SIMILAR PATTERNS OF AMINO ACIDS FOR 3M7R_A_VDXA425

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		5 LEU A   8
LEU A  15
VAL A  14
VAL A  98
LEU A  75
 None
 1.26A 3m7rA-1k26A:
0.0		 3m7rA-1k26A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kw2 VITAMIN D-BINDING
PROTEIN

(Homo sapiens) 		PF00273
(Serum_albumin)
PF09164
(VitD-bind_III) 		5 LEU A 361
VAL A 359
SER A 457
SER A 411
LEU A 470
 None
 1.32A 3m7rA-1kw2A:
1.0		 3m7rA-1kw2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lht MYOGLOBIN

(Caretta caretta) 		PF00042
(Globin) 		5 LEU A  72
LEU A  69
VAL A  68
LEU A 104
HIS A  93
 HEM  A 155 ( 4.5A)
None
HEM  A 155 ( 4.0A)
HEM  A 155 ( 4.6A)
HEM  A 155 (-3.4A)
 1.30A 3m7rA-1lhtA:
0.0		 3m7rA-1lhtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 521
LEU A 522
VAL A 518
VAL A 204
LEU A 273
 None
 1.22A 3m7rA-1lnsA:
0.0		 3m7rA-1lnsA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A 113
LEU A 310
LEU A 166
SER A 303
SER A 299
 None
 1.25A 3m7rA-1q1nA:
undetectable		 3m7rA-1q1nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 202
LEU A 205
VAL A 206
VAL A 187
LEU A 222
 None
 1.16A 3m7rA-1sqhA:
0.0		 3m7rA-1sqhA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 LEU A 206
LEU A 183
VAL A 182
VAL A 208
LEU A 233
 None
 1.32A 3m7rA-1tjrA:
0.0		 3m7rA-1tjrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 LEU A 123
VAL A 121
SER A 115
SER A 180
LEU A  14
 None
 1.29A 3m7rA-1tp7A:
undetectable		 3m7rA-1tp7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvd T CELL RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 LEU A  20
LEU A  73
VAL A  74
SER A  61
VAL A 112
 None
 1.32A 3m7rA-1tvdA:
undetectable		 3m7rA-1tvdA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.26A 3m7rA-1ukwA:
2.1		 3m7rA-1ukwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  34
LEU A  37
VAL A  38
SER A  41
VAL A  51
 None
 1.24A 3m7rA-1ulqA:
undetectable		 3m7rA-1ulqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A  89
LEU A 145
SER A  83
VAL A 159
LEU A  32
 None
None
PD8  A1421 ( 3.7A)
None
None
 1.33A 3m7rA-1w78A:
undetectable		 3m7rA-1w78A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 311
LEU A 314
VAL A 315
SER A 318
VAL A 293
 None
 1.02A 3m7rA-1xm9A:
undetectable		 3m7rA-1xm9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebz REGULATOR OF
G-PROTEIN SIGNALING
12

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  23
LEU A  22
SER A 121
GLN A  49
LEU A  46
 None
 1.15A 3m7rA-2ebzA:
undetectable		 3m7rA-2ebzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 LEU A 180
VAL A 184
SER A 155
VAL A 230
LEU A  69
 None
 1.29A 3m7rA-2gsnA:
undetectable		 3m7rA-2gsnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 0.98A 3m7rA-2h21A:
undetectable		 3m7rA-2h21A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 TYR A 236
VAL A 148
SER A 165
SER A 145
VAL A  82
 None
 1.30A 3m7rA-2i44A:
undetectable		 3m7rA-2i44A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ju1 ERYTHRONOLIDE
SYNTHASE

