SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXI_B_CAMB423_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bs0 | PROTEIN(8-AMINO-7-OXONANOATE SYNTHASE) (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | THR A 209GLY A 242VAL A 231ASP A 204VAL A 232 | None | 1.31A | 3lxiB-1bs0A:0.0 | 3lxiB-1bs0A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1col | COLICIN A (Escherichiacoli) |
PF01024(Colicin) | 5 | TYR A 125LEU A 178LEU A 179GLY A 176VAL A 167 | None | 1.24A | 3lxiB-1colA:0.0 | 3lxiB-1colA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fsu | N-ACETYLGALACTOSAMINE-4-SULFATASE (Homo sapiens) |
PF00884(Sulfatase) | 5 | THR A 368THR A 107LEU A 371GLY A 101VAL A 122 | None | 1.29A | 3lxiB-1fsuA:undetectable | 3lxiB-1fsuA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxi | PEROXISOME TARGETINGSIGNAL 1 RECEPTORPEX5 (Trypanosomabrucei) |
no annotation | 5 | THR A 392LEU A 360LEU A 357GLY A 356VAL A 375 | None | 1.27A | 3lxiB-1hxiA:undetectable | 3lxiB-1hxiA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 5 | TYR A 164THR A 215LEU A 121GLY A 122THR A 138 | None | 1.06A | 3lxiB-1ibqA:undetectable | 3lxiB-1ibqA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | TYR A 165THR A 215LEU A 122GLY A 123THR A 139 | None | 1.07A | 3lxiB-1izeA:undetectable | 3lxiB-1izeA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7j | PROTEIN YCIO (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC) | 5 | THR A 118THR A 98VAL A 195ASP A 186VAL A 184 | NoneSO4 A 207 ( 4.9A)NoneNoneNone | 1.07A | 3lxiB-1k7jA:undetectable | 3lxiB-1k7jA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n0w | DNA REPAIR PROTEINRAD51 HOMOLOG 1 (Homo sapiens) |
PF08423(Rad51) | 5 | THR A 298LEU A 109LEU A 113GLY A 116VAL A 264 | NoneNone MG A 401 (-4.2A) MG A 401 (-3.8A)None | 1.19A | 3lxiB-1n0wA:undetectable | 3lxiB-1n0wA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q90 | APOCYTOCHROME FCYTOCHROME B6FCOMPLEX SUBUNIT PETLCYTOCHROME B6FCOMPLEX SUBUNIT PETN (Chlamydomonasreinhardtii;Chlamydomonasreinhardtii;Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N)PF05115(PetL)PF03742(PetN) | 5 | TRP N 93LEU L 23LEU L 19GLY L 20VAL A 267 | None | 1.31A | 3lxiB-1q90N:undetectable | 3lxiB-1q90N:8.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs0 | 2-OXOISOVALERATEDEHYDROGENASEBETA-SUBUNIT (Pseudomonasputida) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | THR B 217LEU B 178GLY B 229THR B 227VAL B 248 | None | 1.20A | 3lxiB-1qs0B:undetectable | 3lxiB-1qs0B:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri3 | MRNA CAPPING ENZYME (Encephalitozooncuniculi) |
PF03291(Pox_MCEL) | 5 | LEU A 57THR A 62VAL A 68ASP A 70VAL A 136 | NoneNoneNoneSAH A 299 ( 4.9A)None | 1.06A | 3lxiB-1ri3A:undetectable | 3lxiB-1ri3A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ued | P450 MONOOXYGENASE (Amycolatopsisorientalis) |
PF00067(p450) | 5 | LEU A 244GLY A 245THR A 249VAL A 292VAL A 396 | PG4 A4502 ( 4.3A)PG4 A4502 ( 3.7A)HEM A1430 (-3.5A)HEM A1430 (-4.4A)None | 1.06A | 3lxiB-1uedA:37.3 | 3lxiB-1uedA:26.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umg | 385AA LONG CONSERVEDHYPOTHETICAL PROTEIN (Sulfurisphaeratokodaii) |
