SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXI_B_CAMB423

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
None
1.31A 3lxiB-1bs0A:
0.0
3lxiB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli)
PF01024
(Colicin)
5 TYR A 125
LEU A 178
LEU A 179
GLY A 176
VAL A 167
None
1.24A 3lxiB-1colA:
0.0
3lxiB-1colA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
5 THR A 368
THR A 107
LEU A 371
GLY A 101
VAL A 122
None
1.29A 3lxiB-1fsuA:
undetectable
3lxiB-1fsuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxi PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5


(Trypanosoma
brucei)
no annotation 5 THR A 392
LEU A 360
LEU A 357
GLY A 356
VAL A 375
None
1.27A 3lxiB-1hxiA:
undetectable
3lxiB-1hxiA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
5 TYR A 164
THR A 215
LEU A 121
GLY A 122
THR A 138
None
1.06A 3lxiB-1ibqA:
undetectable
3lxiB-1ibqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
None
1.07A 3lxiB-1izeA:
undetectable
3lxiB-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
5 THR A 118
THR A  98
VAL A 195
ASP A 186
VAL A 184
None
SO4  A 207 ( 4.9A)
None
None
None
1.07A 3lxiB-1k7jA:
undetectable
3lxiB-1k7jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.19A 3lxiB-1n0wA:
undetectable
3lxiB-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6F
COMPLEX SUBUNIT PETL
CYTOCHROME B6F
COMPLEX SUBUNIT PETN


(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
PF05115
(PetL)
PF03742
(PetN)
5 TRP N  93
LEU L  23
LEU L  19
GLY L  20
VAL A 267
None
1.31A 3lxiB-1q90N:
undetectable
3lxiB-1q90N:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT


(Pseudomonas
putida)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 THR B 217
LEU B 178
GLY B 229
THR B 227
VAL B 248
None
1.20A 3lxiB-1qs0B:
undetectable
3lxiB-1qs0B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
5 LEU A  57
THR A  62
VAL A  68
ASP A  70
VAL A 136
None
None
None
SAH  A 299 ( 4.9A)
None
1.06A 3lxiB-1ri3A:
undetectable
3lxiB-1ri3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis)
PF00067
(p450)
5 LEU A 244
GLY A 245
THR A 249
VAL A 292
VAL A 396
PG4  A4502 ( 4.3A)
PG4  A4502 ( 3.7A)
HEM  A1430 (-3.5A)
HEM  A1430 (-4.4A)
None
1.06A 3lxiB-1uedA:
37.3
3lxiB-1uedA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN


(Sulfurisphaera
tokodaii)
PF01950
(FBPase_3)
5 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
None
1.19A 3lxiB-1umgA:
undetectable
3lxiB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 251
LEU A 384
LEU A 390
GLY A 341
VAL A 260
None
1.19A 3lxiB-1v8bA:
undetectable
3lxiB-1v8bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 398
LEU A 401
GLY A 402
VAL A 369
VAL A 366
None
1.14A 3lxiB-1xb7A:
undetectable
3lxiB-1xb7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z54 PROBABLE
THIOESTERASE


(Thermus
thermophilus)
PF03061
(4HBT)
5 THR A 105
LEU A  59
LEU A  61
VAL A  75
VAL A  93
None
1.21A 3lxiB-1z54A:
undetectable
3lxiB-1z54A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE


(Plasmodium
yoelii)
PF00202
(Aminotran_3)
5 THR A 385
THR A 381
LEU A 348
GLY A 203
VAL A 377
None
1.19A 3lxiB-1z7dA:
undetectable
3lxiB-1z7dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
5 TYR A 117
GLY A 162
THR A  45
VAL A  51
VAL A  49
None
1.14A 3lxiB-1zjrA:
undetectable
3lxiB-1zjrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Mycobacterium
tuberculosis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 LEU A 242
LEU A 218
GLY A 217
VAL A 131
VAL A 126
None
1.30A 3lxiB-2bpqA:
undetectable
3lxiB-2bpqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
None
1.30A 3lxiB-2e7uA:
undetectable
3lxiB-2e7uA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
6 TYR A  96
THR A 101
LEU A 244
GLY A 248
THR A 252
VAL A 295
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
1.26A 3lxiB-2m56A:
57.4
3lxiB-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
9 TYR A  96
THR A 101
THR A 185
LEU A 244
GLY A 248
THR A 252
VAL A 295
ASP A 297
VAL A 396
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
0.64A 3lxiB-2m56A:
57.4
3lxiB-2m56A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
None
1.16A 3lxiB-2ogaA:
undetectable
3lxiB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A)
PF00426
(VP4_haemagglut)
5 THR A 191
THR A 176
LEU A 103
GLY A  95
VAL A 167
None
1.15A 3lxiB-2p3jA:
undetectable
3lxiB-2p3jA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN


(Bordetella
pertussis)
PF03480
(DctP)
5 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
None
1.23A 3lxiB-2pfyA:
undetectable
3lxiB-2pfyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
5 TYR A 165
THR A 214
LEU A 122
GLY A 123
THR A 139
None
1.16A 3lxiB-2wedA:
undetectable
3lxiB-2wedA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae)
PF00328
(His_Phos_2)
5 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
None
1.05A 3lxiB-2wu0A:
undetectable
3lxiB-2wu0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 226
GLY A 230
THR A 234
VAL A 277
VAL A 381
HEM  A1400 (-4.4A)
PG4  A1399 ( 3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.72A 3lxiB-2xkrA:
43.8
3lxiB-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE


(Thermus
thermophilus)
PF05175
(MTS)
5 LEU A 220
LEU A 223
VAL A 258
ASP A 239
VAL A 237
None
None
None
SAH  A 376 ( 4.2A)
None
1.18A 3lxiB-2zwvA:
undetectable
3lxiB-2zwvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
None
0.92A 3lxiB-3asaA:
undetectable
3lxiB-3asaA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 THR A  50
LEU A 107
LEU A 105
GLY A  61
VAL A  24
None
1.13A 3lxiB-3b3dA:
undetectable
3lxiB-3b3dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 211
THR A 130
LEU A 323
LEU A 324
GLY A 321
NAD  A 400 (-3.5A)
None
None
None
None
1.18A 3lxiB-3cinA:
undetectable
3lxiB-3cinA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 211
THR A 130
LEU A 324
GLY A 321
THR A  15
NAD  A 400 (-3.5A)
None
None
None
None
1.04A 3lxiB-3cinA:
undetectable
3lxiB-3cinA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Mycobacterium
tuberculosis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
None
1.25A 3lxiB-3dlaA:
undetectable
3lxiB-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti)
PF06114
(Peptidase_M78)
5 THR A 166
LEU A 134
GLY A 138
THR A 140
VAL A 170
None
1.13A 3lxiB-3dteA:
undetectable
3lxiB-3dteA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE


(Cytophaga
hutchinsonii)
PF00682
(HMGL-like)
5 THR A 211
LEU A 215
LEU A 218
THR A 259
VAL A   7
None
1.23A 3lxiB-3eegA:
undetectable
3lxiB-3eegA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE


(Bacteroides
fragilis)
PF00881
(Nitroreductase)
5 THR A  48
LEU A 144
THR A 155
VAL A  67
VAL A  73
None
1.19A 3lxiB-3eofA:
undetectable
3lxiB-3eofA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Glutamicibacter
protophormiae)
PF03644
(Glyco_hydro_85)
5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
None
1.24A 3lxiB-3fhaA:
undetectable
3lxiB-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
None
1.26A 3lxiB-3g1uA:
undetectable
3lxiB-3g1uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
1.29A 3lxiB-3i4kA:
undetectable
3lxiB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
None
1.31A 3lxiB-3jb9X:
undetectable
3lxiB-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE


(Plasmodium
falciparum)
PF00202
(Aminotran_3)
5 THR A 386
THR A 382
LEU A 349
GLY A 204
VAL A 378
None
1.16A 3lxiB-3lg0A:
undetectable
3lxiB-3lg0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica)
PF00923
(TAL_FSA)
5 THR A 179
LEU A 162
GLY A 146
THR A 112
VAL A 116
None
1.30A 3lxiB-3m16A:
undetectable
3lxiB-3m16A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpo PREDICTED HYDROLASE
OF THE HAD
SUPERFAMILY


(Lactobacillus
brevis)
PF08282
(Hydrolase_3)
5 THR A 216
LEU A 200
GLY A 198
THR A 225
ASP A   9
None
0.98A 3lxiB-3mpoA:
undetectable
3lxiB-3mpoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus)
PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.26A 3lxiB-3mwtA:
undetectable
3lxiB-3mwtA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A  87
GLY A 234
THR A 238
VAL A 281
VAL A 384
HEM  A 417 (-4.1A)
HEM  A 417 (-4.0A)
HEM  A 417 (-3.6A)
HEM  A 417 ( 4.8A)
None
1.16A 3lxiB-3oftA:
49.9
3lxiB-3oftA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 324
LEU A 241
GLY A 276
VAL A 290
VAL A 267
None
1.28A 3lxiB-3oneA:
undetectable
3lxiB-3oneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis)
PF03051
(Peptidase_C1_2)
5 THR A  45
LEU A  70
LEU A  69
GLY A  75
ASP A  78
None
None
None
None
K  A 408 (-3.3A)
1.13A 3lxiB-3pw3A:
undetectable
3lxiB-3pw3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE


(Paenarthrobacter
aurescens)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
5 THR A  27
LEU A  54
LEU A  46
GLY A  47
VAL A 119
None
1.17A 3lxiB-3rcnA:
undetectable
3lxiB-3rcnA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
5 THR A  56
GLY A  35
THR A  42
VAL A  44
VAL A 231
None
1.20A 3lxiB-3rmtA:
undetectable
3lxiB-3rmtA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
5 THR A  56
GLY A  35
THR A  42
VAL A  74
VAL A  44
None
1.19A 3lxiB-3rmtA:
undetectable
3lxiB-3rmtA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
None
1.13A 3lxiB-3sh5A:
undetectable
3lxiB-3sh5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1


