SIMILAR PATTERNS OF AMINO ACIDS FOR 3M6V_B_SAMB465
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 5 | PRO A 62GLY A 63GLY A 64ASP A 57LEU A 109 | SAM A 301 (-3.4A)SAM A 301 (-3.9A)SAM A 301 (-3.1A)NoneNone | 1.06A | 3m6vB-1eizA:10.0 | 3m6vB-1eizA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eiz | FTSJ (Escherichiacoli) |
PF01728(FtsJ) | 5 | PRO A 62GLY A 63GLY A 64ASP A 124LEU A 143 | SAM A 301 (-3.4A)SAM A 301 (-3.9A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-4.6A) | 0.33A | 3m6vB-1eizA:10.0 | 3m6vB-1eizA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1inl | SPERMIDINE SYNTHASE (Thermotogamaritima) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | GLY A 102GLY A 103VAL A 122ASP A 123ASP A 170LEU A 182 | None | 0.78A | 3m6vB-1inlA:10.4 | 3m6vB-1inlA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | ALA A 127GLY A 130GLY A 131VAL A 151ASP A 152 | None | 0.85A | 3m6vB-1ixkA:34.3 | 3m6vB-1ixkA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | GLY A 130GLY A 131LYS A 132ASP A 194LEU A 228 | None | 1.10A | 3m6vB-1ixkA:34.3 | 3m6vB-1ixkA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | GLY A 130GLY A 131LYS A 132VAL A 151ASP A 152 | None | 0.86A | 3m6vB-1ixkA:34.3 | 3m6vB-1ixkA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6y | S-ADENOSYL-METHYLTRANSFERASE MRAW (Thermotogamaritima) |
PF01795(Methyltransf_5) | 5 | GLY A 36GLY A 37VAL A 56ASP A 57ASP A 103 | SAH A 401 (-4.1A)SAH A 401 (-3.3A)SAH A 401 (-4.3A)NoneSAH A 401 (-3.7A) | 0.72A | 3m6vB-1m6yA:14.0 | 3m6vB-1m6yA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 86GLY A 87ASP A 106ASP A 158LEU A 169 | None | 0.84A | 3m6vB-1mjfA:10.2 | 3m6vB-1mjfA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ons | CHAPERONE PROTEINHCHA (Escherichiacoli) |
no annotation | 5 | PRO A 151GLY A 152GLY A 153VAL A 180LEU A 193 | None | 1.02A | 3m6vB-1onsA:3.0 | 3m6vB-1onsA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 6 | PRO A 237GLY A 236GLY A 235ASP A 16PRO A 90LEU A 215 | NoneNoneNone CA A2001 (-2.2A)NoneNone | 1.42A | 3m6vB-1q8fA:3.4 | 3m6vB-1q8fA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5b | 3-ISOPROPYLMALATEDEHYDROGENASE (Bacilluscoagulans) |
PF00180(Iso_dh) | 5 | ALA A 73PRO A 88GLY A 44GLY A 45PRO A 277 | None | 0.99A | 3m6vB-1v5bA:undetectable | 3m6vB-1v5bA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vm7 | RIBOKINASE (Thermotogamaritima) |
PF00294(PfkB) | 5 | ALA A 273GLY A 216GLY A 219ASP A 246PRO A 287 | None | 1.10A | 3m6vB-1vm7A:3.6 | 3m6vB-1vm7A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 132GLY A 133ASP A 153ASP A 201LEU A 212 | None | 0.88A | 3m6vB-1xj5A:9.8 | 3m6vB-1xj5A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a87 | THIOREDOXINREDUCTASE (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 5 | ALA A 121GLY A 50GLY A 49VAL A 290ASP A 291 | NoneFAD A 348 (-2.8A)FAD A 348 (-3.9A)NoneNone | 0.93A | 3m6vB-2a87A:2.5 | 3m6vB-2a87A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a87 | THIOREDOXINREDUCTASE (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 5 | ALA A 286PRO A 24GLY A 23VAL A 290ASP A 291 | NoneFAD A 348 (-3.7A)FAD A 348 (-3.4A)NoneNone | 1.09A | 3m6vB-2a87A:2.5 | 3m6vB-2a87A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akj | FERREDOXIN--NITRITEREDUCTASE,CHLOROPLAST (Spinaciaoleracea) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | PRO A 191VAL A 195ASP A 196PRO A 248ASP A 234 | None | 1.10A | 3m6vB-2akjA:undetectable | 3m6vB-2akjA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9e | NOL1/NOP2/SUN DOMAINFAMILY, MEMBER 5ISOFORM 2 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | GLY A 238LYS A 240ASP A 260ARG A 263ASP A 305 | SAM A1201 (-3.9A)SAM A1201 (-3.1A)NoneSAM A1201 (-3.9A)SAM A1201 (-3.7A) | 0.99A | 3m6vB-2b9eA:29.6 | 3m6vB-2b9eA:26.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpo | METHYLASE YHHF (Escherichiacoli) |
PF03602(Cons_hypoth95) | 5 | GLY A 64ASP A 84ASP A 127PRO A 129LEU A 134 | NoneNoneNoneNone CL A 401 (-4.5A) | 0.96A | 3m6vB-2fpoA:12.7 | 3m6vB-2fpoA:19.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | ALA A 125PRO A 128GLY A 129ARG A 154ASP A 194PRO A 196 | None | 1.07A | 3m6vB-2frxA:38.2 | 3m6vB-2frxA:35.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | ALA A 125PRO A 128GLY A 129ASP A 194PRO A 196LEU A 228 | None | 0.85A | 3m6vB-2frxA:38.2 | 3m6vB-2frxA:35.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2frx | HYPOTHETICAL PROTEINYEBU (Escherichiacoli) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N) | 6 | PRO A 128GLY A 129LYS A 131ARG A 154ASP A 194PRO A 196 | None | 1.25A | 3m6vB-2frxA:38.2 | 3m6vB-2frxA:35.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | GLY A 236GLY A 289ASP A 231ASP A 254LEU A 259 | None | 1.00A | 3m6vB-2ftpA:undetectable | 3m6vB-2ftpA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hvv | DEOXYCYTIDYLATEDEAMINASE (Streptococcusmutans) |
PF00383(dCMP_cyt_deam_1) | 5 | GLY A 46GLY A 47VAL A 94PRO A 98LEU A 106 | SO4 A 151 ( 4.0A)SO4 A 151 (-4.6A)NoneNoneNone | 1.09A | 3m6vB-2hvvA:undetectable | 3m6vB-2hvvA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 5 | GLY A 22GLY A 23ASP A 42PRO A 80LEU A 100 | NoneSAH A 328 (-3.6A)NoneSAH A 328 (-4.0A)SAH A 328 ( 4.9A) | 0.85A | 3m6vB-2i9kA:8.0 | 3m6vB-2i9kA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mf9 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP8 (Homo sapiens) |
PF00254(FKBP_C) | 5 | ALA A 137PRO A 134GLY A 123LYS A 119ASP A 117 | None | 1.09A | 3m6vB-2mf9A:undetectable | 3m6vB-2mf9A:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2y | ALPHA-RIBAZOLE-5'-PHOSPHATE PHOSPHATASE (Thermusthermophilus) |
