SIMILAR PATTERNS OF AMINO ACIDS FOR 3ME6_C_CGEC501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqq TYPE 2 RHINOVIRUS 3C
PROTEASE

(Rhinovirus A) 		PF00548
(Peptidase_C3) 		5 VAL A  30
ILE A  90
ALA A 172
VAL A 150
VAL A 157
 None
 1.25A 3me6C-1cqqA:
undetectable		 3me6C-1cqqA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		5 ILE A 313
PHE A 309
ALA A 306
VAL A 341
VAL A 316
 None
 1.13A 3me6C-1ei6A:
0.0		 3me6C-1ei6A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL A 105
PHE A  39
ILE A  75
ALA A 127
VAL A  35
 None
 0.89A 3me6C-1ethA:
0.0		 3me6C-1ethA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 VAL A 366
PHE A 429
ILE A 407
VAL A 375
VAL A 353
 None
 1.08A 3me6C-1g7rA:
undetectable		 3me6C-1g7rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 VAL A 443
ILE A 480
ALA A 399
VAL A 403
VAL A 466
 None
 1.10A 3me6C-1hp1A:
undetectable		 3me6C-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL A 104
PHE A  38
ILE A  74
ALA A 126
VAL A  34
 None
 1.07A 3me6C-1hplA:
0.0		 3me6C-1hplA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 VAL A 143
ALA A 187
THR A 188
VAL A 152
VAL A 150
 None
ZN  A 460 ( 4.2A)
None
None
None
 1.19A 3me6C-1i4gA:
0.0		 3me6C-1i4gA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 VAL A 109
ILE A  74
ALA A  77
VAL A  46
VAL A 215
 None
 1.19A 3me6C-1j2qA:
undetectable		 3me6C-1j2qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 VAL A  41
ILE A  72
PHE A  98
ALA A 101
VAL A  74
 None
 1.21A 3me6C-1kbvA:
0.0		 3me6C-1kbvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C

(Enterovirus C) 		PF00548
(Peptidase_C3) 		5 VAL A  30
ILE A  90
ALA A 172
VAL A 150
VAL A 157
 None
 1.22A 3me6C-1l1nA:
undetectable		 3me6C-1l1nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL B 104
PHE B  38
ILE B  74
ALA B 126
VAL B  34
 None
 1.02A 3me6C-1lpbB:
undetectable		 3me6C-1lpbB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 VAL A  34
ILE A 355
PHE A  17
ALA A  20
VAL A  69
 None
 1.24A 3me6C-1musA:
undetectable		 3me6C-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 VAL A  34
ILE A 355
PHE A  17
ALA A  77
VAL A  69
 None
 1.12A 3me6C-1musA:
undetectable		 3me6C-1musA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6e CAPSID PROTEIN P40

(Human
gammaherpesvirus
4) 		PF00716
(Peptidase_S21) 		5 VAL A  54
ILE A 142
ALA A 107
VAL A   7
VAL A   9
 None
 1.02A 3me6C-1o6eA:
undetectable		 3me6C-1o6eA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8a PROTEIN TYROSINE
PHOSPHATASE

(Tritrichomonas
suis) 		PF01451
(LMWPc) 		5 VAL A 106
ILE A  94
PHE A  77
THR A  73
VAL A  10
 None
 1.25A 3me6C-1p8aA:
undetectable		 3me6C-1p8aA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		6 VAL A 372
PHE A 426
ALA A 396
THR A 395
VAL A 410
VAL A 388
 None
 1.47A 3me6C-1q5nA:
undetectable		 3me6C-1q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ANP  A 901 (-3.2A)
None
 1.13A 3me6C-1qvrA:
undetectable		 3me6C-1qvrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL X 106
PHE X  39
ILE X  76
ALA X 128
VAL X  35
 None
 1.18A 3me6C-1w52X:
undetectable		 3me6C-1w52X:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 VAL A 268
ILE A 213
ALA A 306
THR A 310
VAL A 211
 None
 1.17A 3me6C-1w61A:
undetectable		 3me6C-1w61A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 VAL A  48
PHE A  79
ILE A  31
ALA A 125
VAL A  75
 None
 1.05A 3me6C-1zchA:
undetectable		 3me6C-1zchA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		5 VAL A 111
ILE A  19
ALA A  25
VAL A 126
VAL A 124
 None
 1.22A 3me6C-2cu5A:
undetectable		 3me6C-2cu5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		5 VAL A  45
PHE A  12
ILE A 107
PHE A 176
VAL A 115
 None
 1.25A 3me6C-2i3fA:
undetectable		 3me6C-2i3fA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ

