SIMILAR PATTERNS OF AMINO ACIDS FOR 3MDV_B_CL6B506_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a27 | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE (Homo sapiens) |
PF00106(adh_short) | 6 | LEU A 22PHE A 30VAL A 86THR A 3ALA A 243THR A 242 | None | 1.48A | 3mdvB-1a27A:0.0 | 3mdvB-1a27A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amo | NADPH-CYTOCHROMEP450 REDUCTASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 5 | LEU A 292LEU A 579THR A 535ILE A 537ALA A 538 | NoneNoneNAP A 752 (-3.5A)NoneFAD A 750 (-3.7A) | 0.76A | 3mdvB-1amoA:0.0 | 3mdvB-1amoA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cqj | SUCCINYL-COASYNTHETASE ALPHACHAIN (Escherichiacoli) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 6 | LEU A 48THR A 32ILE A 28ALA A 27GLU A 25THR A 21 | None | 1.41A | 3mdvB-1cqjA:0.0 | 3mdvB-1cqjA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddk | IMP-1 METALLOBETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 5 | LEU A 168THR A 209ALA A 213ALA A 175ALA A 171 | None | 0.99A | 3mdvB-1ddkA:0.0 | 3mdvB-1ddkA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkd | GROEL (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | LEU A 309LEU A 237ILE A 230ALA A 258ALA A 275 | None | 0.90A | 3mdvB-1dkdA:undetectable | 3mdvB-1dkdA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2z | CYTOCHROME F (Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 6 | LEU A 214LEU A 185GLU A 193ALA A 181ALA A 184THR A 183 | None | 1.40A | 3mdvB-1e2zA:undetectable | 3mdvB-1e2zA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwl | OUTER-MEMBRANELIPOPROTEINS CARRIERPROTEIN (Escherichiacoli) |
PF03548(LolA) | 5 | PHE A 127LEU A 10THR A 128ILE A 129ALA A 2 | None | 0.96A | 3mdvB-1iwlA:undetectable | 3mdvB-1iwlA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js6 | DOPA DECARBOXYLASE (Sus scrofa) |
PF00282(Pyridoxal_deC) | 5 | LEU A 180VAL A 204LEU A 167ILE A 235ALA A 159 | None | 0.92A | 3mdvB-1js6A:0.0 | 3mdvB-1js6A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kc8 | RIBOSOMAL PROTEINL18 (Haloarculamarismortui) |
PF17144(Ribosomal_L5e) | 6 | LEU O 102LEU O 136ILE O 123ALA O 122GLU O 120ALA O 81 | A A2413 ( 4.6A)NoneNoneNoneNoneNone | 1.36A | 3mdvB-1kc8O:undetectable | 3mdvB-1kc8O:17.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n97 | CYP175A1 (Thermusthermophilus) |
PF00067(p450) | 5 | THR A 217ALA A 221THR A 225ALA A 268THR A 372 | NoneHEM A 602 (-3.3A)HEM A 602 (-3.8A)HEM A 602 ( 4.0A)None | 0.72A | 3mdvB-1n97A:40.3 | 3mdvB-1n97A:31.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNIT (Klebsiellapneumoniae) |
PF08841(DDR) | 5 | LEU A 213LEU A 249ILE A 98ALA A 162ALA A 199 | None | 0.95A | 3mdvB-1nbwA:undetectable | 3mdvB-1nbwA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5h | FORMIMINOTETRAHYDROFOLATE CYCLODEAMINASE (Thermotogamaritima) |
PF04961(FTCD_C) | 5 | LEU A 119ALA A 65GLU A 67ALA A 43ALA A 37 | None | 1.00A | 3mdvB-1o5hA:undetectable | 3mdvB-1o5hA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | LEU A 31LEU A 205THR A 157ILE A 159ALA A 160 | NoneNoneFAD A 304 (-3.6A)NoneFAD A 304 ( 4.0A) | 0.65A | 3mdvB-1qgzA:undetectable | 3mdvB-1qgzA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | LEU A 31THR A 157ILE A 159ALA A 160THR A 164 | NoneFAD A 304 (-3.6A)NoneFAD A 304 ( 4.0A)None | 0.89A | 3mdvB-1qgzA:undetectable | 3mdvB-1qgzA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yac | YCAC GENE PRODUCT (Escherichiacoli) |
