SIMILAR PATTERNS OF AMINO ACIDS FOR 3MB5_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 221
GLY A 156
LEU A 154
ILE A 159
LEU A 216
 None
 1.03A 3mb5A-1bucA:
undetectable		 3mb5A-1bucA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 191
GLY A 121
ALA A 123
ILE A 218
PRO A 364
 None
FAD  A 510 (-4.1A)
None
FAD  A 510 ( 4.6A)
AND  A 508 ( 4.6A)
 0.96A 3mb5A-1coyA:
3.2		 3mb5A-1coyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 310
VAL A 309
GLY A 533
ALA A 531
ILE A 550
 None
None
FAD  A 600 (-3.5A)
None
FAD  A 600 (-4.3A)
 0.85A 3mb5A-1d4eA:
3.1		 3mb5A-1d4eA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 ILE A  13
VAL A  14
LEU A 333
ARG A 337
ILE A 399
 None
 0.94A 3mb5A-1dkpA:
undetectable		 3mb5A-1dkpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		5 ILE A  72
GLY A  16
ILE A 180
ILE A 176
PRO A 205
 None
 0.96A 3mb5A-1ekeA:
undetectable		 3mb5A-1ekeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN

(Sus scrofa;
Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin)
PF00089
(Trypsin) 		5 ILE C 212
VAL C 213
GLY A  44
ALA A  55
ILE B  73
 None
 0.97A 3mb5A-1eptC:
undetectable		 3mb5A-1eptC:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ILE E 212
VAL E 213
GLY E  44
ALA E  55
ILE E  73
 None
 1.01A 3mb5A-1h9hE:
undetectable		 3mb5A-1h9hE:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		5 ALA A 162
LEU A 160
ILE A 348
ARG A 344
LEU A 151
 None
None
None
GLC  A 671 (-4.4A)
None
 0.99A 3mb5A-1hsjA:
undetectable		 3mb5A-1hsjA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 GLY A 109
SER A 110
ALA A 112
LEU A 113
ARG A 133
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
None
 0.29A 3mb5A-1i9gA:
29.8		 3mb5A-1i9gA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 ILE A  17
VAL A  16
GLY A 284
ALA A 327
LEU A 326
 None
 1.04A 3mb5A-1ituA:
undetectable		 3mb5A-1ituA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 ILE T 212
VAL T 213
GLY T  44
ALA T  55
ILE T  73
 None
ZEN  T   1 (-4.1A)
None
None
None
 0.97A 3mb5A-1j17T:
undetectable		 3mb5A-1j17T:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 ILE A 166
VAL A 143
ILE A  27
LEU A  40
PRO A  41
 None
 0.86A 3mb5A-1j31A:
undetectable		 3mb5A-1j31A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 ILE A 166
VAL A 143
ILE A 230
ILE A  27
LEU A  40
 None
 1.04A 3mb5A-1j31A:
undetectable		 3mb5A-1j31A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 344
VAL A 343
GLY A 427
LEU A 424
PRO A 322
 None
 0.93A 3mb5A-1j6uA:
5.9		 3mb5A-1j6uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		6 ILE A 634
SER A 635
ALA A 655
ILE A 323
TYR A  63
LEU A 321
 None
 1.42A 3mb5A-1lf9A:
undetectable		 3mb5A-1lf9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nze OXYGEN-EVOLVING
ENHANCER PROTEIN 3