(Bradyrhizobium
sp. WM9) 		PF05830
(NodZ) 		5 VAL A 174
ILE A 205
ALA A 197
VAL A 228
VAL A 232
 None
 1.24A 3me6C-2ocxA:
undetectable		 3me6C-2ocxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 PHE B  64
PHE B 298
ALA B 248
VAL B 241
VAL B 300
 None
 1.22A 3me6C-2odrB:
undetectable		 3me6C-2odrB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE

(Avian
coronavirus) 		PF05409
(Peptidase_C30) 		5 VAL A 146
PHE A 157
ILE A  17
ALA A  12
VAL A 120
 None
 1.25A 3me6C-2q6dA:
undetectable		 3me6C-2q6dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		5 VAL A  84
PHE A 129
ILE A 132
PHE A 162
ALA A 163
 None
 1.07A 3me6C-2qm0A:
undetectable		 3me6C-2qm0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re2 UNCHARACTERIZED
PROTEIN TA1041

(Thermoplasma
acidophilum) 		PF02579
(Nitro_FeMo-Co) 		5 ILE A  98
PHE A   3
ALA A   4
VAL A  12
VAL A  86
 None
 1.11A 3me6C-2re2A:
undetectable		 3me6C-2re2A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  70
ILE A  29
PHE A  23
ALA A  24
VAL A  62
 None
 1.25A 3me6C-2rsvA:
undetectable		 3me6C-2rsvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 5 VAL A 243
PHE A 239
PHE A 191
PHE A 106
VAL A  10
 None
 1.21A 3me6C-2w3yA:
undetectable		 3me6C-2w3yA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		5 VAL A 144
PHE A 174
ILE A 158
ALA A 182
VAL A 150
 None
 1.18A 3me6C-2wlcA:
undetectable		 3me6C-2wlcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsh ENDONUCLEASE II

(Escherichia
virus T4) 		PF01541
(GIY-YIG) 		5 VAL A  90
ILE A  39
ALA A  78
THR A  75
VAL A  46
 None
 1.16A 3me6C-2wshA:
undetectable		 3me6C-2wshA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		5 PHE A  38
PHE A 280
ILE A  48
ALA A 245
VAL A  60
 None
 1.26A 3me6C-2wymA:
undetectable		 3me6C-2wymA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 VAL 3 204
PHE 3  81
ALA 3  80
VAL 3 185
VAL 3 160
 None
 0.94A 3me6C-2wzr3:
undetectable		 3me6C-2wzr3:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  35
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.06A 3me6C-2y3sA:
undetectable		 3me6C-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 194
PHE A 489
ILE A  41
ALA A  48
VAL A  76
 FAD  A 600 ( 4.2A)
None
None
None
None
 1.23A 3me6C-2y3sA:
undetectable		 3me6C-2y3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
 None
 0.89A 3me6C-2zghA:
undetectable		 3me6C-2zghA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 VAL A 179
ILE A 197
ALA A 170
VAL A 154
VAL A 163
 None
 1.17A 3me6C-3a9xA:
undetectable		 3me6C-3a9xA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 VAL A 585
PHE A 589
ILE A 635
THR A 672
VAL A 716
 None
 1.04A 3me6C-3aqpA:
undetectable		 3me6C-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		5 VAL A 196
ILE A 200
ALA A 218
VAL A 210
VAL A 208
 NAD  A 463 (-4.2A)
None
None
None
None
 1.15A 3me6C-3efvA:
undetectable		 3me6C-3efvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2w SYNDAPIN