PF00857(Isochorismatase) | 5 | LEU A 17LEU A 52ILE A 109ALA A 42ALA A 47 | None | 1.00A | 3mdvB-1yacA:undetectable | 3mdvB-1yacA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zch | HYPOTHETICALOXIDOREDUCTASE YCND (Bacillussubtilis) |
PF00881(Nitroreductase) | 6 | LEU A 161VAL A 48LEU A 130THR A 50ALA A 33ALA A 125 | None | 1.39A | 3mdvB-1zchA:undetectable | 3mdvB-1zchA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bqx | INORGANICPYROPHOSPHATASE (Helicobacterpylori) |
PF00719(Pyrophosphatase) | 7 | VAL A 68THR A 60ILE A 168ALA A 167GLU A 165ALA A 160ALA A 12 | None | 1.18A | 3mdvB-2bqxA:undetectable | 3mdvB-2bqxA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2euh | NADP DEPENDENT NONPHOSPHORYLATINGGLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Streptococcusmutans) |
PF00171(Aldedh) | 5 | LEU A 311LEU A 383ILE A 304ALA A 269ALA A 276 | None | 0.99A | 3mdvB-2euhA:undetectable | 3mdvB-2euhA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gfq | UPF0204 PROTEINPH0006 (Pyrococcushorikoshii) |
PF04414(tRNA_deacylase) | 5 | LEU A 146ILE A 74ALA A 75ALA A 110THR A 94 | None | 0.92A | 3mdvB-2gfqA:undetectable | 3mdvB-2gfqA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxo | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | LEU A 152LEU A 97ILE A 127ALA A 89ALA A 94 | None | 0.99A | 3mdvB-2hxoA:undetectable | 3mdvB-2hxoA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ism | PUTATIVEOXIDOREDUCTASE (Thermusthermophilus) |
PF07995(GSDH) | 5 | LEU A 61ILE A 46ALA A 47ALA A 65THR A 63 | None | 0.98A | 3mdvB-2ismA:undetectable | 3mdvB-2ismA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlz | CEPHALOSPORINACYLASE (Bacillushalodurans) |
PF01019(G_glu_transpept) | 5 | VAL A 26ILE A 40ALA A 50ALA A 55THR A 56 | None | 0.93A | 3mdvB-2nlzA:undetectable | 3mdvB-2nlzA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oew | PROGRAMMED CELLDEATH 6-INTERACTINGPROTEIN (Homo sapiens) |
PF03097(BRO1) | 5 | LEU A 65LEU A 124ILE A 347THR A 341ALA A 128 | None | 0.92A | 3mdvB-2oewA:undetectable | 3mdvB-2oewA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pun | METHYLTHIORIBOSEKINASE (Bacillussubtilis) |
PF01636(APH) | 5 | LEU A 144PHE A 296ILE A 326GLU A 329ALA A 334 | None | 0.98A | 3mdvB-2punA:undetectable | 3mdvB-2punA:22.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q9g | CYTOCHROME P450 46A1 (Homo sapiens) |
PF00067(p450) | 12 | LEU A 112PHE A 121VAL A 126LEU A 219THR A 298ILE A 301ALA A 302GLU A 305THR A 306ALA A 367ALA A 474THR A 475 | NoneNoneHEM A 505 ( 3.8A)NoneNoneNoneHEM A 505 (-3.7A)NoneHEM A 505 (-3.7A)HEM A 505 (-3.5A)NoneNone | 0.39A | 3mdvB-2q9gA:66.1 | 3mdvB-2q9gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfc | PLCR PROTEIN (Bacillusthuringiensis) |
PF01381(HTH_3) | 5 | VAL A 121LEU A 142ILE A 161ALA A 160GLU A 158 | None | 1.00A | 3mdvB-2qfcA:undetectable | 3mdvB-2qfcA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qtz | METHIONINE SYNTHASEREDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | LEU A 284LEU A 593THR A 547ILE A 549ALA A 550 | NoneNoneFAD A 700 ( 4.6A)NoneFAD A 700 ( 4.7A) | 0.72A | 3mdvB-2qtzA:undetectable | 3mdvB-2qtzA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qul | D-TAGATOSE3-EPIMERASE (Pseudomonascichorii) |
