SIMILAR PATTERNS OF AMINO ACIDS FOR 3LZS_A_017A200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)


(Escherichia
coli)
PF00490
(ALAD)
5 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
None
0.87A 3lzsA-1b4eA:
undetectable
3lzsA-1b4eA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN


(Thermotoga
maritima)
PF02463
(SMC_N)
5 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
None
0.95A 3lzsA-1e69A:
undetectable
3lzsA-1e69A:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
12 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
GLY A  49
ILE A  50
PRO A  81
VAL A  82
ILE A  84
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 ( 4.3A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
0.38A 3lzsA-1hvcA:
13.7
3lzsA-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
11 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
GLY A  49
ILE A  50
VAL A  82
ILE A  84
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
A79  A 800 ( 4.4A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
0.43A 3lzsA-1hvcA:
13.7
3lzsA-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
9 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  30
VAL A  32
PRO A  81
VAL A  82
ILE A  84
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 ( 4.9A)
A79  A 800 ( 4.4A)
A79  A 800 ( 3.9A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
0.53A 3lzsA-1hvcA:
13.7
3lzsA-1hvcA:
45.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE


(Escherichia
coli)
PF00815
(Histidinol_dh)
5 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
None
0.84A 3lzsA-1kaeA:
undetectable
3lzsA-1kaeA:
13.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens)
PF00077
(RVP)
7 ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
ILE A  84
None
0.51A 3lzsA-1q9pA:
9.9
3lzsA-1q9pA:
88.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 LEU A  71
GLY A  53
ASP A  21
VAL A  74
ILE A  16
None
None
CA  A 698 (-3.2A)
None
None
0.97A 3lzsA-1qhoA:
undetectable
3lzsA-1qhoA:
9.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
0.41A 3lzsA-1sivA:
19.0
3lzsA-1sivA:
51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii)
PF00161
(RIP)
5 LEU A 215
GLY A 231
ALA A 230
VAL A 213
ILE A 225
None
0.94A 3lzsA-1tcsA:
undetectable
3lzsA-1tcsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT


(Salmonella
enterica)
PF01791
(DeoC)
5 LEU A 184
GLY A 188
ALA A 189
ASP A 190
ILE A 158
None
0.78A 3lzsA-1to3A:
undetectable
3lzsA-1to3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE


(Escherichia
coli)
PF12697
(Abhydrolase_6)
5 LEU A 281
GLY A  61
ALA A  60
ILE A  54
VAL A 277
None
0.85A 3lzsA-1u2eA:
undetectable
3lzsA-1u2eA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT


(Thermotoga
maritima)
PF13393
(tRNA-synt_His)
5 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
None
0.65A 3lzsA-1usyC:
undetectable
3lzsA-1usyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
0.89A 3lzsA-1v5fA:
undetectable
3lzsA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5j KIAA1355 PROTEIN

(Homo sapiens)
PF00041
(fn3)
5 GLY A  85
ALA A  84
VAL A  33
GLY A  60
PRO A  11
None
0.98A 3lzsA-1v5jA:
undetectable
3lzsA-1v5jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE


(Homo sapiens)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 LEU A 152
VAL A 192
GLY A 166
VAL A 207
ILE A 205
LEU  A 152 ( 0.6A)
VAL  A 192 ( 0.6A)
GLY  A 166 ( 0.0A)
VAL  A 207 ( 0.6A)
ILE  A 205 ( 0.4A)
0.85A 3lzsA-1wsvA:
undetectable
3lzsA-1wsvA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
None
0.61A 3lzsA-2bc0A:
undetectable
3lzsA-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN


(Thermus
thermophilus)
PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2)
5 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
None
0.93A 3lzsA-2cvjA:
undetectable
3lzsA-2cvjA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
5 ASP A  25
ALA A  28
VAL A  32
GLY A  54
ILE A  89
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
None
LP1  A 201 (-3.6A)
LP1  A 201 (-4.2A)
0.76A 3lzsA-2fmbA:
15.2
3lzsA-2fmbA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
VAL A  32
GLY A  55
PRO A  86
VAL A  87
ILE A  89
None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
None
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 ( 4.9A)
LP1  A 201 (-4.2A)
0.47A 3lzsA-2fmbA:
15.2
3lzsA-2fmbA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT


(Escherichia
coli)
PF00456
(Transketolase_N)
5 LEU A 565
GLY A 573
PRO A 594
VAL A 516
ILE A 518
None
0.81A 3lzsA-2g28A:
undetectable
3lzsA-2g28A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzl 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Escherichia
coli)
PF02542
(YgbB)
5 GLY A  37
ASP A   8
GLY A 145
PRO A 103
ILE A  20
None
ZN  A 900 ( 2.4A)
None
None
None
0.94A 3lzsA-2gzlA:
undetectable
3lzsA-2gzlA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN


(Homo sapiens)
PF05971
(Methyltransf_10)
5 GLY A  84
ALA A  85
GLY A  69
VAL A 120
ILE A 118
None
None
None
DTU  A2140 (-4.0A)
None
0.95A 3lzsA-2h00A:
undetectable
3lzsA-2h00A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II


(Caldanaerobacter
subterraneus)
PF00753
(Lactamase_B)
5 LEU A  38
GLY A 145
ILE A 149
VAL A  47
ILE A  45
None
0.89A 3lzsA-2p4zA:
undetectable
3lzsA-2p4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 LEU A  28
GLY A  14
ALA A   9
VAL A  56
ILE A  30
None
0.94A 3lzsA-2ph3A:
undetectable
3lzsA-2ph3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE


(Paraburkholderia
xenovorans)
PF12697
(Abhydrolase_6)
5 LEU A 283
GLY A  63
ALA A  62
VAL A 279
ILE A 280
None
0.82A 3lzsA-2ri6A:
undetectable
3lzsA-2ri6A:
14.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.9A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
AB1  A 501 ( 4.2A)
0.32A 3lzsA-2rkfA:
20.9
3lzsA-2rkfA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rsp RSV PROTEASE

(Rous sarcoma
virus)
PF00077
(RVP)
6 LEU A  35
ASP A  37
GLY A  39
ALA A  40
ASP A  41
ILE A 108
None
0.40A 3lzsA-2rspA:
12.9
3lzsA-2rspA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 LEU A 188
GLY A 255
ALA A 254
ILE A 248
ILE A 185
None
0.73A 3lzsA-2wskA:
undetectable
3lzsA-2wskA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG


(Saccharomyces
cerevisiae)
PF00344
(SecY)
PF10559
(Plug_translocon)
5 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
None
0.93A 3lzsA-2ww9A:
undetectable
3lzsA-2ww9A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
None
0.92A 3lzsA-3aqpA:
undetectable
3lzsA-3aqpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN


(Bacteroides
thetaiotaomicron)
PF00459
(Inositol_P)
6 ALA A   6
ASP A   5
VAL A 112
GLY A  11
ILE A  14
ILE A 100
None
1.27A 3lzsA-3b8bA:
undetectable
3lzsA-3b8bA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c26 PUTATIVE
ACETYLTRANSFERASE
TA0821


(Thermoplasma
acidophilum)
PF00583
(Acetyltransf_1)
5 ASP A  45
GLY A  87
ILE A  74
VAL A  56
ILE A  52
NO3  A 266 (-3.1A)
EDO  A 269 (-3.4A)
None
None
None
0.94A 3lzsA-3c26A:
undetectable
3lzsA-3c26A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c26 PUTATIVE
ACETYLTRANSFERASE
TA0821


(Thermoplasma
acidophilum)
PF00583
(Acetyltransf_1)
5 ASP A  45
VAL A  51
GLY A  87
ILE A  74
VAL A  56
NO3  A 266 (-3.1A)
None
EDO  A 269 (-3.4A)
None
None
0.97A 3lzsA-3c26A:
undetectable
3lzsA-3c26A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571


(Deinococcus
radiodurans)
PF01266
(DAO)
5 LEU A 370
GLY A 200
VAL A  40
VAL A 230
ILE A 228
None
0.87A 3lzsA-3c4nA:
undetectable
3lzsA-3c4nA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
5 GLY A 359
ALA A 360
ASP A 361
PRO A  24
ILE A 356
None
0.84A 3lzsA-3dbgA:
undetectable
3lzsA-3dbgA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE


(Deinococcus
radiodurans)
PF03275
(GLF)
PF13450
(NAD_binding_8)
5 GLY A  38
ALA A  37
VAL A 237
VAL A  55
ILE A  57
FAD  A 450 (-3.3A)
None
None
None
None
0.88A 3lzsA-3hdyA:
undetectable
3lzsA-3hdyA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh1 TETRAPYRROLE
METHYLASE FAMILY
PROTEIN


(Chlorobaculum
tepidum)
PF00590
(TP_methylase)
5 LEU A  79
GLY A 111
ALA A 110
VAL A  75
ILE A  76
None
0.87A 3lzsA-3hh1A:
undetectable
3lzsA-3hh1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 211
GLY A 216
ALA A 217
ASP A 218
ILE A 190
None
0.68A 3lzsA-3jv7A:
undetectable
3lzsA-3jv7A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
5 LEU A 130
GLY A  73
ALA A  72
GLY A  80
ILE A 127
None
0.82A 3lzsA-3khzA:
undetectable
3lzsA-3khzA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF02940
(mRNA_triPase)
5 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
None
0.95A 3lzsA-3kyhA:
undetectable
3lzsA-3kyhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
None
0.88A 3lzsA-3ladA:
undetectable
3lzsA-3ladA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans)
PF05572
(Peptidase_M43)
5 ALA A 209
ASP A 207
VAL A 175
ILE A  93
ILE A 205
None
0.90A 3lzsA-3lunA:
undetectable
3lzsA-3lunA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq0 TRANSCRIPTIONAL
REPRESSOR OF THE
BLCABC OPERON


(Agrobacterium
tumefaciens)
PF01614
(IclR)
PF09339
(HTH_IclR)
5 LEU A 240
GLY A 254
VAL A 121
PRO A 118
ILE A 238
None
0.93A 3lzsA-3mq0A:
undetectable
3lzsA-3mq0A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
PRO A  81
VAL A  82
ILE A  84
None
0.45A 3lzsA-3mwsA:
20.1
3lzsA-3mwsA:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
11 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
VAL A  32
GLY A  49
ILE A  50
PRO A  81
VAL A  82
ILE A  84
None
0.29A 3lzsA-3mwsA:
20.1
3lzsA-3mwsA:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B


(Aspergillus
aculeatus)
PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3)
5 GLY A 346
ASP A 349
VAL A 336
GLY A 420
ILE A 419
None
CA  A 800 (-2.9A)
None
None
None
0.97A 3lzsA-3njxA:
undetectable
3lzsA-3njxA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
5 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 3lzsA-3o8lA:
undetectable
3lzsA-3o8lA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
5 GLY A 213
ALA A 212
ILE A 206
VAL A 121
ILE A 122
None
0.82A 3lzsA-3s8mA:
undetectable
3lzsA-3s8mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN


(Murine leukemia
virus)
PF00077
(RVP)
5 ASP A  32
GLY A  34
ALA A  35
VAL A  39
PRO A  89
3TL  A 126 (-2.4A)
3TL  A 126 (-3.1A)
3TL  A 126 ( 4.0A)
None
3TL  A 126 (-4.0A)
0.56A 3lzsA-3slzA:
11.3
3lzsA-3slzA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN


(Murine leukemia
virus)
PF00077
(RVP)
6 LEU A  30
ASP A  32
GLY A  34
ALA A  35
VAL A  39
GLY A  56
None
3TL  A 126 (-2.4A)
3TL  A 126 (-3.1A)
3TL  A 126 ( 4.0A)
None
3TL  A 126 (-3.4A)
0.50A 3lzsA-3slzA:
11.3
3lzsA-3slzA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ASP A  25
ALA A  28
ASP A  30
GLY A  49
ILE A  50
SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-3.5A)
017  A 201 (-4.2A)
017  A 201 (-4.0A)
017  A 201 (-3.3A)
1.25A 3lzsA-3t3cA:
19.4
3lzsA-3t3cA:
80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
GLY A  49
ILE A  50
PRO A  81
SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-3.4A)
017  A 201 (-3.5A)
017  A 201 (-3.5A)
017  A 201 (-4.2A)
None
017  A 201 (-4.0A)
017  A 201 (-3.3A)
None
0.60A 3lzsA-3t3cA:
19.4
3lzsA-3t3cA:
80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
017  A 201 (-2.6A)
017  A 201 (-3.6A)
017  A 201 (-3.4A)
017  A 201 (-3.3A)
017  A 201 (-4.6A)
017  A 201 (-3.0A)
017  A 201 (-3.3A)
017  A 201 (-4.1A)
017  A 201 (-4.7A)
0.31A 3lzsA-3ttpA:
20.3
3lzsA-3ttpA:
82.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ASP A  25
ALA A  28
ASP A  30
GLY A  49
ILE A  50
None
017  A 202 ( 2.5A)
017  A 201 (-3.4A)
017  A 201 ( 4.0A)
017  A 202 (-2.9A)
017  A 201 ( 3.5A)
1.26A 3lzsA-3u7sA:
19.8
3lzsA-3u7sA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
9 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
PRO A  81
None
017  A 202 ( 2.5A)
017  A 201 ( 3.5A)
017  A 201 (-3.4A)
017  A 201 (-3.2A)
017  A 201 ( 4.0A)
017  A 202 (-2.9A)
017  A 201 ( 3.5A)
017  A 202 (-4.0A)
0.36A 3lzsA-3u7sA:
19.8
3lzsA-3u7sA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
PRO A  81
VAL A  82
None
0.42A 3lzsA-3uhlA:
16.4
3lzsA-3uhlA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4clc UPF0303 PROTEIN
YBR137W


(Saccharomyces
cerevisiae)
PF03928
(Haem_degrading)
5 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
None
0.95A 3lzsA-4clcE:
undetectable
3lzsA-4clcE:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE


(Brucella suis)
PF00815
(Histidinol_dh)
6 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
None
1.35A 3lzsA-4g09A:
undetectable
3lzsA-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR


(Homo sapiens)
PF00001
(7tm_1)
5 VAL A  44
GLY A  90
ILE A  94
VAL A  39
ILE A  43
None
0.87A 3lzsA-4gbrA:
undetectable
3lzsA-4gbrA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes)
PF02016
(Peptidase_S66)
5 LEU A 162
ALA A 309
GLY A 306
ILE A 305
ILE A 321
None
0.84A 3lzsA-4injA:
undetectable
3lzsA-4injA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3


(Zea mays)
PF01156
(IU_nuc_hydro)
5 GLY A  10
ASP A  12
GLY A 124
ILE A  34
ILE A  17
None
CA  A 401 ( 4.8A)
CA  A 401 ( 4.3A)
None
None
0.89A 3lzsA-4kpoA:
undetectable
3lzsA-4kpoA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Mycobacterium
tuberculosis)
PF00475
(IGPD)
5 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
None
0.85A 3lzsA-4lomA:
undetectable
3lzsA-4lomA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae)
PF00155
(Aminotran_1_2)
5 GLY A 278
ALA A 281
VAL A 311
GLY A 228
ILE A 200
None
0.93A 3lzsA-4m2jA:
undetectable
3lzsA-4m2jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
5 LEU A 105
GLY A 128
ALA A 129
ASP A 130
GLY A 179
GOL  A 503 ( 4.4A)
GOL  A 503 (-3.7A)
None
None
None
0.90A 3lzsA-4maaA:
undetectable
3lzsA-4maaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 180
GLY A 201
ALA A 200
ILE A  12
ILE A 183
None
0.97A 3lzsA-4na3A:
undetectable
3lzsA-4na3A:
9.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ALA A  28
ASP A  29
ASP A  30
GLY A  48
ILE A  84
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
RIT  A 500 (-4.8A)
RIT  A 500 (-4.8A)
RIT  A 500 (-4.3A)
0.73A 3lzsA-4njvA:
20.1
3lzsA-4njvA:
82.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
9 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
PRO A  81
ILE A  84
None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.9A)
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
RIT  A 500 (-4.8A)
None
RIT  A 500 (-3.9A)
RIT  A 500 (-4.3A)
0.49A 3lzsA-4njvA:
20.1
3lzsA-4njvA:
82.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
10 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
VAL A  32
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.9A)
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
None
RIT  A 500 (-3.4A)
RIT  A 500 (-4.3A)
RIT  A 500 (-3.9A)
RIT  A 500 (-4.3A)
0.39A 3lzsA-4njvA:
20.1
3lzsA-4njvA:
82.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum)
PF00719
(Pyrophosphatase)
5 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
None
0.74A 3lzsA-4qlzA:
undetectable
3lzsA-4qlzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1u CINNAMOYL COA
REDUCTASE