(Spinacia
oleracea) 		PF05757
(PsbQ) 		5 VAL A  62
SER A  73
LEU A  78
ILE A 124
PRO A 127
 None
 0.89A 3mb5A-1nzeA:
undetectable		 3mb5A-1nzeA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		6 ILE A  83
VAL A  84
GLY A 110
ALA A 113
ILE A 161
PRO A 178
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 (-3.6A)
None
None
 0.53A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		6 ILE A  83
VAL A  84
GLY A 110
ALA A 113
ILE A 161
TYR A 183
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 (-3.6A)
None
None
 1.18A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		6 ILE A  83
VAL A  84
GLY A 110
SER A 111
ILE A 161
PRO A 178
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 ( 4.4A)
None
None
 0.87A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		6 ILE A  83
VAL A  84
GLY A 110
SER A 111
ILE A 161
TYR A 183
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 ( 4.4A)
None
None
 1.45A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A 162
VAL A 163
ALA A 137
LEU A 138
PRO A 167
 None
 0.98A 3mb5A-1rk2A:
4.1		 3mb5A-1rk2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
OKT3 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF16680
(Ig_4)
PF16681
(Ig_5)
PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  24
ARG A 186
ILE H  48
TYR H  60
LEU H  70
 None
 0.96A 3mb5A-1sy6H:
undetectable		 3mb5A-1sy6H:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 ILE A  88
VAL A  89
ALA A 119
LEU A 120
PRO A  93
 None
None
None
None
FMN  A 200 (-4.2A)
 1.02A 3mb5A-1t0iA:
2.4		 3mb5A-1t0iA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 6 VAL A 132
GLY A 115
ALA A 110
LEU A 109
LEU A 121
PRO A 163
 None
 1.29A 3mb5A-1ufoA:
3.1		 3mb5A-1ufoA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		5 ILE A 107
VAL A 106
GLY A 109
ALA A   7
ILE A  52
 None
 1.01A 3mb5A-1vh0A:
undetectable		 3mb5A-1vh0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		5 ILE A  43
VAL A  44
GLY A  41
ALA A  26
ILE A 135
 None
EDO  A 205 ( 4.7A)
None
None
None
 1.02A 3mb5A-1vraA:
undetectable		 3mb5A-1vraA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xat XENOBIOTIC
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep) 		5 VAL A 153
GLY A 120
SER A 139
ALA A 141
ILE A  59
 None
 0.98A 3mb5A-1xatA:
undetectable		 3mb5A-1xatA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		5 ILE A 137
VAL A 138
GLY A 135
LEU A 143
ILE A 154
 None
 1.05A 3mb5A-1xc3A:
undetectable		 3mb5A-1xc3A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 GLY A  30
SER A  31
LEU A  33
ILE A   5
ILE A  27
 NAP  A1500 (-4.2A)
NAP  A1500 (-2.7A)
None
None
None
 0.89A 3mb5A-2ahrA:
3.6		 3mb5A-2ahrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 ILE A 471
VAL A 472
ALA A 519
ILE A 497
LEU A 542
 None
 0.90A 3mb5A-2dkdA:
undetectable		 3mb5A-2dkdA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		5 VAL A  59
GLY A  28
SER A  27
ARG A 385
ILE A 389
 None
None
None
SO4  A 604 (-3.9A)
None
 1.04A 3mb5A-2dwcA:
3.9		 3mb5A-2dwcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		5 VAL A 202
GLY A 104
SER A 103
LEU A  94
ILE A  72
 None
 1.04A 3mb5A-2ewnA:
undetectable		 3mb5A-2ewnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		5 ILE A 208
VAL A 207
GLY A 201
ALA A 205
ILE A  83
 None
 1.00A 3mb5A-2ha9A:
undetectable		 3mb5A-2ha9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ILE A 127
VAL A  75
ALA A  73
ARG A 176
ILE A 179
 None
 1.04A 3mb5A-2hpiA:
undetectable		 3mb5A-2hpiA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iep MUSCLE-SPECIFIC
KINASE RECEPTOR

(Rattus
norvegicus) 		PF07679
(I-set) 		5 VAL A  37
ALA A 114
LEU A 115
ILE A  59
ILE A  77
 None
 1.00A 3mb5A-2iepA:
undetectable		 3mb5A-2iepA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE A  73
VAL A  51
GLY A  71
LEU A 483
ILE A 395
 None
 0.87A 3mb5A-2ifyA:
5.2		 3mb5A-2ifyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE

(Escherichia
coli) 		PF02611
(CDH) 		5 GLY A 208
SER A 209
ALA A 237
ILE A  84
LEU A  92
 None
 1.03A 3mb5A-2pofA:
undetectable		 3mb5A-2pofA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		5 VAL A  57
ALA A  59
LEU A  60
ILE A 281
LEU A 168
 None
 1.04A 3mb5A-2q7sA:
undetectable		 3mb5A-2q7sA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 ILE B 457
VAL B 458
GLY B 469
LEU B 466
LEU B 481
 None
 1.04A 3mb5A-2qm6B:
undetectable		 3mb5A-2qm6B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		5 ILE A  59
VAL A  58
GLY A  33
LEU A  30
PRO A  67
 None
 0.97A 3mb5A-2r3bA:
4.6		 3mb5A-2r3bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p AQUAPORIN PIP2-7
7


(Komagataella
pastoris) 		PF00230
(MIP) 		5 ILE A 204
GLY A  93
ILE A  88
ILE A  86
LEU A 213
 None
 0.98A 3mb5A-2w1pA:
undetectable		 3mb5A-2w1pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ILE A 601
GLY A 644
SER A 645
ARG A 676
ILE A 666
 None
 0.98A 3mb5A-2wl1A:
undetectable		 3mb5A-2wl1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		6 ILE A  60
VAL A  53
ALA A 153
LEU A 156
ILE A 121
LEU A 163
 None
 1.21A 3mb5A-2wnrA:
undetectable		 3mb5A-2wnrA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzl PHOSPHOPROTEIN