(Saccharopolyspora
erythraea) 		PF00550
(PP-binding) 		5 LEU A  21
LEU A  24
VAL A  25
SER A  28
HIS A  80
 None
 1.13A 3m7rA-2ju1A:
undetectable		 3m7rA-2ju1A:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 226
VAL A 230
SER A 233
VAL A 296
LEU A 309
 VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 4.4A)
None
 1.18A 3m7rA-2o4jA:
38.9		 3m7rA-2o4jA:
88.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		10 TYR A 143
LEU A 226
LEU A 229
VAL A 230
SER A 271
SER A 274
CYH A 284
VAL A 296
LEU A 305
HIS A 393
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.8A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
VD4  A 500 ( 4.4A)
None
VD4  A 500 ( 3.9A)
 0.29A 3m7rA-2o4jA:
38.9		 3m7rA-2o4jA:
88.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		10 TYR A 143
LEU A 226
VAL A 230
SER A 233
SER A 271
SER A 274
CYH A 284
VAL A 296
LEU A 305
HIS A 393
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
VD4  A 500 ( 4.4A)
None
VD4  A 500 ( 3.9A)
 0.60A 3m7rA-2o4jA:
38.9		 3m7rA-2o4jA:
88.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A  20
LEU A 335
SER A 208
VAL A  15
LEU A 129
 None
 1.29A 3m7rA-2qveA:
undetectable		 3m7rA-2qveA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 286
LEU A 300
SER A 316
SER A 601
GLN A 285
 None
 1.25A 3m7rA-2va8A:
undetectable		 3m7rA-2va8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		5 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.31A 3m7rA-2wduA:
undetectable		 3m7rA-2wduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 LEU A   9
LEU A 205
VAL A 204
SER A  52
VAL A  16
 None
 1.32A 3m7rA-2xdrA:
undetectable		 3m7rA-2xdrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 207
LEU A 198
VAL A 205
SER A 203
LEU A 308
 None
 1.04A 3m7rA-2ycbA:
undetectable		 3m7rA-2ycbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk3 CYTOCHROME C

(Crithidia
fasciculata) 		PF00034
(Cytochrom_C) 		5 LEU A 109
LEU A  46
VAL A  47
VAL A 105
LEU A   9
 None
HEM  A 200 (-4.3A)
None
None
None
 1.21A 3m7rA-2yk3A:
undetectable		 3m7rA-2yk3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yru STEROID RECEPTOR RNA
ACTIVATOR 1

(Mus musculus) 		PF07304
(SRA1) 		5 LEU A  22
LEU A  19
VAL A  18
VAL A 102
LEU A  87
 None
 1.24A 3m7rA-2yruA:
undetectable		 3m7rA-2yruA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzk OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Aeropyrum
pernix) 		PF00156
(Pribosyltran) 		5 LEU A 160
LEU A 153
VAL A 158
SER A 125
VAL A 141
 None
 1.33A 3m7rA-2yzkA:
undetectable		 3m7rA-2yzkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 VAL A 298
SER A 299
SER A 291
LEU A 202
HIS A  38
 None
 1.25A 3m7rA-3ctzA:
undetectable		 3m7rA-3ctzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A 326
LEU A 352
VAL A 353
CYH A 345
VAL A 362
 None
 1.28A 3m7rA-3ec1A:
undetectable		 3m7rA-3ec1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		5 LEU A  76
LEU A  48
VAL A  78
SER A 170
HIS A  68
 None
 1.22A 3m7rA-3fcxA:
undetectable		 3m7rA-3fcxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp4 GDSL-ESTERASE

