SIMILAR PATTERNS OF AMINO ACIDS FOR 3M0W_B_P77B203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		5 ASP X 250
SER X 253
SER X 268
PHE X 281
GLU X 282
 NAI  X 401 ( 4.5A)
None
None
None
NAI  X 401 ( 3.2A)
 1.32A 3m0wA-3fmxX:
0.6
3m0wB-3fmxX:
undetectable
3m0wC-3fmxX:
undetectable
3m0wD-3fmxX:
undetectable		 3m0wA-3fmxX:
13.41
3m0wB-3fmxX:
13.41
3m0wC-3fmxX:
13.41
3m0wD-3fmxX:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		5 PHE A 611
ASP A  57
SER A  56
PHE A 572
ASP A 593
 None
None
C8E  A 702 ( 4.9A)
None
None
 1.39A 3m0wA-5ivaA:
undetectable
3m0wB-5ivaA:
undetectable
3m0wC-5ivaA:
undetectable
3m0wD-5ivaA:
undetectable		 3m0wA-5ivaA:
11.73
3m0wB-5ivaA:
11.73
3m0wC-5ivaA:
11.73
3m0wD-5ivaA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens) 		no annotation 5 SER N 187
SER D 301
PHE D 343
GLU D 344
ASP D 395
 None
 1.41A 3m0wA-6cetN:
undetectable
3m0wB-6cetN:
undetectable
3m0wC-6cetN:
undetectable
3m0wD-6cetN:
undetectable		 3m0wA-6cetN:
19.00
3m0wB-6cetN:
19.00
3m0wC-6cetN:
19.00
3m0wD-6cetN:
19.00