(Mokola
lyssavirus) 		PF03012
(PP_M1) 		5 SER A 294
ALA A 297
LEU A 299
ARG A 261
LEU A 258
 None
 1.03A 3mb5A-2wzlA:
undetectable		 3mb5A-2wzlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		6 VAL A 226
GLY A 220
ARG A 323
ILE A 358
TYR A 355
LEU A 193
 None
SF4  A 502 (-3.5A)
None
None
None
None
 1.44A 3mb5A-2xsjA:
undetectable		 3mb5A-2xsjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ALA A 188
LEU A 186
ILE A 374
ARG A 370
LEU A 177
 EDO  A1490 ( 3.7A)
None
None
MAL  A1488 (-4.3A)
None
 0.99A 3mb5A-2xz3A:
undetectable		 3mb5A-2xz3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		6 ILE A  74
GLY A 101
SER A 102
ALA A 104
LEU A 105
TYR A 172
 SAM  A 601 ( 4.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.6A)
SAM  A 601 (-4.0A)
 0.74A 3mb5A-2yvlA:
23.7		 3mb5A-2yvlA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		5 ILE A 130
GLY A 166
ALA A 168
LEU A 169
ILE A 183
 None
 1.00A 3mb5A-2zleA:
undetectable		 3mb5A-2zleA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zp2 KINASE A INHIBITOR