(Medicago
truncatula)
PF01370
(Epimerase)
5 GLY A  97
ASP A  59
GLY A   8
VAL A  70
ILE A  66
None
0.87A 3lzsA-4r1uA:
undetectable
3lzsA-4r1uA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN


(Yersinia pestis)
PF13407
(Peripla_BP_4)
5 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.90A 3lzsA-4rweA:
undetectable
3lzsA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY


(Sulfolobus
solfataricus)
PF00011
(HSP20)
5 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
None
0.92A 3lzsA-4rzkA:
undetectable
3lzsA-4rzkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
5 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
None
0.90A 3lzsA-4tnbA:
undetectable
3lzsA-4tnbA:
10.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydf HTLV-1 PROTEASE

(Primate
T-lymphotropic
virus 1)
PF00077
(RVP)
7 ASP A  32
GLY A  34
ALA A  35
ASP A  36
VAL A  39
GLY A  58
ILE A 100
4B1  A 201 (-2.9A)
4B1  A 201 ( 4.6A)
4B1  A 201 (-3.6A)
4B1  A 201 (-4.4A)
None
4B1  A 201 (-3.4A)
4B1  A 201 (-4.8A)
0.53A 3lzsA-4ydfA:
13.1
3lzsA-4ydfA:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydf HTLV-1 PROTEASE

(Primate
T-lymphotropic
virus 1)
PF00077
(RVP)
7 LEU A  30
ASP A  32
GLY A  34
ALA A  35
ASP A  36
GLY A  58
ILE A 100
None
4B1  A 201 (-2.9A)
4B1  A 201 ( 4.6A)
4B1  A 201 (-3.6A)
4B1  A 201 (-4.4A)
4B1  A 201 (-3.4A)
4B1  A 201 (-4.8A)
0.43A 3lzsA-4ydfA:
13.1
3lzsA-4ydfA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135


(Acanthamoeba
polyphaga
mimivirus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
None
0.79A 3lzsA-4z26A:
undetectable
3lzsA-4z26A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2


(Legionella
pneumophila)
PF00905
(Transpeptidase)
5 LEU A 512
ALA A 367
GLY A 364
ILE A 600
ILE A 509
None
0.97A 3lzsA-4ztkA:
undetectable
3lzsA-4ztkA:
16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 GLY A  27
ALA A  28
ASP A  29
ASP A  30
PRO A  81
ILE A  84
None
0.40A 3lzsA-5b18A:
17.7
3lzsA-5b18A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b18 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 GLY A  27
ALA A  28
ASP A  29
GLY A  49
ILE A  84
None
0.73A 3lzsA-5b18A:
17.7
3lzsA-5b18A:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw5 BRCA1/BRCA2-CONTAINI
NG COMPLEX SUBUNIT 3


(Camponotus
floridanus)
PF01398
(JAB)
5 LEU A  79
VAL A  89
GLY A  33
ILE A  51
ILE A  36
None
0.96A 3lzsA-5cw5A:
undetectable
3lzsA-5cw5A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME, PUTATIVE

(Plasmodium
falciparum)
PF00227
(Proteasome)
5 ASP H 157
VAL H  12
ILE H  37
VAL H 231
ILE H 233
None
0.95A 3lzsA-5fmgH:
undetectable
3lzsA-5fmgH:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5


(Homo sapiens)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
5 LEU A 157
GLY A 132
VAL A 177
VAL A 167
ILE A 169
None
0.76A 3lzsA-5h1kA:
undetectable
3lzsA-5h1kA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h34 METHIONINE-TRNA
LIGASE


(Nanoarchaeum
equitans)
PF01588
(tRNA_bind)
5 LEU A 713
GLY A 716
VAL A 690
VAL A 704
ILE A 702
None
0.94A 3lzsA-5h34A:
undetectable
3lzsA-5h34A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4b CEREBELLIN-4

