SIMILAR PATTERNS OF AMINO ACIDS FOR 3MBH_D_PXLD400_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itx | GLYCOSYL HYDROLASE (Bacilluscirculans) |
PF00704(Glyco_hydro_18) | 5 | ASP A 410VAL A 395SER A 414HIS A 291VAL A 314 | None | 1.16A | 3mbhD-1itxA:undetectable | 3mbhD-1itxA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1olt | OXYGEN-INDEPENDENTCOPROPORPHYRINOGENIII OXIDASE (Escherichiacoli) |
PF04055(Radical_SAM)PF06969(HemN_C) | 5 | ASP A 295SER A 205LEU A 297THR A 315GLN A 316 | None | 1.37A | 3mbhD-1oltA:2.9 | 3mbhD-1oltA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1td2 | PYRIDOXAMINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 6 | HIS A 44THR A 45GLN A 46TYR A 83VAL A 114ASP A 224 | PXL A 288 (-4.9A)PXL A 288 (-2.7A)PXL A 288 (-3.9A)PXL A 288 (-3.8A)NonePXL A 288 (-2.5A) | 0.38A | 3mbhD-1td2A:33.8 | 3mbhD-1td2A:27.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1td2 | PYRIDOXAMINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 5 | SER A 10HIS A 44THR A 45GLN A 46VAL A 114 | PXL A 288 (-2.4A)PXL A 288 (-4.9A)PXL A 288 (-2.7A)PXL A 288 (-3.9A)None | 1.28A | 3mbhD-1td2A:33.8 | 3mbhD-1td2A:27.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqx | D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE,PUTATIVE (Plasmodiumfalciparum) |
PF00834(Ribul_P_3_epim) | 5 | ASP A 38SER A 11LEU A 13GLN A 154VAL A 45 | ZN A 900 (-2.6A)NoneNoneNoneNone | 1.38A | 3mbhD-1tqxA:undetectable | 3mbhD-1tqxA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1up2 | CELA1 PROTEIN (Mycobacteriumtuberculosis) |
PF01341(Glyco_hydro_6) | 5 | ASP A 244SER A 272VAL A 275THR A 160TYR A 162 | NoneNoneNoneNoneIFM A 383 (-4.3A) | 1.39A | 3mbhD-1up2A:3.4 | 3mbhD-1up2A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g6t | UNCHARACTERIZEDPROTEIN, HOMOLOGHI1244 FROMHAEMOPHILUSINFLUENZAE (Clostridiumacetobutylicum) |
PF08942(DUF1919) | 5 | ASP A 233VAL A 253SER A 252HIS A 244TYR A 250 | None | 1.35A | 3mbhD-2g6tA:3.6 | 3mbhD-2g6tA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gbz | OLIGORIBONUCLEASE (Xanthomonascampestris) |
PF00929(RNase_T) | 5 | ASP A 169SER A 165SER A 158HIS A 161GLN A 68 | None | 1.43A | 3mbhD-2gbzA:undetectable | 3mbhD-2gbzA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1j | PUTATIVE SORTASE (Streptococcuspneumoniae) |
PF04203(Sortase) | 5 | ASP A 178LEU A 204THR A 189VAL A 182TYR A 187 | None | 1.48A | 3mbhD-2w1jA:undetectable | 3mbhD-2w1jA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1v | NITRILASE HOMOLOG 2 (Mus musculus) |
PF00795(CN_hydrolase) | 5 | SER A 177SER A 175THR A 134TYR A 132ASP A 174 | None | 1.16A | 3mbhD-2w1vA:3.7 | 3mbhD-2w1vA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULTMYOSIN LIGHT CHAIN3, SKELETAL MUSCLEISOFORM (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N)no annotation | 5 | VAL C 110LEU C 91THR M 790GLN M 791VAL C 123 | None | 1.20A | 3mbhD-2w4gC:undetectable | 3mbhD-2w4gC:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr4 | LECTIN (Burkholderiacenocepacia) |
PF07472(PA-IIL) | 5 | ASP A 97SER A 95VAL A 68SER A 75THR A 20 | None | 1.26A | 3mbhD-2xr4A:undetectable | 3mbhD-2xr4A:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddr | HASR PROTEIN (Serratiamarcescens) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ASP A 199SER A 278HIS A 325THR A 350GLN A 349 | None | 1.24A | 3mbhD-3ddrA:undetectable | 3mbhD-3ddrA:16.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h74 | PYRIDOXAL KINASE (Lactobacillusplantarum) |
