SIMILAR PATTERNS OF AMINO ACIDS FOR 3M0W_G_P77G203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ASP A 164
SER A 171
PHE A 410
ILE A 395
PHE A 298
 None
 1.13A 3m0wG-3eafA:
undetectable
3m0wH-3eafA:
undetectable
3m0wI-3eafA:
undetectable
3m0wJ-3eafA:
undetectable		 3m0wG-3eafA:
12.08
3m0wH-3eafA:
12.08
3m0wI-3eafA:
12.08
3m0wJ-3eafA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		5 ASP A  88
PHE A 100
ILE A 215
LEU A 186
ASP A 188
 CL  A 381 ( 3.0A)
None
None
None
LLP  A 222 ( 2.7A)
 1.37A 3m0wG-3fdbA:
undetectable
3m0wH-3fdbA:
undetectable
3m0wI-3fdbA:
undetectable
3m0wJ-3fdbA:
undetectable		 3m0wG-3fdbA:
14.55
3m0wH-3fdbA:
14.55
3m0wI-3fdbA:
14.55
3m0wJ-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 310
PHE A 311
ILE A 276
LEU A 107
ASP A 111
 None
 1.10A 3m0wG-3r11A:
undetectable
3m0wH-3r11A:
undetectable
3m0wI-3r11A:
undetectable
3m0wJ-3r11A:
undetectable		 3m0wG-3r11A:
12.14
3m0wH-3r11A:
12.14
3m0wI-3r11A:
12.14
3m0wJ-3r11A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 ASP A 256
SER A 129
ILE A 179
LEU A 164
ASP A 195
 None
 1.26A 3m0wG-4e69A:
undetectable
3m0wH-4e69A:
undetectable
3m0wI-4e69A:
undetectable
3m0wJ-4e69A:
undetectable		 3m0wG-4e69A:
11.55
3m0wH-4e69A:
11.55
3m0wI-4e69A:
11.55
3m0wJ-4e69A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE

(Thermotoga
maritima) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 ASP A 161
ILE A  67
CYH A 165
LEU A  61
ASP A  58
 None
 1.40A 3m0wG-4kr9A:
undetectable
3m0wH-4kr9A:
undetectable
3m0wI-4kr9A:
undetectable
3m0wJ-4kr9A:
undetectable		 3m0wG-4kr9A:
12.24
3m0wH-4kr9A:
12.24
3m0wI-4kr9A:
12.24
3m0wJ-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfz POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 ASP A 164
PHE A  46
ILE A  78
LEU A 109
ASP A 111
 None
 1.37A 3m0wG-4nfzA:
1.0
3m0wH-4nfzA:
0.9
3m0wI-4nfzA:
0.9
3m0wJ-4nfzA:
1.0		 3m0wG-4nfzA:
16.90
3m0wH-4nfzA:
16.90
3m0wI-4nfzA:
16.90
3m0wJ-4nfzA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 5 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.20A 3m0wG-4u5aA:
1.8
3m0wH-4u5aA:
1.8
3m0wI-4u5aA:
1.8
3m0wJ-4u5aA:
1.9		 3m0wG-4u5aA:
19.80
3m0wH-4u5aA:
19.80
3m0wI-4u5aA:
19.80
3m0wJ-4u5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A 316
PHE A 314
ILE A 353
LEU A 357
ASP A 359
 None
 1.46A 3m0wG-5w4xA:
undetectable
3m0wH-5w4xA:
undetectable
3m0wI-5w4xA:
undetectable
3m0wJ-5w4xA:
undetectable		 3m0wG-5w4xA:
12.33
3m0wH-5w4xA:
12.33
3m0wI-5w4xA:
12.33
3m0wJ-5w4xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 ASP A 363
PHE A 339
ILE A 328
LEU A 353
ASP A 355
 None
 1.42A 3m0wG-6bo6A:
undetectable
3m0wH-6bo6A:
undetectable
3m0wI-6bo6A:
undetectable
3m0wJ-6bo6A:
undetectable		 3m0wG-6bo6A:
undetectable
3m0wH-6bo6A:
undetectable
3m0wI-6bo6A:
undetectable
3m0wJ-6bo6A:
undetectable