SIMILAR PATTERNS OF AMINO ACIDS FOR 3M0W_E_P77E203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 SER A  22
PHE A  29
LEU A  67
ASP A  66
 None
 1.01A 3m0wE-1gsoA:
undetectable
3m0wF-1gsoA:
undetectable
3m0wG-1gsoA:
undetectable
3m0wH-1gsoA:
undetectable		 3m0wE-1gsoA:
14.51
3m0wF-1gsoA:
14.51
3m0wG-1gsoA:
14.51
3m0wH-1gsoA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		4 PHE A 250
SER A 252
LEU A 204
ASP A 237
 None
None
None
PLP  A 500 (-3.5A)
 1.06A 3m0wE-1iayA:
undetectable
3m0wF-1iayA:
undetectable
3m0wG-1iayA:
undetectable
3m0wH-1iayA:
undetectable		 3m0wE-1iayA:
11.03
3m0wF-1iayA:
11.03
3m0wG-1iayA:
11.03
3m0wH-1iayA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 SER A 236
PHE A  40
LEU A 202
ASP A 201
 None
 0.93A 3m0wE-1jeqA:
undetectable
3m0wF-1jeqA:
undetectable
3m0wG-1jeqA:
undetectable
3m0wH-1jeqA:
undetectable		 3m0wE-1jeqA:
10.67
3m0wF-1jeqA:
10.67
3m0wG-1jeqA:
10.67
3m0wH-1jeqA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER X 280
CYH X 275
LEU X 298
ASP X 299
 None
 1.03A 3m0wE-1jpdX:
undetectable
3m0wF-1jpdX:
undetectable
3m0wG-1jpdX:
undetectable
3m0wH-1jpdX:
undetectable		 3m0wE-1jpdX:
16.12
3m0wF-1jpdX:
16.12
3m0wG-1jpdX:
16.12
3m0wH-1jpdX:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 ASP A 189
SER A 188
SER A 250
CYH A 438
 None
 1.04A 3m0wE-1js6A:
undetectable
3m0wF-1js6A:
undetectable
3m0wG-1js6A:
undetectable
3m0wH-1js6A:
undetectable		 3m0wE-1js6A:
11.27
3m0wF-1js6A:
11.27
3m0wG-1js6A:
11.27
3m0wH-1js6A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8m E2 COMPONENT OF
BRANCHED-CHAIN
ALPHA-KETOACID
DEHYDROGENASE

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		4 ASP A  85
SER A  10
CYH A  39
LEU A  75
 None
 1.04A 3m0wE-1k8mA:
undetectable
3m0wF-1k8mA:
undetectable
3m0wG-1k8mA:
undetectable
3m0wH-1k8mA:
undetectable		 3m0wE-1k8mA:
19.61
3m0wF-1k8mA:
19.61
3m0wG-1k8mA:
19.61
3m0wH-1k8mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A 268
PHE A 195
LEU A 233
ASP A 230
 None
 1.04A 3m0wE-1l8kA:
undetectable
3m0wF-1l8kA:
undetectable
3m0wG-1l8kA:
undetectable
3m0wH-1l8kA:
undetectable		 3m0wE-1l8kA:
14.42
3m0wF-1l8kA:
14.42
3m0wG-1l8kA:
14.42
3m0wH-1l8kA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 PHE A  70
CYH A  82
LEU A  74
ASP A  73
 None
 1.00A 3m0wE-1mx8A:
undetectable
3m0wF-1mx8A:
undetectable
3m0wG-1mx8A:
undetectable
3m0wH-1mx8A:
undetectable		 3m0wE-1mx8A:
20.90
3m0wF-1mx8A:
20.90
3m0wG-1mx8A:
20.90
3m0wH-1mx8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1via SHIKIMATE KINASE

(Campylobacter
jejuni) 		PF01202
(SKI) 		4 ASP A  34
SER A 116
LEU A 110
ASP A 111
 None
 1.00A 3m0wE-1viaA:
undetectable
3m0wF-1viaA:
undetectable
3m0wG-1viaA:
undetectable
3m0wH-1viaA:
undetectable		 3m0wE-1viaA:
22.76
3m0wF-1viaA:
22.76
3m0wG-1viaA:
22.76
3m0wH-1viaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 ASP A 277
SER A 280
LEU A 110
ASP A 111
 None
 0.79A 3m0wE-1vp4A:
undetectable
3m0wF-1vp4A:
undetectable
3m0wG-1vp4A:
undetectable
3m0wH-1vp4A:
undetectable		 3m0wE-1vp4A:
13.21
3m0wF-1vp4A:
13.21
3m0wG-1vp4A:
13.21
3m0wH-1vp4A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 PHE A 120
SER A 134
LEU A 116
ASP A 161
 None
 0.81A 3m0wE-1w61A:
undetectable
3m0wF-1w61A:
undetectable
3m0wG-1w61A:
undetectable
3m0wH-1w61A:
undetectable		 3m0wE-1w61A:
13.33
3m0wF-1w61A:
13.33
3m0wG-1w61A:
13.33
3m0wH-1w61A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ASP A 714
SER A 717
LEU A 188
ASP A 184
 None
 1.00A 3m0wE-1z8lA:
undetectable
3m0wF-1z8lA:
undetectable
3m0wG-1z8lA:
undetectable
3m0wH-1z8lA:
undetectable		 3m0wE-1z8lA:
9.25
3m0wF-1z8lA:
9.25
3m0wG-1z8lA:
9.25
3m0wH-1z8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4e CADHERIN-11

