SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXK_A_MI1A1125

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
TYR A 476
CYH A 481
 None
 0.80A 3lxkA-1k2pA:
30.3		 3lxkA-1k2pA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  70
GLY A  71
VAL A  78
ALA A  91
LYS A  93
VAL A 118
MET A 138
ASP A 207
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 ( 4.5A)
None
STU  A 401 (-3.2A)
STU  A 401 (-3.6A)
 0.51A 3lxkA-1nxkA:
21.8		 3lxkA-1nxkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LYS A 101
VAL A 131
MET A 147
 ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.5A)
ATP  A 535 ( 3.4A)
 0.80A 3lxkA-1s9iA:
9.5		 3lxkA-1s9iA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
VAL A 654
TYR A 672
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
 0.61A 3lxkA-1t46A:
16.5		 3lxkA-1t46A:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.62A 3lxkA-1t46A:
16.5		 3lxkA-1t46A:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.90A 3lxkA-1u59A:
32.8		 3lxkA-1u59A:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 None
 0.76A 3lxkA-1u5qA:
25.4		 3lxkA-1u5qA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-3.9A)
 0.80A 3lxkA-1zltA:
24.8		 3lxkA-1zltA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
 0.58A 3lxkA-1zltA:
24.8		 3lxkA-1zltA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 605
GLY A 606
VAL A 613
ALA A 626
LYS A 628
MET A 788
TYR A 790
 None
None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.40A 3lxkA-1zy4A:
21.3		 3lxkA-1zy4A:
27.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
GLY X  18
VAL X  25
ALA X  37
LYS X  39
VAL X  67
TYR X  84
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.94A 3lxkA-2dq7X:
33.4		 3lxkA-2dq7X:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.76A 3lxkA-2gcdA:
26.5		 3lxkA-2gcdA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
GLY A 249
VAL A 256
ALA A 269
LYS A 271
VAL A 299
ALA A 380
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.1A)
 0.65A 3lxkA-2hz0A:
33.0		 3lxkA-2hz0A:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
GLY A 249
VAL A 256
ALA A 269
VAL A 299
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.65A 3lxkA-2hz0A:
33.0		 3lxkA-2hz0A:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
ALA A 369
LYS A 371
TYR A 422
ALA A 483
 PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
 0.65A 3lxkA-2i0eA:
23.3		 3lxkA-2i0eA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
VAL A  82
ASP A 165
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
J60  A1305 ( 4.7A)
J60  A1305 ( 3.6A)
 0.75A 3lxkA-2jamA:
20.0		 3lxkA-2jamA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
VAL A 399
MET A 414
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
 0.76A 3lxkA-2ozoA:
27.0		 3lxkA-2ozoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  27
VAL A  34
ALA A  47
LYS A  49
MET A  95
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.89A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 1.01A 3lxkA-2xikA:
27.4		 3lxkA-2xikA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
VAL A 125
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.90A 3lxkA-2z7rA:
22.5		 3lxkA-2z7rA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
 0.49A 3lxkA-3a62A:
22.8		 3lxkA-3a62A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
MET A 117
TYR A 119
ASP A 185
 DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
 0.93A 3lxkA-3eb0A:
23.5		 3lxkA-3eb0A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
MET A 117
TYR A 119
LEU A 173
ASP A 185
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
 0.96A 3lxkA-3eb0A:
23.5		 3lxkA-3eb0A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  59
GLY A  60
VAL A  67
ALA A  80
LYS A  82
VAL A 113
MET A 129
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
STU  A   1 ( 3.8A)
STU  A   1 (-4.4A)
 0.79A 3lxkA-3fmeA:
21.5		 3lxkA-3fmeA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
VAL A 892
TYR A 911
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
 0.67A 3lxkA-3hngA:
29.6		 3lxkA-3hngA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.53A 3lxkA-3hztA:
19.7		 3lxkA-3hztA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.78A 3lxkA-3lm5A:
25.6		 3lxkA-3lm5A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 171
GLY A 172
VAL A 179
ALA A 192
LYS A 194
VAL A 224
TYR A 242
LEU A 293
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.98A 3lxkA-3mtlA:
22.8		 3lxkA-3mtlA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.84A 3lxkA-3mvjA:
24.5		 3lxkA-3mvjA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		8 LEU A 348
GLY A 349
VAL A 356
ALA A 369
LYS A 371
MET A 420
TYR A 422
ALA A 483
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 ( 3.8A)
 0.83A 3lxkA-3pfqA:
22.0		 3lxkA-3pfqA:
16.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
CYH A 805
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.71A 3lxkA-3pp0A:
34.2		 3lxkA-3pp0A:
34.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		8 LEU A  21
GLY A  22
VAL A  29
ALA A  42
LYS A  44
VAL A  74
MET A  96
TYR A  98
 None
 0.79A 3lxkA-3qa8A:
20.4		 3lxkA-3qa8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
TYR A 155
ALA A 217
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