PF01950(FBPase_3) | 5 | THR A 49LEU A 292LEU A 293GLY A 294VAL A 8 | None | 1.19A | 3lxiB-1umgA:undetectable | 3lxiB-1umgA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 251LEU A 384LEU A 390GLY A 341VAL A 260 | None | 1.19A | 3lxiB-1v8bA:undetectable | 3lxiB-1v8bA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 398LEU A 401GLY A 402VAL A 369VAL A 366 | None | 1.14A | 3lxiB-1xb7A:undetectable | 3lxiB-1xb7A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z54 | PROBABLETHIOESTERASE (Thermusthermophilus) |
PF03061(4HBT) | 5 | THR A 105LEU A 59LEU A 61VAL A 75VAL A 93 | None | 1.21A | 3lxiB-1z54A:undetectable | 3lxiB-1z54A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7d | ORNITHINEAMINOTRANSFERASE (Plasmodiumyoelii) |
PF00202(Aminotran_3) | 5 | THR A 385THR A 381LEU A 348GLY A 203VAL A 377 | None | 1.19A | 3lxiB-1z7dA:undetectable | 3lxiB-1z7dA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | TYR A 117GLY A 162THR A 45VAL A 51VAL A 49 | None | 1.14A | 3lxiB-1zjrA:undetectable | 3lxiB-1zjrA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bpq | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | LEU A 242LEU A 218GLY A 217VAL A 131VAL A 126 | None | 1.30A | 3lxiB-2bpqA:undetectable | 3lxiB-2bpqA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7u | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 5 | TRP A 394LEU A 417LEU A 420VAL A 350VAL A 359 | None | 1.30A | 3lxiB-2e7uA:undetectable | 3lxiB-2e7uA:23.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 6 | TYR A 96THR A 101LEU A 244GLY A 248THR A 252VAL A 295 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A) | 1.26A | 3lxiB-2m56A:57.4 | 3lxiB-2m56A:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 9 | TYR A 96THR A 101THR A 185LEU A 244GLY A 248THR A 252VAL A 295ASP A 297VAL A 396 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)HEM A 501 (-2.8A)None | 0.64A | 3lxiB-2m56A:57.4 | 3lxiB-2m56A:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oga | TRANSAMINASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 206LEU A 218GLY A 77VAL A 162VAL A 184 | None | 1.16A | 3lxiB-2ogaA:undetectable | 3lxiB-2ogaA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3j | VP4 (Rotavirus A) |
PF00426(VP4_haemagglut) | 5 | THR A 191THR A 176LEU A 103GLY A 95VAL A 167 | None | 1.15A | 3lxiB-2p3jA:undetectable | 3lxiB-2p3jA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfy | PUTATIVE EXPORTEDPROTEIN (Bordetellapertussis) |
PF03480(DctP) | 5 | THR A 99LEU A 295LEU A 296ASP A 80VAL A 82 | None | 1.23A | 3lxiB-2pfyA:undetectable | 3lxiB-2pfyA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | TYR A 165THR A 214LEU A 122GLY A 123THR A 139 | None | 1.16A | 3lxiB-2wedA:undetectable | 3lxiB-2wedA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu0 | PHYTASE (Klebsiellapneumoniae) |
