SIMILAR PATTERNS OF AMINO ACIDS FOR 3MB5_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 321
GLU A 388
ASP A 390
ASP A 434
 None
 1.39A 3mb5A-1aqlA:
undetectable		 3mb5A-1aqlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		4 GLY A 226
GLU A 319
ASP A 312
ASP A 228
 None
 1.16A 3mb5A-1bw0A:
4.6		 3mb5A-1bw0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 GLY A  34
GLU A 238
ASP A  30
ASP A  38
 GDP  A 500 (-3.6A)
None
GDP  A 500 (-4.3A)
None
 1.42A 3mb5A-1dj3A:
2.2		 3mb5A-1dj3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 GLY A  82
GLU A 105
ASP A 130
ASP A 150
 None
 0.92A 3mb5A-1fbnA:
17.5		 3mb5A-1fbnA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLY A 107
GLU A 131
ASP A 161
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.36A 3mb5A-1i9gA:
29.8		 3mb5A-1i9gA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 GLY A  67
GLU A  61
ASP A  35
ASP A  68
 None
 1.28A 3mb5A-1j5tA:
undetectable		 3mb5A-1j5tA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 GLY H 255
GLU H 253
ASP H 250
ASP H 259
 None
 1.06A 3mb5A-1mdaH:
undetectable		 3mb5A-1mdaH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  82
GLU A 104
ASP A 141
ASP A 158
 None
 0.83A 3mb5A-1mjfA:
14.1		 3mb5A-1mjfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 GLY A  65
GLU A  88
ASP A 113
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.7A)
 0.48A 3mb5A-1nt2A:
16.3		 3mb5A-1nt2A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A1004 (-3.9A)
NA  A1004 (-4.2A)
None
None
 1.16A 3mb5A-1o4zA:
undetectable		 3mb5A-1o4zA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLY A 108
GLU A 132
ASP A 160
ASP A 176
 None
 0.39A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1roe FERREDOXIN

(Synechococcus
elongatus) 		PF00111
(Fer2) 		4 GLY A  55
GLU A  56
ASP A  58
ASP A  85
 None
 1.39A 3mb5A-1roeA:
undetectable		 3mb5A-1roeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		4 GLY A 218
GLU A 225
ASP A 253
ASP A 215
 None
None
MG  A 500 (-3.3A)
None
 1.43A 3mb5A-1t5jA:
undetectable		 3mb5A-1t5jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 GLY A 104
GLU A 129
ASP A 146
ASP A  83
 CA  A1237 ( 4.3A)
None
None
None
 1.33A 3mb5A-1v6mA:
undetectable		 3mb5A-1v6mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		4 GLY A 235
GLU A 236
ASP A 219
ASP A 234
 None
 1.25A 3mb5A-1xcoA:
3.4		 3mb5A-1xcoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 GLY A 223
GLU A 127
ASP A 125
ASP A 225
 None
 1.29A 3mb5A-1xfiA:
5.0		 3mb5A-1xfiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 128
GLU A 151
ASP A 182
ASP A 201
 None
 0.91A 3mb5A-1xj5A:
14.1		 3mb5A-1xj5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		4 GLY A 148
GLU A 264
ASP A 143
ASP A 157
 None
 1.30A 3mb5A-1y56A:
3.7		 3mb5A-1y56A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		4 GLY A  98
GLU A 122
ASP A 150
ASP A 166
 None
 0.57A 3mb5A-1yb2A:
19.5		 3mb5A-1yb2A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb3 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF11447
(DUF3201) 		4 GLY A  48
GLU A 117
ASP A 112
ASP A  47
 None
 1.33A 3mb5A-1yb3A:
undetectable		 3mb5A-1yb3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 GLY A 111
GLU A 135
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.36A 3mb5A-2b25A:
23.8		 3mb5A-2b25A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		4 GLY A 138
GLU A 140
ASP A 106
ASP A 137
 None
None
CA  A 195 ( 2.5A)
None
 1.22A 3mb5A-2ervA:
undetectable		 3mb5A-2ervA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwo DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13

(Homo sapiens) 		PF00782
(DSPc) 		4 GLY A  81
GLU A 103
ASP A 105
ASP A  86
 None
 1.42A 3mb5A-2gwoA:
undetectable		 3mb5A-2gwoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		4 GLY A 168
GLU A 192
ASP A 217
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
 0.38A 3mb5A-2ipxA:
17.6		 3mb5A-2ipxA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 251
GLU A 252
ASP A  73
ASP A 222
 None
 1.36A 3mb5A-2lgzA:
undetectable		 3mb5A-2lgzA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7z CD63-LIKE PROTEIN
SM-TSP-2