PF01261(AP_endonuc_2) | 6 | LEU A 33VAL A 244LEU A 100ILE A 36ALA A 106ALA A 102 | None | 1.20A | 3mdvB-2qulA:undetectable | 3mdvB-2qulA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r05 | PROGRAMMED CELLDEATH 6-INTERACTINGPROTEIN (Homo sapiens) |
PF03097(BRO1)PF13949(ALIX_LYPXL_bnd) | 5 | LEU A 65LEU A 124ILE A 347THR A 341ALA A 128 | None | 0.93A | 3mdvB-2r05A:undetectable | 3mdvB-2r05A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc5 | FERREDOXIN-NADPREDUCTASE (Leptospirainterrogans) |
PF00175(NAD_binding_1) | 5 | LEU A 32LEU A 217THR A 175ILE A 177ALA A 178 | NoneNoneFAD A 415 (-3.4A)NoneFAD A 415 ( 3.9A) | 0.55A | 3mdvB-2rc5A:undetectable | 3mdvB-2rc5A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | VAL A 644LEU A 586ILE A 618ALA A 620ALA A 626 | None | 0.78A | 3mdvB-2vdcA:undetectable | 3mdvB-2vdcA:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | ILE A 243ALA A 244GLU A 247THR A 248ALA A 291 | VDX A 501 (-4.2A)HEM A 413 (-3.5A)NoneHEM A 413 (-3.2A)HEM A 413 ( 3.7A) | 0.96A | 3mdvB-2zbzA:33.5 | 3mdvB-2zbzA:27.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahm | OLIGOPEPTIDASE (Geobacillus sp.MO-1) |
no annotation | 5 | LEU A 131THR A 204ILE A 206ALA A 207ALA A 221 | None | 0.97A | 3mdvB-3ahmA:undetectable | 3mdvB-3ahmA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 5 | LEU B 73LEU B 116THR B 138ILE B 139ALA B 119 | None2DE B 329 ( 4.6A)NoneNoneNone | 0.97A | 3mdvB-3aqcB:undetectable | 3mdvB-3aqcB:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bw2 | 2-NITROPROPANEDIOXYGENASE (Streptomycesansochromogenes) |
PF03060(NMO) | 5 | VAL A 14LEU A 200ALA A 233ALA A 168ALA A 171 | None | 0.88A | 3mdvB-3bw2A:undetectable | 3mdvB-3bw2A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2u | XYLOSIDASE/ARABINOSIDASE (Selenomonasruminantium) |
PF04616(Glyco_hydro_43)PF07081(DUF1349) | 5 | LEU A 497THR A 417THR A 412ALA A 384ALA A 511 | None | 0.93A | 3mdvB-3c2uA:undetectable | 3mdvB-3c2uA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6g | CYTOCHROME P450 2R1 (Homo sapiens) |
PF00067(p450) | 5 | ILE A 309ALA A 310GLU A 313THR A 314THR A 488 | NoneHEM A 601 (-3.3A)NoneHEM A 601 (-3.4A)VD3 A 701 ( 4.6A) | 0.60A | 3mdvB-3c6gA:36.0 | 3mdvB-3c6gA:27.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbg | O-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF01596(Methyltransf_3) | 5 | LEU A 159PHE A 137ILE A 89ALA A 121THR A 124 | NoneNoneNoneSAH A 301 (-3.4A)None | 0.90A | 3mdvB-3cbgA:undetectable | 3mdvB-3cbgA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A1143ILE A1128ALA A1125GLU A1127ALA A1174 | None | 0.90A | 3mdvB-3cmtA:undetectable | 3mdvB-3cmtA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A2143ILE A2128ALA A2125GLU A2127ALA A2174 | None | 0.91A | 3mdvB-3cmtA:undetectable | 3mdvB-3cmtA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A4143ILE A4128ALA A4125GLU A4127ALA A4174 | None | 0.90A | 3mdvB-3cmtA:undetectable | 3mdvB-3cmtA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A 143ILE A 128ALA A 125GLU A 127ALA A 174 | None | 0.82A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A1143ILE A1128ALA A1125GLU A1127ALA A1174 | None | 0.82A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A2143ILE A2128ALA A2125GLU A2127ALA A2174 | None | 0.82A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A3143ILE A3128ALA A3125GLU A3127ALA A3174 | None | 0.83A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A4143ILE A4128ALA A4125GLU A4127ALA A4174 | None | 0.83A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | VAL A5143ILE A5128ALA A5125GLU A5127ALA A5174 | None | 0.83A | 3mdvB-3cmuA:undetectable | 3mdvB-3cmuA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cqy | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Shewanellaoneidensis) |
PF03702(AnmK) | 5 | LEU A 81ILE A 91ALA A 93ALA A 122THR A 125 | None | 0.94A | 3mdvB-3cqyA:undetectable | 3mdvB-3cqyA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djd | FRUCTOSYL AMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | LEU A 164VAL A 41LEU A 86GLU A 170ALA A 22 | None | 0.99A | 3mdvB-3djdA:undetectable | 3mdvB-3djdA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h6e | CARBOHYDRATE KINASE,FGGY (Novosphingobiumaromaticivorans) |
PF00370(FGGY_N) | 5 | VAL A 223LEU A 56ILE A 213ALA A 214ALA A 63 | None | 0.98A | 3mdvB-3h6eA:undetectable | 3mdvB-3h6eA:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hlk | ACYL-COENZYME ATHIOESTERASE 2,MITOCHONDRIAL (Homo sapiens) |
PF04775(Bile_Hydr_Trans)PF08840(BAAT_C) | 5 | LEU A 96VAL A 94ALA A 116GLU A 121ALA A 65 | None | 0.92A | 3mdvB-3hlkA:undetectable | 3mdvB-3hlkA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifq | PLAKOGLOBIN (Homo sapiens) |
PF00514(Arm) | 6 | LEU A 497LEU A 459ILE A 485ALA A 484ALA A 445ALA A 455 | None | 1.33A | 3mdvB-3ifqA:undetectable | 3mdvB-3ifqA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kkd | TRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
PF00440(TetR_N) | 5 | LEU A 82LEU A 47ALA A 62GLU A 64ALA A 39 | None | 0.95A | 3mdvB-3kkdA:undetectable | 3mdvB-3kkdA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyf | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasputida) |
PF07238(PilZ)PF07317(YcgR) | 5 | PHE A 217VAL A 215LEU A 190ILE A 158ALA A 186 | None | 0.90A | 3mdvB-3kyfA:undetectable | 3mdvB-3kyfA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxy | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE (Yersinia pestis) |
PF04166(PdxA) | 5 | LEU A 319THR A 11ILE A 10ALA A 115ALA A 322 | None | 0.97A | 3mdvB-3lxyA:undetectable | 3mdvB-3lxyA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | LEU A 387ILE A 4ALA A 3ALA A 30ALA A 385 | None | 0.92A | 3mdvB-3mduA:undetectable | 3mdvB-3mduA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mfd | D-ALANYL-D-ALANINECARBOXYPEPTIDASEDACB (Bacillussubtilis) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 5 | LEU A 300THR A 343ILE A 344ALA A 345ALA A 273 | None | 0.99A | 3mdvB-3mfdA:undetectable | 3mdvB-3mfdA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nec | INFLAMMATORYPROFILIN (Toxoplasmagondii) |
PF00235(Profilin) | 5 | VAL A 77LEU A 152THR A 112ILE A 111ALA A 155 | None | 0.90A | 3mdvB-3necA:undetectable | 3mdvB-3necA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ow2 | 50S RIBOSOMALPROTEIN L19E (Haloarculamarismortui) |
PF01280(Ribosomal_L19e) | 5 | LEU O 3PHE O 23ILE O 49ALA O 48ALA O 34 | C 01396 ( 3.8A)NoneNoneNoneNone | 0.98A | 3mdvB-3ow2O:undetectable | 3mdvB-3ow2O:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppb | PUTATIVE TETR FAMILYTRANSCRIPTIONREGULATOR (Shewanellaloihica) |