PF00300(His_Phos_1) | 5 | GLY A 134GLY A 135ARG A 54PRO A 66LEU A 68 | CL A1001 (-3.6A)NoneNoneNoneNone | 1.03A | 3m6vB-2p2yA:undetectable | 3m6vB-2p2yA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 128GLY A 129ASP A 149ASP A 196LEU A 207 | NoneNoneNoneS4M A 501 (-2.6A)S4M A 501 (-4.4A) | 0.68A | 3m6vB-2pt6A:9.2 | 3m6vB-2pt6A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qdx | FERREDOXIN REDUCTASE (Pseudomonasaeruginosa) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | PRO A 106GLY A 107VAL A 100ASP A 102ASP A 248 | None | 0.96A | 3m6vB-2qdxA:3.3 | 3m6vB-2qdxA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgh | DIAMINOPIMELATEDECARBOXYLASE (Helicobacterpylori) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | GLY A 224GLY A 223VAL A 265ASP A 65LEU A 54 | PLP A 406 (-3.7A)PLP A 406 ( 4.4A)NonePLP A 406 (-3.7A)None | 1.06A | 3m6vB-2qghA:undetectable | 3m6vB-2qghA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 5 | ALA A 186PRO A 183GLY A 113ASP A 178ARG A 181 | None | 1.09A | 3m6vB-2wknA:undetectable | 3m6vB-2wknA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 5 | ALA A 166GLY A 293GLY A 294ARG A 184LEU A 132 | None | 1.07A | 3m6vB-2xgoA:2.3 | 3m6vB-2xgoA:25.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 5 | PRO A 89GLY A 140GLY A 139ASP A 94LEU A 152 | NoneGSP A 900 (-3.3A)GSP A 900 (-3.3A)NoneNone | 1.02A | 3m6vB-2xkaA:3.0 | 3m6vB-2xkaA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xlr | FLAVIN-CONTAININGMONOOXYGENASE (Methylophagaaminisulfidivorans) |
PF00743(FMO-like) | 5 | GLY A 49GLY A 16VAL A 107ASP A 110PRO A 103 | NoneFAD A 500 (-3.5A)NoneNoneNone | 1.06A | 3m6vB-2xlrA:undetectable | 3m6vB-2xlrA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 8 | ALA A 267GLY A 271GLY A 272LYS A 273VAL A 292ASP A 293ARG A 296ASP A 337 | SFG A5748 (-3.4A)SFG A5748 (-3.7A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)SFG A5748 ( 3.9A)NoneSFG A5748 (-3.0A)SFG A5748 (-3.6A) | 0.92A | 3m6vB-2yxlA:37.5 | 3m6vB-2yxlA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 6 | ALA A 267GLY A 272LYS A 273ASP A 293ARG A 296ASP A 337 | SFG A5748 (-3.4A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)NoneSFG A5748 (-3.0A)SFG A5748 (-3.6A) | 1.09A | 3m6vB-2yxlA:37.5 | 3m6vB-2yxlA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 7 | ALA A 267GLY A 272LYS A 273ASP A 293ASP A 337PRO A 339LEU A 371 | SFG A5748 (-3.4A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)NoneSFG A5748 (-3.6A)SFG A5748 (-4.0A)None | 0.92A | 3m6vB-2yxlA:37.5 | 3m6vB-2yxlA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 10 | ALA A 267PRO A 270GLY A 271GLY A 272LYS A 273VAL A 292ASP A 293ASP A 337PRO A 339LEU A 371 | SFG A5748 (-3.4A)SFG A5748 (-3.6A)SFG A5748 (-3.7A)SFG A5748 (-3.7A)SFG A5748 (-3.3A)SFG A5748 ( 3.9A)NoneSFG A5748 (-3.6A)SFG A5748 (-4.0A)None | 0.84A | 3m6vB-2yxlA:37.5 | 3m6vB-2yxlA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 6 | PRO A 270GLY A 271VAL A 292ASP A 293PRO A 339LEU A 367 | SFG A5748 (-3.6A)SFG A5748 (-3.7A)SFG A5748 ( 3.9A)NoneSFG A5748 (-4.0A)None | 1.47A | 3m6vB-2yxlA:37.5 | 3m6vB-2yxlA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxx | DIAMINOPIMELATEDECARBOXYLASE (Thermotogamaritima) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | GLY A 213GLY A 212VAL A 252ASP A 