(Drosophila
melanogaster) 		PF00611
(FCH) 		5 PHE A 241
ILE A 111
PHE A 242
VAL A 249
VAL A 107
 None
 1.25A 3me6C-3i2wA:
undetectable		 3me6C-3i2wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 167
ALA A 227
THR A 231
VAL A 239
VAL A  82
 None
 1.17A 3me6C-3ifrA:
undetectable		 3me6C-3ifrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		5 VAL A 103
PHE A 105
ILE A 135
ALA A 127
THR A 157
 None
 1.16A 3me6C-3krvA:
undetectable		 3me6C-3krvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 VAL A 292
PHE A 454
ILE A 302
VAL A 271
VAL A 273
 None
 1.24A 3me6C-3kveA:
undetectable		 3me6C-3kveA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 PHE A 392
ILE A 369
PHE A  22
ALA A 399
VAL A 432
 None
 1.25A 3me6C-3lmlA:
undetectable		 3me6C-3lmlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lno PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacillus
anthracis) 		PF01883
(FeS_assembly_P) 		5 VAL A  64
ILE A  26
ALA A  12
VAL A  35
VAL A  32
 None
 1.13A 3me6C-3lnoA:
undetectable		 3me6C-3lnoA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 PHE A 146
ALA A 163
THR A 443
VAL A 430
VAL A 428
 None
 1.10A 3me6C-3lnpA:
undetectable		 3me6C-3lnpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjz FG41 MALONATE
SEMIALDEHYDE
DECARBOXYLASE

(coryneform
bacterium) 		PF14552
(Tautomerase_2) 		5 VAL A  23
ILE A  68
THR A   8
VAL A  97
VAL A 102
 None
 1.13A 3me6C-3mjzA:
undetectable		 3me6C-3mjzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A 247
ILE A 318
ALA A 288
VAL A 332
VAL A 301
 None
 1.20A 3me6C-3plrA:
undetectable		 3me6C-3plrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.97A 3me6C-3pxgA:
undetectable		 3me6C-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.97A 3me6C-3pxiA:
undetectable		 3me6C-3pxiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd7 UNCHARACTERIZED
PROTEIN YDAL

(Escherichia
coli) 		PF01713
(Smr) 		5 VAL X 138
PHE X 105
ILE X 119
VAL X 148
VAL X 166
 None
 1.18A 3me6C-3qd7X:
undetectable		 3me6C-3qd7X:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 VAL A 138
PHE A 256
ILE A 257
ALA A 274
VAL A 184
 None
 1.17A 3me6C-3ry7A:
undetectable		 3me6C-3ry7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 5 VAL A 233
PHE A 540
ILE A 488
ALA A 493
VAL A 425
 None
 1.24A 3me6C-3sksA:
undetectable		 3me6C-3sksA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sno HYPOTHETICAL
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF01063
(Aminotran_4) 		5 PHE A 250
ILE A 231
ALA A 248
VAL A 279
VAL A 224
 None
 0.97A 3me6C-3snoA:
undetectable		 3me6C-3snoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
 None
 1.25A 3me6C-3t1wA:
undetectable		 3me6C-3t1wA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		7 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.56A 3me6C-3tk3A:
62.9		 3me6C-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		6 VAL A 104
PHE A 108
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.06A 3me6C-3tk3A:
62.9		 3me6C-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urg ALR1010 PROTEIN