(Bacillus
subtilis) 		PF02682
(CT_C_D) 		5 ILE A 172
GLY A 178
ILE A 160
ILE A 131
LEU A 116
 None
 0.79A 3mb5A-2zp2A:
undetectable		 3mb5A-2zp2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 ALA A 162
LEU A 160
ILE A 348
ARG A 344
LEU A 151
 None
 1.05A 3mb5A-3a3cA:
undetectable		 3mb5A-3a3cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 399
ALA A 404
LEU A 401
ILE A 307
LEU A 336
 None
 1.05A 3mb5A-3aoeA:
undetectable		 3mb5A-3aoeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomyces
pombe) 		PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		5 ILE B  39
VAL B  38
ALA B  45
LEU B  44
ILE B 154
 None
 0.99A 3mb5A-3ayhB:
undetectable		 3mb5A-3ayhB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 ILE A  30
VAL A  31
ALA A  17
LEU A  18
PRO A  52
 None
 0.87A 3mb5A-3ba3A:
undetectable		 3mb5A-3ba3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		6 GLY A  94
ALA A  14
ARG A 184
ILE A  68
TYR A  53
LEU A 178
 None
 1.34A 3mb5A-3bc1A:
undetectable		 3mb5A-3bc1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 ILE A 128
VAL A 129
GLY A  94
LEU A  96
LEU A 178
 None
 0.88A 3mb5A-3bc1A:
undetectable		 3mb5A-3bc1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		5 ALA A  91
LEU A  90
ILE A 138
ILE A 120
PRO A  80
 None
 0.80A 3mb5A-3cpgA:
undetectable		 3mb5A-3cpgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  81
VAL A  80
GLY A  22
SER A  83
ARG A  49
 None
 1.00A 3mb5A-3e82A:
6.5		 3mb5A-3e82A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 VAL A  71
SER A  76
ALA A  74
ILE A 178
LEU A 128
 None
 1.01A 3mb5A-3edmA:
8.8		 3mb5A-3edmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 ILE A 471
LEU A 475
ILE A 383
TYR A 398
LEU A 353
 None
 1.05A 3mb5A-3eo7A:
undetectable		 3mb5A-3eo7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 GLY A 119
SER A 120
LEU A 117
ILE A 102
LEU A 290
 PLP  A 458 (-3.1A)
PLP  A 458 (-2.7A)
None
None
None
 0.99A 3mb5A-3fcrA:
undetectable		 3mb5A-3fcrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 GLY A 120
SER A 121
LEU A 118
ILE A 103
LEU A 291
 PLP  A 460 (-3.2A)
LLP  A 289 (-2.7A)
None
None
None
 1.03A 3mb5A-3gjuA:
undetectable		 3mb5A-3gjuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 ILE A 185
ALA A 172
LEU A 173
ILE A 290
ILE A  82
 None
 1.03A 3mb5A-3gqjA:
undetectable		 3mb5A-3gqjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		5 GLY A 238
SER A 239
ALA A 287
ILE A 262
LEU A 271
 None
 0.94A 3mb5A-3gzaA:
undetectable		 3mb5A-3gzaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9s INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		PF00583
(Acetyltransf_1) 		5 ILE A  56
VAL A  55
GLY A  66
ALA A  68
ILE A  21
 None
 1.03A 3mb5A-3i9sA:
undetectable		 3mb5A-3i9sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE B 258
VAL B 259
LEU B 267
ILE B 146
TYR B 143
 None
 0.84A 3mb5A-3igzB:
4.8		 3mb5A-3igzB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		5 VAL A 355
GLY A 307
ARG A 407
ILE A 402
LEU A 376
 None
 1.03A 3mb5A-3iuyA:
3.6		 3mb5A-3iuyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		5 SER A 246
ALA A 215
ILE A 101
ILE A 263
LEU A 113
 PLP  A 406 (-2.8A)
PLP  A 406 ( 3.7A)
None
None
None
 0.89A 3mb5A-3k7yA:
3.0		 3mb5A-3k7yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		5 ILE A 166
VAL A 143
ILE A  27
LEU A  40
PRO A  41
 None
 0.80A 3mb5A-3ki8A:
undetectable		 3mb5A-3ki8A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 504
LEU A 501
ILE A 510
ILE A 524
PRO A 547
 None
ANP  A 400 (-4.0A)
None
None
None
 1.04A 3mb5A-3kn5A:
undetectable		 3mb5A-3kn5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans) 		PF00501
(AMP-binding) 		5 ILE A 292
SER A 264
ALA A 267
LEU A 268
ILE A 139
 None
 1.06A 3mb5A-3l2kA:
undetectable		 3mb5A-3l2kA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 ILE A  76
VAL A  77
ALA A 106
LEU A 107
ILE A 154
LEU A 168
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.3A)
None
 1.44A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		12 ILE A  76
VAL A  77
GLY A 103
SER A 104
ALA A 106
LEU A 107
ILE A 126
ARG A 127
ILE A 154
TYR A 155
LEU A 170
PRO A 171
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
None
SAH  A 301 (-4.3A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.8A)
 0.58A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		5 VAL A  57
GLY A 194
ILE A 189
ILE A 174
TYR A 181
 None
 0.99A 3mb5A-3mstA:
undetectable		 3mb5A-3mstA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		5 VAL A 415
GLY A 341
ILE A 357
ILE A 323
LEU A 338
 None
 1.05A 3mb5A-3mweA:
undetectable		 3mb5A-3mweA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ILE A  77
GLY A  97
ALA A 129
LEU A 131
ILE A 226
 None
 0.90A 3mb5A-3o7qA:
undetectable		 3mb5A-3o7qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 VAL A 305
GLY A  12
SER A  14
ALA A  18
TYR A 246
LEU A 107
 None
None
None
None
FAD  A 500 (-4.5A)
None
 1.22A 3mb5A-3oc4A:
4.4		 3mb5A-3oc4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 GLY A  48
ALA A  75
ILE A  60
ILE A 409
PRO A 424
 None
 1.02A 3mb5A-3oksA:
undetectable		 3mb5A-3oksA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 GLY A  44
ALA A 232
LEU A 231
ILE A  40
LEU A  19
 None
 1.00A 3mb5A-3qfoA:
undetectable		 3mb5A-3qfoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		5 VAL A  23
ALA A  42
LEU A  41
ARG A  14
LEU A  38
 None
 0.74A 3mb5A-3rnsA:
undetectable		 3mb5A-3rnsA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 327
GLY A 246
LEU A 323
ILE A 285
LEU A 240
 None
 1.00A 3mb5A-3sxfA:
undetectable		 3mb5A-3sxfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 ILE A 168
VAL A 167
GLY A 173
ALA A  97
LEU A 179
 None
 0.96A 3mb5A-3uufA:
undetectable		 3mb5A-3uufA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		5 ILE A  11
VAL A  10
GLY A  13
ALA A 229
ILE A  48
 None
 0.99A 3mb5A-3v7iA:
undetectable		 3mb5A-3v7iA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A2641
GLY A2829
ALA A2834
LEU A2835
LEU A2879
 None
 0.99A 3mb5A-3vkgA:
undetectable		 3mb5A-3vkgA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 VAL A 307
GLY A 403
ALA A 401
ILE A 376
TYR A 380
 None
 1.04A 3mb5A-3vs8A:
undetectable		 3mb5A-3vs8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Thermus
thermophilus) 		PF00696
(AA_kinase) 		5 ILE A   2
VAL A   3
ALA A 186
LEU A 187
LEU A 181
 None
 0.90A 3mb5A-3wwnA:
4.3		 3mb5A-3wwnA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 VAL A 383
ALA A 385
LEU A 384
ILE A 360
LEU A 377
 None
 1.04A 3mb5A-4a0wA:
undetectable		 3mb5A-4a0wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 ILE A 168
VAL A 169
GLY A 165
TYR A  67
PRO A  64
 None
 0.96A 3mb5A-4aeeA:
undetectable		 3mb5A-4aeeA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE C  55
VAL C  54
GLY C 118
ALA C 116
LEU C 115
 None
 0.98A 3mb5A-4b3iC:
undetectable		 3mb5A-4b3iC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 GLY A 597
ALA A 602
LEU A 603
ARG A 645
ILE A 654
 None
 0.96A 3mb5A-4bwpA:
undetectable		 3mb5A-4bwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 ILE A 133
VAL A 134
ILE A 205
TYR A 204
LEU A 152
 None
 1.04A 3mb5A-4conA:
undetectable		 3mb5A-4conA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		5 ILE A 376
GLY A 371
ALA A 437
LEU A 438
ILE A  71
 None
 0.88A 3mb5A-4d1dA:
undetectable		 3mb5A-4d1dA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 GLY A 237
LEU A 345
ILE A 230
ILE A 213
PRO A 184
 None
 1.06A 3mb5A-4ddqA:
undetectable		 3mb5A-4ddqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 GLY A  99
ALA A 101
ILE A  28
ILE A 244
LEU A 289
 None
 0.89A 3mb5A-4diaA:
undetectable		 3mb5A-4diaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 ILE A 211
GLY A  75
SER A  76
ILE A 190
ILE A  71
 ILE  A 211 ( 0.7A)
GLY  A  75 ( 0.0A)
SER  A  76 ( 0.0A)
ILE  A 190 ( 0.7A)
ILE  A  71 ( 0.7A)
 1.05A 3mb5A-4g41A:
undetectable		 3mb5A-4g41A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		6 GLY A  13
SER A  14
ALA A 135
LEU A 134
ILE A   7
PRO A  68
 None
 1.47A 3mb5A-4hujA:
4.2		 3mb5A-4hujA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A  81
VAL A 206
LEU A  83
ILE A 259
ILE A 214
 None
 0.99A 3mb5A-4hyvA:
3.7		 3mb5A-4hyvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes) 		PF02618
(YceG) 		5 ILE A  50
GLY A  53
SER A  54
ILE A 133
LEU A 118
 None
 0.95A 3mb5A-4iiwA:
undetectable		 3mb5A-4iiwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 163
LEU A 161
ILE A 349
ARG A 345
LEU A 152
 None
None
None
MAL  A 501 (-4.2A)
None
 1.03A 3mb5A-4ikmA:
undetectable		 3mb5A-4ikmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		5 VAL A 134
GLY A 170
ALA A 168
ILE A 278
ARG A 230
 None
FMN  A 401 (-3.3A)
None
FMN  A 401 ( 4.9A)
None
 1.05A 3mb5A-4iqlA:
undetectable		 3mb5A-4iqlA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ILE A 394
ALA A 441
LEU A 438
ILE A 421
LEU A 432
 None
 0.98A 3mb5A-4ksiA:
undetectable		 3mb5A-4ksiA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 321
GLU A 388
ASP A 390
ASP A 434
 None
 1.39A 3mb5A-1aqlA:
undetectable		 3mb5A-1aqlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		4 GLY A 226
GLU A 319
ASP A 312
ASP A 228
 None
 1.16A 3mb5A-1bw0A:
4.6		 3mb5A-1bw0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 GLY A  34
GLU A 238
ASP A  30
ASP A  38
 GDP  A 500 (-3.6A)
None
GDP  A 500 (-4.3A)
None
 1.42A 3mb5A-1dj3A:
2.2		 3mb5A-1dj3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 GLY A  82
GLU A 105
ASP A 130
ASP A 150
 None
 0.92A 3mb5A-1fbnA:
17.5		 3mb5A-1fbnA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLY A 107
GLU A 131
ASP A 161
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.36A 3mb5A-1i9gA:
29.8		 3mb5A-1i9gA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 GLY A  67
GLU A  61
ASP A  35
ASP A  68
 None
 1.28A 3mb5A-1j5tA:
undetectable		 3mb5A-1j5tA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 GLY H 255
GLU H 253
ASP H 250
ASP H 259
 None
 1.06A 3mb5A-1mdaH:
undetectable		 3mb5A-1mdaH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  82
GLU A 104
ASP A 141
ASP A 158
 None
 0.83A 3mb5A-1mjfA:
14.1		 3mb5A-1mjfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		4 GLY A  65
GLU A  88
ASP A 113
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.7A)
 0.48A 3mb5A-1nt2A:
16.3		 3mb5A-1nt2A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A1004 (-3.9A)
NA  A1004 (-4.2A)
None
None
 1.16A 3mb5A-1o4zA:
undetectable		 3mb5A-1o4zA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 GLY A 108
GLU A 132
ASP A 160
ASP A 176
 None
 0.39A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1roe FERREDOXIN