PF00440(TetR_N) | 5 | LEU A 55LEU A 20ALA A 35GLU A 37ALA A 12 | None | 1.00A | 3mdvB-3ppbA:undetectable | 3mdvB-3ppbA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3prl | NADP-DEPENDENTGLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Bacillushalodurans) |
PF00171(Aldedh) | 5 | LEU A 320LEU A 392ILE A 313ALA A 278ALA A 285 | None | 0.94A | 3mdvB-3prlA:undetectable | 3mdvB-3prlA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3h | O-METHYLTRANSFERASE,SAM-DEPENDENT (Legionellapneumophila) |
PF01596(Methyltransf_3) | 5 | LEU A 159PHE A 137ILE A 89ALA A 121THR A 124 | None | 0.69A | 3mdvB-3r3hA:undetectable | 3mdvB-3r3hA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT ANADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
PF00507(Oxidored_q4)no annotation | 5 | VAL A 80LEU N 137ALA K 70GLU K 72ALA K 65 | None | 0.91A | 3mdvB-3rkoA:undetectable | 3mdvB-3rkoA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t1u | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Azotobactervinelandii) |
PF00160(Pro_isomerase) | 5 | THR A 82ILE A 83ALA A 84ALA A 24THR A 23 | None | 0.95A | 3mdvB-3t1uA:undetectable | 3mdvB-3t1uA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tal | DNA DOUBLE-STRANDBREAK REPAIR PROTEINNURA (Pyrococcusfuriosus) |
PF09376(NurA) | 5 | LEU A 428ILE A 64ALA A 85THR A 62ALA A 438 | None | 0.94A | 3mdvB-3talA:undetectable | 3mdvB-3talA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3trc | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Coxiellaburnetii) |
PF01590(GAF) | 5 | LEU A 35THR A 147ALA A 143GLU A 141ALA A 0 | None | 0.96A | 3mdvB-3trcA:undetectable | 3mdvB-3trcA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvs | PUTATIVEMONOOXYGENASE (Streptomycessp. SN-593) |
PF00067(p450) | 5 | LEU A 176ILE A 240ALA A 241GLU A 244THR A 245 | RRM A 502 (-4.9A)RRM A 502 ( 3.9A)HEM A 501 (-3.8A)NoneHEM A 501 (-3.3A) | 0.73A | 3mdvB-3wvsA:32.3 | 3mdvB-3wvsA:24.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atq | 4-AMINOBUTYRATETRANSAMINASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 5 | VAL A 268LEU A 167ALA A 137GLU A 139THR A 165 | PLP A1456 (-4.2A)NoneNoneNoneNone | 1.00A | 3mdvB-4atqA:undetectable | 3mdvB-4atqA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 5 | VAL A 63LEU A 128THR A 116ALA A 24ALA A 126 | None | 0.95A | 3mdvB-4bk1A:undetectable | 3mdvB-4bk1A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvx | EUKARYOTICTRANSLATIONELONGATION FACTOR 1EPSILON-1 (Homo sapiens) |
PF00043(GST_C) | 6 | LEU B 61VAL B 71LEU B 10THR B 114ILE B 118ALA B 48 | None | 1.27A | 3mdvB-4bvxB:undetectable | 3mdvB-4bvxB:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 65VAL A 6LEU A 73ALA A 115GLU A 113 | None | 0.99A | 3mdvB-4dhgA:undetectable | 3mdvB-4dhgA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dmg | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA1493 (Thermusthermophilus) |
PF02475(Met_10) | 5 | LEU A 315PHE A 281VAL A 284ALA A 270THR A 273 | NoneNoneNoneSAM A 401 (-3.7A)None | 0.96A | 3mdvB-4dmgA:undetectable | 3mdvB-4dmgA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4etz | PELD (Pseudomonasaeruginosa) |
PF13492(GAF_3)PF16963(PelD_GGDEF) | 6 | LEU A 192VAL A 265LEU A 160ILE A 298ALA A 297ALA A 304 | None | 1.50A | 3mdvB-4etzA:undetectable | 3mdvB-4etzA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ex6 | ALNB (Streptomycessp. CM020) |