PF00328(His_Phos_2) | 5 | THR A 104GLY A 58VAL A 65ASP A 110VAL A 64 | None | 1.05A | 3lxiB-2wu0A:undetectable | 3lxiB-2wu0A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | LEU A 226GLY A 230THR A 234VAL A 277VAL A 381 | HEM A1400 (-4.4A)PG4 A1399 ( 3.2A)HEM A1400 (-3.7A)HEM A1400 (-4.5A)None | 0.72A | 3lxiB-2xkrA:43.8 | 3lxiB-2xkrA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 5 | LEU A 220LEU A 223VAL A 258ASP A 239VAL A 237 | NoneNoneNoneSAH A 376 ( 4.2A)None | 1.18A | 3lxiB-2zwvA:undetectable | 3lxiB-2zwvA:25.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 5 | TRP A 247THR A 207LEU A 292LEU A 289GLY A 288 | None | 0.92A | 3lxiB-3asaA:undetectable | 3lxiB-3asaA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3d | PUTATIVE MORPHINEDEHYDROGENASE (Bacillussubtilis) |
PF00248(Aldo_ket_red) | 5 | THR A 50LEU A 107LEU A 105GLY A 61VAL A 24 | None | 1.13A | 3lxiB-3b3dA:undetectable | 3lxiB-3b3dA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 211THR A 130LEU A 323LEU A 324GLY A 321 | NAD A 400 (-3.5A)NoneNoneNoneNone | 1.18A | 3lxiB-3cinA:undetectable | 3lxiB-3cinA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 211THR A 130LEU A 324GLY A 321THR A 15 | NAD A 400 (-3.5A)NoneNoneNoneNone | 1.04A | 3lxiB-3cinA:undetectable | 3lxiB-3cinA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | TYR A 7THR A 276LEU A 310LEU A 166VAL A 196 | None | 1.25A | 3lxiB-3dlaA:undetectable | 3lxiB-3dlaA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dte | IRRE PROTEIN (Deinococcusdeserti) |
PF06114(Peptidase_M78) | 5 | THR A 166LEU A 134GLY A 138THR A 140VAL A 170 | None | 1.13A | 3lxiB-3dteA:undetectable | 3lxiB-3dteA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeg | 2-ISOPROPYLMALATESYNTHASE (Cytophagahutchinsonii) |
PF00682(HMGL-like) | 5 | THR A 211LEU A 215LEU A 218THR A 259VAL A 7 | None | 1.23A | 3lxiB-3eegA:undetectable | 3lxiB-3eegA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eof | PUTATIVEOXIDOREDUCTASE (Bacteroidesfragilis) |
PF00881(Nitroreductase) | 5 | THR A 48LEU A 144THR A 155VAL A 67VAL A 73 | None | 1.19A | 3lxiB-3eofA:undetectable | 3lxiB-3eofA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 5 | TRP A 282LEU A 55LEU A 296GLY A 297VAL A 271 | None | 1.24A | 3lxiB-3fhaA:undetectable | 3lxiB-3fhaA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 274LEU A 191GLY A 226VAL A 240VAL A 217 | None | 1.26A | 3lxiB-3g1uA:undetectable | 3lxiB-3g1uA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 340LEU A 336GLY A 332THR A 303VAL A 54 | TYR A 340 ( 1.3A)LEU A 336 ( 0.6A)GLY A 332 ( 0.0A)THR A 303 (-0.8A)VAL A 54 ( 0.6A) | 1.29A | 3lxiB-3i4kA:undetectable | 3lxiB-3i4kA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 5 | THR X 774LEU X 765LEU X 761GLY X 738THR X 744 | None | 1.31A | 3lxiB-3jb9X:undetectable | 3lxiB-3jb9X:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg0 | ORNITHINEAMINOTRANSFERASE (Plasmodiumfalciparum) |
PF00202(Aminotran_3) | 5 | THR A 386THR A 382LEU A 349GLY A 204VAL A 378 | None | 1.16A | 3lxiB-3lg0A:undetectable | 3lxiB-3lg0A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m16 | TRANSALDOLASE (Oleispiraantarctica) |
PF00923(TAL_FSA) | 5 | THR A 179LEU A 162GLY A 146THR A 112VAL A 116 | None | 1.30A | 3lxiB-3m16A:undetectable | 3lxiB-3m16A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpo | PREDICTED HYDROLASEOF THE HADSUPERFAMILY (Lactobacillusbrevis) |