(Synechococcus
elongatus) 		PF00111
(Fer2) 		4 GLY A  55
GLU A  56
ASP A  58
ASP A  85
 None
 1.39A 3mb5A-1roeA:
undetectable		 3mb5A-1roeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		4 GLY A 218
GLU A 225
ASP A 253
ASP A 215
 None
None
MG  A 500 (-3.3A)
None
 1.43A 3mb5A-1t5jA:
undetectable		 3mb5A-1t5jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 GLY A 104
GLU A 129
ASP A 146
ASP A  83
 CA  A1237 ( 4.3A)
None
None
None
 1.33A 3mb5A-1v6mA:
undetectable		 3mb5A-1v6mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		4 GLY A 235
GLU A 236
ASP A 219
ASP A 234
 None
 1.25A 3mb5A-1xcoA:
3.4		 3mb5A-1xcoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 GLY A 223
GLU A 127
ASP A 125
ASP A 225
 None
 1.29A 3mb5A-1xfiA:
5.0		 3mb5A-1xfiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 128
GLU A 151
ASP A 182
ASP A 201
 None
 0.91A 3mb5A-1xj5A:
14.1		 3mb5A-1xj5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		4 GLY A 148
GLU A 264
ASP A 143
ASP A 157
 None
 1.30A 3mb5A-1y56A:
3.7		 3mb5A-1y56A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		4 GLY A  98
GLU A 122
ASP A 150
ASP A 166
 None
 0.57A 3mb5A-1yb2A:
19.5		 3mb5A-1yb2A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb3 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF11447
(DUF3201) 		4 GLY A  48
GLU A 117
ASP A 112
ASP A  47
 None
 1.33A 3mb5A-1yb3A:
undetectable		 3mb5A-1yb3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 GLY A 111
GLU A 135
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.36A 3mb5A-2b25A:
23.8		 3mb5A-2b25A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		4 GLY A 138
GLU A 140
ASP A 106
ASP A 137
 None
None
CA  A 195 ( 2.5A)
None
 1.22A 3mb5A-2ervA:
undetectable		 3mb5A-2ervA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwo DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13