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 134
SER A 141
LEU A  63
ASP A  64
 CA  A 301 ( 3.3A)
None
None
CA  A 303 (-2.9A)
 1.07A 3m0wE-2a4eA:
undetectable
3m0wF-2a4eA:
undetectable
3m0wG-2a4eA:
undetectable
3m0wH-2a4eA:
undetectable		 3m0wE-2a4eA:
18.98
3m0wF-2a4eA:
18.98
3m0wG-2a4eA:
18.98
3m0wH-2a4eA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an1 PUTATIVE KINASE

(Salmonella
enterica) 		PF01513
(NAD_kinase) 		4 PHE A 170
SER A 173
LEU A 231
ASP A 257
 PHE  A 170 ( 1.3A)
SER  A 173 ( 0.0A)
LEU  A 231 ( 0.5A)
ASP  A 257 ( 0.6A)
 1.06A 3m0wE-2an1A:
undetectable
3m0wF-2an1A:
undetectable
3m0wG-2an1A:
undetectable
3m0wH-2an1A:
undetectable		 3m0wE-2an1A:
13.79
3m0wF-2an1A:
13.79
3m0wG-2an1A:
13.79
3m0wH-2an1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 ASP X 349
PHE X   8
SER X  56
LEU X 183
 None
 1.00A 3m0wE-2b5dX:
undetectable
3m0wF-2b5dX:
undetectable
3m0wG-2b5dX:
undetectable
3m0wH-2b5dX:
undetectable		 3m0wE-2b5dX:
12.21
3m0wF-2b5dX:
12.21
3m0wG-2b5dX:
12.21
3m0wH-2b5dX:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 SER A 730
SER A 818
LEU A 821
ASP A 824
 None
 1.05A 3m0wE-2b5mA:
undetectable
3m0wF-2b5mA:
undetectable
3m0wG-2b5mA:
undetectable
3m0wH-2b5mA:
undetectable		 3m0wE-2b5mA:
7.20
3m0wF-2b5mA:
7.20
3m0wG-2b5mA:
7.20
3m0wH-2b5mA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfa THYMIDYLATE SYNTHASE

(Paramecium
bursaria
Chlorella virus
1) 		PF02511
(Thy1) 		4 SER B  81
CYH B 198
PHE B 202
LEU B 194
 FAD  B1217 (-2.6A)
None
None
None
 1.04A 3m0wE-2cfaB:
undetectable
3m0wF-2cfaB:
undetectable
3m0wG-2cfaB:
undetectable
3m0wH-2cfaB:
undetectable		 3m0wE-2cfaB:
18.04
3m0wF-2cfaB:
18.04
3m0wG-2cfaB:
18.04
3m0wH-2cfaB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ASP B 274
SER A 208
PHE B 270
SER A 319
 None
 1.00A 3m0wE-2f2aB:
undetectable
3m0wF-2f2aB:
undetectable
3m0wG-2f2aB:
undetectable
3m0wH-2f2aB:
undetectable		 3m0wE-2f2aB:
13.93
3m0wF-2f2aB:
13.93
3m0wG-2f2aB:
13.93
3m0wH-2f2aB:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		4 SER A 118
PHE A  99
LEU A 103
ASP A 102
 None
 1.06A 3m0wE-2g18A:
undetectable
3m0wF-2g18A:
undetectable
3m0wG-2g18A:
undetectable
3m0wH-2g18A:
undetectable		 3m0wE-2g18A:
18.03
3m0wF-2g18A:
18.03
3m0wG-2g18A:
18.03
3m0wH-2g18A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 PHE A 449
CYH A 405
LEU A 456
ASP A 455
 None
 1.07A 3m0wE-2hmfA:
undetectable
3m0wF-2hmfA:
1.1
3m0wG-2hmfA:
1.1
3m0wH-2hmfA:
1.0		 3m0wE-2hmfA:
12.22
3m0wF-2hmfA:
12.22
3m0wG-2hmfA:
12.22
3m0wH-2hmfA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml6 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		no annotation 4 PHE A  88
SER A  76
PHE A  14
ASP A  57
 None
 0.85A 3m0wE-2ml6A:
undetectable
3m0wF-2ml6A:
undetectable
3m0wG-2ml6A:
undetectable
3m0wH-2ml6A:
undetectable		 3m0wE-2ml6A:
24.83
3m0wF-2ml6A:
24.83
3m0wG-2ml6A:
24.83
3m0wH-2ml6A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 ASP A  57
SER A  37
PHE A  72
LEU A  43
 None
 0.90A 3m0wE-2n57A:
undetectable
3m0wF-2n57A:
2.1
3m0wG-2n57A:
2.1
3m0wH-2n57A:
undetectable		 3m0wE-2n57A:
20.59
3m0wF-2n57A:
20.59
3m0wG-2n57A:
20.59
3m0wH-2n57A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 SER A 429
PHE A 575
LEU A 468
ASP A 423
 None
None
None
DHK  A4733 (-2.8A)
 1.01A 3m0wE-2o7qA:
undetectable
3m0wF-2o7qA:
undetectable
3m0wG-2o7qA:
undetectable
3m0wH-2o7qA:
undetectable		 3m0wE-2o7qA:
11.31
3m0wF-2o7qA:
11.31
3m0wG-2o7qA:
11.31
3m0wH-2o7qA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans) 		PF03099
(BPL_LplA_LipB) 		4 PHE A  27
SER A  32
LEU A  18
ASP A  19
 None
 1.00A 3m0wE-2p5iA:
undetectable
3m0wF-2p5iA:
undetectable
3m0wG-2p5iA:
undetectable
3m0wH-2p5iA:
undetectable		 3m0wE-2p5iA:
20.00
3m0wF-2p5iA:
20.00
