SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXN_A_MI1A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.70A 3lxnA-1k9aA:
30.6		 3lxnA-1k9aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLY A 212
GLY A 214
VAL A 219
ALA A 230
LYS A 232
TYR A 282
SER A 287
LEU A 340
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.71A 3lxnA-1py5A:
27.8		 3lxnA-1py5A:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.49A 3lxnA-1t46A:
22.8		 3lxnA-1t46A:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
TYR A 107
SER A 111
LEU A 158
 None
 0.48A 3lxnA-1u5qA:
26.0		 3lxnA-1u5qA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
ALA X  37
LYS X  39
TYR X  84
SER X  89
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.0A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.67A 3lxnA-2dq7X:
32.2		 3lxnA-2dq7X:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
GLY X  20
VAL X  25
ALA X  37
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.58A 3lxnA-2dq7X:
32.2		 3lxnA-2dq7X:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
VAL X  25
ALA X  37
LYS X  39
TYR X  84
SER X  89
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.0A)
STU  X 902 (-4.4A)
 0.60A 3lxnA-2dq7X:
32.2		 3lxnA-2dq7X:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
ILE A  89
TYR A 107
SER A 111
LEU A 158
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.6A)
 0.42A 3lxnA-2gcdA:
26.9		 3lxnA-2gcdA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
TYR A 107
LEU A 158
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.56A 3lxnA-2gcdA:
26.9		 3lxnA-2gcdA:
32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.57A 3lxnA-2h8hA:
28.4		 3lxnA-2h8hA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.69A 3lxnA-2hckA:
27.9		 3lxnA-2hckA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
GLY A  56
VAL A  63
ALA A  76
LYS A  78
SER A 131
LEU A 177
 None
 0.53A 3lxnA-2hw6A:
21.5		 3lxnA-2hw6A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LYS A  48
ILE A  87
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
ATP  A 381 ( 4.8A)
 0.53A 3lxnA-2phkA:
26.0		 3lxnA-2phkA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LYS A  75
ILE A 102
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.67A 3lxnA-2w4oA:
21.3		 3lxnA-2w4oA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LYS A  75
VAL A 121
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-3.9A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.78A 3lxnA-2w4oA:
21.3		 3lxnA-2w4oA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU C  55
GLY C  56
GLY C  58
VAL C  63
ALA C  76
ILE C 111
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.63A 3lxnA-2wtkC:
25.3		 3lxnA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
GLY A 113
VAL A 120
ALA A 133
ILE A 164
TYR A 182
VAL A 183
 16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
 0.50A 3lxnA-2x4fA:
17.3		 3lxnA-2x4fA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  27
VAL A  34
ALA A  47
LYS A  49
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.67A 3lxnA-2xikA:
27.8		 3lxnA-2xikA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
GLY A  71
VAL A  76
ALA A  92
LYS A  94
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.51A 3lxnA-2z7rA:
22.6		 3lxnA-2z7rA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
 0.39A 3lxnA-3a62A:
22.5		 3lxnA-3a62A:
27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
GLY A 490
VAL A 495
ALA A 515
TYR A 566
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.44A 3lxnA-3b2tA:
32.2		 3lxnA-3b2tA:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 490
VAL A 495
ALA A 515
ILE A 548
TYR A 566
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.59A 3lxnA-3b2tA:
32.2		 3lxnA-3b2tA:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.70A 3lxnA-3d7uA:
31.4		 3lxnA-3d7uA:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
ILE A  63
TYR A 119
LEU A 173
ASP A 185
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
 0.79A 3lxnA-3eb0A:
23.6		 3lxnA-3eb0A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
GLY A  62
VAL A  67
ALA A  80
SER A 135
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-3.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.4A)
 0.48A 3lxnA-3fmeA:
21.8		 3lxnA-3fmeA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
VAL A  67
ALA A  80
LYS A  82
SER A 135
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
STU  A   1 (-3.2A)
STU  A   1 (-4.4A)
 0.50A 3lxnA-3fmeA:
21.8		 3lxnA-3fmeA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 210
GLY A 212
VAL A 217
ALA A 228
LYS A 230
TYR A 281
SER A 286
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
None
ADP  A 900 (-3.6A)
 0.65A 3lxnA-3g2fA:
27.8		 3lxnA-3g2fA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 210
GLY A 212
VAL A 217
ALA A 228
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.55A 3lxnA-3g2fA:
27.8		 3lxnA-3g2fA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-4.9A)
None
 0.60A 3lxnA-3hngA:
28.6		 3lxnA-3hngA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
GLY A 681
GLY A 683
VAL A 689
ALA A 700
ILE A 729
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.6A)
ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-4.4A)
 0.58A 3lxnA-3lj0A:
24.3		 3lxnA-3lj0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ILE A  94
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.70A 3lxnA-3lm5A:
25.5		 3lxnA-3lm5A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 GLY A 211
VAL A 218
ALA A 229
LYS A 231
TYR A 281
SER A 286
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.59A 3lxnA-3mdyA:
27.4		 3lxnA-3mdyA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
TYR A 122
VAL A 123
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
None
 0.69A 3lxnA-3mvjA:
25.1		 3lxnA-3mvjA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LYS A  72
TYR A 122
VAL A 123
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
None
 0.66A 3lxnA-3mvjA:
25.1		 3lxnA-3mvjA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
GLY A  89
GLY A  91
VAL A  96
ALA A 109
LYS A 111
TYR A 161
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
SO4  A   5 ( 4.4A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
 0.63A 3lxnA-3nuuA:
25.4		 3lxnA-3nuuA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
ALA A 369
LYS A 371
TYR A 422
VAL A 423
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
 0.70A 3lxnA-3pfqA:
22.3		 3lxnA-3pfqA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.40A 3lxnA-3pp0A:
34.3		 3lxnA-3pp0A:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
GLY A 560
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.57A 3lxnA-3ppzA:
29.5		 3lxnA-3ppzA:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
LYS A  44
TYR A  98
 None
 0.67A 3lxnA-3qa8A:
21.0		 3lxnA-3qa8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
GLY A  85
VAL A  90
ALA A 103
LYS A 105
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.63A 3lxnA-3qfvA:
22.5		 3lxnA-3qfvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
GLY A  85
VAL A  90
ALA A 103
TYR A 155
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.54A 3lxnA-3qfvA:
22.5		 3lxnA-3qfvA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
GLY A 487
VAL A 492
ALA A 512
LYS A 514
ILE A 545
TYR A 563
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
None
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
 0.52A 3lxnA-3tt0A:
28.3		 3lxnA-3tt0A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.53A 3lxnA-3wigA:
23.1		 3lxnA-3wigA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
ALA A 104
LYS A 106
TYR A 156
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.56A 3lxnA-4aw2A:
22.8		 3lxnA-4aw2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
ALA A  40
LYS A  42
TYR A  91
VAL A  92
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.58A 3lxnA-4bgqA:
23.7		 3lxnA-4bgqA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
GLY A 247
VAL A 254
ALA A 267
LYS A 269
ILE A 302
TYR A 320
LEU A 371
 None
 0.58A 3lxnA-4c0tA:
23.2		 3lxnA-4c0tA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
VAL A  98
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.69A 3lxnA-4fg8A:
22.6		 3lxnA-4fg8A:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
GLY A 858
VAL A 863
ALA A 880
LYS A 882
TYR A 931
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
IZA  A2001 ( 3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
 0.43A 3lxnA-4gl9A:
38.5		 3lxnA-4gl9A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
ALA A 880
LYS A 882
SER A 936
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
 0.49A 3lxnA-4gl9A:
38.5		 3lxnA-4gl9A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
ALA A 880
LYS A 882
TYR A 931
SER A 936
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
 0.44A 3lxnA-4gl9A:
38.5		 3lxnA-4gl9A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
GLY A 831
VAL A 836
ALA A 853
LYS A 855
TYR A 904
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
 0.55A 3lxnA-4hviA:
31.0		 3lxnA-4hviA:
45.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
VAL A 836
ALA A 853
LYS A 855
TYR A 904
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
 0.21A 3lxnA-4hviA:
31.0		 3lxnA-4hviA:
45.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
GLY A 135
VAL A 140
ALA A 156
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.58A 3lxnA-4id7A:
33.1		 3lxnA-4id7A:
38.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
SER A 476
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
T28  A 701 (-3.8A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.72A 3lxnA-4idtA:
25.3		 3lxnA-4idtA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
LYS A 295
TYR A 340
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.7A)
 0.65A 3lxnA-4k11A:
28.1		 3lxnA-4k11A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-4.5A)
 0.58A 3lxnA-4k11A:
28.1		 3lxnA-4k11A:
25.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
ILE A 539
TYR A 557
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.4A)
 0.49A 3lxnA-4k33A:
26.0		 3lxnA-4k33A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
LYS A 508
ILE A 539
TYR A 557
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
None
 0.34A 3lxnA-4k33A:
26.0		 3lxnA-4k33A:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A  43
VAL A  50
ALA A  61
LYS A  63
TYR A 106
SER A 111
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
None
1UL  A 501 (-4.3A)
 0.55A 3lxnA-4l52A:
27.7		 3lxnA-4l52A:
27.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.58A 3lxnA-4lggA:
26.6		 3lxnA-4lggA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
GLY B  33
VAL B  38
ALA B  51
LYS B  53
TYR B 101
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
 0.60A 3lxnA-4o27B:
27.7		 3lxnA-4o27B:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
GLY B  33
VAL B  38
ALA B  51
LYS B  53
TYR B 101
SER B 106
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-3.4A)
 0.61A 3lxnA-4o27B:
27.7		 3lxnA-4o27B:
30.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
GLY A 906
VAL A 911
ALA A 928
TYR A 980
VAL A 981
SER A 985
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
None
 0.60A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
GLY A 904
ILE A 960
VAL A 981
SER A 985
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
None
2TT  A1202 (-3.7A)
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.65A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
ILE A 960
TYR A 980
VAL A 981
SER A 985
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
None
2TT  A1202 (-4.4A)