(Homo sapiens) 		PF00782
(DSPc) 		4 GLY A  81
GLU A 103
ASP A 105
ASP A  86
 None
 1.42A 3mb5A-2gwoA:
undetectable		 3mb5A-2gwoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		4 GLY A 168
GLU A 192
ASP A 217
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-3.4A)
MTA  A4001 (-4.3A)
 0.38A 3mb5A-2ipxA:
17.6		 3mb5A-2ipxA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 251
GLU A 252
ASP A  73
ASP A 222
 None
 1.36A 3mb5A-2lgzA:
undetectable		 3mb5A-2lgzA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7z CD63-LIKE PROTEIN
SM-TSP-2

(Schistosoma
mansoni) 		PF00335
(Tetraspannin) 		4 GLY A  69
GLU A  68
ASP A  76
ASP A  46
 None
 1.36A 3mb5A-2m7zA:
undetectable		 3mb5A-2m7zA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 GLY A  30
GLU A  17
ASP A  34
ASP A  29
 CA  A 202 (-4.4A)
CA  A 202 (-3.4A)
None
None
 1.35A 3mb5A-2ml1A:
undetectable		 3mb5A-2ml1A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2e NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 4 GLY A 196
GLU A 197
ASP A 155
ASP A 194
 None
 1.19A 3mb5A-2n2eA:
undetectable		 3mb5A-2n2eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		4 GLY A  41
GLU A  44
ASP A  46
ASP A  59
 None
 1.29A 3mb5A-2p1gA:
undetectable		 3mb5A-2p1gA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.75A 3mb5A-2pt6A:
12.8		 3mb5A-2pt6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		4 GLY A 263
GLU A 262
ASP A 241
ASP A 264
 None
 1.33A 3mb5A-2qczA:
undetectable		 3mb5A-2qczA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		4 GLY A  86
GLU A 121
ASP A 176
ASP A 198
 None
 0.63A 3mb5A-2qy6A:
11.2		 3mb5A-2qy6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 112
GLU A 111
ASP A 105
ASP A 116
 None
 1.43A 3mb5A-2wbaA:
2.9		 3mb5A-2wbaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A  56
GLU A  57
ASP A  59
ASP A  98
 None
 1.40A 3mb5A-2wdwA:
undetectable		 3mb5A-2wdwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 GLY B 372
GLU B 347
ASP B 378
ASP B 431
 None
 1.38A 3mb5A-2wfxB:
undetectable		 3mb5A-2wfxB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 546
GLU A 147
ASP A 542
ASP A 547
 None
 1.09A 3mb5A-2wk2A:
undetectable		 3mb5A-2wk2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yue PROTEIN NEURALIZED

(Drosophila
melanogaster) 		PF07177
(Neuralized) 		4 GLY A  25
GLU A 158
ASP A 161
ASP A  24
 None
 1.38A 3mb5A-2yueA:
undetectable		 3mb5A-2yueA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 GLY A  99
GLU A 120
ASP A 148
ASP A 165
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.4A)
 0.33A 3mb5A-2yvlA:
25.5		 3mb5A-2yvlA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.62A 3mb5A-2zsuA:
14.3		 3mb5A-2zsuA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 198
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.81A 3mb5A-3c6mA:
14.7		 3mb5A-3c6mA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN

(Mus musculus) 		PF13806
(Rieske_2) 		4 GLY A 127
GLU A  23
ASP A  25
ASP A 125
 None
 1.33A 3mb5A-3d89A:
undetectable		 3mb5A-3d89A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 318
GLU A 322
ASP A 342
ASP A 315
 None
 1.42A 3mb5A-3e9yA:
4.4		 3mb5A-3e9yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 GLY X  45
GLU X  43
ASP X   8
ASP X  53
 None
 1.34A 3mb5A-3ewbX:
undetectable		 3mb5A-3ewbX:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		4 GLY A  34
GLU A   9
ASP A 160
ASP A  13
 None
 1.30A 3mb5A-3ewmA:
3.5		 3mb5A-3ewmA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 GLY A  94
GLU A 117
ASP A 144
ASP A 163
 None
FMT  A 315 (-3.6A)
None
None
 0.66A 3mb5A-3gjyA:
13.9		 3mb5A-3gjyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 479
GLU B 552
ASP B  33
ASP B 571
 None
 1.30A 3mb5A-3hkzB:
undetectable		 3mb5A-3hkzB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLU A  70
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 0.56A 3mb5A-3ihtA:
11.2		 3mb5A-3ihtA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 GLY A  87
GLU A  56
ASP A  61
ASP A  90
 None
TRS  A 157 (-2.8A)
None
None
 1.42A 3mb5A-3kipA:
undetectable		 3mb5A-3kipA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus) 		PF05708
(Peptidase_C92) 		4 GLY A   2
GLU A 180
ASP A 185
ASP A   4
 None
 1.26A 3mb5A-3kw0A:
undetectable		 3mb5A-3kw0A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 GLY A 101
GLU A 125
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.23A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		4 GLY A 261
GLU A 282
ASP A 221
ASP A 260
 None
 1.28A 3mb5A-3licA:
undetectable		 3mb5A-3licA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 GLY A  99
GLU A 119
ASP A 148
ASP A 167
 None
None
None
EDO  A 507 (-4.1A)
 1.25A 3mb5A-3ll7A:
13.1		 3mb5A-3ll7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		4 GLY A  37
GLU A  79
ASP A   8
ASP A  38
 None
 1.02A 3mb5A-3lmbA:
undetectable		 3mb5A-3lmbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLY A 491
GLU A 493
ASP A 513
ASP A 462
 None
 1.38A 3mb5A-3muoA:
undetectable		 3mb5A-3muoA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngh PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		4 GLY A   6
GLU A 108
ASP A 106
ASP A  88
 None
 1.28A 3mb5A-3nghA:
undetectable		 3mb5A-3nghA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.46A 3mb5A-3ps9A:
10.5		 3mb5A-3ps9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 GLY A  66
GLU A 101
ASP A 156
ASP A 178
 None
 0.52A 3mb5A-3pvcA:
11.6		 3mb5A-3pvcA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 101
GLU A 124
ASP A 155
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.0A)
 0.68A 3mb5A-3rw9A:
12.9		 3mb5A-3rw9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 320
GLU A 322
ASP A 385
ASP A 296
 None
None
None
C8E  A 471 ( 4.8A)
 1.40A 3mb5A-3sybA:
undetectable		 3mb5A-3sybA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 320
GLU A 322
ASP A 385
ASP A 319
 None
 1.16A 3mb5A-3sybA:
undetectable		 3mb5A-3sybA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 GLY A 123
GLU A 124
ASP A  22
ASP A 272
 None
 1.42A 3mb5A-3uboA:
3.9		 3mb5A-3uboA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 104
GLU A 133
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.47A 3mb5A-3vywA:
11.5		 3mb5A-3vywA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLY A 555
GLU A 559
ASP A 440
ASP A 518
 None
 1.40A 3mb5A-3w5nA:
undetectable		 3mb5A-3w5nA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 308
GLU A 281
ASP A 286
ASP A 332
 None
 0.98A 3mb5A-4a35A:
undetectable		 3mb5A-4a35A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A 500 (-4.0A)
NA  A 500 (-3.8A)
None
None
 1.17A 3mb5A-4atfA:
undetectable		 3mb5A-4atfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C  16
GLU C 207
ASP C 204
ASP C 262
 None
 1.42A 3mb5A-4b3iC:
undetectable		 3mb5A-4b3iC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		4 GLY E  81
GLU E 105
ASP E 130
ASP E 150
 None
None
None
C  X   5 ( 3.2A)
 0.60A 3mb5A-4by9E:
14.5		 3mb5A-4by9E:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 GLY A 199
GLU A 184
ASP A 201
ASP A 197
 None
 1.27A 3mb5A-4cvuA:
undetectable		 3mb5A-4cvuA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		4 GLY A  85
GLU A 109
ASP A 134
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.6A)
 0.32A 3mb5A-4df3A:
17.4		 3mb5A-4df3A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		4 GLY A 486
GLU A 487
ASP A 494
ASP A 518
 None
 1.41A 3mb5A-4ebaA:
undetectable		 3mb5A-4ebaA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 GLY A 149
GLU A 148
ASP A 195
ASP A 151
 None
 1.41A 3mb5A-4fozA:
undetectable		 3mb5A-4fozA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 254
GLU A 230
ASP A 235
ASP A 278
 None
MG  A 405 ( 4.8A)
None
None
 0.96A 3mb5A-4h19A:
undetectable		 3mb5A-4h19A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 233
GLU A 221
ASP A 237
ASP A 231
 None
 1.12A 3mb5A-4k2bA:
3.3		 3mb5A-4k2bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN B CHAIN
GLOBIN C CHAIN

(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		PF00042
(Globin)
PF00042
(Globin) 		4 GLY C  62
GLU C  61
ASP C  58
ASP B  82
 None
 1.21A 3mb5A-4u8uC:
2.3		 3mb5A-4u8uC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
 0.76A 3mb5A-4uoeA:
12.5		 3mb5A-4uoeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)
RIBOSOME BIOGENESIS
PROTEIN (RRS1),
PUTATIVE
(AFU_ORTHOLOGUE
AFUA_7G04430)