PF08282(Hydrolase_3) | 5 | THR A 216LEU A 200GLY A 198THR A 225ASP A 9 | None | 0.98A | 3lxiB-3mpoA:undetectable | 3lxiB-3mpoA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 5 | THR A 324LEU A 182GLY A 243VAL A 50VAL A 47 | None | 1.26A | 3lxiB-3mwtA:undetectable | 3lxiB-3mwtA:23.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3oft | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | LEU A 87GLY A 234THR A 238VAL A 281VAL A 384 | HEM A 417 (-4.1A)HEM A 417 (-4.0A)HEM A 417 (-3.6A)HEM A 417 ( 4.8A)None | 1.16A | 3lxiB-3oftA:49.9 | 3lxiB-3oftA:35.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 324LEU A 241GLY A 276VAL A 290VAL A 267 | None | 1.28A | 3lxiB-3oneA:undetectable | 3lxiB-3oneA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pw3 | AMINOPEPTIDASE C (Parabacteroidesdistasonis) |
PF03051(Peptidase_C1_2) | 5 | THR A 45LEU A 70LEU A 69GLY A 75ASP A 78 | NoneNoneNoneNone K A 408 (-3.3A) | 1.13A | 3lxiB-3pw3A:undetectable | 3lxiB-3pw3A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcn | BETA-N-ACETYLHEXOSAMINIDASE (Paenarthrobacteraurescens) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b) | 5 | THR A 27LEU A 54LEU A 46GLY A 47VAL A 119 | None | 1.17A | 3lxiB-3rcnA:undetectable | 3lxiB-3rcnA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | THR A 56GLY A 35THR A 42VAL A 44VAL A 231 | None | 1.20A | 3lxiB-3rmtA:undetectable | 3lxiB-3rmtA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | THR A 56GLY A 35THR A 42VAL A 74VAL A 44 | None | 1.19A | 3lxiB-3rmtA:undetectable | 3lxiB-3rmtA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sh5 | LG3 PEPTIDE (Homo sapiens) |
PF00054(Laminin_G_1) | 5 | THR A 40LEU A 73LEU A 68GLY A 67VAL A 160 | None | 1.13A | 3lxiB-3sh5A:undetectable | 3lxiB-3sh5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4c | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE 1 (Burkholderiaambifaria) |
PF00793(DAHP_synth_1) | 5 | TYR A 49THR A 29THR A 89LEU A 76GLY A 72 | None | 0.99A | 3lxiB-3t4cA:undetectable | 3lxiB-3t4cA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t5q | NUCLEOPROTEIN (Mopeia Lassavirusreassortant 29) |
PF00843(Arena_nucleocap) | 5 | THR A 324LEU A 182GLY A 243VAL A 50VAL A 47 | None | 1.30A | 3lxiB-3t5qA:undetectable | 3lxiB-3t5qA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v57 | PHYCOERYTHRIN ALPHASUBUNIT (Porphyridiumpurpureum) |
PF00502(Phycobilisome) | 5 | THR A 134LEU A 159LEU A 156VAL A 52VAL A 51 | NoneNoneNoneNonePEB A 202 (-4.7A) | 1.31A | 3lxiB-3v57A:undetectable | 3lxiB-3v57A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | LEU A 229GLY A 233THR A 237VAL A 280VAL A 383 | HEM A1402 ( 4.6A)EDO A1406 ( 3.4A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 0.78A | 3lxiB-3zbyA:41.5 | 3lxiB-3zbyA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | THR A 172THR A 142LEU A 167GLY A 163THR A 76 | None | 1.11A | 3lxiB-4ad9A:undetectable | 3lxiB-4ad9A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | TYR A 180THR A 172THR A 142GLY A 163THR A 76 | None | 1.06A | 3lxiB-4ad9A:undetectable | 3lxiB-4ad9A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | THR