SIMILAR PATTERNS OF AMINO ACIDS FOR 3M0W_F_P77F203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU X 183
SER X  56
ILE X 181
PHE X   8
ASP X 349
 None
 1.40A 3m0wC-2b5dX:
undetectable
3m0wD-2b5dX:
undetectable
3m0wE-2b5dX:
undetectable
3m0wF-2b5dX:
undetectable		 3m0wC-2b5dX:
12.21
3m0wD-2b5dX:
12.21
3m0wE-2b5dX:
12.21
3m0wF-2b5dX:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		5 LEU A 434
ASP A 436
ILE A 301
PHE A   7
PHE A 446
 None
 1.43A 3m0wC-2bdeA:
undetectable
3m0wD-2bdeA:
undetectable
3m0wE-2bdeA:
1.2
3m0wF-2bdeA:
undetectable		 3m0wC-2bdeA:
12.32
3m0wD-2bdeA:
12.32
3m0wE-2bdeA:
12.32
3m0wF-2bdeA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 LEU A 703
ASP A 705
ILE A 580
ASP A 713
SER A 717
 None
 1.46A 3m0wC-2c4mA:
undetectable
3m0wD-2c4mA:
undetectable
3m0wE-2c4mA:
0.4
3m0wF-2c4mA:
undetectable		 3m0wC-2c4mA:
9.02
3m0wD-2c4mA:
9.02
3m0wE-2c4mA:
9.02
3m0wF-2c4mA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 LEU A 154
ASP A 155
PHE A 218
ASP A 100
SER A 128
 None
NI  A 231 (-4.2A)
None
None
None
 1.45A 3m0wC-3cc8A:
undetectable
3m0wD-3cc8A:
undetectable
3m0wE-3cc8A:
undetectable
3m0wF-3cc8A:
undetectable		 3m0wC-3cc8A:
19.02
3m0wD-3cc8A:
19.02
3m0wE-3cc8A:
19.02
3m0wF-3cc8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		5 LEU A 182
ASP A 183
SER A 163
ILE A 169
SER A 289
 None
 1.27A 3m0wC-3hdoA:
undetectable
3m0wD-3hdoA:
undetectable
3m0wE-3hdoA:
undetectable
3m0wF-3hdoA:
undetectable		 3m0wC-3hdoA:
14.33
3m0wD-3hdoA:
14.33
3m0wE-3hdoA:
14.33
3m0wF-3hdoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q64 MLL3774 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		5 LEU A 108
ASP A  83
ILE A 106
PHE A  26
PHE A  53
 None
 1.49A 3m0wC-3q64A:
undetectable
3m0wD-3q64A:
undetectable
3m0wE-3q64A:
undetectable
3m0wF-3q64A:
undetectable		 3m0wC-3q64A:
18.18
3m0wD-3q64A:
18.18
3m0wE-3q64A:
18.18
3m0wF-3q64A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 LEU A 229
ASP A 228
ILE A 295
ASP A 463
SER A 266
 None
 1.43A 3m0wC-3t5oA:
undetectable
3m0wD-3t5oA:
undetectable
3m0wE-3t5oA:
undetectable
3m0wF-3t5oA:
undetectable		 3m0wC-3t5oA:
8.29
3m0wD-3t5oA:
8.29
3m0wE-3t5oA:
8.29
3m0wF-3t5oA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 SER A 188
ILE A 236
CYH A 172
PHE A 291
SER A 260
 None
 1.37A 3m0wC-3upyA:
undetectable
3m0wD-3upyA:
undetectable
3m0wE-3upyA:
undetectable
3m0wF-3upyA:
undetectable		 3m0wC-3upyA:
12.75
3m0wD-3upyA:
12.75
3m0wE-3upyA:
12.75
3m0wF-3upyA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE

(Thermotoga
maritima) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 LEU A  61
ASP A  58
ILE A  67
CYH A 165
ASP A 161
 None
 1.49A 3m0wC-4kr9A:
undetectable
3m0wD-4kr9A:
undetectable
3m0wE-4kr9A:
undetectable
3m0wF-4kr9A:
undetectable		 3m0wC-4kr9A:
12.24
3m0wD-4kr9A:
12.24
3m0wE-4kr9A:
12.24
3m0wF-4kr9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 LEU A 188
CYH A 236
PHE A 235
ASP A 297
SER A 202
 None
None
None
C  O   1 ( 4.8A)
None
 1.14A 3m0wC-4u8tA:
undetectable
3m0wD-4u8tA:
undetectable
3m0wE-4u8tA:
undetectable
3m0wF-4u8tA:
undetectable		 3m0wC-4u8tA:
20.12
3m0wD-4u8tA:
20.12
3m0wE-4u8tA:
20.12
3m0wF-4u8tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A1063
SER A 722
ILE A 730
CYH A 743
ASP A 747
 None
 1.37A 3m0wC-5a0zA:
0.2
3m0wD-5a0zA:
undetectable
3m0wE-5a0zA:
undetectable
3m0wF-5a0zA:
undetectable		 3m0wC-5a0zA:
8.98
3m0wD-5a0zA:
8.98
3m0wE-5a0zA:
8.98
3m0wF-5a0zA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU B 276
ASP B 275
SER B 296
ILE B 305
SER B 170
 None
None
None
None
TCR  B 609 (-2.8A)
 1.27A 3m0wC-5fbhB:
undetectable
3m0wD-5fbhB:
undetectable
3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable		 3m0wC-5fbhB:
9.68
3m0wD-5fbhB:
9.68
3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 368
ILE A 413
PHE A 420
ASP A 346
SER A 363
 None
 1.24A 3m0wC-5kshA:
undetectable
3m0wD-5kshA:
undetectable
3m0wE-5kshA:
undetectable
3m0wF-5kshA:
undetectable		 3m0wC-5kshA:
11.32
3m0wD-5kshA:
11.32
3m0wE-5kshA:
11.32
3m0wF-5kshA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ASP Z 171
ILE Z 195
PHE Z 177
PHE Z 215
SER Z 222
 MN  Z 401 (-2.7A)
None
None
None
None
 1.20A 3m0wC-5v07Z:
undetectable
3m0wD-5v07Z:
undetectable
3m0wE-5v07Z:
undetectable
3m0wF-5v07Z:
undetectable		 3m0wC-5v07Z:
14.16
3m0wD-5v07Z:
14.16
3m0wE-5v07Z:
14.16
3m0wF-5v07Z:
14.16