(Mus musculus)
PF00386
(C1q)
5 GLY A 143
ALA A 142
VAL A 117
GLY A 173
VAL A 120
None
0.98A 3lzsA-5h4bA:
undetectable
3lzsA-5h4bA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7


(synthetic
construct)
PF12796
(Ank_2)
5 LEU A 121
GLY A 126
ALA A 127
ASP A 128
VAL A  86
None
0.96A 3lzsA-5hs0A:
undetectable
3lzsA-5hs0A:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ASP A  25
ALA A  28
ASP A  30
GLY A  49
PRO A  81
None
1.39A 3lzsA-5t2zA:
21.0
3lzsA-5t2zA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
11 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
VAL A  32
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
0.26A 3lzsA-5t2zA:
21.0
3lzsA-5t2zA:
77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00106
(adh_short)
5 ALA A 170
ASP A 172
GLY A 164
ILE A 163
VAL A 137
None
0.95A 3lzsA-5u2wA:
undetectable
3lzsA-5u2wA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve3 BPPRF

(Paraburkholderia
phytofirmans)
no annotation 5 GLY B  88
ALA B  89
ASP B  90
VAL B  59
ILE B  80
None
0.72A 3lzsA-5ve3B:
undetectable
3lzsA-5ve3B:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
None
0.83A 3lzsA-5vm2A:
undetectable
3lzsA-5vm2A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029


(Streptococcus
pneumoniae)
no annotation 5 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
None
0.89A 3lzsA-5xj1A:
undetectable
3lzsA-5xj1A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE


(Homo sapiens)
no annotation 5 GLY A 121
ALA A 122
GLY A 106
VAL A 157
ILE A 155
None
0.95A 3lzsA-6b92A:
undetectable
3lzsA-6b92A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus)
PF00077
(RVP)
6 LEU A  28
ASP A  30
GLY A  32
ALA A  33
ASP A  34
GLY A  58
None
3TL  A 201 (-3.5A)
3TL  A 201 (-3.4A)
3TL  A 201 (-4.0A)
3TL  A 201 (-3.9A)
3TL  A 201 (-3.4A)
0.19A 3lzsA-6fivA:
15.5
3lzsA-6fivA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus)
PF00077
(RVP)
6 LEU A  28
ASP A  30
GLY A  32
ALA A  33
ASP A  34
VAL A  99
None
3TL  A 201 (-3.5A)
3TL  A 201 (-3.4A)
3TL  A 201 (-4.0A)
3TL  A 201 (-3.9A)
None
0.45A 3lzsA-6fivA:
15.5
3lzsA-6fivA:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
8 LEU A  23
ASP A  25
ALA A  28
ASP A  29
ASP A  30
GLY A  49
PRO A  81
ILE A  84
None
NIU  A 100 (-2.8A)
NIU  A 100 (-3.6A)
None
None
NIU  A 100 ( 3.8A)
None
None
0.63A 3lzsA-6upjA:
18.2
3lzsA-6upjA:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
8 LEU A  23
ASP A  25
GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  84
None
NIU  A 100 (-2.8A)
NIU  A 100 (-4.5A)
NIU  A 100 (-3.6A)
None
None
NIU  A 100 ( 3.8A)
None
0.60A 3lzsA-6upjA:
18.2
3lzsA-6upjA:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
7 LEU A  23
ASP A  29
ASP A  30
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
None
None
NIU  A 100 ( 3.8A)
NIU  A 100 (-3.9A)
None
None
0.85A 3lzsA-6upjA:
18.2
3lzsA-6upjA:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
6 LEU A  23
ASP A  30
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
None
NIU  A 100 ( 3.8A)
NIU  A 100 (-3.9A)
None
None
1.22A 3lzsA-6upjA:
18.2
3lzsA-6upjA:
51.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
7 LEU A  23
GLY A  27
ASP A  29
ASP A  30
GLY A  49
ILE A  50
ILE A  84
None
NIU  A 100 (-4.5A)
None
None
NIU  A 100 ( 3.8A)
NIU  A 100 (-3.9A)
None
0.78A 3lzsA-6upjA:
18.2
3lzsA-6upjA:
51.52