 None
 1.23A 3me6D-4c8tA:
undetectable		 3me6D-4c8tA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 VAL A 273
ILE A 267
ALA A 310
THR A 313
VAL A  99
 None
 1.27A 3me6D-4e77A:
undetectable		 3me6D-4e77A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		5 ILE A 159
PHE A  93
ALA A  97
VAL A 140
VAL A 157
 None
 1.22A 3me6D-4f1kA:
undetectable		 3me6D-4f1kA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		6 VAL A 260
PHE A  52
ILE A  94
ALA A  74
VAL A  83
VAL A  87
 None
 1.43A 3me6D-4h1xA:
undetectable		 3me6D-4h1xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		5 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ADP  A 602 (-3.6A)
None
 0.87A 3me6D-4hseA:
undetectable		 3me6D-4hseA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 PHE A  94
PHE A 183
ILE A 150
ALA A 275
VAL A 283
 None
 1.22A 3me6D-4i4nA:
undetectable		 3me6D-4i4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN

(Kribbella
flavida) 		PF13407
(Peripla_BP_4) 		5 VAL A 289
PHE A 361
ILE A 358
ALA A 298
THR A 351
 None
 1.24A 3me6D-4kvfA:
undetectable		 3me6D-4kvfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsd FIBRONECTIN TYPE III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A 100
PHE A  62
ILE A  64
THR A  84
VAL A  48
 None
 1.19A 3me6D-4lsdA:
undetectable		 3me6D-4lsdA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 261
ILE A  78
PHE A  76
ALA A  75
VAL A 198
 None
 1.26A 3me6D-4oc9A:
undetectable		 3me6D-4oc9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		5 VAL A 221
ILE A 401
ALA A 406
VAL A 272
VAL A 330
 None
 1.14A 3me6D-4qjiA:
undetectable		 3me6D-4qjiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
 None
 1.26A 3me6D-4qt8B:
undetectable		 3me6D-4qt8B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 VAL 3 205
PHE 3  80
ALA 3  79
VAL 3 186
VAL 3 161
 None
 0.96A 3me6D-5aca3:
undetectable		 3me6D-5aca3:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 1.10A 3me6D-5e0eA:
53.8		 3me6D-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		6 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 0.82A 3me6D-5e0eA:
53.8		 3me6D-5e0eA:
79.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 VAL A 390
ILE A 337
PHE A 421
THR A 351
VAL A 354
 None
 1.27A 3me6D-5ecoA:
undetectable		 3me6D-5ecoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 VAL A 472
ILE A 402
THR A 410
VAL A 426
VAL A 385
 None
 1.25A 3me6D-5eodA:
undetectable		 3me6D-5eodA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		5 VAL A 284
PHE A 317
ILE A 227
PHE A 306
ALA A 368
 None
 1.24A 3me6D-5fubA:
undetectable		 3me6D-5fubA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 VAL A 390
PHE A 383
ILE A 369
ALA A 413
VAL A 361
 None
 0.97A 3me6D-5i2tA:
undetectable		 3me6D-5i2tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 PHE A 463
PHE A 445
ALA A 477
THR A 443
VAL A 199
 None
 1.28A 3me6D-5iheA:
undetectable		 3me6D-5iheA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		5 VAL A 281
PHE A 370
ILE A 285
ALA A 291
VAL A 258
 None
 1.12A 3me6D-5j78A:
undetectable		 3me6D-5j78A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		5 VAL A 268
PHE A 212
ALA A 225
VAL A 272
VAL A 253
 None
 1.24A 3me6D-5m7oA:
undetectable		 3me6D-5m7oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
 None
 1.26A 3me6D-5mr7A:
undetectable		 3me6D-5mr7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n47 FIBRONECTIN

(Homo sapiens) 		no annotation 5 VAL B1414
ILE B1407
ALA B1403
VAL B1427
VAL B1429
 None
 1.21A 3me6D-5n47B:
undetectable		 3me6D-5n47B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 VAL A 262
ILE A 242
ALA A  20
VAL A 253
VAL A 244
 None
 1.20A 3me6D-5u03A:
undetectable		 3me6D-5u03A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utt SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		5 VAL A 170
PHE A 179
ILE A 114
PHE A 143
ALA A 144
 None
 1.10A 3me6D-5uttA:
undetectable		 3me6D-5uttA:
16.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 9 VAL A 104
PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
 0.62A 3me6D-5wbgA:
59.1		 3me6D-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 7 VAL A 104
PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
 1.47A 3me6D-5wbgA:
59.1		 3me6D-5wbgA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 PHE A 277
ILE A 282
ALA A 275
VAL A 325
VAL A 262
 None
None
AFY  A 401 (-3.6A)
None
None
 0.97A 3me6D-5wgcA:
undetectable		 3me6D-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		5 VAL A  58
PHE A 324
ILE A 311
ALA A 305
VAL A 314
 None
 1.28A 3me6D-5y1iA:
15.2		 3me6D-5y1iA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN

(Mus musculus) 		no annotation 5 VAL A 548
PHE A 547
PHE A 517
ILE A 520
PHE A 488
 None
 1.26A 3me6D-5z1wA:
1.5		 3me6D-5z1wA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 VAL A 145
PHE A 102
PHE A 120
ILE A 123
VAL A 127
 None
 1.28A 3me6D-6bx6A:
undetectable		 3me6D-6bx6A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 ILE B 179
PHE B 211
ALA B  99
THR B  97
VAL B 106
 None
None
NAD  B 500 (-3.2A)
None
None
 1.24A 3me6D-6dftB:
undetectable		 3me6D-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 5 VAL A 548
PHE A 547
PHE A 517
ILE A 520
PHE A 488
 None
 1.18A 3me6D-6du8A:
undetectable		 3me6D-6du8A:
undetectable