(Nostoc sp. PCC
7120) 		PF11535
(Calci_bind_CcbP) 		5 VAL A  65
PHE A  42
ILE A 100
ALA A 112
VAL A 105
 None
NA  A 127 (-4.5A)
None
None
None
 0.93A 3me6C-3urgA:
undetectable		 3me6C-3urgA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 VAL A 710
PHE A 711
ILE A 799
ALA A 792
VAL A 703
 None
 1.06A 3me6C-3ux8A:
undetectable		 3me6C-3ux8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 187
PHE A 449
ALA A 450
THR A 290
VAL A 282
 None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-4.2A)
None
 1.19A 3me6C-3v8dA:
26.5		 3me6C-3v8dA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 VAL A 369
PHE A 280
ALA A 287
THR A 289
VAL A 330
 None
 1.18A 3me6C-3vz0A:
undetectable		 3me6C-3vz0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 VAL A 369
PHE A 280
ILE A 347
ALA A 287
THR A 289
 None
 1.21A 3me6C-3vz0A:
undetectable		 3me6C-3vz0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAF PROTEIN

(Escherichia
coli) 		PF03743
(TrbI) 		5 VAL A 889
ILE A 820
THR A 816
VAL A 767
VAL A 787
 None
 0.86A 3me6C-3zbiA:
undetectable		 3me6C-3zbiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		6 VAL A 260
PHE A  52
ILE A  94
ALA A  74
VAL A  83
VAL A  87
 None
 1.34A 3me6C-4h1xA:
undetectable		 3me6C-4h1xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 VAL A 167
PHE A 236
ALA A 203
THR A 206
VAL A 245
 LLP  A  41 ( 4.1A)
None
None
None
None
 1.07A 3me6C-4h27A:
undetectable		 3me6C-4h27A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		5 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ADP  A 602 (-3.6A)
None
 0.97A 3me6C-4hseA:
undetectable		 3me6C-4hseA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 PHE A  94
PHE A 183
ILE A 150
ALA A 275
VAL A 283
 None
 1.19A 3me6C-4i4nA:
undetectable		 3me6C-4i4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je1 PROBABLE THIOL
PEROXIDASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		5 VAL A  82
ILE A  80
PHE A  27
ALA A  25
VAL A 136
 None
 1.17A 3me6C-4je1A:
undetectable		 3me6C-4je1A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgi UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF13678
(Peptidase_M85) 		5 VAL A 189
ILE A 105
PHE A  90
THR A  79
VAL A 161
 None
 1.08A 3me6C-4lgiA:
undetectable		 3me6C-4lgiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Xylanimonas
cellulosilytica) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		5 VAL A 207
ILE A 209
PHE A 279
ALA A 284
VAL A 303
 None
 1.21A 3me6C-4lpqA:
undetectable		 3me6C-4lpqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 VAL A  32
PHE A  18
PHE A  11
ALA A  56
THR A  54
 None
 1.05A 3me6C-4nenA:
undetectable		 3me6C-4nenA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 ILE A 131
ALA A 169
THR A  42
VAL A 148
VAL A  75
 None
 1.23A 3me6C-4o0mA:
undetectable		 3me6C-4o0mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 VAL A 189
ILE A 105
PHE A  90
THR A  79
VAL A 161
 None
 1.18A 3me6C-4o2iA:
undetectable		 3me6C-4o2iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		5 VAL A 221
ILE A 401
ALA A 406
VAL A 272
VAL A 330
 None
 1.19A 3me6C-4qjiA:
undetectable		 3me6C-4qjiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
 None
 1.21A 3me6C-4qt8B:
undetectable		 3me6C-4qt8B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		5 VAL A 142
PHE A  96
ALA A  59
VAL A  72
VAL A  68
 None
 1.26A 3me6C-4rl1A:
undetectable		 3me6C-4rl1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1