A 44THR A 12LEU A 80VAL A 5ASP A 6 | None | 1.09A | 3lxiB-4c7vA:undetectable | 3lxiB-4c7vA:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 8 | TRP A 89TYR A 98THR A 103LEU A 252LEU A 255GLY A 256THR A 260VAL A 303 | NoneNoneGOL A1419 (-3.8A)HEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A) | 1.32A | 3lxiB-4c9mA:71.0 | 3lxiB-4c9mA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 11 | TRP A 89TYR A 98THR A 103THR A 187LEU A 252LEU A 255GLY A 256THR A 260VAL A 303ASP A 305VAL A 404 | NoneNoneGOL A1419 (-3.8A)NoneHEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)HEM A1418 (-2.7A)GOL A1419 (-3.5A) | 0.27A | 3lxiB-4c9mA:71.0 | 3lxiB-4c9mA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckb | MRNA-CAPPING ENZYMECATALYTIC SUBUNIT (Vaccinia virus) |
PF03291(Pox_MCEL)PF10640(Pox_ATPase-GT) | 5 | LEU A 250GLY A 249THR A 359VAL A 363VAL A 362 | None | 1.18A | 3lxiB-4ckbA:undetectable | 3lxiB-4ckbA:18.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | THR A 101LEU A 250GLY A 254THR A 258VAL A 301VAL A 402 | HEM A 501 ( 4.8A)HEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)None | 0.81A | 3lxiB-4dxyA:54.9 | 3lxiB-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101LEU A 250LEU A 253GLY A 254THR A 258 | HEM A 501 ( 4.8A)HEM A 501 (-4.3A)NonePEG A 502 (-3.8A)HEM A 501 (-3.7A) | 0.78A | 3lxiB-4dxyA:54.9 | 3lxiB-4dxyA:61.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gj1 | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Campylobacterjejuni) |
PF00977(His_biosynth) | 5 | THR A 2LEU A 241LEU A 211VAL A 184VAL A 182 | None | 1.26A | 3lxiB-4gj1A:undetectable | 3lxiB-4gj1A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hac | MEVALONATE KINASE (Methanosarcinamazei) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | THR A 291THR A 257LEU A 31LEU A 92GLY A 8 | None | 1.25A | 3lxiB-4hacA:undetectable | 3lxiB-4hacA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hgn | 2-KETO-3-DEOXY-D-MANNO-OCTULOSONATE8-PHOSPHATEPHOSPHOHYDROLASE (Bacteroidesthetaiotaomicron) |
PF08282(Hydrolase_3) | 5 | THR A 61THR A 38GLY A 20THR A 25VAL A 27 | NoneNone MG A 200 ( 4.3A)NoneNone | 1.14A | 3lxiB-4hgnA:undetectable | 3lxiB-4hgnA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k9q | BENZOYLFORMATEDECARBOXYLASE (Polynucleobacternecessarius) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 441THR A 19LEU A 412GLY A 409VAL A 65 | None | 1.21A | 3lxiB-4k9qA:undetectable | 3lxiB-4k9qA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0k | ADENINEPHOSPHORIBOSYLTRANSFERASE (Rhodothermusmarinus) |
PF00156(Pribosyltran) | 5 | THR A 173LEU A 165GLY A 161VAL A 126ASP A 124 | NoneNoneNoneAMP A 300 (-3.9A)AMP A 300 (-3.0A) | 1.28A | 3lxiB-4m0kA:undetectable | 3lxiB-4m0kA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfi | SN-GLYCEROL-3-PHOSPHATE ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN USPB (Mycobacteriumtuberculosis) |
PF13416(SBP_bac_8) | 5 | THR A 331LEU A 99LEU A 309GLY A 308VAL A 348 | None | 1.00A | 3lxiB-4mfiA:undetectable | 3lxiB-4mfiA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n91 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Anaerococcusprevotii) |
