SIMILAR PATTERNS OF AMINO ACIDS FOR 3MBG_A_ACTA206

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 118
ARG A 157
THR A 114
ALA A 156
 None
 1.41A 3mbgA-1gycA:
undetectable		 3mbgA-1gycA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		4 ASP A 157
ARG A 159
THR A 182
ALA A 185
 None
 1.35A 3mbgA-2cc1A:
0.0		 3mbgA-2cc1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		4 ASP A 247
ARG A 246
THR A 180
ALA A 164
 None
 1.27A 3mbgA-2vdtA:
undetectable		 3mbgA-2vdtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		4 ASP A  23
ARG A  26
THR A  30
ALA A  27
 CA  A 401 (-3.0A)
MES  A 301 (-3.7A)
None
MES  A 301 (-4.6A)
 1.28A 3mbgA-2z0jA:
0.0		 3mbgA-2z0jA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 139
ARG A 178
THR A 135
ALA A 177
 None
 1.40A 3mbgA-3x1bA:
undetectable		 3mbgA-3x1bA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ASP A 619
ARG A 510
THR A 614
ALA A 615
 None
 1.40A 3mbgA-4j3bA:
0.1		 3mbgA-4j3bA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 ASP A 251
ARG A 250
THR A 254
ALA A 256
 None
 1.19A 3mbgA-4mx8A:
undetectable		 3mbgA-4mx8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxh BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD9

(Homo sapiens) 		PF02214
(BTB_2) 		4 ASP A  46
ARG A  48
THR A   7
ALA A  50
 None
 1.43A 3mbgA-5bxhA:
undetectable		 3mbgA-5bxhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 118
ARG A 157
THR A 114
ALA A 156
 None
 1.34A 3mbgA-5ehfA:
undetectable		 3mbgA-5ehfA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 ASP A 106
ARG A  52
THR A  50
ALA A  39
 None
 1.41A 3mbgA-5infA:
0.0		 3mbgA-5infA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ASP A 265
ARG A 365
THR A 367
ALA A 225
 None
 1.48A 3mbgA-5xmjA:
0.0		 3mbgA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 ASP D  80
ARG D  73
THR D  70
ALA D  69
 None
 1.47A 3mbgA-6fosD:
undetectable		 3mbgA-6fosD:
undetectable