65LEU A 54 | PLP A 401 ( 4.1A)PLP A 401 ( 4.6A)NonePLP A 401 (-4.1A)None | 0.90A | 3m6vB-2yxxA:undetectable | 3m6vB-2yxxA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsu | SPERMIDINE SYNTHASE (Pyrococcushorikoshii) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 88GLY A 89ASP A 109ASP A 161LEU A 172 | NoneNoneNoneAG3 A1001 (-2.8A)None | 0.80A | 3m6vB-2zsuA:10.7 | 3m6vB-2zsuA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 5 | GLY A 96LYS A 97ASP A 163PRO A 165LEU A 193 | SFG A 500 (-3.5A)SFG A 500 (-2.8A)SFG A 500 (-3.7A)SFG A 500 (-3.9A)None | 1.05A | 3m6vB-3a4tA:31.1 | 3m6vB-3a4tA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 5 | LYS A 97ARG A 120ASP A 163PRO A 165LEU A 193 | SFG A 500 (-2.8A)SFG A 500 (-4.4A)SFG A 500 (-3.7A)SFG A 500 (-3.9A)None | 1.02A | 3m6vB-3a4tA:31.1 | 3m6vB-3a4tA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a4t | PUTATIVEMETHYLTRANSFERASEMJ0026 (Methanocaldococcusjannaschii) |
PF01189(Methyltr_RsmB-F) | 7 | PRO A 94GLY A 95GLY A 96LYS A 97ASP A 163PRO A 165LEU A 193 | SFG A 500 (-3.9A)SFG A 500 (-4.0A)SFG A 500 (-3.5A)SFG A 500 (-2.8A)SFG A 500 (-3.7A)SFG A 500 (-3.9A)None | 0.47A | 3m6vB-3a4tA:31.1 | 3m6vB-3a4tA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | PRO A 531GLY A 480GLY A 479ASP A 534LEU A 43 | None | 0.97A | 3m6vB-3aqpA:undetectable | 3m6vB-3aqpA:24.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 5 | PRO A 211GLY A 210GLY A 236VAL A 230LEU A 62 | NoneNoneNoneNone K A 703 ( 4.9A) | 1.04A | 3m6vB-3bolA:undetectable | 3m6vB-3bolA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 6 | GLY A 541GLY A 543ASP A 263ARG A 260PRO A 257LEU A 290 | MGD A1246 (-3.0A)MGD A1246 (-3.5A)NoneMGD A1246 ( 3.7A)NoneNone | 1.43A | 3m6vB-3egwA:undetectable | 3m6vB-3egwA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejg | NON-STRUCTURALPROTEIN 3 (Humancoronavirus229E) |
PF01661(Macro) | 5 | GLY A 43GLY A 42ASP A 18ASP A 50LEU A 84 | None | 0.99A | 3m6vB-3ejgA:undetectable | 3m6vB-3ejgA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewr | NON-STRUCTURALPROTEIN 3 (Humancoronavirus229E) |
PF01661(Macro) | 5 | GLY A 44GLY A 43ASP A 19ASP A 51LEU A 85 | APR A 169 (-3.2A)APR A 169 ( 4.5A)NoneNoneNone | 0.98A | 3m6vB-3ewrA:undetectable | 3m6vB-3ewrA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eza | PHOSPHOTRANSFERASESYSTEM, ENZYME I (Escherichiacoli) |
PF00391(PEP-utilizers)PF05524(PEP-utilisers_N) | 5 | GLY A 4GLY A 204VAL A 223ASP A 221PRO A 200 | None | 1.07A | 3m6vB-3ezaA:undetectable | 3m6vB-3ezaA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ga7 | ACETYL ESTERASE (Salmonellaenterica) |
PF07859(Abhydrolase_3) | 5 | ALA A 168GLY A 94GLY A 93ASP A 267ASP A 164 | SEP A 165 ( 3.3A)SEP A 165 ( 3.5A)SEP A 165 ( 3.6A)NoneSEP A 165 ( 4.4A) | 1.05A | 3m6vB-3ga7A:undetectable | 3m6vB-3ga7A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzy | INTERSECTIN 2 (Homo sapiens) |