3m0wG-2p5iA:
20.00
3m0wH-2p5iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Escherichia
coli) 		PF09107
(SelB-wing_3) 		4 ASP A 607
PHE A 590
LEU A 560
ASP A 561
 None
None
None
CA  A 102 (-3.1A)
 0.83A 3m0wE-2pjpA:
undetectable
3m0wF-2pjpA:
undetectable
3m0wG-2pjpA:
undetectable
3m0wH-2pjpA:
undetectable		 3m0wE-2pjpA:
22.48
3m0wF-2pjpA:
22.48
3m0wG-2pjpA:
22.48
3m0wH-2pjpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 115
CYH A 295
LEU A 248
ASP A 249
 None
 1.06A 3m0wE-2zviA:
undetectable
3m0wF-2zviA:
undetectable
3m0wG-2zviA:
undetectable
3m0wH-2zviA:
undetectable		 3m0wE-2zviA:
13.99
3m0wF-2zviA:
13.99
3m0wG-2zviA:
13.99
3m0wH-2zviA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ASP B 281
SER A 195
PHE B 277
SER A 305
 None
 1.05A 3m0wE-3al0B:
undetectable
3m0wF-3al0B:
undetectable
3m0wG-3al0B:
undetectable
3m0wH-3al0B:
undetectable		 3m0wE-3al0B:
13.92
3m0wF-3al0B:
13.92
3m0wG-3al0B:
13.92
3m0wH-3al0B:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 CYH A 336
PHE A 342
LEU A 332
ASP A 177
 None
None
None
HIU  A 502 (-2.8A)
 1.06A 3m0wE-3bptA:
0.3
3m0wF-3bptA:
undetectable
3m0wG-3bptA:
undetectable
3m0wH-3bptA:
undetectable		 3m0wE-3bptA:
16.45
3m0wF-3bptA:
16.45
3m0wG-3bptA:
16.45
3m0wH-3bptA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 ASP A 100
SER A 128
PHE A 218
LEU A 154
ASP A 155
 None
None
None
None
NI  A 231 (-4.2A)
 1.46A 3m0wE-3cc8A:
undetectable
3m0wF-3cc8A:
undetectable
3m0wG-3cc8A:
undetectable
3m0wH-3cc8A:
undetectable		 3m0wE-3cc8A:
19.02
3m0wF-3cc8A:
19.02
3m0wG-3cc8A:
19.02
3m0wH-3cc8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 ASP A 484
SER A 652
CYH A 522
LEU A 647
 None
 1.03A 3m0wE-3cf0A:
undetectable
3m0wF-3cf0A:
1.4
3m0wG-3cf0A:
1.6
3m0wH-3cf0A:
undetectable		 3m0wE-3cf0A:
18.03
3m0wF-3cf0A:
18.03
3m0wG-3cf0A:
18.03
3m0wH-3cf0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 SER A 362
SER A 159
LEU A  57
ASP A  58
 None
 0.86A 3m0wE-3eb0A:
undetectable
3m0wF-3eb0A:
undetectable
3m0wG-3eb0A:
undetectable
3m0wH-3eb0A:
undetectable		 3m0wE-3eb0A:
12.27
3m0wF-3eb0A:
12.27
3m0wG-3eb0A:
12.27
3m0wH-3eb0A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 SER A 184
PHE A 196
LEU A 134
ASP A 135
 None
 0.98A 3m0wE-3h6eA:
undetectable
3m0wF-3h6eA:
undetectable
3m0wG-3h6eA:
undetectable
3m0wH-3h6eA:
undetectable		 3m0wE-3h6eA:
12.02
3m0wF-3h6eA:
12.02
3m0wG-3h6eA:
12.02
3m0wH-3h6eA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 295
SER A 291
PHE A 316
ASP A 273
 None
 0.81A 3m0wE-3i8bA:
undetectable
3m0wF-3i8bA:
undetectable
3m0wG-3i8bA:
undetectable
3m0wH-3i8bA:
undetectable		 3m0wE-3i8bA:
10.60
3m0wF-3i8bA:
10.60
3m0wG-3i8bA:
10.60
3m0wH-3i8bA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		4 ASP A 317
SER A 322
PHE A 238
LEU A 148
 None
 1.06A 3m0wE-3jtyA:
undetectable
3m0wF-3jtyA:
undetectable
3m0wG-3jtyA:
undetectable
3m0wH-3jtyA:
undetectable		 3m0wE-3jtyA:
14.21
3m0wF-3jtyA:
14.21
3m0wG-3jtyA:
14.21
3m0wH-3jtyA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ASP F 269
SER E 195
PHE F 265
SER E 304
 None
 1.04A 3m0wE-3kfuF:
undetectable
3m0wF-3kfuF:
undetectable
3m0wG-3kfuF:
undetectable
3m0wH-3kfuF:
undetectable		 3m0wE-3kfuF:
10.58
3m0wF-3kfuF:
10.58
3m0wG-3kfuF:
10.58
3m0wH-3kfuF:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ASP A 425
PHE A  50
LEU A 116
ASP A 117
 CA  A 518 (-3.2A)
None
None
None
 0.72A 3m0wE-3lijA:
6.9
3m0wF-3lijA:
6.9
3m0wG-3lijA:
6.8
3m0wH-3lijA:
5.8		 3m0wE-3lijA:
12.18
3m0wF-3lijA:
12.18
3m0wG-3lijA:
12.18
3m0wH-3lijA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		4 SER A 116
SER A 120
PHE A  80
LEU A 314
 None
 1.00A 3m0wE-3m2tA:
undetectable
3m0wF-3m2tA:
undetectable
3m0wG-3m2tA:
undetectable
3m0wH-3m2tA:
undetectable		 3m0wE-3m2tA:
15.12
3m0wF-3m2tA:
15.12
3m0wG-3m2tA:
15.12
3m0wH-3m2tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 ASP A 483
SER A 440
PHE A 560
LEU B 146
 None
 0.99A 3m0wE-3mcaA:
undetectable
3m0wF-3mcaA:
undetectable
3m0wG-3mcaA:
undetectable
3m0wH-3mcaA:
undetectable		 3m0wE-3mcaA:
10.53
3m0wF-3mcaA:
10.53
3m0wG-3mcaA:
10.53
3m0wH-3mcaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 314
PHE A 145
LEU A 173
ASP A 175
 None
None
XFE  A 351 (-4.6A)
None
 1.05A 3m0wE-3mvjA:
undetectable
3m0wF-3mvjA:
undetectable
3m0wG-3mvjA:
undetectable
3m0wH-3mvjA:
undetectable		 3m0wE-3mvjA:
14.45
3m0wF-3mvjA:
14.45
3m0wG-3mvjA:
14.45
3m0wH-3mvjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASP A 234
SER A 229
PHE A 207
SER A 209
 None
 0.94A 3m0wE-3oa2A:
undetectable
3m0wF-3oa2A:
undetectable
3m0wG-3oa2A:
undetectable
3m0wH-3oa2A:
undetectable		 3m0wE-3oa2A:
14.10
3m0wF-3oa2A:
14.10
3m0wG-3oa2A:
14.10
3m0wH-3oa2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd9 QSOX FROM
TRYPANOSOMA BRUCEI
(TBQSOX)

(Trypanosoma
brucei) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 ASP A  37
PHE A  79
LEU A  43
ASP A  42
 None
 0.94A 3m0wE-3qd9A:
1.9
3m0wF-3qd9A:
1.0
3m0wG-3qd9A:
1.9
3m0wH-3qd9A:
1.8		 3m0wE-3qd9A:
13.23
3m0wF-3qd9A:
13.23
3m0wG-3qd9A:
13.23
3m0wH-3qd9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASP A 189
SER A 188
SER A 250
CYH A 438
 None
 0.98A 3m0wE-3rblA:
undetectable
3m0wF-3rblA:
undetectable
3m0wG-3rblA:
undetectable
3m0wH-3rblA:
undetectable		 3m0wE-3rblA:
12.70
3m0wF-3rblA:
12.70
3m0wG-3rblA:
12.70
3m0wH-3rblA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		4 SER A 226
PHE A 262
SER A 332
LEU A 321
 None
 0.97A 3m0wE-3sqnA:
undetectable
3m0wF-3sqnA:
undetectable
3m0wG-3sqnA:
undetectable
3m0wH-3sqnA:
undetectable		 3m0wE-3sqnA:
14.32
3m0wF-3sqnA:
14.32
3m0wG-3sqnA:
14.32
3m0wH-3sqnA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 ASP A 383
SER A 380
PHE A 378
PHE A 390
 None
 0.93A 3m0wE-3t5tA:
undetectable
3m0wF-3t5tA:
undetectable
3m0wG-3t5tA:
undetectable
3m0wH-3t5tA:
undetectable		 3m0wE-3t5tA:
11.45
3m0wF-3t5tA:
11.45
3m0wG-3t5tA:
11.45
3m0wH-3t5tA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A 103
SER A 107
SER A 433
LEU A  33
 QNB  A1162 (-3.1A)
QNB  A1162 (-3.4A)
None
None
 1.04A 3m0wE-3uonA:
undetectable
3m0wF-3uonA:
undetectable
3m0wG-3uonA:
undetectable
3m0wH-3uonA:
undetectable		 3m0wE-3uonA:
12.97
3m0wF-3uonA:
12.97
3m0wG-3uonA:
12.97
3m0wH-3uonA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 SER A 223
PHE A 431
PHE A 466
LEU A 461
 None
None
FAD  A1487 (-4.8A)
None
 0.92A 3m0wE-3zdnA:
undetectable
3m0wF-3zdnA:
undetectable
3m0wG-3zdnA:
0.3
3m0wH-3zdnA:
0.4		 3m0wE-3zdnA:
10.55
3m0wF-3zdnA:
10.55
3m0wG-3zdnA:
10.55
3m0wH-3zdnA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A  17
PHE A 222
LEU A 184
ASP A 186
 None
 0.83A 3m0wE-4c7vA:
undetectable
3m0wF-4c7vA:
undetectable
3m0wG-4c7vA:
1.6
3m0wH-4c7vA:
1.8		 3m0wE-4c7vA:
9.22
3m0wF-4c7vA:
9.22
3m0wG-4c7vA:
9.22
3m0wH-4c7vA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 ASP A 421
PHE A 426
SER A 729
ASP A 676
 None
 0.93A 3m0wE-4ecoA:
undetectable
3m0wF-4ecoA:
undetectable
3m0wG-4ecoA:
undetectable
3m0wH-4ecoA:
undetectable		 3m0wE-4ecoA:
9.90
3m0wF-4ecoA:
9.90
3m0wG-4ecoA:
9.90
3m0wH-4ecoA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 ASP A 305
SER A 291
LEU A 108
ASP A 109
 None
 1.03A 3m0wE-4euoA:
undetectable
3m0wF-4euoA:
undetectable
3m0wG-4euoA:
undetectable
3m0wH-4euoA:
undetectable		 3m0wE-4euoA:
14.52
3m0wF-4euoA:
14.52
3m0wG-4euoA:
14.52
3m0wH-4euoA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 SER A1127
CYH A1172
LEU A1165
ASP A1166
 None
 1.06A 3m0wE-4f0gA:
1.1
3m0wF-4f0gA:
undetectable