PF03480(DctP) | 5 | THR A 147GLY A 48VAL A 93ASP A 242VAL A 244 | NoneNoneNoneGCU A 401 ( 2.7A)None | 0.79A | 3lxiB-4n91A:undetectable | 3lxiB-4n91A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk7 | SERINE/THREONINE-PROTEIN KINASE PLK4 (Drosophilamelanogaster) |
no annotation | 5 | LEU A 409GLY A 412THR A 391VAL A 495VAL A 492 | None | 1.16A | 3lxiB-4nk7A:undetectable | 3lxiB-4nk7A:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh0 | BETA-LACTAMASEOXA-58 (Acinetobacterbaumannii) |
PF00905(Transpeptidase) | 5 | THR A 59LEU A 274GLY A 275VAL A 238VAL A 246 | None | 0.96A | 3lxiB-4oh0A:undetectable | 3lxiB-4oh0A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okr | MICRONEMAL PROTEINMIC2 (Toxoplasmagondii) |
PF00090(TSP_1)PF00092(VWA) | 5 | THR A 155LEU A 80GLY A 160VAL A 198ASP A 194 | None | 1.28A | 3lxiB-4okrA:undetectable | 3lxiB-4okrA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p49 | ANTIBODY SCFV B8 (Gallus gallus) |
PF07686(V-set) | 5 | TYR A 216THR A 214LEU A 165GLY A 164ASP A 36 | None | 1.28A | 3lxiB-4p49A:undetectable | 3lxiB-4p49A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r33 | NOSL (Streptomycesactuosus) |
PF06968(BATS) | 5 | TYR A 242LEU A 187GLY A 158ASP A 195VAL A 172 | None | 1.05A | 3lxiB-4r33A:undetectable | 3lxiB-4r33A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | THR A 708THR A 564LEU A 580LEU A 577GLY A 576 | None | 1.19A | 3lxiB-4rbnA:undetectable | 3lxiB-4rbnA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rj9 | C2 DOMAIN-CONTAININGPROTEIN-LIKE (Oryza sativa) |
PF00168(C2) | 5 | THR A 48THR A 42GLY A 16VAL A 72VAL A 31 | None | 1.11A | 3lxiB-4rj9A:undetectable | 3lxiB-4rj9A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | TYR A 264THR A 233LEU A 354GLY A 355VAL A 344 | None | 1.29A | 3lxiB-4rnzA:undetectable | 3lxiB-4rnzA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1p | UNCHARACTERIZEDPROTEIN (Slackiaheliotrinireducens) |
PF13472(Lipase_GDSL_2) | 5 | TYR A 80THR A 103LEU A 38GLY A 7THR A 11 | None | 1.11A | 3lxiB-4s1pA:undetectable | 3lxiB-4s1pA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | THR A 264GLY A 479VAL A 487ASP A 497VAL A 499 | None | 1.13A | 3lxiB-4w8jA:undetectable | 3lxiB-4w8jA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrn | MALTOSE-BINDINGPERIPLASMICPROTEIN,UROMODULIN (Escherichiacoli;Homo sapiens) |
PF00100(Zona_pellucida)PF13416(SBP_bac_8) | 5 | THR A 589LEU A 601LEU A 602GLY A 641VAL A 637 | None | 1.22A | 3lxiB-4wrnA:undetectable | 3lxiB-4wrnA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | THR A 483LEU A 509GLY A 508THR A 477VAL A 504 | None | 1.27A | 3lxiB-4ypjA:undetectable | 3lxiB-4ypjA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anb | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Dictyosteliumdiscoideum) |