(Schistosoma
mansoni) 		PF00335
(Tetraspannin) 		4 GLY A  69
GLU A  68
ASP A  76
ASP A  46
 None
 1.36A 3mb5A-2m7zA:
undetectable		 3mb5A-2m7zA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 GLY A  30
GLU A  17
ASP A  34
ASP A  29
 CA  A 202 (-4.4A)
CA  A 202 (-3.4A)
None
None
 1.35A 3mb5A-2ml1A:
undetectable		 3mb5A-2ml1A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2e NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 4 GLY A 196
GLU A 197
ASP A 155
ASP A 194
 None
 1.19A 3mb5A-2n2eA:
undetectable		 3mb5A-2n2eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		4 GLY A  41
GLU A  44
ASP A  46
ASP A  59
 None
 1.29A 3mb5A-2p1gA:
undetectable		 3mb5A-2p1gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.75A 3mb5A-2pt6A:
12.8		 3mb5A-2pt6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		4 GLY A 263
GLU A 262
ASP A 241
ASP A 264
 None
 1.33A 3mb5A-2qczA:
undetectable		 3mb5A-2qczA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 GLY A  86
GLU A 121
ASP A 176
ASP A 198
 None
 0.63A 3mb5A-2qy6A:
11.2		 3mb5A-2qy6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 112
GLU A 111
ASP A 105
ASP A 116
 None
 1.43A 3mb5A-2wbaA:
2.9		 3mb5A-2wbaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A  56
GLU A  57
ASP A  59
ASP A  98
 None
 1.40A 3mb5A-2wdwA:
undetectable		 3mb5A-2wdwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 GLY B 372
GLU B 347
ASP B 378
ASP B 431
 None
 1.38A 3mb5A-2wfxB:
undetectable		 3mb5A-2wfxB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 546
GLU A 147
ASP A 542
ASP A 547
 None
 1.09A 3mb5A-2wk2A:
undetectable		 3mb5A-2wk2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yue PROTEIN NEURALIZED

(Drosophila
melanogaster) 		PF07177
(Neuralized) 		4 GLY A  25
GLU A 158
ASP A 161
ASP A  24
 None
 1.38A 3mb5A-2yueA:
undetectable		 3mb5A-2yueA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 GLY A  99
GLU A 120
ASP A 148
ASP A 165
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.4A)
 0.33A 3mb5A-2yvlA:
25.5		 3mb5A-2yvlA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.62A 3mb5A-2zsuA:
14.3		 3mb5A-2zsuA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 198
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.81A 3mb5A-3c6mA:
14.7		 3mb5A-3c6mA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN

(Mus musculus) 		PF13806
(Rieske_2) 		4 GLY A 127
GLU A  23
ASP A  25
ASP A 125
 None
 1.33A 3mb5A-3d89A:
undetectable		 3mb5A-3d89A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 318
GLU A 322
ASP A 342
ASP A 315
 None
 1.42A 3mb5A-3e9yA:
4.4		 3mb5A-3e9yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 GLY X  45
GLU X  43
ASP X   8
ASP X  53
 None
 1.34A 3mb5A-3ewbX:
undetectable		 3mb5A-3ewbX:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		4 GLY A  34
GLU A   9
ASP A 160
ASP A  13
 None
 1.30A 3mb5A-3ewmA:
3.5		 3mb5A-3ewmA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 GLY A  94
GLU A 117
ASP A 144
ASP A 163
 None
FMT  A 315 (-3.6A)
None
None
 0.66A 3mb5A-3gjyA:
13.9		 3mb5A-3gjyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 479
GLU B 552
ASP B  33
ASP B 571
 None
 1.30A 3mb5A-3hkzB:
undetectable		 3mb5A-3hkzB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLU A  70
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 0.56A 3mb5A-3ihtA:
11.2		 3mb5A-3ihtA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 GLY A  87
GLU A  56
ASP A  61
ASP A  90
 None
TRS  A 157 (-2.8A)
None
None
 1.42A 3mb5A-3kipA:
undetectable		 3mb5A-3kipA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus) 		PF05708
(Peptidase_C92) 		4 GLY A   2
GLU A 180
ASP A 185
ASP A   4
 None
 1.26A 3mb5A-3kw0A:
undetectable		 3mb5A-3kw0A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLY A 101
GLU A 125
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.23A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		4 GLY A 261
GLU A 282
ASP A 221
ASP A 260
 None
 1.28A 3mb5A-3licA:
undetectable		 3mb5A-3licA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 GLY A  99
GLU A 119
ASP A 148
ASP A 167
 None
None
None
EDO  A 507 (-4.1A)
 1.25A 3mb5A-3ll7A:
13.1		 3mb5A-3ll7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		4 GLY A  37
GLU A  79
ASP A   8
ASP A  38
 None
 1.02A 3mb5A-3lmbA:
undetectable		 3mb5A-3lmbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLY A 491
GLU A 493
ASP A 513
ASP A 462
 None
 1.38A 3mb5A-3muoA:
undetectable		 3mb5A-3muoA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngh PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		4 GLY A   6
GLU A 108
ASP A 106
ASP A  88
 None
 1.28A 3mb5A-3nghA:
undetectable		 3mb5A-3nghA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.46A 3mb5A-3ps9A:
10.5		 3mb5A-3ps9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
ASP A 156
ASP A 178
 None
 0.52A 3mb5A-3pvcA:
11.6		 3mb5A-3pvcA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 101
GLU A 124
ASP A 155
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.0A)
 0.68A 3mb5A-3rw9A:
12.9		 3mb5A-3rw9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 320
GLU A 322
ASP A 385
ASP A 296
 None
None
None
C8E  A 471 ( 4.8A)
 1.40A 3mb5A-3sybA:
undetectable		 3mb5A-3sybA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 320
GLU A 322
ASP A 385
ASP A 319
 None
 1.16A 3mb5A-3sybA:
undetectable		 3mb5A-3sybA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 GLY A 123
GLU A 124
ASP A  22
ASP A 272
 None
 1.42A 3mb5A-3uboA:
3.9		 3mb5A-3uboA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 104
GLU A 133
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.47A 3mb5A-3vywA:
11.5		 3mb5A-3vywA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLY A 555
GLU A 559
ASP A 440
ASP A 518
 None
 1.40A 3mb5A-3w5nA:
undetectable		 3mb5A-3w5nA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 308
GLU A 281
ASP A 286
ASP A 332
 None
 0.98A 3mb5A-4a35A:
undetectable		 3mb5A-4a35A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A 500 (-4.0A)
NA  A 500 (-3.8A)
None
None
 1.17A 3mb5A-4atfA:
undetectable		 3mb5A-4atfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C  16
GLU C 207
ASP C 204
ASP C 262
 None
 1.42A 3mb5A-4b3iC:
undetectable		 3mb5A-4b3iC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		4 GLY E  81
GLU E 105
ASP E 130
ASP E 150
 None
None
None
C  X   5 ( 3.2A)
 0.60A 3mb5A-4by9E:
14.5		 3mb5A-4by9E:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 GLY A 199
GLU A 184
ASP A 201
ASP A 197
 None
 1.27A 3mb5A-4cvuA:
undetectable		 3mb5A-4cvuA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		4 GLY A  85
GLU A 109
ASP A 134
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
 0.32A 3mb5A-4df3A:
17.4		 3mb5A-4df3A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		4 GLY A 486
GLU A 487
ASP A 494
ASP A 518
 None
 1.41A 3mb5A-4ebaA:
undetectable		 3mb5A-4ebaA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 149
GLU A 148
ASP A 195
ASP A 151
 None
 1.41A 3mb5A-4fozA:
undetectable		 3mb5A-4fozA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 254
GLU A 230
ASP A 235
ASP A 278
 None
MG  A 405 ( 4.8A)
None
None
 0.96A 3mb5A-4h19A:
undetectable		 3mb5A-4h19A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 233
GLU A 221
ASP A 237
ASP A 231
 None
 1.12A 3mb5A-4k2bA:
3.3		 3mb5A-4k2bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN B CHAIN
GLOBIN C CHAIN

(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		PF00042
(Globin)
PF00042
(Globin) 		4 GLY C  62
GLU C  61
ASP C  58
ASP B  82
 None
 1.21A 3mb5A-4u8uC:
2.3		 3mb5A-4u8uC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
 0.76A 3mb5A-4uoeA:
12.5		 3mb5A-4uoeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
RIBOSOME BIOGENESIS
PROTEIN (RRS1),
PUTATIVE
(AFU_ORTHOLOGUE
AFUA_7G04430)

(Aspergillus
nidulans;
Aspergillus
nidulans) 		PF04427
(Brix)
PF04939
(RRS1) 		4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-4xd9A:
undetectable		 3mb5A-4xd9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		4 GLY A 108
GLU A 110
ASP A 112
ASP A 154
 None
 1.24A 3mb5A-4z48A:
undetectable		 3mb5A-4z48A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 GLY A 191
GLU A 144
ASP A 171
ASP A 194
 None
 1.26A 3mb5A-4zm4A:
2.7		 3mb5A-4zm4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2
RRS1