(Pseudoalteromonas
sp. 643A) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  92
LEU A  95
VAL A  96
SER A  99
LEU A 140
 None
 1.09A 3m7rA-3hp4A:
undetectable		 3m7rA-3hp4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		5 LEU A  99
VAL A  52
SER A  94
VAL A  87
GLN A  86
 None
 1.32A 3m7rA-3it7A:
undetectable		 3m7rA-3it7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 5 LEU A 112
LEU A 109
VAL A 108
SER A 105
VAL A 120
 None
 1.28A 3m7rA-3ixlA:
undetectable		 3m7rA-3ixlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 5 LEU A 306
LEU A 310
SER A 313
SER A 585
VAL A 304
 None
 1.29A 3m7rA-3j3iA:
undetectable		 3m7rA-3j3iA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 5 LEU B  43
LEU B  34
SER B  36
VAL B  60
GLN B  61
 None
 1.29A 3m7rA-3k1lB:
undetectable		 3m7rA-3k1lB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 LEU A 102
LEU A 106
SER A 119
GLN A  99
LEU A  93
 None
 1.11A 3m7rA-3nfqA:
undetectable		 3m7rA-3nfqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 324
VAL A 296
SER A 342
CYH A 354
VAL A 318
 None
 1.15A 3m7rA-3of7A:
undetectable		 3m7rA-3of7A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 118
VAL A  81
SER A  82
VAL A 100
LEU A  54
 None
 1.31A 3m7rA-3rb9A:
undetectable		 3m7rA-3rb9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B 818
LEU B 907
VAL B 816
SER B 815
VAL B 854
 None
 1.32A 3m7rA-3tixB:
undetectable		 3m7rA-3tixB:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 230
VAL A 234
SER A 237
VAL A 300
LEU A 313
 ED9  A 501 ( 4.6A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
None
 1.16A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 275
SER A 278
CYH A 288
VAL A 300
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.20A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 TYR A 143
LEU A 230
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.56A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		5 LEU A 196
SER A 120
VAL A 228
LEU A 254
HIS A 253
 None
 1.22A 3m7rA-3wy7A:
undetectable		 3m7rA-3wy7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.33A 3m7rA-3zg6A:
undetectable		 3m7rA-3zg6A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		5 LEU A 411
SER A 447
VAL A 407
GLN A 408
LEU A 403
 None
 1.30A 3m7rA-3zrhA:
undetectable		 3m7rA-3zrhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuh PROTEIN CBBX

(Rhodobacter
sphaeroides) 		PF00004
(AAA) 		5 LEU A  29
LEU A  26
VAL A  25
VAL A  83
LEU A 102
 None
 1.31A 3m7rA-3zuhA:
undetectable		 3m7rA-3zuhA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1448 ( 4.2A)
None
 1.26A 3m7rA-4d4lA:
undetectable		 3m7rA-4d4lA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU B 628
LEU B 631
VAL B 632
CYH B 588
LEU B 500
 None
 1.28A 3m7rA-4f92B:
undetectable		 3m7rA-4f92B:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 550
LEU A 546
SER A 406
SER A 409
CYH A 462
 None
 1.15A 3m7rA-4f99A:
undetectable		 3m7rA-4f99A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 TYR A 166
LEU A 119
VAL A 120
GLN A  87
HIS A  89
 None
None
AZM  A 302 ( 4.8A)
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
 1.30A 3m7rA-4g7aA:
undetectable		 3m7rA-4g7aA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf4 PORIN B

(Pseudomonas
putida) 		PF04966
(OprB) 		5 LEU A 295
LEU A 319
VAL A 320
VAL A 284
GLN A 283
 None
C8E  A 501 ( 4.4A)
None
C8E  A 501 ( 4.8A)
None
 1.32A 3m7rA-4gf4A:
undetectable		 3m7rA-4gf4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.24A 3m7rA-4gqoA:
undetectable		 3m7rA-4gqoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsn GLUTATHIONE
S-TRANSFERASE E2

(Anopheles
gambiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 VAL A 199
SER A 164
SER A 168
GLN A  31
LEU A   6
 None
 1.33A 3m7rA-4gsnA:
undetectable		 3m7rA-4gsnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU N 233
LEU N 236
VAL N 237
SER N 240
LEU N 281
 None
 1.24A 3m7rA-4heaN:
undetectable		 3m7rA-4heaN:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  27
LEU A  29
VAL A  31
SER A  71
LEU A 103
 None
 1.14A 3m7rA-4je3A:
undetectable		 3m7rA-4je3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 TYR A 456
LEU A 408
VAL A 310
VAL A 389
LEU A 368
 None
 1.28A 3m7rA-4kwgA:
undetectable		 3m7rA-4kwgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnn GLUTAREDOXIN RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF13192
(Thioredoxin_3) 		5 LEU A  75
LEU A  78
VAL A  79
SER A  82
VAL A   6
 None
 1.33A 3m7rA-4mnnA:
undetectable		 3m7rA-4mnnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1

(Homo sapiens) 		PF07304
(SRA1) 		5 LEU A 118
LEU A 115
VAL A 114
VAL A 198
LEU A 183
 None
 1.26A 3m7rA-4nboA:
undetectable		 3m7rA-4nboA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.20A 3m7rA-4uucA:
undetectable		 3m7rA-4uucA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 258
LEU A 314
VAL A 315
SER A 293
SER A 324
 None
 1.28A 3m7rA-4w7sA:
undetectable		 3m7rA-4w7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs ECU04_1440 PROTEIN