PF00168(C2) | 5 | PRO A1639GLY A1638VAL A1656ARG A1657LEU A1604 | NoneNoneNoneUNX A 4 ( 4.1A)None | 1.04A | 3m6vB-3jzyA:undetectable | 3m6vB-3jzyA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kin | KINESIN HEAVY CHAINKINESIN HEAVY CHAIN (Rattusnorvegicus;Rattusnorvegicus) |
PF00225(Kinesin)PF00225(Kinesin) | 5 | GLY B 294GLY B 293VAL A 74ASP A 73LEU A 230 | None | 0.80A | 3m6vB-3kinB:undetectable | 3m6vB-3kinB:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmz | PUTATIVE SUGARISOMERASE (Parabacteroidesdistasonis) |
PF01261(AP_endonuc_2) | 5 | PRO A 182LYS A 149ARG A 210PRO A 136ASP A 145 | None | 1.01A | 3m6vB-3lmzA:undetectable | 3m6vB-3lmzA:18.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3m4x | NOL1/NOP2/SUN FAMILYPROTEIN (Enterococcusfaecium) |
PF01189(Methyltr_RsmB-F)PF13636(Methyltranf_PUA)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 7 | PRO A 116GLY A 117GLY A 118LYS A 119PRO A 165ASP A 182PRO A 184 | None | 0.52A | 3m6vB-3m4xA:47.7 | 3m6vB-3m4xA:40.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 6 | ALA A 109GLY A 113PRO A 160ASP A 177PRO A 179LEU A 211 | None | 0.92A | 3m6vB-3m6xA:65.7 | 3m6vB-3m6xA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 12 | ALA A 109PRO A 112GLY A 113GLY A 114LYS A 115VAL A 134ASP A 135ARG A 138PRO A 160ASP A 177PRO A 179LEU A 211 | None | 0.47A | 3m6vB-3m6xA:65.7 | 3m6vB-3m6xA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 5 | GLY A 114LYS A 115ASP A 177PRO A 179LEU A 211 | None | 1.10A | 3m6vB-3m6xA:65.7 | 3m6vB-3m6xA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg1 | MITOGEN-ACTIVATEDPROTEIN KINASE,PUTATIVE (MAPKINASE-LIKE PROTEIN) (Leishmaniamajor) |
PF00069(Pkinase) | 5 | GLY A 209VAL A 257ASP A 256PRO A 201LEU A 242 | None | 1.10A | 3m6vB-3pg1A:undetectable | 3m6vB-3pg1A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp9 | TYPE I POLYKETIDESYNTHASE PIKAII (Streptomycesvenezuelae) |
PF08659(KR) | 5 | GLY A 170GLY A 171VAL A 86ASP A 87LEU A 60 | None | 1.03A | 3m6vB-3qp9A:5.4 | 3m6vB-3qp9A:25.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 105GLY A 106ASP A 126ASP A 173LEU A 184 | NoneNoneNoneDSH A 303 (-3.0A)DSH A 303 (-4.2A) | 0.68A | 3m6vB-3rw9A:9.8 | 3m6vB-3rw9A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3saj | GLUTAMATE RECEPTOR 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | ALA A 246GLY A 330GLY A 333ARG A 247ASP A 242 | None | 1.09A | 3m6vB-3sajA:2.0 | 3m6vB-3sajA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swo | GLUTARYL-COADEHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 137GLY A 65LYS A 62VAL A 183ASP A 136 | None | 1.10A | 3m6vB-3swoA:undetectable | 3m6vB-3swoA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | PRO A 49GLY A 47VAL A 450ASP A 451LEU A 41 | None | 1.09A | 3m6vB-3t3oA:undetectable | 3m6vB-3t3oA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urh | DIHYDROLIPOYLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PRO A 12GLY A 11GLY A 38VAL A 331ASP A 328 | FAD A 500 (-3.2A)FAD A 500 (-3.2A)NoneNoneNone | 1.09A | 3m6vB-3urhA:2.7 | 3m6vB-3urhA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vab | DIAMINOPIMELATEDECARBOXYLASE 1 (Brucellamelitensis) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | GLY A 239GLY A 238VAL A 282ASP A 80LEU A 69 | LLP A 61 ( 3.6A)LLP A 61 ( 4.8A)NoneLLP A 61 ( 4.0A)None | 1.06A | 3m6vB-3vabA:undetectable | 3m6vB-3vabA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxx | ACRH (Aeromonashydrophila) |