 0.57A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
GLY A  25
ALA A  45
LYS A  47
ILE A  79
TYR A  97
VAL A  98
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
 0.52A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
ILE A  79
TYR A  97
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.53A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
TYR A  97
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.56A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.48A 3lxnA-4rt7A:
22.4		 3lxnA-4rt7A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
TYR A 177
VAL A 178
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-4.5A)
 0.51A 3lxnA-4wb7A:
25.2		 3lxnA-4wb7A:
24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.62A 3lxnA-4xufA:
28.2		 3lxnA-4xufA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.70A 3lxnA-4y93A:
28.3		 3lxnA-4y93A:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 470
VAL A 477
ALA A 488
ILE A 522
TYR A 541
SER A 546
LEU A 595
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.61A 3lxnA-4yffA:
26.2		 3lxnA-4yffA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 470
VAL A 477
ALA A 488
LYS A 490
ILE A 522
TYR A 541
LEU A 595
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.59A 3lxnA-4yffA:
26.2		 3lxnA-4yffA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.61A 3lxnA-4ysjA:
26.5		 3lxnA-4ysjA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
ILE A 545
TYR A 563
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
 0.42A 3lxnA-5a46A:
28.2		 3lxnA-5a46A:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		7 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
VAL A 614
LEU A 664
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
 0.60A 3lxnA-5ezrA:
21.8		 3lxnA-5ezrA:
14.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
ILE A 960
TYR A 980
VAL A 981
SER A 985
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.42A 3lxnA-5f1zA:
40.2		 3lxnA-5f1zA:
89.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 731
VAL A 738
ALA A 756
ILE A 788
TYR A 806
SER A 811
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.64A 3lxnA-5fm2A:
31.2		 3lxnA-5fm2A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
ILE A 788
TYR A 806
SER A 811
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
PP1  A2012 ( 4.7A)
 0.68A 3lxnA-5fm2A:
31.2		 3lxnA-5fm2A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.41A 3lxnA-5grnA:
21.2		 3lxnA-5grnA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
VAL A  93
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.57A 3lxnA-5hu3A:
27.1		 3lxnA-5hu3A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
ILE A  77
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.5A)
 0.63A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
ILE A  77
VAL A  96
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.0A)
 0.67A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
TYR A  95
VAL A  96
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
 0.62A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.48A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 277
GLY A 279
VAL A 284
ALA A 297
LYS A 299
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.58A 3lxnA-5kbrA:
23.6		 3lxnA-5kbrA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 7 LEU A 468
GLY A 469
GLY A 471
VAL A 476
ALA A 489
LYS A 491
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-3.5A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 (-2.8A)
AGS  A 801 ( 4.8A)
 0.50A 3lxnA-5o0yA:
23.8		 3lxnA-5o0yA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 7 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
TYR A  94
VAL A  95
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
G93  A 301 (-4.1A)
 0.44A 3lxnA-5u94A:
27.0		 3lxnA-5u94A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
SER A 761
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.73A 3lxnA-5vilA:
27.4		 3lxnA-5vilA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 757
SER A 761
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
 0.62A 3lxnA-5vilA:
27.4		 3lxnA-5vilA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
GLY A  27
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 9WS  A 401 ( 4.2A)
None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.64A 3lxnA-5w5jA:
23.4		 3lxnA-5w5jA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
GLY A 892
GLY A 894
VAL A 899
ALA A 917
LYS A 919
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.61A 3lxnA-5wnoA:
27.8		 3lxnA-5wnoA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 7 LEU A  22
GLY A  23
GLY A  25
ALA A  43
ILE A  77
TYR A  95
VAL A  96
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
 0.63A 3lxnA-6bx6A:
18.9		 3lxnA-6bx6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 7 LEU A  22
GLY A  23
GLY A  25
VAL A  30
ALA A  43
ILE A  77
TYR A  95
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
 0.61A 3lxnA-6bx6A:
18.9		 3lxnA-6bx6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.52A 3lxnA-6c7yA:
27.2		 3lxnA-6c7yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.59A 3lxnA-6c7yA:
27.2		 3lxnA-6c7yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 8 GLY A 193
GLY A 195
VAL A 200
ALA A 211
LYS A 213
TYR A 264
SER A 269
LEU A 318
 CJT  A 502 ( 3.9A)
None
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
 0.56A 3lxnA-6f3dA:
24.8		 3lxnA-6f3dA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 9 LEU A 730
GLY A 731
GLY A 733
VAL A 738
ALA A 756
ILE A 788
TYR A 806
SER A 811
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.55A 3lxnA-6fekA:
32.6		 3lxnA-6fekA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
SER A 247
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.70A 3lxnA-6fyoA:
24.4		 3lxnA-6fyoA:
undetectable