PF01912(eIF-6) | 5 | LEU I 70LEU I 71GLY I 65THR I 110VAL I 135 | None | 1.29A | 3lxiB-5anbI:undetectable | 3lxiB-5anbI:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | THR A 141LEU A 153LEU A 152THR A 189VAL A 166 | None | 1.12A | 3lxiB-5b04A:undetectable | 3lxiB-5b04A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | LEU A 26LEU A 29GLY A 30ASP A 43VAL A 107 | NoneNoneNoneSAH A 301 ( 4.5A)None | 1.15A | 3lxiB-5bp7A:undetectable | 3lxiB-5bp7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | LEU A 26LEU A 29GLY A 30VAL A 41VAL A 107 | None | 0.77A | 3lxiB-5bp7A:undetectable | 3lxiB-5bp7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | THR A 365GLY A 344THR A 351VAL A 384VAL A 353 | None | 1.16A | 3lxiB-5bs5A:undetectable | 3lxiB-5bs5A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3l | NANOBODY NB15 (Camelusdromedarius) |
PF07686(V-set) | 5 | LEU D 79LEU D 81VAL D 47ASP D 50VAL D 48 | None | 1.28A | 3lxiB-5c3lD:undetectable | 3lxiB-5c3lD:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8m | METAGENOMIC CARBOXYLESTERASE MGS0156 (unculturedorganism) |
no annotation | 5 | THR A 252THR A 230LEU A 242VAL A 198VAL A 166 | None | 1.25A | 3lxiB-5d8mA:undetectable | 3lxiB-5d8mA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfa | BETA-GALACTOSIDASE (Geobacillusstearothermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | THR A 48THR A 10LEU A 359LEU A 320VAL A 406 | None | 1.13A | 3lxiB-5dfaA:undetectable | 3lxiB-5dfaA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | LEU A 25LEU A 28GLY A 29ASP A 42VAL A 106 | NoneNoneNoneSAH A 301 ( 4.5A)None | 1.18A | 3lxiB-5epeA:undetectable | 3lxiB-5epeA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | LEU A 25LEU A 28GLY A 29VAL A 40VAL A 106 | None | 0.76A | 3lxiB-5epeA:undetectable | 3lxiB-5epeA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxm | PRIB (Streptomycessp. RM-5-8) |
PF11991(Trp_DMAT) | 5 | THR A 91LEU A 35GLY A 36VAL A 111VAL A 93 | None | 0.84A | 3lxiB-5jxmA:undetectable | 3lxiB-5jxmA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9x | TRYPTOPHAN SYNTHASEALPHA CHAIN (Legionellapneumophila) |
PF00290(Trp_syntA) | 5 | THR A 33LEU A 99LEU A 50GLY A 51ASP A 80 | None | 1.07A | 3lxiB-5k9xA:undetectable | 3lxiB-5k9xA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kju | SHIKIMATEO-HYDROXYCINNAMOYLTRANSFERASE (Arabidopsisthaliana) |
PF02458(Transferase) | 5 | LEU A 279LEU A 366GLY A 367VAL A 402VAL A 414 | None | 1.25A | 3lxiB-5kjuA:undetectable | 3lxiB-5kjuA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | THR A 222THR A 279GLY A 19VAL A 35VAL A 10 | None | 1.14A | 3lxiB-5laeA:undetectable | 3lxiB-5laeA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT BTUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT C (Methanothermobactersp. CaT2;Methanothermobacterwolfeii) |
PF00384(Molybdopterin)PF01493(GXGXG) | 5 | TYR B 207THR B 268LEU C 219GLY C 221VAL B 227 | None | 1.30A | 3lxiB-5t5iB:undetectable | 3lxiB-5t5iB:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xw3 | O-ACETYLSERINE LYASE (Bacillusanthracis) |
PF00291(PALP) | 5 | THR A 284THR A 288LEU A 30VAL A 200VAL A 174 | None | 1.27A | 3lxiB-5xw3A:undetectable | 3lxiB-5xw3A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cet | GATOR COMPLEXPROTEIN NPRL2 (Homo sapiens) |
no annotation | 5 | TYR N 43THR N 24LEU N 50VAL N 88ASP N 38 | None | 1.30A | 3lxiB-6cetN:undetectable | 3lxiB-6cetN:undetectable |