no annotation | 5 | ALA A 24GLY A 21GLY A 20ASP A 28ASP A 64 | None | 1.10A | 3m6vB-3wxxA:undetectable | 3m6vB-3wxxA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ALA A 164PRO A 159GLY A 112PRO A 138LEU A 131 | None | 1.05A | 3m6vB-3zyvA:undetectable | 3m6vB-3zyvA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a27 | SYNAPTIC VESICLEMEMBRANE PROTEINVAT-1 HOMOLOG-LIKE (Homo sapiens) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 5 | GLY A 246LYS A 267VAL A 186ASP A 248LEU A 172 | None | 0.77A | 3m6vB-4a27A:5.4 | 3m6vB-4a27A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bko | PUTATIVE REDUCTASEBURPS305_1051 (Burkholderiapseudomallei) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 5 | GLY A 263GLY A 262VAL A 136PRO A 41LEU A 312 | None | 0.98A | 3m6vB-4bkoA:6.4 | 3m6vB-4bkoA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx9 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 33A (Homo sapiens) |
PF00995(Sec1) | 5 | ALA A 577GLY A 552VAL A 575ASP A 150LEU A 182 | None | 0.90A | 3m6vB-4bx9A:3.2 | 3m6vB-4bx9A:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ebj | AMINOGLYCOSIDENUCLEOTIDYLTRANSFERASE (Pseudomonasaeruginosa) |
PF01909(NTP_transf_2) | 5 | GLY A 220ARG A 186PRO A 123PRO A 226LEU A 231 | None | 1.10A | 3m6vB-4ebjA:undetectable | 3m6vB-4ebjA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fm9 | DNA TOPOISOMERASE2-ALPHA (Homo sapiens) |
PF00521(DNA_topoisoIV)PF01751(Toprim)PF16898(TOPRIM_C) | 6 | ALA A 444GLY A 448GLY A 449VAL A 483ASP A 442ASP A 446 | None | 1.46A | 3m6vB-4fm9A:undetectable | 3m6vB-4fm9A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwt | ELONGATION FACTORTS, ELONGATIONFACTOR TU, LINKER, QBETA REPLICASE (Escherichiacoli;Escherichiavirus Qbeta) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2)PF03431(RNA_replicase_B) | 5 | ALA A1165PRO A1158GLY A1160PRO A1186LEU A 709 | None | 1.09A | 3m6vB-4fwtA:undetectable | 3m6vB-4fwtA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | GLY A 186LYS A 187ASP A 255PRO A 257LEU A 291 | SAM A 401 (-3.9A)SAM A 401 (-3.5A)SAM A 401 (-3.7A)SAM A 401 (-4.0A)None | 1.02A | 3m6vB-4fzvA:28.7 | 3m6vB-4fzvA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 8 | PRO A 185GLY A 185GLY A 186LYS A 187ARG A 209ASP A 255PRO A 257LEU A 291 | SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-3.9A)SAM A 401 (-3.5A)SAM A 401 (-3.6A)SAM A 401 (-3.7A)SAM A 401 (-4.0A)None | 0.48A | 3m6vB-4fzvA:28.7 | 3m6vB-4fzvA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvf | BETA-HEXOSAMINIDASE (Salmonellaenterica) |