PF13419(HAD_2) | 5 | THR A 29ILE A 30ALA A 26ALA A 90ALA A 85 | None | 0.97A | 3mdvB-4ex6A:undetectable | 3mdvB-4ex6A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fi4 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Caulobacter sp.K31) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 233LEU A 202ILE A 147THR A 132ALA A 198 | None | 0.98A | 3mdvB-4fi4A:undetectable | 3mdvB-4fi4A:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6j | F-BOX/LRR-REPEATPROTEIN 3 (Homo sapiens) |
PF12937(F-box-like) | 6 | LEU B 144PHE B 115VAL B 117ILE B 130ALA B 126ALA B 163 | None | 1.13A | 3mdvB-4i6jB:undetectable | 3mdvB-4i6jB:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4isy | CYSTEINE DESULFURASE (Mycobacteriumtuberculosis) |
PF00266(Aminotran_5) | 6 | LEU A 356PHE A 302LEU A 371GLU A 281ALA A 377ALA A 370 | None | 1.48A | 3mdvB-4isyA:undetectable | 3mdvB-4isyA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kng | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 5 (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | LEU A 236LEU A 262THR A 255ILE A 253ALA A 252 | None | 0.89A | 3mdvB-4kngA:undetectable | 3mdvB-4kngA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfz | DBV8 PROTEIN (Nonomuraeagerenzanensis) |
no annotation | 5 | LEU A 213THR A 233ILE A 316ALA A 231ALA A 216 | None | 0.97A | 3mdvB-4mfzA:undetectable | 3mdvB-4mfzA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3n | MGS-M5 (unidentified) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 14LEU A 74THR A 78ALA A 119ALA A 237 | None | 0.99A | 3mdvB-4q3nA:undetectable | 3mdvB-4q3nA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 6 | LEU A 67THR A 139ILE A 140ALA A 79ALA A 155THR A 156 | None | 1.44A | 3mdvB-4q73A:undetectable | 3mdvB-4q73A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfk | ABC TRANSPORTERPERIPLASMICPEPTIDE-BINDINGPROTEIN (Pseudoalteromonassp. SM9913) |
no annotation | 5 | LEU H 276THR H 251ILE H 254ALA H 255THR H 259 | None | 0.93A | 3mdvB-4qfkH:undetectable | 3mdvB-4qfkH:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qwv | HIGH-AFFINITYLEUCINE-SPECIFICTRANSPORT SYSTEMPERIPLASMIC BINDINGPROTEIN, CHEMOTAXISPROTEIN CHEY (Escherichiacoli;Thermotogamaritima) |
PF00072(Response_reg)PF13458(Peripla_BP_6) | 5 | VAL A 5LEU A 298ILE A 97ALA A 282THR A 281 | None | 0.94A | 3mdvB-4qwvA:undetectable | 3mdvB-4qwvA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubs | PENTALENIC ACIDSYNTHASE (Streptomycesavermitilis) |
PF00067(p450) | 6 | LEU A 178ILE A 240ALA A 241GLU A 244THR A 245ALA A 288 | NoneDIF A 502 (-3.3A)HEM A 501 ( 3.8A)NoneHEM A 501 ( 3.3A)HEM A 501 ( 3.7A) | 0.99A | 3mdvB-4ubsA:33.6 | 3mdvB-4ubsA:26.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udn | PERIPLASMIC SOLUTEBINDING PROTEIN (CandidatusLiberibacterasiaticus) |
PF01297(ZnuA) | 5 | LEU A 58VAL A 28ILE A 21ALA A 22ALA A 124 | None | 0.96A | 3mdvB-4udnA:undetectable | 3mdvB-4udnA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ufs | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 5 (Homo sapiens) |
PF00560(LRR_1)PF01462(LRRNT)PF13855(LRR_8) | 5 | LEU A 236LEU A 262THR A 255ILE A 253ALA A 252 | None | 0.84A | 3mdvB-4ufsA:undetectable | 3mdvB-4ufsA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzs | ECU04_1440 PROTEIN (Encephalitozooncuniculi) |