(Encephalitozoon
cuniculi) 		PF00352
(TBP) 		5 LEU D 162
LEU D 172
VAL D 171
SER D 121
LEU D 130
 None
 1.03A 3m7rA-4wzsD:
undetectable		 3m7rA-4wzsD:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkj CRISPR-ASSOCIATED
PROTEIN CAS1

(Streptococcus
pyogenes) 		PF01867
(Cas_Cas1) 		5 LEU A  15
LEU A  50
VAL A  49
VAL A   9
HIS A  12
 None
 1.31A 3m7rA-4zkjA:
undetectable		 3m7rA-4zkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		5 TYR H 263
LEU H 133
VAL H 129
GLN H 137
LEU H 169
 None
 1.32A 3m7rA-5a5tH:
undetectable		 3m7rA-5a5tH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1447 ( 4.0A)
None
 1.27A 3m7rA-5ajzA:
undetectable		 3m7rA-5ajzA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 SER A  98
SER A  43
GLN A 164
LEU A 165
HIS A 127
 None
 1.31A 3m7rA-5awpA:
undetectable		 3m7rA-5awpA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 LEU A 153
VAL A 152
SER A 150
VAL A 202
LEU A  78
 None
 1.27A 3m7rA-5cb2A:
undetectable		 3m7rA-5cb2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 377
LEU D 420
VAL D 421
SER D 416
LEU D 574
 None
 1.26A 3m7rA-5exrD:
undetectable		 3m7rA-5exrD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		5 LEU O 204
LEU O 214
VAL O 213
SER O 163
LEU O 172
 None
 1.21A 3m7rA-5fz5O:
undetectable		 3m7rA-5fz5O:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		5 LEU F 185
LEU F 182
VAL F 181
SER F 178
VAL F 168
 None
 1.30A 3m7rA-5gjwF:
undetectable		 3m7rA-5gjwF:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli) 		PF09704
(Cas_Cas5d) 		5 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.27A 3m7rA-5h9fJ:
undetectable		 3m7rA-5h9fJ:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		6 LEU B1101
LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
 None
 1.50A 3m7rA-5hb4B:
undetectable		 3m7rA-5hb4B:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A  60
VAL A  61
SER A  12
SER A  94
LEU A 144
 None
None
None
None
GLU  A 301 ( 3.8A)
 1.22A 3m7rA-5ictA:
undetectable		 3m7rA-5ictA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 TYR A 458
LEU A 410
LEU A 309
VAL A 310
VAL A 391
 None
 1.20A 3m7rA-5iuwA:
undetectable		 3m7rA-5iuwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		5 LEU B 131
LEU B 135
SER A 187
VAL B 294
GLN B 128
 None
 1.19A 3m7rA-5j1lB:
undetectable		 3m7rA-5j1lB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 LEU A  33
LEU A  40
VAL A  43
VAL A  29
LEU A  25
 None
 1.29A 3m7rA-5jmdA:
undetectable		 3m7rA-5jmdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 466
VAL A 470
SER A 473
VAL A 545
LEU A 547
 None
 1.32A 3m7rA-5kqiA:
undetectable		 3m7rA-5kqiA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3) 		5 LEU K  75
LEU K  78
VAL K  79
SER K  82
VAL J  66
 None
 1.14A 3m7rA-5lc5K:
undetectable		 3m7rA-5lc5K:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l HEMOGLOBIN CHAIN D1

