SIMILAR PATTERNS OF AMINO ACIDS FOR 3M8P_A_65BA562

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 LEU A 183
VAL A 172
VAL A 166
TYR A 261
PHE A 226
 None
 1.21A 3m8pA-1cptA:
0.0
3m8pB-1cptA:
0.0		 3m8pA-1cptA:
22.26
3m8pB-1cptA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 LEU A 163
VAL A 244
VAL A 250
TRP A 181
LEU A 179
 None
 1.44A 3m8pA-1i2lA:
0.0
3m8pB-1i2lA:
0.0		 3m8pA-1i2lA:
16.73
3m8pB-1i2lA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU A 169
LYS A  15
TYR A 231
LEU A 198
TYR A 170
 None
 1.37A 3m8pA-1i4gA:
undetectable
3m8pB-1i4gA:
0.0		 3m8pA-1i4gA:
17.64
3m8pB-1i4gA:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.13A 3m8pA-1mu2A:
29.8
3m8pB-1mu2A:
13.6		 3m8pA-1mu2A:
61.21
3m8pB-1mu2A:
60.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LYS A 277
TYR A 281
TYR A 248
LEU A 190
GLU A 227
 None
 1.28A 3m8pA-1serA:
1.8
3m8pB-1serA:
1.2		 3m8pA-1serA:
20.45
3m8pB-1serA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 LEU A 573
VAL A 518
TYR A 559
LEU A 563
GLU A 575
 None
 1.11A 3m8pA-1yiqA:
0.0
3m8pB-1yiqA:
0.0		 3m8pA-1yiqA:
22.21
3m8pB-1yiqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 554
VAL A 262
VAL A 250
PHE A 245
LEU A 242
 TPO  A 555 ( 4.1A)
None
None
None
None
 1.48A 3m8pA-1zrzA:
1.1
3m8pB-1zrzA:
0.0		 3m8pA-1zrzA:
20.00
3m8pB-1zrzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.49A 3m8pA-2cswA:
0.0
3m8pB-2cswA:
undetectable		 3m8pA-2cswA:
13.62
3m8pB-2cswA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		5 TYR A 212
TRP A 165
LEU A 121
TYR A 150
GLU A 156
 None
 1.26A 3m8pA-2e3zA:
0.0
3m8pB-2e3zA:
0.8		 3m8pA-2e3zA:
21.86
3m8pB-2e3zA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.73A 3m8pA-2hnzA:
37.9
3m8pB-2hnzA:
14.4		 3m8pA-2hnzA:
99.26
3m8pB-2hnzA:
99.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS A 103
VAL A 106
VAL A 179
PHE A 227
TYR A 318
 None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.3A)
 0.90A 3m8pA-2hnzA:
37.9
3m8pB-2hnzA:
14.4		 3m8pA-2hnzA:
99.26
3m8pB-2hnzA:
99.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 LEU A 193
VAL A 151
VAL A 174
TYR A 171
LEU A 206
 None
 1.29A 3m8pA-2imrA:
2.6
3m8pB-2imrA:
2.3		 3m8pA-2imrA:
20.61
3m8pB-2imrA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 VAL A 792
TYR A 848
TYR A 801
LEU A 851
GLU A 847
 None
 1.43A 3m8pA-2q1fA:
1.3
3m8pB-2q1fA:
0.3		 3m8pA-2q1fA:
19.54
3m8pB-2q1fA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2x 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA-2

(Homo sapiens) 		PF00169
(PH) 		5 LEU C  34
VAL C  65
VAL C  91
PHE C 105
TRP C 104
 None
 1.18A 3m8pA-2w2xC:
undetectable
3m8pB-2w2xC:
undetectable		 3m8pA-2w2xC:
13.42
3m8pB-2w2xC:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		5 TYR D 172
TYR D 169
PHE D 166
TRP D 162
GLU D 175
 None
 1.45A 3m8pA-2z6bD:
undetectable
3m8pB-2z6bD:
undetectable		 3m8pA-2z6bD:
20.42
3m8pB-2z6bD:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A 108
VAL A 155
TYR A 152
TYR A 176
LEU A 195
 None
 1.37A 3m8pA-3a5kA:
undetectable
3m8pB-3a5kA:
undetectable		 3m8pA-3a5kA:
20.76
3m8pB-3a5kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		5 LYS A 277
TYR A 281
TYR A 248
LEU A 190
GLU A 227
 AMP  A1507 (-3.6A)
None
None
None
None
 1.40A 3m8pA-3errA:
0.5
3m8pB-3errA:
1.7		 3m8pA-3errA:
22.20
3m8pB-3errA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN

(Staphylococcus
haemolyticus) 		PF13377
(Peripla_BP_3) 		5 VAL A 110
VAL A 156
TYR A 154
TYR A  89
GLU A 150
 None
 1.14A 3m8pA-3huuA:
0.2
3m8pB-3huuA:
undetectable		 3m8pA-3huuA:
20.83
3m8pB-3huuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Escherichia
coli) 		PF01135
(PCMT) 		5 LEU A  93
VAL A  23
VAL A  64
LEU A  73
GLU A  81
 None
None
None
None
SAH  A 300 ( 4.7A)
 1.44A 3m8pA-3lbfA:
0.3
3m8pB-3lbfA:
undetectable		 3m8pA-3lbfA:
17.02
3m8pB-3lbfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 LEU A 645
VAL A 667
PHE A 481
LEU A 479
GLU A 654
 None
 1.38A 3m8pA-3lvvA:
0.3
3m8pB-3lvvA:
2.5		 3m8pA-3lvvA:
21.04
3m8pB-3lvvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 251
VAL A 221
VAL A 258
TYR A 254
TYR A 238
 None
 1.40A 3m8pA-3ppcA:
undetectable
3m8pB-3ppcA:
undetectable		 3m8pA-3ppcA:
24.10
3m8pB-3ppcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 VAL A 205
VAL A 224
TYR A 176
PHE A 177
LEU A  72
 None
 1.47A 3m8pA-3sopA:
undetectable
3m8pB-3sopA:
undetectable		 3m8pA-3sopA:
19.50
3m8pB-3sopA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 297
VAL A 309
TYR A 366
PHE A 336
LEU A 334
 None
 1.36A 3m8pA-3tx8A:
4.0
3m8pB-3tx8A:
3.0		 3m8pA-3tx8A:
20.25
3m8pB-3tx8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 LEU A 447
VAL A 410
LEU A 425
TYR A 443
GLU A 450
 None
 1.50A 3m8pA-4eppA:
undetectable
3m8pB-4eppA:
undetectable		 3m8pA-4eppA:
23.60
3m8pB-4eppA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h9k HOG CHOLERA VIRUS

(Pestivirus C) 		PF05550
(Peptidase_C53) 		5 LEU A 141
VAL A 165
TYR A  98
LEU A 103
TYR A 129
 None
 1.30A 3m8pA-4h9kA:
undetectable
3m8pB-4h9kA:
undetectable		 3m8pA-4h9kA:
14.39
3m8pB-4h9kA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  60
LYS A  89
VAL A  91
TYR A  56
TRP A  80
 None
 1.49A 3m8pA-4hadA:
undetectable
3m8pB-4hadA:
undetectable		 3m8pA-4hadA:
22.01
3m8pB-4hadA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		5 VAL A 124
VAL A 133
TYR A  66
LEU A  86
TYR A  94
 None
None
NDG  A 501 (-3.9A)
None
None
 1.29A 3m8pA-4kruA:
undetectable
3m8pB-4kruA:
1.7		 3m8pA-4kruA:
17.22
3m8pB-4kruA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 LEU A 367
VAL A 334
VAL A 411
PHE A 360
LEU A 363
 None
 1.37A 3m8pA-4o9rA:
0.8
3m8pB-4o9rA:
undetectable		 3m8pA-4o9rA:
21.55
3m8pB-4o9rA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A1939
LYS A1944
VAL A1946
LEU A1992
GLU A1938
 None
 1.33A 3m8pA-4rh7A:
undetectable
3m8pB-4rh7A:
undetectable		 3m8pA-4rh7A:
9.81
3m8pB-4rh7A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 LEU A 242
VAL A  89
VAL A  40
TYR A  97
TYR A 219
 None
 1.33A 3m8pA-4wcjA:
undetectable
3m8pB-4wcjA:
1.6		 3m8pA-4wcjA:
18.49
3m8pB-4wcjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		5 LEU A 315
VAL A 324
TYR A 239
TRP A 223
LEU A 220
 None
 1.21A 3m8pA-4y4vA:
undetectable
3m8pB-4y4vA:
undetectable		 3m8pA-4y4vA:
22.05
3m8pB-4y4vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		5 LEU A  40
TYR A 203
PHE B  89
LEU B  65
TYR A  36
 None
 1.30A 3m8pA-5c5bA:
2.3
3m8pB-5c5bA:
undetectable		 3m8pA-5c5bA:
20.11
3m8pB-5c5bA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		5 LEU E 376
VAL E 355
VAL E 323
TYR E 321
LEU E 389
 None
 1.22A 3m8pA-5cmnE:
undetectable
3m8pB-5cmnE:
undetectable		 3m8pA-5cmnE:
17.54
3m8pB-5cmnE:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 LEU A 116
VAL A 138
VAL A 134
TRP A 105
TYR A 117
 None
 1.32A 3m8pA-5d1rA:
0.0
3m8pB-5d1rA:
undetectable		 3m8pA-5d1rA:
16.40
3m8pB-5d1rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 LEU A 102
VAL A 372
PHE A 184
LEU A  65
GLU A  97
 None
 1.49A 3m8pA-5eefA:
undetectable
3m8pB-5eefA:
undetectable		 3m8pA-5eefA:
20.24
3m8pB-5eefA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fka STAPHYLOCOCCAL
ENTEROTOXIN E

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU C 169
LYS C  15
TYR C 231
LEU C 198
TYR C 170
 None
 1.34A 3m8pA-5fkaC:
undetectable
3m8pB-5fkaC:
undetectable		 3m8pA-5fkaC:
19.15
3m8pB-5fkaC:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		5 LEU C 444
VAL C 423
VAL C 391
TYR C 389
LEU C 457
 None
 1.17A 3m8pA-5fttC:
undetectable
3m8pB-5fttC:
undetectable		 3m8pA-5fttC:
21.03
3m8pB-5fttC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 TYR A 224
TRP A 167
LEU A 123
TYR A 152
GLU A 158
 None
 1.23A 3m8pA-5jboA:
undetectable
3m8pB-5jboA:
undetectable		 3m8pA-5jboA:
20.90
3m8pB-5jboA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.18A 3m8pA-5u8sE:
2.7
3m8pB-5u8sE:
undetectable		 3m8pA-5u8sE:
20.91
3m8pB-5u8sE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 5 LEU A  13
VAL A  75
VAL A 102
LEU A  69
GLU A  80
 None
None
None
None
NAP  A 500 ( 4.7A)
 1.39A 3m8pA-6dzsA:
4.8
3m8pB-6dzsA:
2.4		 3m8pA-6dzsA:
undetectable
3m8pB-6dzsA:
undetectable