(Glossoscolex
paulistus) 		PF16915
(Eryth_link_C) 		5 VAL M 115
ILE M 208
PHE M 153
ALA M 152
VAL M 192
 None
 1.11A 3me6C-4u8uM:
undetectable		 3me6C-4u8uM:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 VAL 3 205
PHE 3  80
ALA 3  79
VAL 3 186
VAL 3 161
 None
 1.02A 3me6C-5aca3:
undetectable		 3me6C-5aca3:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 VAL A 104
PHE A 108
ILE A 209
ALA A 298
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
HEM  A 501 ( 4.4A)
 1.02A 3me6C-5e0eA:
53.6		 3me6C-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 VAL A 104
PHE A 108
ILE A 209
THR A 302
VAL A 367
 None
None
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 0.80A 3me6C-5e0eA:
53.6		 3me6C-5e0eA:
79.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A 673
ILE A 761
ALA A 661
THR A 658
VAL A 784
 None
 1.24A 3me6C-5eawA:
undetectable		 3me6C-5eawA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 VAL A 390
ILE A 337
PHE A 421
THR A 351
VAL A 354
 None
 1.21A 3me6C-5ecoA:
undetectable		 3me6C-5ecoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 504
ILE A 535
ALA A 568
THR A 567
VAL A 538
 None
 1.01A 3me6C-5fjiA:
undetectable		 3me6C-5fjiA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 VAL A 390
PHE A 383
ILE A 369
ALA A 413
VAL A 361
 None
 0.98A 3me6C-5i2tA:
undetectable		 3me6C-5i2tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwx 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02542
(YgbB) 		5 VAL A  85
ILE A 155
ALA A 123
VAL A  45
VAL A 153
 None
 1.23A 3me6C-5iwxA:
undetectable		 3me6C-5iwxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		5 VAL A 281
PHE A 370
ILE A 285
ALA A 291
VAL A 258
 None
 1.11A 3me6C-5j78A:
undetectable		 3me6C-5j78A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 5 VAL A 262
ILE A 285
ALA A 280
THR A 320
VAL A 302
 None
 1.25A 3me6C-5lw3A:
undetectable		 3me6C-5lw3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
 None
 1.25A 3me6C-5mr7A:
undetectable		 3me6C-5mr7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		5 ILE A  25
ALA A  32
THR A 178
VAL A  78
VAL A 107
 None
 1.24A 3me6C-5uscA:
undetectable		 3me6C-5uscA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utt SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		5 VAL A 170
PHE A 179
ILE A 114
PHE A 143
ALA A 144
 None
 0.98A 3me6C-5uttA:
undetectable		 3me6C-5uttA:
16.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 9 VAL A 104
PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
 0.46A 3me6C-5wbgA:
59.1		 3me6C-5wbgA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 7 VAL A 104
PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
 1.42A 3me6C-5wbgA:
59.1		 3me6C-5wbgA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 PHE A 277
ILE A 282
ALA A 275
VAL A 325
VAL A 262
 None
None
AFY  A 401 (-3.6A)
None
None
 0.92A 3me6C-5wgcA:
undetectable		 3me6C-5wgcA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 VAL A 884
PHE A 940
ILE A 952
VAL A 874
VAL A 865
 None
 1.24A 3me6C-5wugA:
undetectable		 3me6C-5wugA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 5 ILE A 135
PHE A  68
ALA A  54
VAL A 140
VAL A 138
 None
 1.17A 3me6C-5yqwA:
undetectable		 3me6C-5yqwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 VAL A 145
PHE A 102
PHE A 120
ILE A 123
VAL A 127
 None
 1.26A 3me6C-6bx6A:
undetectable		 3me6C-6bx6A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 VAL A 229
ILE A  67
ALA A 149
THR A 153
VAL A  84
 None
 1.19A 3me6C-6cc4A:
undetectable		 3me6C-6cc4A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 ILE B 179
PHE B 211
ALA B  99
THR B  97
VAL B 106
 None
None
NAD  B 500 (-3.2A)
None
None
 1.17A 3me6C-6dftB:
undetectable		 3me6C-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 5 VAL A 548
PHE A 547
PHE A 517
ILE A 520
PHE A 488
 None
 1.16A 3me6C-6du8A:
undetectable		 3me6C-6du8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 233
PHE B 283
ILE B 240
ALA B 350
VAL B 256
 None
 1.25A 3me6C-6f42B:
undetectable		 3me6C-6f42B:
11.44