PF08543(Phos_pyr_kin) | 7 | ASP A 9SER A 11SER A 17LEU A 40HIS A 43THR A 44ASP A 213 | None | 0.77A | 3mbhD-3h74A:33.7 | 3mbhD-3h74A:33.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h74 | PYRIDOXAL KINASE (Lactobacillusplantarum) |
PF08543(Phos_pyr_kin) | 7 | ASP A 9SER A 11SER A 17LEU A 40HIS A 43VAL A 107ASP A 213 | None | 0.98A | 3mbhD-3h74A:33.7 | 3mbhD-3h74A:33.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h74 | PYRIDOXAL KINASE (Lactobacillusplantarum) |
PF08543(Phos_pyr_kin) | 7 | ASP A 9SER A 17LEU A 40HIS A 43TYR A 80VAL A 107ASP A 213 | None | 1.02A | 3mbhD-3h74A:33.7 | 3mbhD-3h74A:33.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h74 | PYRIDOXAL KINASE (Lactobacillusplantarum) |
PF08543(Phos_pyr_kin) | 5 | ASP A 9TYR A 80VAL A 107TYR A 115ASP A 213 | None | 0.91A | 3mbhD-3h74A:33.7 | 3mbhD-3h74A:33.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 5 | VAL A1011LEU A1071THR A1191VAL A 824ASP A1012 | None | 1.38A | 3mbhD-3jb9A:undetectable | 3mbhD-3jb9A:8.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngo | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | SER A 413SER A 417LEU A 411THR A 375ASP A 434 | None | 1.47A | 3mbhD-3ngoA:undetectable | 3mbhD-3ngoA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pu9 | PROTEINSERINE/THREONINEPHOSPHATASE (Sphaerobacterthermophilus) |
PF07228(SpoIIE) | 5 | ASP A 96VAL A 115SER A 113LEU A 158GLN A 127 | None | 1.34A | 3mbhD-3pu9A:2.0 | 3mbhD-3pu9A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzs | PYRIDOXAMINE KINASE (Yersinia pestis) |
PF08543(Phos_pyr_kin) | 5 | HIS A 43GLN A 45TYR A 82VAL A 113ASP A 223 | NoneNoneNoneNoneSO4 A 288 (-3.4A) | 0.76A | 3mbhD-3pzsA:34.2 | 3mbhD-3pzsA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzs | PYRIDOXAMINE KINASE (Yersinia pestis) |
PF08543(Phos_pyr_kin) | 5 | HIS A 43THR A 44GLN A 45TYR A 82ASP A 223 | NoneNoneNoneNoneSO4 A 288 (-3.4A) | 0.89A | 3mbhD-3pzsA:34.2 | 3mbhD-3pzsA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzs | PYRIDOXAMINE KINASE (Yersinia pestis) |
PF08543(Phos_pyr_kin) | 5 | SER A 9THR A 44GLN A 45TYR A 82ASP A 223 | NoneNoneNoneNoneSO4 A 288 (-3.4A) | 1.44A | 3mbhD-3pzsA:34.2 | 3mbhD-3pzsA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r8e | HYPOTHETICAL SUGARKINASE (Cytophagahutchinsonii) |
PF00480(ROK) | 5 | ASP A 215SER A 194LEU A 196THR A 182GLN A 185 | None | 1.13A | 3mbhD-3r8eA:undetectable | 3mbhD-3r8eA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 5 | ASP A 278SER A 245VAL A 243THR A 155VAL A 103 | FMN A 401 (-2.8A)FMN A 401 (-3.4A)NoneFMN A 401 (-2.8A)None | 1.31A | 3mbhD-3sgzA:undetectable | 3mbhD-3sgzA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va9 | SENSOR HISTIDINEKINASE (Rhodopseudomonaspalustris) |
PF05227(CHASE3) | 5 | SER A 160VAL A 163LEU A 116HIS A 112GLN A 109 | None | 1.41A | 3mbhD-3va9A:undetectable | 3mbhD-3va9A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zs7 | PYRIDOXAL KINASE (Trypanosomabrucei) |
PF08543(Phos_pyr_kin) | 5 | VAL A 18HIS A 45TYR A 84VAL A 119ASP A 229 | NoneNoneNoneATP A1301 ( 3.9A)ATP A1301 ( 4.5A) | 0.63A | 3mbhD-3zs7A:33.1 | 3mbhD-3zs7A:27.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmb | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | VAL A 62HIS A 65GLN A 47VAL A 20TYR A 141 | NoneLAT A1155 (-3.9A) NA A1156 (-3.3A)NoneGOL A1157 (-3.6A) | 1.49A | 3mbhD-4bmbA:undetectable | 3mbhD-4bmbA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcm | CYCLODEXTRINGLUCANOTRANSFERASE ([Bacillus]clarkii) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | VAL A 449LEU A 420THR A 341VAL A 477ASP A 448 | None | 1.45A | 3mbhD-4jcmA:undetectable | 3mbhD-4jcmA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6l | PUTATIVEPERTUSSIS-LIKE TOXINSUBUNIT (Salmonellaenterica) |