3m0wG-4f0gA:
1.0
3m0wH-4f0gA:
0.9		 3m0wE-4f0gA:
16.06
3m0wF-4f0gA:
16.06
3m0wG-4f0gA:
16.06
3m0wH-4f0gA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 4 ASP A  29
SER A 139
LEU A 159
ASP A 136
 None
 0.98A 3m0wE-4fbvA:
undetectable
3m0wF-4fbvA:
undetectable
3m0wG-4fbvA:
undetectable
3m0wH-4fbvA:
undetectable		 3m0wE-4fbvA:
13.16
3m0wF-4fbvA:
13.16
3m0wG-4fbvA:
13.16
3m0wH-4fbvA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		4 ASP A 111
SER A  91
PHE A 104
LEU A 140
 None
 0.99A 3m0wE-4fidA:
undetectable
3m0wF-4fidA:
undetectable
3m0wG-4fidA:
undetectable
3m0wH-4fidA:
undetectable		 3m0wE-4fidA:
15.25
3m0wF-4fidA:
15.25
3m0wG-4fidA:
15.25
3m0wH-4fidA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ASP A 143
SER A  62
SER A  57
LEU A 155
 CNA  A 402 (-3.7A)
CNA  A 402 ( 4.1A)
None
None
 0.84A 3m0wE-4g1cA:
undetectable
3m0wF-4g1cA:
undetectable
3m0wG-4g1cA:
undetectable
3m0wH-4g1cA:
undetectable		 3m0wE-4g1cA:
20.95
3m0wF-4g1cA:
20.95
3m0wG-4g1cA:
20.95
3m0wH-4g1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 SER A1029
SER A1035
LEU A 977
ASP A 976
 None
 1.00A 3m0wE-4gl9A:
undetectable
3m0wF-4gl9A:
0.6
3m0wG-4gl9A:
undetectable
3m0wH-4gl9A:
0.6		 3m0wE-4gl9A:
17.76
3m0wF-4gl9A:
17.76
3m0wG-4gl9A:
17.76
3m0wH-4gl9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 ASP A 174
PHE A 123
SER A 117
LEU A  33
 NAI  A 401 (-2.7A)
None
NAI  A 401 ( 4.5A)
None
 1.01A 3m0wE-4h8aA:
undetectable
3m0wF-4h8aA:
undetectable
3m0wG-4h8aA:
undetectable
3m0wH-4h8aA:
undetectable		 3m0wE-4h8aA:
13.89
3m0wF-4h8aA:
13.89
3m0wG-4h8aA:
13.89
3m0wH-4h8aA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 ASP A 361
SER A 360
LEU B 102
ASP B 103
 None
 1.02A 3m0wE-4hjlA:
undetectable
3m0wF-4hjlA:
undetectable
3m0wG-4hjlA:
undetectable
3m0wH-4hjlA:
undetectable		 3m0wE-4hjlA:
10.54
3m0wF-4hjlA:
10.54
3m0wG-4hjlA:
10.54
3m0wH-4hjlA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		4 ASP A 299
SER A 297
PHE A 162
LEU A 174
 None
 0.94A 3m0wE-4iw7A:
undetectable
3m0wF-4iw7A:
undetectable
3m0wG-4iw7A:
undetectable
3m0wH-4iw7A:
undetectable		 3m0wE-4iw7A:
15.32
3m0wF-4iw7A:
15.32
3m0wG-4iw7A:
15.32
3m0wH-4iw7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3x HEMAGGLUTININ HA1
HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 SER B  65
SER A 113
LEU A 108
ASP A 107
 None
 0.95A 3m0wE-4k3xB:
0.8
3m0wF-4k3xB:
0.9
3m0wG-4k3xB:
undetectable
3m0wH-4k3xB:
undetectable		 3m0wE-4k3xB:
22.29
3m0wF-4k3xB:
22.29
3m0wG-4k3xB:
22.29
3m0wH-4k3xB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		4 ASP A  77
PHE A 120
LEU A  86
ASP A  84
 None
 1.02A 3m0wE-4kruA:
undetectable
3m0wF-4kruA:
undetectable
3m0wG-4kruA:
undetectable
3m0wH-4kruA:
undetectable		 3m0wE-4kruA:
18.94
3m0wF-4kruA:
18.94
3m0wG-4kruA:
18.94
3m0wH-4kruA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 SER A 343
PHE A 203
LEU A 178
ASP A 177
 None
None
None
NA  A 603 (-3.4A)
 1.01A 3m0wE-4l3aA:
undetectable
3m0wF-4l3aA:
undetectable
3m0wG-4l3aA:
undetectable
3m0wH-4l3aA:
undetectable		 3m0wE-4l3aA:
10.81
3m0wF-4l3aA:
10.81
3m0wG-4l3aA:
10.81
3m0wH-4l3aA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 SER A  45
PHE A  64
SER A 132
LEU A 126
 None
 1.05A 3m0wE-4l6uA:
undetectable
3m0wF-4l6uA:
undetectable
3m0wG-4l6uA:
undetectable
3m0wH-4l6uA:
undetectable		 3m0wE-4l6uA:
14.72
3m0wF-4l6uA:
14.72
3m0wG-4l6uA:
14.72
3m0wH-4l6uA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 SER A 394
SER A 110
LEU A 105
ASP A 104
 None
 0.94A 3m0wE-4mc5A:
0.8
3m0wF-4mc5A:
0.8
3m0wG-4mc5A:
undetectable
3m0wH-4mc5A:
0.8		 3m0wE-4mc5A:
10.74
3m0wF-4mc5A:
10.74
3m0wG-4mc5A:
10.74
3m0wH-4mc5A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		4 ASP A 386
SER A 335
LEU A 356
ASP A 357