PF00352(TBP) | 6 | PHE D 113VAL D 32ALA D 94ALA D 71ALA D 84THR D 69 | None | 1.46A | 3mdvB-4wzsD:undetectable | 3mdvB-4wzsD:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq2 | CALE6 (Micromonosporaechinospora) |
PF01053(Cys_Met_Meta_PP) | 5 | VAL A 205LEU A 61THR A 196ILE A 199ALA A 200 | NoneNoneLLP A 197 ( 3.5A)NoneLLP A 197 ( 4.7A) | 0.94A | 3mdvB-4xq2A:undetectable | 3mdvB-4xq2A:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypl | LON PROTEASE (Meiothermustaiwanensis) |
PF00004(AAA)PF05362(Lon_C) | 5 | LEU A 663VAL A 665LEU A 653ALA A 686ALA A 640 | None | 0.95A | 3mdvB-4yplA:undetectable | 3mdvB-4yplA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zz7 | METHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Oceanimonasdoudoroffii) |
PF00171(Aldedh) | 5 | ILE A 46ALA A 45GLU A 43ALA A 37ALA A 210 | None | 0.94A | 3mdvB-4zz7A:undetectable | 3mdvB-4zz7A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0z | CHOLINETRIMETHYLAMINE LYASE (Klebsiellapneumoniae) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | LEU A 402ALA A 645GLU A 647ALA A 703ALA A 651 | None | 1.00A | 3mdvB-5a0zA:undetectable | 3mdvB-5a0zA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0z | CHOLINETRIMETHYLAMINE LYASE (Klebsiellapneumoniae) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | LEU A 599ALA A 645GLU A 647ALA A 703ALA A 651 | None | 0.88A | 3mdvB-5a0zA:undetectable | 3mdvB-5a0zA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bmo | PUTATIVEUNCHARACTERIZEDPROTEIN LNMX (Streptomycesatroolivaceus) |
PF02585(PIG-L) | 5 | LEU A 143ILE A 173ALA A 174ALA A 17ALA A 142 | None | 0.95A | 3mdvB-5bmoA:undetectable | 3mdvB-5bmoA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5boh | BETA-LACTAMASE (Acinetobacterbaumannii) |
PF00905(Transpeptidase) | 5 | LEU A 193PHE A 195LEU A 151ILE A 92ALA A 90 | NoneNoneNoneNoneKCX A 86 ( 3.4A) | 0.84A | 3mdvB-5bohA:undetectable | 3mdvB-5bohA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 5 | LEU A1066LEU A1075ILE A 687ALA A 684THR A1079 | None | 1.00A | 3mdvB-5cjuA:undetectable | 3mdvB-5cjuA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dku | PREX DNA POLYMERASE (Plasmodiumfalciparum) |
PF00476(DNA_pol_A)PF01612(DNA_pol_A_exo1) | 5 | PHE A 498LEU A 488ILE A 461ALA A 462ALA A 482 | None | 0.97A | 3mdvB-5dkuA:undetectable | 3mdvB-5dkuA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 8 | LEU A 75LEU A 181ILE A 263ALA A 264GLU A 267THR A 268ALA A 328THR A 438 | NoneNoneNoneHEM A 501 (-3.6A)NoneHEM A 501 (-3.4A)HEM A 501 ( 3.8A)None | 1.25A | 3mdvB-5e78A:43.2 | 3mdvB-5e78A:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 6 | THR A 260ALA A 264GLU A 267THR A 268ALA A 328THR A 438 | NoneHEM A 501 (-3.6A)NoneHEM A 501 (-3.4A)HEM A 501 ( 3.8A)None | 0.97A | 3mdvB-5e78A:43.2 | 3mdvB-5e78A:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8c | UL31 (Suidalphaherpesvirus1) |
PF02718(Herpes_UL31) | 5 | LEU A 125PHE A 124VAL A 128LEU A 115ALA A 236 | None | 0.98A | 3mdvB-5e8cA:undetectable | 3mdvB-5e8cA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ei0 | SERPIN A12 (Homo sapiens) |
PF00079(Serpin) | 5 | VAL A 384LEU A 299THR A 258ILE A 259GLU A 261 | None | 0.99A | 3mdvB-5ei0A:undetectable | 3mdvB-5ei0A:22.70 |