NM7  A 416 (-3.6A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.5A)
 0.78A 3lxkA-3qfvA:
22.5		 3lxkA-3qfvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  50
GLY A  51
VAL A  58
ALA A  71
LYS A  73
VAL A  98
MET A 118
LEU A 173
ASP A 187
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 ( 3.9A)
None
I85  A 350 (-3.3A)
 0.90A 3lxkA-3sheA:
20.5		 3lxkA-3sheA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
CYH A 496
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
None
PP2  A   1 (-4.6A)
 0.83A 3lxkA-3sxsA:
31.5		 3lxkA-3sxsA:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
TYR A 563
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
 0.67A 3lxkA-3tt0A:
28.8		 3lxkA-3tt0A:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
GLY A 362
VAL A 369
ALA A 382
LYS A 384
MET A 433
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.87A 3lxkA-3txoA:
20.4		 3lxkA-3txoA:
24.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
 0.77A 3lxkA-3vidA:
27.9		 3lxkA-3vidA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
VAL A 128
MET A 144
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.67A 3lxkA-3wigA:
22.3		 3lxkA-3wigA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
TYR A 156
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 (-4.9A)
None
None
 0.79A 3lxkA-4aw2A:
22.7		 3lxkA-4aw2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
None
 0.88A 3lxkA-4aw2A:
22.7		 3lxkA-4aw2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		9 GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.94A 3lxkA-4cfhA:
26.4		 3lxkA-4cfhA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
 1.01A 3lxkA-4cfhA:
26.4		 3lxkA-4cfhA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 4.5A)
 0.74A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
VAL A 721
MET A 737
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3lxkA-4crsA:
24.1		 3lxkA-4crsA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		7 LEU A  16
GLY A  17
VAL A  24
ALA A  37
MET A  87
TYR A  89
LEU A 140
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
ANP  A 300 (-4.7A)
 0.79A 3lxkA-4eqmA:
22.6		 3lxkA-4eqmA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 3.7A)
 0.66A 3lxkA-4eutA:
22.3		 3lxkA-4eutA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.5A)
 0.66A 3lxkA-4eutA:
22.3		 3lxkA-4eutA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.7A)
BX7  A 401 (-3.6A)
 0.68A 3lxkA-4euuA:
25.4		 3lxkA-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
VAL A  79
MET A  95
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 ( 4.3A)
 0.46A 3lxkA-4fg8A:
22.7		 3lxkA-4fg8A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
VAL A 433
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
 0.65A 3lxkA-4fl3A:
28.6		 3lxkA-4fl3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 598
GLY A 599
VAL A 606
ALA A 619
LYS A 621
VAL A 651
ASP A 954
 924  A1101 ( 4.1A)
None
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-4.6A)
924  A1101 (-3.7A)
 0.67A 3lxkA-4g34A:
22.3		 3lxkA-4g34A:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 855
GLY A 856
VAL A 863
ALA A 880
LYS A 882
VAL A 911
MET A 929
TYR A 931
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
None
IZA  A2001 ( 4.5A)
 0.72A 3lxkA-4gl9A:
29.6		 3lxkA-4gl9A:
57.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
GLY A 856
VAL A 863
ALA A 880
VAL A 911
MET A 929
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.94A 3lxkA-4gl9A:
29.6		 3lxkA-4gl9A:
57.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
VAL A 164
ALA A 177
LYS A 179
MET A 227
TYR A 229
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
 0.69A 3lxkA-4gv1A:
23.7		 3lxkA-4gv1A:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 828
GLY A 829
VAL A 836
ALA A 853
LYS A 855
VAL A 884
MET A 902
TYR A 904
CYH A 909
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.66A 3lxkA-4hviA:
43.1		 3lxkA-4hviA:
99.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
GLY A 829
VAL A 884
TYR A 904
CYH A 909
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
None
19S  A1201 (-4.7A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.89A 3lxkA-4hviA:
43.1		 3lxkA-4hviA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
VAL A 453
MET A 469
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-2.6A)
T28  A 701 ( 3.4A)
 0.83A 3lxkA-4idtA:
24.5		 3lxkA-4idtA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
MET A 469
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 (-2.6A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.98A 3lxkA-4idtA:
24.5		 3lxkA-4idtA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
 0.74A 3lxkA-4k11A:
29.5		 3lxkA-4k11A:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
LYS A 508
TYR A 557
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
None
 0.70A 3lxkA-4k33A:
33.9		 3lxkA-4k33A:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A  43
VAL A  50
ALA A  61
LYS A  63
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.64A 3lxkA-4l52A:
26.7		 3lxkA-4l52A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
GLY A  34
VAL A  41
ALA A  54
VAL A  83
MET A  99
TYR A 101
 GOL  A 404 ( 3.6A)
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
 0.78A 3lxkA-4lg4A:
23.8		 3lxkA-4lg4A:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
LYS B  53
MET B  99
TYR B 101
ALA B 161
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
 0.76A 3lxkA-4o27B:
27.6		 3lxkA-4o27B:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.67A 3lxkA-4oliA:
37.7		 3lxkA-4oliA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
ALA A 763
 None
 0.88A 3lxkA-4otdA:
24.6		 3lxkA-4otdA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 627
VAL A 635
ALA A 648
LYS A 650
VAL A 685
TYR A 703
LEU A 753
ALA A 763
ASP A 764
 None
 1.08A 3lxkA-4otdA:
24.6		 3lxkA-4otdA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
 None
 0.79A 3lxkA-4redA:
16.9		 3lxkA-4redA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		10 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.74A 3lxkA-4rewA:
26.3		 3lxkA-4rewA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
 0.61A 3lxkA-4rt7A:
24.5		 3lxkA-4rt7A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.67A 3lxkA-4rt7A:
24.5		 3lxkA-4rt7A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 GLY A 105
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
LEU A 228
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.91A 3lxkA-4wb7A:
24.6		 3lxkA-4wb7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
GLY A 105
VAL A 112
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.71A 3lxkA-4wb7A:
24.6		 3lxkA-4wb7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 264
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
 0.76A 3lxkA-4wboA:
20.7		 3lxkA-4wboA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
GLY A 409
VAL A 416
ALA A 428
VAL A 458
TYR A 476
CYH A 481
LEU A 528
 None
 1.26A 3lxkA-4xi2A:
27.8		 3lxkA-4xi2A:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.82A 3lxkA-4xufA:
28.6		 3lxkA-4xufA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 470
VAL A 477
ALA A 488
LYS A 490
TYR A 541
LEU A 595
ALA A 605
ASP A 606
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
 0.88A 3lxkA-4yffA:
25.7		 3lxkA-4yffA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  23
VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
None
 0.83A 3lxkA-5ci7A:
26.5		 3lxkA-5ci7A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  63
VAL A  70
ALA A  83
LYS A  85
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 0.98A 3lxkA-5es1A:
23.6		 3lxkA-5es1A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
VAL A 116
MET A 132
TYR A 134
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 ( 3.9A)
 0.75A 3lxkA-5es1A:
23.6		 3lxkA-5es1A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 ( 4.9A)
 0.50A 3lxkA-5f1zA:
37.3		 3lxkA-5f1zA:
47.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.68A 3lxkA-5f1zA:
37.3		 3lxkA-5f1zA:
47.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
VAL A 658
TYR A 676
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
 0.49A 3lxkA-5grnA:
23.2		 3lxkA-5grnA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.56A 3lxkA-5grnA:
23.2		 3lxkA-5grnA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.69A 3lxkA-5i3oA:
25.9		 3lxkA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.75A 3lxkA-5i3oA:
25.9		 3lxkA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		9 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.86A 3lxkA-5isoA:
26.3		 3lxkA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		9 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.76A 3lxkA-5isoA:
26.3		 3lxkA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
MET A  90
LEU A 143
ALA A 153
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.88A 3lxkA-5j5tA:
22.8		 3lxkA-5j5tA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  99
VAL A 106
ALA A 119
LYS A 121
VAL A 153
MET A 169
TYR A 171
ALA A 231
 None
 0.82A 3lxkA-5u7qA:
22.2		 3lxkA-5u7qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  99
VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
ALA A 231
 None
 0.86A 3lxkA-5u7qA:
22.2		 3lxkA-5u7qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 9 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 3.2A)
 0.76A 3lxkA-5u94A:
26.4		 3lxkA-5u94A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 738
MET A 754
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.6A)
 0.65A 3lxkA-5vilA:
22.3		 3lxkA-5vilA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.83A 3lxkA-5vilA:
22.3		 3lxkA-5vilA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.72A 3lxkA-5wnoA:
27.9		 3lxkA-5wnoA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 GLY A 734
VAL A 741
ALA A 754
LYS A 756
VAL A 787
TYR A 815
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 1.03A 3lxkA-6b3eA:
25.1		 3lxkA-6b3eA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 GLY A 734
VAL A 741
ALA A 754
VAL A 787
TYR A 815
LEU A 866
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 1.02A 3lxkA-6b3eA:
25.1		 3lxkA-6b3eA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.70A 3lxkA-6c0tA:
24.8		 3lxkA-6c0tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
 0.50A 3lxkA-6c7yA:
29.6		 3lxkA-6c7yA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 10 GLY A  67
VAL A  74
ALA A  87
LYS A  89
VAL A 120
MET A 136
TYR A 138
LEU A 189
ALA A 199
ASP A 200
 None
 1.04A 3lxkA-6c9dA:
24.5		 3lxkA-6c9dA:
14.78