 None
None
None
MG  A 605 (-3.8A)
 0.96A 3m0wE-4mndA:
undetectable
3m0wF-4mndA:
undetectable
3m0wG-4mndA:
undetectable
3m0wH-4mndA:
undetectable		 3m0wE-4mndA:
12.66
3m0wF-4mndA:
12.66
3m0wG-4mndA:
12.66
3m0wH-4mndA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 SER A 314
SER A 342
CYH A 375
LEU A 377
 None
 1.01A 3m0wE-4qnlA:
undetectable
3m0wF-4qnlA:
undetectable
3m0wG-4qnlA:
undetectable
3m0wH-4qnlA:
undetectable		 3m0wE-4qnlA:
9.99
3m0wF-4qnlA:
9.99
3m0wG-4qnlA:
9.99
3m0wH-4qnlA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1

(Saccharomyces
cerevisiae) 		PF04146
(YTH) 		4 ASP A 274
CYH A 213
PHE A 212
LEU A 165
 None
None
None
UNX  A 401 ( 4.7A)
 1.02A 3m0wE-4rcmA:
undetectable
3m0wF-4rcmA:
undetectable
3m0wG-4rcmA:
undetectable
3m0wH-4rcmA:
undetectable		 3m0wE-4rcmA:
22.29
3m0wF-4rcmA:
22.29
3m0wG-4rcmA:
22.29
3m0wH-4rcmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ASP A2031
SER A2080
LEU A1437
ASP A1435
 None
 1.04A 3m0wE-4rh7A:
undetectable
3m0wF-4rh7A:
undetectable
3m0wG-4rh7A:
undetectable
3m0wH-4rh7A:
undetectable		 3m0wE-4rh7A:
2.96
3m0wF-4rh7A:
2.96
3m0wG-4rh7A:
2.96
3m0wH-4rh7A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 ASP A 297
SER A 202
CYH A 236
PHE A 235
LEU A 188
 C  O   1 ( 4.8A)
None
None
None
None
 1.17A 3m0wE-4u8tA:
undetectable
3m0wF-4u8tA:
undetectable
3m0wG-4u8tA:
undetectable
3m0wH-4u8tA:
undetectable		 3m0wE-4u8tA:
20.12
3m0wF-4u8tA:
20.12
3m0wG-4u8tA:
20.12
3m0wH-4u8tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		4 ASP A  25
SER A  56
LEU A 150
ASP A 151
 None
 0.94A 3m0wE-4u9pA:
undetectable
3m0wF-4u9pA:
undetectable
3m0wG-4u9pA:
undetectable
3m0wH-4u9pA:
undetectable		 3m0wE-4u9pA:
16.14
3m0wF-4u9pA:
16.14
3m0wG-4u9pA:
16.14
3m0wH-4u9pA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASP A 350
PHE A 368
LEU A 403
ASP A 402
 None
 0.92A 3m0wE-4udrA:
undetectable
3m0wF-4udrA:
undetectable
3m0wG-4udrA:
undetectable
3m0wH-4udrA:
undetectable		 3m0wE-4udrA:
10.66
3m0wF-4udrA:
10.66
3m0wG-4udrA:
10.66
3m0wH-4udrA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wkr LA-RELATED PROTEIN 7

(Homo sapiens) 		PF00076
(RRM_1)
PF05383
(La) 		4 ASP A  66
SER A  64
LEU A 102
ASP A 103
 None
 0.74A 3m0wE-4wkrA:
undetectable
3m0wF-4wkrA:
undetectable
3m0wG-4wkrA:
undetectable
3m0wH-4wkrA:
undetectable		 3m0wE-4wkrA:
19.71
3m0wF-4wkrA:
19.71
3m0wG-4wkrA:
19.71
3m0wH-4wkrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa) 		PF00814
(Peptidase_M22) 		4 ASP A  95
SER A  10
SER A  15
LEU A 192
 None
NA  A 302 (-3.5A)
None
None
 1.02A 3m0wE-4y0wA:
undetectable
3m0wF-4y0wA:
undetectable
3m0wG-4y0wA:
undetectable
3m0wH-4y0wA:
undetectable		 3m0wE-4y0wA:
14.66
3m0wF-4y0wA:
14.66
3m0wG-4y0wA:
14.66
3m0wH-4y0wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASP A 285
SER A 283
LEU A 138
ASP A 136
 None
 0.98A 3m0wE-4zwvA:
undetectable
3m0wF-4zwvA:
undetectable
3m0wG-4zwvA:
undetectable
3m0wH-4zwvA:
undetectable		 3m0wE-4zwvA:
14.13
3m0wF-4zwvA:
14.13
3m0wG-4zwvA:
14.13
3m0wH-4zwvA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		4 ASP 6 288
SER 6  32
LEU 6  27
ASP 6  26
 None
 0.73A 3m0wE-5ady6:
undetectable
3m0wF-5ady6:
undetectable
3m0wG-5ady6:
undetectable
3m0wH-5ady6:
undetectable		 3m0wE-5ady6:
12.02
3m0wF-5ady6:
12.02
3m0wG-5ady6:
12.02
3m0wH-5ady6:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 SER A 762
SER A 636
LEU A 751
ASP A 775
 None
 1.05A 3m0wE-5bp1A:
undetectable
3m0wF-5bp1A:
undetectable
3m0wG-5bp1A:
undetectable
3m0wH-5bp1A:
undetectable		 3m0wE-5bp1A:
6.98
3m0wF-5bp1A:
6.98
3m0wG-5bp1A:
6.98
3m0wH-5bp1A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ASP A 169
SER A 141
PHE A 122
SER A 103
 None
 0.87A 3m0wE-5bshA:
2.6
3m0wF-5bshA:
2.7
3m0wG-5bshA:
2.7