(Aspergillus
nidulans;
Aspergillus
nidulans) 		PF04427
(Brix)
PF04939
(RRS1) 		4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-5by8A:
undetectable		 3mb5A-5by8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 GLY A 111
GLU A 135
ASP A 163
ASP A 181
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.7A)
SAH  A 301 (-2.4A)
 0.26A 3mb5A-5ccxA:
22.6		 3mb5A-5ccxA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		4 GLY A 116
GLU A  26
ASP A 268
ASP A 118
 None
 1.29A 3mb5A-5d6oA:
undetectable		 3mb5A-5d6oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 535
GLU A 138
ASP A 531
ASP A 536
 None
 1.15A 3mb5A-5df0A:
undetectable		 3mb5A-5df0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		4 GLY A 113
GLU A  24
ASP A 265
ASP A 115
 None
 1.28A 3mb5A-5e4yA:
undetectable		 3mb5A-5e4yA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 GLY B 118
GLU B 139
ASP B 168
ASP B 203
 SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
 0.30A 3mb5A-5ergB:
22.2		 3mb5A-5ergB:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY B 268
GLU B 270
ASP B 262
ASP B  17
 None
 1.18A 3mb5A-5fwxB:
5.0		 3mb5A-5fwxB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		4 GLY E  84
GLU E 108
ASP E 133
ASP E 153
 SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
 0.42A 3mb5A-5ginE:
17.3		 3mb5A-5ginE:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 539
GLU A 140
ASP A 535
ASP A 540
 GLY  A 539 ( 0.0A)
GLU  A 140 ( 0.6A)
ASP  A 535 ( 0.6A)
ASP  A 540 ( 0.5A)
 1.26A 3mb5A-5gprA:
undetectable		 3mb5A-5gprA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLY A 175
GLU A 177
ASP A 893
ASP A 174
 None
 1.34A 3mb5A-5j6sA:
undetectable		 3mb5A-5j6sA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		4 GLY A  54
GLU A  71
ASP A 286
ASP A 107
 None
 1.42A 3mb5A-5j9rA:
undetectable		 3mb5A-5j9rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		4 GLY C 263
GLU A 283
ASP C 241
ASP C 283
 None
 1.18A 3mb5A-5k1cC:
undetectable		 3mb5A-5k1cC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A  53
GLU A  56
ASP A 574
ASP A  47
 None
 1.41A 3mb5A-5lewA:
2.0		 3mb5A-5lewA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 4 GLY H  15
GLU H 218
ASP H 215
ASP H 252
 None
 1.30A 3mb5A-5lp7H:
undetectable		 3mb5A-5lp7H:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 451
GLU A 159
ASP A 161
ASP A 447
 AYE  A 602 (-4.7A)
AYE  A 602 (-3.5A)
None
None
 1.32A 3mb5A-5ohkA:
undetectable		 3mb5A-5ohkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLY A 212
GLU A 186
ASP A 176
ASP A 213
 None
None
K  A 402 (-3.4A)
None
 1.38A 3mb5A-5vi6A:
4.0		 3mb5A-5vi6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A  17
GLU A 142
ASP A 113
ASP A  18
 None
 1.19A 3mb5A-5vk4A:
undetectable		 3mb5A-5vk4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		4 GLY A 501
GLU A 524
ASP A 551
ASP A 575
 SAH  A 705 (-3.5A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 0.47A 3mb5A-5wcjA:
15.4		 3mb5A-5wcjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 GLY A 548
GLU A 147
ASP A 544
ASP A 549
 None
GOL  A 704 ( 4.5A)
None
GOL  A 701 ( 4.1A)
 1.08A 3mb5A-5zl9A:
undetectable		 3mb5A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 4 GLY A  62
GLU A  85
ASP A 113
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.37A 3mb5A-5zw4A:
18.7		 3mb5A-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 4 GLY A 426
GLU A 441
ASP A 443
ASP A 408
 None
None
None
AMP  A 600 (-2.8A)
 1.39A 3mb5A-6avhA:
undetectable		 3mb5A-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 GLY A  21
GLU A  10
ASP A 151
ASP A  22
 None
QPS  A 602 ( 4.5A)
QPS  A 602 (-3.3A)
ADP  A 601 ( 4.6A)
 0.89A 3mb5A-6gnfA:
4.2		 3mb5A-6gnfA:
undetectable