SIMILAR PATTERNS OF AMINO ACIDS FOR 3MBH_C_PXLC400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 VAL A 136
LEU A 160
THR A 163
VAL A  95
TYR A  99
 None
 1.27A 3mbhC-1gjvA:
undetectable		 3mbhC-1gjvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		5 ASP A  38
SER A  11
LEU A  13
GLN A 153
VAL A  45
 None
SO4  A1224 ( 4.6A)
None
None
None
 1.26A 3mbhC-1h1yA:
undetectable		 3mbhC-1h1yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 ASP A 410
VAL A 395
SER A 414
HIS A 291
VAL A 314
 None
 1.17A 3mbhC-1itxA:
undetectable		 3mbhC-1itxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 ASP A 295
SER A 205
LEU A 297
THR A 315
GLN A 316
 None
 1.35A 3mbhC-1oltA:
4.3		 3mbhC-1oltA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		6 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.33A 3mbhC-1td2A:
34.0		 3mbhC-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 SER A  10
HIS A  44
THR A  45
GLN A  46
VAL A 114
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
None
 1.26A 3mbhC-1td2A:
34.0		 3mbhC-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		5 ASP A  38
SER A  11
LEU A  13
GLN A 154
VAL A  45
 ZN  A 900 (-2.6A)
None
None
None
None
 1.35A 3mbhC-1tqxA:
undetectable		 3mbhC-1tqxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 ASP A 244
SER A 272
VAL A 275
THR A 160
TYR A 162
 None
None
None
None
IFM  A 383 (-4.3A)
 1.39A 3mbhC-1up2A:
2.1		 3mbhC-1up2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 VAL A  30
LEU A  54
TYR A  96
VAL A 127
ASP A 233
 PXL  A1003 ( 4.3A)
PXL  A1003 ( 4.9A)
PXL  A1003 ( 3.9A)
None
PXL  A1003 (-3.7A)
 0.84A 3mbhC-2ddwA:
29.5		 3mbhC-2ddwA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		5 ASP A 233
VAL A 253
SER A 252
HIS A 244
TYR A 250
 None
 1.33A 3mbhC-2g6tA:
3.6		 3mbhC-2g6tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbz OLIGORIBONUCLEASE

(Xanthomonas
campestris) 		PF00929
(RNase_T) 		5 ASP A 169
SER A 165
SER A 158
HIS A 161
GLN A  68
 None
 1.43A 3mbhC-2gbzA:
undetectable		 3mbhC-2gbzA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ASP A 178
LEU A 204
THR A 189
VAL A 182
TYR A 187
 None
 1.47A 3mbhC-2w1jA:
undetectable		 3mbhC-2w1jA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		5 SER A 177
SER A 175
THR A 134
TYR A 132
ASP A 174
 None
 1.14A 3mbhC-2w1vA:
3.8		 3mbhC-2w1vA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N)
no annotation 		5 VAL C 110
LEU C  91
THR M 790
GLN M 791
VAL C 123
 None
 1.23A 3mbhC-2w4gC:
undetectable		 3mbhC-2w4gC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr4 LECTIN

(Burkholderia
cenocepacia) 		PF07472
(PA-IIL) 		5 ASP A  97
SER A  95
VAL A  68
SER A  75
THR A  20
 None
 1.26A 3mbhC-2xr4A:
undetectable		 3mbhC-2xr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		5 ASP A 106
SER A 100
SER A  18
TYR A  27
VAL A  45
 SRO  A 158 (-3.2A)
None
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
None
 1.46A 3mbhC-3brnA:
undetectable		 3mbhC-3brnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASP A 199
SER A 278
HIS A 325
THR A 350
GLN A 349
 None
 1.24A 3mbhC-3ddrA:
undetectable		 3mbhC-3ddrA:
16.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		8 ASP A   9
SER A  11
SER A  17
LEU A  40
HIS A  43
THR A  44
VAL A 107
ASP A 213
 None
 0.95A 3mbhC-3h74A:
33.4		 3mbhC-3h74A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		6 ASP A   9
SER A  17
LEU A  40
TYR A  80
VAL A 107
ASP A 213
 None
 0.91A 3mbhC-3h74A:
33.4		 3mbhC-3h74A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		5 ASP A   9
TYR A  80
VAL A 107
TYR A 115
ASP A 213
 None
 0.91A 3mbhC-3h74A:
33.4		 3mbhC-3h74A:
33.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 VAL A1011
LEU A1071
THR A1191
VAL A 824
ASP A1012
 None
 1.39A 3mbhC-3jb9A:
undetectable		 3mbhC-3jb9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 SER A 413
SER A 417
LEU A 411
THR A 375
ASP A 434
 None
 1.48A 3mbhC-3ngoA:
undetectable		 3mbhC-3ngoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE

(Sphaerobacter
thermophilus) 		PF07228
(SpoIIE) 		5 ASP A  96
VAL A 115
SER A 113
LEU A 158
GLN A 127
 None
 1.32A 3mbhC-3pu9A:
2.1		 3mbhC-3pu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		5 HIS A  43
GLN A  45
TYR A  82
VAL A 113
ASP A 223
 None
None
None
None
SO4  A 288 (-3.4A)
 0.73A 3mbhC-3pzsA:
34.4		 3mbhC-3pzsA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		5 HIS A  43
THR A  44
GLN A  45
TYR A  82
ASP A 223
 None
None
None
None
SO4  A 288 (-3.4A)
 0.89A 3mbhC-3pzsA:
34.4		 3mbhC-3pzsA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		5 SER A   9
THR A  44
GLN A  45
TYR A  82
ASP A 223
 None
None
None
None
SO4  A 288 (-3.4A)
 1.39A 3mbhC-3pzsA:
34.4		 3mbhC-3pzsA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		5 ASP A 215
SER A 194
LEU A 196
THR A 182
GLN A 185
 None
 1.15A 3mbhC-3r8eA:
undetectable		 3mbhC-3r8eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.30A 3mbhC-3sgzA:
undetectable		 3mbhC-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va9 SENSOR HISTIDINE
KINASE

(Rhodopseudomonas
palustris) 		PF05227
(CHASE3) 		5 SER A 160
VAL A 163
LEU A 116
HIS A 112
GLN A 109
 None
 1.44A 3mbhC-3va9A:
undetectable		 3mbhC-3va9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		5 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.61A 3mbhC-3zs7A:
33.1		 3mbhC-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A1155 (-3.9A)
NA  A1156 (-3.3A)
None
GOL  A1157 (-3.6A)
 1.46A 3mbhC-4bmbA:
undetectable		 3mbhC-4bmbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		5 SER A 203
VAL A  99
LEU A 205
THR A 209
ASP A  97
 None
 1.11A 3mbhC-4fn4A:
6.8		 3mbhC-4fn4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		5 ASP A  57
SER A 178
LEU A 161
GLN A 154
TYR A  20
 None
 1.49A 3mbhC-4ibnA:
undetectable		 3mbhC-4ibnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 VAL A 449
LEU A 420
THR A 341
VAL A 477
ASP A 448
 None
 1.47A 3mbhC-4jcmA:
2.9		 3mbhC-4jcmA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1) 		5 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
 None
 1.36A 3mbhC-4k6lG:
undetectable		 3mbhC-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 ASP A  77
VAL A 129
SER A  79
LEU A  51
ASP A 128
 None
 1.20A 3mbhC-4nbrA:
6.8		 3mbhC-4nbrA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		7 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.61A 3mbhC-4s1iB:
33.8		 3mbhC-4s1iB:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.42A 3mbhC-4wvwA:
undetectable		 3mbhC-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 5 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.12A 3mbhC-4xmmE:
undetectable		 3mbhC-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 5 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.41A 3mbhC-4xmmE:
undetectable		 3mbhC-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		5 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.66A 3mbhC-5b6aA:
34.8		 3mbhC-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.43A 3mbhC-5e3cA:
undetectable		 3mbhC-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 5 ASP B   6
SER B 198
SER B 202
TYR B 201
VAL B 177
 None
 1.29A 3mbhC-5e9uB:
3.4		 3mbhC-5e9uB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 5 SER I 321
SER I 349
LEU I 330
THR I 306
VAL I 287
 None
 1.24A 3mbhC-5furI:
undetectable		 3mbhC-5furI:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzg GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.45A 3mbhC-5gzgA:
undetectable		 3mbhC-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 SER A  58
VAL A  60
SER A  55
THR A 151
VAL A 127
 None
 1.25A 3mbhC-5inrA:
undetectable		 3mbhC-5inrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of3 UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		no annotation 5 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.33A 3mbhC-5of3C:
undetectable		 3mbhC-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		5 ASP A 709
SER A 710
LEU A 959
THR A 956
VAL A 978
 None
 1.39A 3mbhC-5tj6A:
3.1		 3mbhC-5tj6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		5 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.81A 3mbhC-5trwA:
33.7		 3mbhC-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		5 HIS A  44
THR A  45
GLN A  46
VAL A 114
ASP A 222
 None
 0.72A 3mbhC-5trwA:
33.7		 3mbhC-5trwA:
24.68