3m0wH-5bshA:
2.6		 3m0wE-5bshA:
15.75
3m0wF-5bshA:
15.75
3m0wG-5bshA:
15.75
3m0wH-5bshA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cn1 ADP-RIBOSYLATION
FACTOR-BINDING
PROTEIN GGA1

(Saccharomyces
cerevisiae) 		PF02883
(Alpha_adaptinC2) 		4 SER A 502
PHE A 484
LEU A 447
ASP A 456
 None
 0.83A 3m0wE-5cn1A:
undetectable
3m0wF-5cn1A:
undetectable
3m0wG-5cn1A:
undetectable
3m0wH-5cn1A:
undetectable		 3m0wE-5cn1A:
22.14
3m0wF-5cn1A:
22.14
3m0wG-5cn1A:
22.14
3m0wH-5cn1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 SER A 502
PHE A 506
SER A 461
ASP A 535
 None
 0.98A 3m0wE-5cslA:
1.6
3m0wF-5cslA:
undetectable
3m0wG-5cslA:
undetectable
3m0wH-5cslA:
undetectable		 3m0wE-5cslA:
4.02
3m0wF-5cslA:
4.02
3m0wG-5cslA:
4.02
3m0wH-5cslA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 PHE A  36
SER A 453
LEU A   9
ASP A  10
 None
 0.98A 3m0wE-5czzA:
undetectable
3m0wF-5czzA:
undetectable
3m0wG-5czzA:
undetectable
3m0wH-5czzA:
undetectable		 3m0wE-5czzA:
6.40
3m0wF-5czzA:
6.40
3m0wG-5czzA:
6.40
3m0wH-5czzA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		4 ASP A  96
PHE A  93
LEU A  74
ASP A  75
 None
 0.97A 3m0wE-5ddzA:
undetectable
3m0wF-5ddzA:
undetectable
3m0wG-5ddzA:
undetectable
3m0wH-5ddzA:
undetectable		 3m0wE-5ddzA:
15.75
3m0wF-5ddzA:
15.75
3m0wG-5ddzA:
15.75
3m0wH-5ddzA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASP A  85
CYH A 124
PHE A 101
ASP A 120
 None
 1.03A 3m0wE-5eioA:
undetectable
3m0wF-5eioA:
undetectable
3m0wG-5eioA:
undetectable
3m0wH-5eioA:
undetectable		 3m0wE-5eioA:
15.08
3m0wF-5eioA:
15.08
3m0wG-5eioA:
15.08
3m0wH-5eioA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 SER A 430
SER A 461
LEU A 524
ASP A 525
 None
 0.96A 3m0wE-5esoA:
undetectable
3m0wF-5esoA:
undetectable
3m0wG-5esoA:
undetectable
3m0wH-5esoA:
undetectable		 3m0wE-5esoA:
10.09
3m0wF-5esoA:
10.09
3m0wG-5esoA:
10.09
3m0wH-5esoA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ASP A 427
SER A 425
LEU A 477
ASP A 476
 None
 1.07A 3m0wE-5f75A:
undetectable
3m0wF-5f75A:
undetectable
3m0wG-5f75A:
undetectable
3m0wH-5f75A:
undetectable		 3m0wE-5f75A:
10.40
3m0wF-5f75A:
10.40
3m0wG-5f75A:
10.40
3m0wH-5f75A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 SER B 170
SER B 296
LEU B 276
ASP B 275
 TCR  B 609 (-2.8A)
None
None
None
 0.86A 3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable
3m0wG-5fbhB:
undetectable
3m0wH-5fbhB:
undetectable		 3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
3m0wG-5fbhB:
9.68
3m0wH-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		4 ASP A 200
SER A 146
PHE A 193
LEU A 217
 None
 1.05A 3m0wE-5hciA:
undetectable
3m0wF-5hciA:
undetectable
3m0wG-5hciA:
undetectable
3m0wH-5hciA:
undetectable		 3m0wE-5hciA:
16.86
3m0wF-5hciA:
16.86
3m0wG-5hciA:
16.86
3m0wH-5hciA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		4 SER A 208
PHE A 228
CYH A 185
PHE A 184
 None
 0.94A 3m0wE-5i2cA:
undetectable
3m0wF-5i2cA:
undetectable
3m0wG-5i2cA:
undetectable
3m0wH-5i2cA:
undetectable		 3m0wE-5i2cA:
14.89
3m0wF-5i2cA:
14.89
3m0wG-5i2cA:
14.89
3m0wH-5i2cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ASP A 308
SER A  81
PHE A 322
LEU A 137
 None
None
NAG  A 818 ( 4.8A)
None
 1.05A 3m0wE-5jifA:
undetectable
3m0wF-5jifA:
undetectable
3m0wG-5jifA:
undetectable
3m0wH-5jifA:
undetectable		 3m0wE-5jifA:
14.25
3m0wF-5jifA:
14.25
3m0wG-5jifA:
14.25
3m0wH-5jifA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 372
CYH A 313
PHE A 314
LEU A 220
 None
None
6L1  A 601 (-4.4A)
None
 0.90A 3m0wE-5jjqA:
undetectable
3m0wF-5jjqA:
undetectable
3m0wG-5jjqA:
undetectable
3m0wH-5jjqA:
undetectable		 3m0wE-5jjqA:
10.69
3m0wF-5jjqA:
10.69
3m0wG-5jjqA:
10.69
3m0wH-5jjqA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Rattus