PF02917(Pertussis_S1) | 5 | VAL G 149GLN G 96VAL G 72TYR G 23ASP G 162 | None | 1.34A | 3mbhD-4k6lG:undetectable | 3mbhD-4k6lG:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbr | HYPOTHETICAL3-OXOACYL-(ACYL-CARRIER PROTEIN)REDUCTASE (Brucellaabortus) |
PF13561(adh_short_C2) | 5 | ASP A 77VAL A 129SER A 79LEU A 51ASP A 128 | None | 1.20A | 3mbhD-4nbrA:6.7 | 3mbhD-4nbrA:20.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4s1i | PYRIDOXAL KINASE (Entamoebahistolytica) |
PF08543(Phos_pyr_kin) | 7 | VAL B 17LEU B 41HIS B 44THR B 45TYR B 83TYR B 121ASP B 218 | PLP B 302 (-4.4A)PLP B 302 (-4.9A)PLP B 302 (-3.8A)PLP B 302 (-3.2A)PLP B 302 (-3.8A)PLP B 302 ( 4.0A)PLP B 302 (-3.5A) | 0.62A | 3mbhD-4s1iB:33.8 | 3mbhD-4s1iB:30.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tz5 | PUTATIVE SECRETEDPROTEIN (Streptomycessp. SirexAA-E) |
no annotation | 5 | VAL A 467LEU A 477THR A 496TYR A 524VAL A 526 | None | 1.49A | 3mbhD-4tz5A:undetectable | 3mbhD-4tz5A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvw | GALECTIN (Gallus gallus) |
PF00337(Gal-bind_lectin) | 5 | VAL A 61HIS A 64GLN A 46VAL A 19TYR A 140 | NoneSLT A 201 (-3.9A)SLT A 201 (-3.4A)NoneNone | 1.45A | 3mbhD-4wvwA:undetectable | 3mbhD-4wvwA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xmm | NUCLEOPORIN NUP120 (Saccharomycescerevisiae) |
no annotation | 5 | HIS E 151THR E 130GLN E 132TYR E 194ASP E 190 | None | 1.15A | 3mbhD-4xmmE:undetectable | 3mbhD-4xmmE:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xmm | NUCLEOPORIN NUP120 (Saccharomycescerevisiae) |
no annotation | 5 | VAL E 192HIS E 151THR E 130GLN E 132ASP E 190 | None | 1.40A | 3mbhD-4xmmE:undetectable | 3mbhD-4xmmE:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b6a | PYRIDOXAL KINASEPDXY (Pseudomonasaeruginosa) |
PF08543(Phos_pyr_kin) | 5 | HIS A 46THR A 47GLN A 48VAL A 116ASP A 225 | NoneTRS A 301 (-3.0A)None MG A 302 (-4.8A) MG A 302 (-3.0A) | 0.69A | 3mbhD-5b6aA:34.4 | 3mbhD-5b6aA:26.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3c | DIPEPTIDYL PEPTIDASE3 (Homo sapiens) |
PF03571(Peptidase_M49) | 5 | VAL A 126LEU A 80HIS A 78GLN A 70TYR A 89 | None | 1.45A | 3mbhD-5e3cA:undetectable | 3mbhD-5e3cA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9u | GLYCOSYLTRANSFERASE-STABILIZING PROTEINGTF2 (Streptococcusgordonii) |
no annotation | 5 | ASP B 6SER B 198SER B 202TYR B 201VAL B 177 | None | 1.28A | 3mbhD-5e9uB:3.5 | 3mbhD-5e9uB:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fur | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 2 (Homo sapiens) |
no annotation | 5 | SER I 321SER I 349LEU I 330THR I 306VAL I 287 | None | 1.24A | 3mbhD-5furI:undetectable | 3mbhD-5furI:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzg | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | VAL A 62HIS A 65GLN A 47VAL A 20TYR A 141 | NoneLAT A 201 (-3.9A) NA A 202 (-3.3A)NoneNone | 1.48A | 3mbhD-5gzgA:undetectable | 3mbhD-5gzgA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of3 | UNCHARACTERIZEDPROTEIN (Sulfolobussolfataricus) |
no annotation | 5 | VAL C 79LEU C 64TYR C 83VAL C 87TYR C 57 | None | 1.35A | 3mbhD-5of3C:undetectable | 3mbhD-5of3C:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5trw | PYRIDOXAL KINASEPDXY (Paraburkholderiaxenovorans) |
PF08543(Phos_pyr_kin) | 5 | HIS A 44GLN A 46TYR A 83VAL A 114ASP A 222 | None | 0.83A | 3mbhD-5trwA:33.4 | 3mbhD-5trwA:24.68 |