PF00933(Glyco_hydro_3) | 5 | GLY A 93GLY A 89ASP A 151PRO A 119LEU A 121 | None | 1.05A | 3m6vB-4gvfA:2.2 | 3m6vB-4gvfA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 6 | ALA A 147GLY A 205VAL A 178ARG A 280PRO A 181LEU A 195 | None | 1.24A | 3m6vB-4j5iA:undetectable | 3m6vB-4j5iA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 6 | ALA A 147GLY A 205VAL A 178ARG A 280PRO A 181LEU A 195 | None | 1.27A | 3m6vB-4j5iA:undetectable | 3m6vB-4j5iA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kry | ACETYL ESTERASE (Escherichiacoli) |
PF07859(Abhydrolase_3) | 5 | ALA A 168GLY A 94GLY A 93ASP A 267ASP A 164 | SEB A 165 ( 3.4A)SEB A 165 ( 3.5A)SEB A 165 ( 3.6A)PGE A 401 ( 4.4A)SEB A 165 ( 4.4A) | 1.10A | 3m6vB-4kryA:undetectable | 3m6vB-4kryA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw5 | OXIDOREDUCTASE (Mycobacteriumtuberculosis) |
PF01565(FAD_binding_4)PF04030(ALO) | 5 | ALA A 126GLY A 177GLY A 179PRO A 116LEU A 98 | NoneNoneFAD A 501 (-3.3A)FAD A 501 (-4.5A)None | 1.05A | 3m6vB-4kw5A:undetectable | 3m6vB-4kw5A:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mks | ENOLASE 2 (Lactobacillusgasseri) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 230VAL A 179ARG A 180PRO A 145ASP A 236 | None | 1.09A | 3m6vB-4mksA:undetectable | 3m6vB-4mksA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n49 | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF01728(FtsJ) | 5 | PRO A 280GLY A 281GLY A 282ASP A 364LEU A 383 | SAM A 601 (-3.6A)SAM A 601 (-3.6A)SAM A 601 (-3.1A)SAM A 601 (-3.6A)SAM A 601 (-4.6A) | 0.55A | 3m6vB-4n49A:10.1 | 3m6vB-4n49A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oht | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Streptococcuspyogenes) |
PF00171(Aldedh) | 5 | ALA A 235GLY A 410VAL A 380ASP A 383ASP A 234 | None | 0.98A | 3m6vB-4ohtA:3.2 | 3m6vB-4ohtA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trt | DNA POLYMERASE IIISUBUNIT BETA (Deinococcusradiodurans) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 6 | ALA A 331GLY A 348GLY A 350VAL A 250PRO A 253LEU A 257 | None | 1.50A | 3m6vB-4trtA:undetectable | 3m6vB-4trtA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 128GLY A 129ASP A 149ASP A 196LEU A 207 | NoneNoneNone4ZY A 501 ( 3.6A)MTA A 401 (-4.4A) | 0.72A | 3m6vB-4uoeA:10.1 | 3m6vB-4uoeA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv7 | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 5 | ALA A 154GLY A 147GLY A 183VAL A 271ASP A 310 | None | 1.09A | 3m6vB-4yv7A:undetectable | 3m6vB-4yv7A:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 6 | ALA A 387GLY A 754LYS A 757ASP A 393ARG A 698ASP A 383 | None | 1.40A | 3m6vB-5a22A:7.9 | 3m6vB-5a22A:12.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e31 | PENICILLIN BINDINGPROTEIN 2 PRIME (Enterococcusfaecium) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF05223(MecA_N) | 5 | ALA A 270GLY A 361GLY A 360ASP A 386ASP A 357 | None | 1.09A | 3m6vB-5e31A:2.6 | 3m6vB-5e31A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ehf | LACCASE (Antrodiellafaginea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ALA A 149PRO A 123GLY A 122GLY A 33PRO A 208 | None | 1.08A | 3m6vB-5ehfA:undetectable | 3m6vB-5ehfA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ew5 | COLICIN-E9 (Escherichiacoli) |