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 LEU D  77
LEU D  74
VAL D  73
SER D  70
HIS D 101
 None
None
HEM  D 201 ( 4.8A)
None
HEM  D 201 (-3.5A)
 1.05A 3m7rA-5m3lD:
undetectable		 3m7rA-5m3lD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 5 LEU G 326
VAL G 180
SER G 230
SER G 234
VAL G 240
 None
 1.26A 3m7rA-5mlvG:
undetectable		 3m7rA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 TYR A 170
LEU A 158
SER A 146
VAL A 150
LEU A 390
 None
 1.30A 3m7rA-5mqmA:
undetectable		 3m7rA-5mqmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 LEU A 537
LEU A 472
SER A 611
SER A 475
GLN A 545
 None
 1.23A 3m7rA-5mqsA:
undetectable		 3m7rA-5mqsA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		5 LEU A  49
VAL A  51
SER A 122
CYH A 129
VAL A 184
 None
 1.27A 3m7rA-5nthA:
undetectable		 3m7rA-5nthA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU B 110
LEU B 123
SER B 131
GLN B 106
LEU B   5
 None
 1.33A 3m7rA-5swiB:
undetectable		 3m7rA-5swiB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 554
LEU A 557
VAL A 558
SER A 561
VAL A 477
 None
 1.19A 3m7rA-5uv2A:
undetectable		 3m7rA-5uv2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 TYR A1028
LEU A1295
LEU A1293
VAL A1294
VAL A1299
 None
 1.06A 3m7rA-5vadA:
undetectable		 3m7rA-5vadA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
26S PROTEASOME
REGULATORY SUBUNIT
6B

(Homo sapiens) 		PF00004
(AAA)
PF00023
(Ank)
PF12796
(Ank_2) 		5 TYR G  15
LEU D 395
VAL D 394
SER G  49
LEU D 360
 None
 1.13A 3m7rA-5vhoG:
undetectable		 3m7rA-5vhoG:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 543
SER A 544
SER A 576
CYH A 589
VAL A 601
 None
 1.28A 3m7rA-5welA:
undetectable		 3m7rA-5welA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 LEU A1162
SER A1157
SER A1139
SER A1136
VAL A1205
 None
 1.33A 3m7rA-5wveA:
undetectable		 3m7rA-5wveA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5v GD

(Suid
alphaherpesvirus
1) 		PF01537
(Herpes_glycop_D) 		5 LEU A  71
LEU A 151
SER A 138
VAL A 181
LEU A  62
 None
 1.20A 3m7rA-5x5vA:
undetectable		 3m7rA-5x5vA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 VAL A 429
SER A 428
VAL A 611
GLN A 491
HIS A 494
 None
 1.07A 3m7rA-6bhuA:
undetectable		 3m7rA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 LEU I 251
SER I 256
CYH I 321
VAL I 341
LEU I 378
 None
 1.29A 3m7rA-6bnpI:
undetectable		 3m7rA-6bnpI:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4

(Homo sapiens) 		no annotation 5 LEU H 108
VAL H 107
SER H 155
SER H 111
GLN H  92
 None
 1.25A 3m7rA-6d6qH:
undetectable		 3m7rA-6d6qH:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 5 LEU A 102
SER A 323
SER A 162
SER A 202
GLN A 101
 PLP  A 601 (-3.6A)
PLP  A 601 ( 4.8A)
PLP  A 601 (-2.5A)
PLP  A 601 ( 3.9A)
None
 1.24A 3m7rA-6enzA:
undetectable		 3m7rA-6enzA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2s COAT PROTEIN SUBUNIT
I

(Ageratum yellow
vein virus) 		no annotation 5 TYR I  78
LEU I 180
LEU I 140
VAL I 141
SER I  94
 None
 1.20A 3m7rA-6f2sI:
undetectable		 3m7rA-6f2sI:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 7 TYR A 175
LEU A 258
LEU A 261
SER A 303
SER A 306
CYH A 316
VAL A 328
 None
DZW  A 501 (-3.8A)
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
 0.84A 3m7rA-6fobA:
37.4		 3m7rA-6fobA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 9 TYR A 175
LEU A 261
VAL A 262
SER A 303
SER A 306
CYH A 316
VAL A 328
LEU A 337
HIS A 423
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
None
DZW  A 501 (-4.0A)
 0.24A 3m7rA-6fobA:
37.4		 3m7rA-6fobA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 9 TYR A 175
VAL A 262
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
LEU A 337
HIS A 423
 None
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
None
DZW  A 501 (-4.0A)
 0.60A 3m7rA-6fobA:
37.4		 3m7rA-6fobA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Mus musculus) 		no annotation 5 LEU K  75
LEU K  78
VAL K  79
SER K  82
VAL J  65
 None
 1.31A 3m7rA-6g2jK:
undetectable		 3m7rA-6g2jK:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		5 PHE A  76
ILE A  23
LEU A 214
TYR A 199
VAL A 167
 None
 1.37A 3m7rA-1cq3A:
undetectable		 3m7rA-1cq3A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P11
CASPASE-7 SUBUNIT
P20