(Aspergillus
nidulans;
Aspergillus
nidulans) 		PF04427
(Brix)
PF04939
(RRS1) 		4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-4xd9A:
undetectable		 3mb5A-4xd9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		4 GLY A 108
GLU A 110
ASP A 112
ASP A 154
 None
 1.24A 3mb5A-4z48A:
undetectable		 3mb5A-4z48A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 GLY A 191
GLU A 144
ASP A 171
ASP A 194
 None
 1.26A 3mb5A-4zm4A:
2.7		 3mb5A-4zm4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2
RRS1

(Aspergillus
nidulans;
Aspergillus
nidulans) 		PF04427
(Brix)
PF04939
(RRS1) 		4 GLY A 150
GLU A 195
ASP A 155
ASP B  40
 None
 1.10A 3mb5A-5by8A:
undetectable		 3mb5A-5by8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 GLY A 111
GLU A 135
ASP A 163
ASP A 181
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.7A)
SAH  A 301 (-2.4A)
 0.26A 3mb5A-5ccxA:
22.6		 3mb5A-5ccxA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		4 GLY A 116
GLU A  26
ASP A 268
ASP A 118
 None
 1.29A 3mb5A-5d6oA:
undetectable		 3mb5A-5d6oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 535
GLU A 138
ASP A 531
ASP A 536
 None
 1.15A 3mb5A-5df0A:
undetectable		 3mb5A-5df0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		4 GLY A 113
GLU A  24
ASP A 265
ASP A 115
 None
 1.28A 3mb5A-5e4yA:
undetectable		 3mb5A-5e4yA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 GLY B 118
GLU B 139
ASP B 168
ASP B 203
 SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
 0.30A 3mb5A-5ergB:
22.2		 3mb5A-5ergB:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY B 268
GLU B 270
ASP B 262
ASP B  17
 None
 1.18A 3mb5A-5fwxB:
5.0		 3mb5A-5fwxB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		4 GLY E  84
GLU E 108
ASP E 133
ASP E 153
 SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
 0.42A 3mb5A-5ginE:
17.3		 3mb5A-5ginE:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLY A 539
GLU A 140
ASP A 535
ASP A 540
 GLY  A 539 ( 0.0A)
GLU  A 140 ( 0.6A)
ASP  A 535 ( 0.6A)
ASP  A 540 ( 0.5A)
 1.26A 3mb5A-5gprA:
undetectable		 3mb5A-5gprA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLY A 175
GLU A 177
ASP A 893
ASP A 174
 None
 1.34A 3mb5A-5j6sA:
undetectable		 3mb5A-5j6sA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		4 GLY A  54
GLU A  71
ASP A 286
ASP A 107
 None
 1.42A 3mb5A-5j9rA:
undetectable		 3mb5A-5j9rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		4 GLY C 263
GLU A 283
ASP C 241
ASP C 283
 None
 1.18A 3mb5A-5k1cC:
undetectable		 3mb5A-5k1cC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A  53
GLU A  56
ASP A 574
ASP A  47
 None
 1.41A 3mb5A-5lewA:
2.0		 3mb5A-5lewA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 4 GLY H  15
GLU H 218
ASP H 215
ASP H 252
 None
 1.30A 3mb5A-5lp7H:
undetectable		 3mb5A-5lp7H:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 GLY A 451
GLU A 159
ASP A 161
ASP A 447
 AYE  A 602 (-4.7A)
AYE  A 602 (-3.5A)
None
None
 1.32A 3mb5A-5ohkA:
undetectable		 3mb5A-5ohkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLY A 212
GLU A 186
ASP A 176
ASP A 213
 None
None
K  A 402 (-3.4A)
None
 1.38A 3mb5A-5vi6A:
4.0		 3mb5A-5vi6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A  17
GLU A 142
ASP A 113
ASP A  18
 None
 1.19A 3mb5A-5vk4A:
undetectable		 3mb5A-5vk4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		4 GLY A 501
GLU A 524
ASP A 551
ASP A 575
 SAH  A 705 (-3.5A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 0.47A 3mb5A-5wcjA:
15.4		 3mb5A-5wcjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 GLY A 548
GLU A 147
ASP A 544
ASP A 549
 None
GOL  A 704 ( 4.5A)
None
GOL  A 701 ( 4.1A)
 1.08A 3mb5A-5zl9A:
undetectable		 3mb5A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 4 GLY A  62
GLU A  85
ASP A 113
ASP A 133
 SAM  A 302 (-3.4A)
SAM  A 302 (-2.7A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.37A 3mb5A-5zw4A:
18.7		 3mb5A-5zw4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 4 GLY A 426
GLU A 441
ASP A 443
ASP A 408
 None
None
None
AMP  A 600 (-2.8A)
 1.39A 3mb5A-6avhA:
undetectable		 3mb5A-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 GLY A  21
GLU A  10
ASP A 151
ASP A  22
 None
QPS  A 602 ( 4.5A)
QPS  A 602 (-3.3A)
ADP  A 601 ( 4.6A)
 0.89A 3mb5A-6gnfA:
4.2		 3mb5A-6gnfA:
undetectable