norvegicus) 		PF13599
(Pentapeptide_4) 		4 ASP B 546
PHE B 507
LEU B 503
ASP B 524
 None
 0.97A 3m0wE-5jmcB:
undetectable
3m0wF-5jmcB:
undetectable
3m0wG-5jmcB:
undetectable
3m0wH-5jmcB:
undetectable		 3m0wE-5jmcB:
22.66
3m0wF-5jmcB:
22.66
3m0wG-5jmcB:
22.66
3m0wH-5jmcB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 228
PHE A 187
LEU A 174
ASP A 175
 None
 1.03A 3m0wE-5necA:
undetectable
3m0wF-5necA:
undetectable
3m0wG-5necA:
undetectable
3m0wH-5necA:
undetectable		 3m0wE-5necA:
18.00
3m0wF-5necA:
18.00
3m0wG-5necA:
18.00
3m0wH-5necA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 PHE A 221
SER A 268
LEU A 262
ASP A 261
 None
 1.00A 3m0wE-5o82A:
undetectable
3m0wF-5o82A:
undetectable
3m0wG-5o82A:
undetectable
3m0wH-5o82A:
undetectable		 3m0wE-5o82A:
26.26
3m0wF-5o82A:
26.26
3m0wG-5o82A:
26.26
3m0wH-5o82A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 ASP A  17
SER A  15
CYH A  89
ASP A 218
 None
 0.97A 3m0wE-5vbbA:
undetectable
3m0wF-5vbbA:
undetectable
3m0wG-5vbbA:
undetectable
3m0wH-5vbbA:
undetectable		 3m0wE-5vbbA:
14.56
3m0wF-5vbbA:
14.56
3m0wG-5vbbA:
14.56
3m0wH-5vbbA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		no annotation 4 PHE A 336
PHE A 302
LEU A 364
ASP A 365
 None
 0.95A 3m0wE-5w2mA:
undetectable
3m0wF-5w2mA:
undetectable
3m0wG-5w2mA:
undetectable
3m0wH-5w2mA:
undetectable		 3m0wE-5w2mA:
26.67
3m0wF-5w2mA:
26.67
3m0wG-5w2mA:
26.67
3m0wH-5w2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ASP A 477
PHE A 266
CYH A 290
LEU A 298
 None
 0.93A 3m0wE-5x49A:
undetectable
3m0wF-5x49A:
undetectable
3m0wG-5x49A:
undetectable
3m0wH-5x49A:
undetectable		 3m0wE-5x49A:
13.77
3m0wF-5x49A:
13.77
3m0wG-5x49A:
13.77
3m0wH-5x49A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER A 277
PHE A 198
LEU A 207
ASP A 204
 None
 1.01A 3m0wE-5xh9A:
undetectable
3m0wF-5xh9A:
undetectable
3m0wG-5xh9A:
undetectable
3m0wH-5xh9A:
undetectable		 3m0wE-5xh9A:
9.73
3m0wF-5xh9A:
9.73
3m0wG-5xh9A:
9.73
3m0wH-5xh9A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11

(Homo sapiens) 		no annotation 4 ASP V  11
SER V  24
CYH V  75
ASP V  17
 None
 0.92A 3m0wE-5xtcV:
undetectable
3m0wF-5xtcV:
undetectable
3m0wG-5xtcV:
undetectable
3m0wH-5xtcV:
undetectable		 3m0wE-5xtcV:
19.31
3m0wF-5xtcV:
19.31
3m0wG-5xtcV:
19.31
3m0wH-5xtcV:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 4 SER A 240
PHE A 393
SER A  51
LEU A 338
 None
 1.02A 3m0wE-5y0qA:
undetectable
3m0wF-5y0qA:
undetectable
3m0wG-5y0qA:
undetectable
3m0wH-5y0qA:
undetectable		 3m0wE-5y0qA:
undetectable
3m0wF-5y0qA:
undetectable
3m0wG-5y0qA:
undetectable
3m0wH-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ASP B  72
SER B 145
LEU B 111
ASP B 109
 None
 0.91A 3m0wE-5y3rB:
undetectable
3m0wF-5y3rB:
undetectable
3m0wG-5y3rB:
undetectable
3m0wH-5y3rB:
undetectable		 3m0wE-5y3rB:
11.45
3m0wF-5y3rB:
11.45
3m0wG-5y3rB:
11.45
3m0wH-5y3rB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 4 ASP A 305
PHE A 315
LEU A 126
ASP A  36
 None
None
None
K95  A 401 ( 2.6A)
 1.06A 3m0wE-5yidA:
undetectable
3m0wF-5yidA:
undetectable
3m0wG-5yidA:
undetectable
3m0wH-5yidA:
undetectable		 3m0wE-5yidA:
15.89
3m0wF-5yidA:
15.89
3m0wG-5yidA:
15.89
3m0wH-5yidA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 ASP A1080
SER A 612
LEU A 437
ASP A 436
 None
 0.83A 3m0wE-6bhuA:
0.6
3m0wF-6bhuA:
undetectable
3m0wG-6bhuA:
0.0
3m0wH-6bhuA:
undetectable		 3m0wE-6bhuA:
0.00
3m0wF-6bhuA:
0.00
3m0wG-6bhuA:
0.00
3m0wH-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 ASP P 461
PHE P 475
CYH P 483
LEU P 448
 None
 0.96A 3m0wE-6c1dP:
undetectable
3m0wF-6c1dP:
undetectable
3m0wG-6c1dP:
undetectable
3m0wH-6c1dP:
0.6		 3m0wE-6c1dP:
19.82
3m0wF-6c1dP:
19.82
3m0wG-6c1dP:
19.82
3m0wH-6c1dP:
19.82