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU B 295
ARG B 264
TYR B 300
LEU A 104
VAL B 291
 None
 1.26A 3m7rA-1i51B:
0.4		 3m7rA-1i51B:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 PHE A 667
LEU A 713
ILE A 575
ARG A 643
TYR A 634
 None
None
None
None
MLZ  A 638 ( 3.6A)
 1.44A 3m7rA-1iv8A:
0.0		 3m7rA-1iv8A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 295
ARG A 264
TYR A 300
LEU A 104
VAL A 291
 None
 1.24A 3m7rA-1k86A:
0.0		 3m7rA-1k86A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 PHE A 340
LEU A 333
LEU A 580
TYR A 408
VAL A 249
 None
 1.47A 3m7rA-2dfsA:
0.0		 3m7rA-2dfsA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 PHE A 250
LEU A 194
LEU A  87
TYR A 158
VAL A 139
 None
 1.50A 3m7rA-2hnhA:
0.0		 3m7rA-2hnhA:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		9 PHE A 150
LEU A 223
ILE A 267
ARG A 270
TRP A 282
TYR A 291
LEU A 309
TYR A 397
VAL A 414
 None
None
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.7A)
None
None
None
None
 0.29A 3m7rA-2o4jA:
38.9		 3m7rA-2o4jA:
88.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		5 ILE A 144
ARG A 167
TYR A 202
LEU A 164
VAL A 225
 None
 1.50A 3m7rA-2qgqA:
0.0		 3m7rA-2qgqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		5 LEU A  60
ILE A  26
ARG A  79
LEU A 128
VAL A  38
 None
 1.29A 3m7rA-3doaA:
undetectable		 3m7rA-3doaA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 PHE A 655
LEU A 698
ILE A 572
ARG A 631
TYR A 622
 None
 1.45A 3m7rA-3hjeA:
undetectable		 3m7rA-3hjeA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		5 LEU A 251
ARG A 239
TRP A 241
LEU A  95
VAL A 271
 None
 1.45A 3m7rA-3m4aA:
undetectable		 3m7rA-3m4aA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 150
LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 295
LEU A 313
TYR A 401
VAL A 418
 None
None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
None
None
None
 0.17A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 PHE A 294
ILE A 350
TYR A 302
LEU A 322
VAL A 345
 None
 1.49A 3m7rA-4g1gA:
undetectable		 3m7rA-4g1gA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		5 PHE A  43
LEU A 264
ILE A  51
LEU A 179
VAL A  34
 None
 1.35A 3m7rA-5e2fA:
undetectable		 3m7rA-5e2fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		5 LEU A 613
ARG A 589
LEU A 603
TYR A 638
VAL A 579
 None
 1.30A 3m7rA-5h11A:
undetectable		 3m7rA-5h11A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq9 UNCHARACTERIZED
PROTEIN YACP

(Bacillus
subtilis) 		PF05991
(NYN_YacP) 		5 PHE A  73
ILE A  34
TYR A   9
TYR A  40
VAL A  48
 None
 1.42A 3m7rA-5mq9A:
undetectable		 3m7rA-5mq9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 PHE C1082
ILE C1138
ARG C1090
TYR C1107
LEU C1153
 None
 1.47A 3m7rA-5y3rC:
undetectable		 3m7rA-5y3rC:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 9 PHE A 182
LEU A 255
ILE A 299
ARG A 302
TRP A 314
TYR A 323
LEU A 341
TYR A 427
VAL A 444
 None
None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
DZW  A 501 (-3.6A)
None
DZW  A 501 (-4.9A)
None
 0.36A 3m7rA-6fobA:
37.4		 3m7rA-6fobA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 PHE A 182
TYR A 323
LEU A 338
TYR A 427
VAL A 444
 None
DZW  A 501 (-3.6A)
None
DZW  A 501 (-4.9A)
None
 1.48A 3m7rA-6fobA:
37.4		 3m7rA-6fobA:
22.54