PF03515(Cloacin) | 5 | GLY A 266ARG A 185PRO A 93ASP A 189LEU A 137 | None | 1.10A | 3m6vB-5ew5A:undetectable | 3m6vB-5ew5A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i61 | POTENTIALRNA-DEPENDENT RNAPOLYMERASE (Humanpicobirnavirus) |
no annotation | 5 | PRO B 84GLY B 29VAL B 202ASP B 91LEU B 306 | None | 0.98A | 3m6vB-5i61B:undetectable | 3m6vB-5i61B:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqm | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAIN (Bacteroidesthetaiotaomicron) |
PF17132(Glyco_hydro_106) | 5 | ALA A 582GLY A 780GLY A 781VAL A 555ASP A 556 | None | 0.99A | 3m6vB-5mqmA:undetectable | 3m6vB-5mqmA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9j | TRANSCRIPTIONINITIATION FACTORIIB,TRANSCRIPTIONINITIATION FACTORIIB (Methanocaldococcusjannaschii) |
no annotation | 5 | ALA A 171GLY A 174GLY A 175ASP A 3LEU A 161 | None | 1.05A | 3m6vB-5o9jA:undetectable | 3m6vB-5o9jA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT BTUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT C (Methanothermobactersp. CaT2;Methanothermobacterwolfeii) |
PF00384(Molybdopterin)PF01493(GXGXG) | 5 | PRO C 181GLY C 182GLY C 201ASP C 134LEU B 124 | None | 1.09A | 3m6vB-5t5iC:undetectable | 3m6vB-5t5iC:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwt | PUTATIVEMETHYLTRANSFERASENSUN6 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | GLY A 247LYS A 248ASP A 323PRO A 325LEU A 354 | None C C 72 ( 3.1A) C C 72 ( 2.8A)NoneNone | 1.00A | 3m6vB-5wwtA:33.4 | 3m6vB-5wwtA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwt | PUTATIVEMETHYLTRANSFERASENSUN6 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 7 | PRO A 245GLY A 246GLY A 247LYS A 248ASP A 323PRO A 325LEU A 354 | C C 72 ( 4.7A)NoneNone C C 72 ( 3.1A) C C 72 ( 2.8A)NoneNone | 0.51A | 3m6vB-5wwtA:33.4 | 3m6vB-5wwtA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4j | XYLOSE ISOMERASE (Streptomycesrubiginosus) |
PF01261(AP_endonuc_2) | 5 | GLY A 62ARG A 68PRO A 36ASP A 56LEU A 15 | None | 1.10A | 3m6vB-5y4jA:undetectable | 3m6vB-5y4jA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0c | NEROL DEHYDROGENASE (Persicariaminor) |
no annotation | 5 | GLY A 247LYS A 270VAL A 190ASP A 250LEU A 176 | None | 0.92A | 3m6vB-5z0cA:6.3 | 3m6vB-5z0cA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fbt | LYTIC MUREINTRANSGLYCOSYLASE (Pseudomonasaeruginosa) |
no annotation | 5 | ALA A 162GLY A 168ASP A 129ASP A 164PRO A 160 | NoneNoneNonePO4 A 701 (-3.0A)None | 1.08A | 3m6vB-6fbtA:undetectable | 3m6vB-6fbtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | PRO A 300VAL A 270ASP A 173PRO A 214LEU A 165 | None | 0.99A | 3m6vB-6gunA:undetectable | 3m6vB-6gunA:undetectable |