(Burkholderia
ambifaria)
PF00793
(DAHP_synth_1)
5 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
None
0.99A 3lxiB-3t4cA:
undetectable
3lxiB-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29)
PF00843
(Arena_nucleocap)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.30A 3lxiB-3t5qA:
undetectable
3lxiB-3t5qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT


(Porphyridium
purpureum)
PF00502
(Phycobilisome)
5 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
None
None
None
None
PEB  A 202 (-4.7A)
1.31A 3lxiB-3v57A:
undetectable
3lxiB-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.78A 3lxiB-3zbyA:
41.5
3lxiB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 THR A 172
THR A 142
LEU A 167
GLY A 163
THR A  76
None
1.11A 3lxiB-4ad9A:
undetectable
3lxiB-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
None
1.06A 3lxiB-4ad9A:
undetectable
3lxiB-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 THR A  44
THR A  12
LEU A  80
VAL A   5
ASP A   6
None
1.09A 3lxiB-4c7vA:
undetectable
3lxiB-4c7vA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
8 TRP A  89
TYR A  98
THR A 103
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
None
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
1.32A 3lxiB-4c9mA:
71.0
3lxiB-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
11 TRP A  89
TYR A  98
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
ASP A 305
VAL A 404
None
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
0.27A 3lxiB-4c9mA:
71.0
3lxiB-4c9mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT)
5 LEU A 250
GLY A 249
THR A 359
VAL A 363
VAL A 362
None
1.18A 3lxiB-4ckbA:
undetectable
3lxiB-4ckbA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 THR A 101
LEU A 250
GLY A 254
THR A 258
VAL A 301
VAL A 402
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
0.81A 3lxiB-4dxyA:
54.9
3lxiB-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
LEU A 250
LEU A 253
GLY A 254
THR A 258
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
0.78A 3lxiB-4dxyA:
54.9
3lxiB-4dxyA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE


(Campylobacter
jejuni)
PF00977
(His_biosynth)
5 THR A   2
LEU A 241
LEU A 211
VAL A 184
VAL A 182
None
1.26A 3lxiB-4gj1A:
undetectable
3lxiB-4gj1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
None
1.25A 3lxiB-4hacA:
undetectable
3lxiB-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgn 2-KETO-3-DEOXY-D-MAN
NO-OCTULOSONATE
8-PHOSPHATE
PHOSPHOHYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
5 THR A  61
THR A  38
GLY A  20
THR A  25
VAL A  27
None
None
MG  A 200 ( 4.3A)
None
None
1.14A 3lxiB-4hgnA:
undetectable
3lxiB-4hgnA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE


(Polynucleobacter
necessarius)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.21A 3lxiB-4k9qA:
undetectable
3lxiB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Rhodothermus
marinus)
PF00156
(Pribosyltran)
5 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.28A 3lxiB-4m0kA:
undetectable
3lxiB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
None
1.00A 3lxiB-4mfiA:
undetectable
3lxiB-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
5 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
None
None
None
GCU  A 401 ( 2.7A)
None
0.79A 3lxiB-4n91A:
undetectable
3lxiB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Drosophila
melanogaster)
no annotation 5 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
None
1.16A 3lxiB-4nk7A:
undetectable
3lxiB-4nk7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58


(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
5 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
None
0.96A 3lxiB-4oh0A:
undetectable
3lxiB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2


(Toxoplasma
gondii)
PF00090
(TSP_1)
PF00092
(VWA)
5 THR A 155
LEU A  80
GLY A 160
VAL A 198
ASP A 194
None
1.28A 3lxiB-4okrA:
undetectable
3lxiB-4okrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p49 ANTIBODY SCFV B8

(Gallus gallus)
PF07686
(V-set)
5 TYR A 216
THR A 214
LEU A 165
GLY A 164
ASP A  36
None
1.28A 3lxiB-4p49A:
undetectable
3lxiB-4p49A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus)
PF06968
(BATS)
5 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
None
1.05A 3lxiB-4r33A:
undetectable
3lxiB-4r33A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 THR A 708
THR A 564
LEU A 580
LEU A 577
GLY A 576
None
1.19A 3lxiB-4rbnA:
undetectable
3lxiB-4rbnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE


(Oryza sativa)
PF00168
(C2)
5 THR A  48
THR A  42
GLY A  16
VAL A  72
VAL A  31
None
1.11A 3lxiB-4rj9A:
undetectable
3lxiB-4rj9A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
5 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
None
1.29A 3lxiB-4rnzA:
undetectable
3lxiB-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN


(Slackia
heliotrinireducens)
PF13472
(Lipase_GDSL_2)
5 TYR A  80
THR A 103
LEU A  38
GLY A   7
THR A  11
None
1.11A 3lxiB-4s1pA:
undetectable
3lxiB-4s1pA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
None
1.13A 3lxiB-4w8jA:
undetectable
3lxiB-4w8jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
None
1.22A 3lxiB-4wrnA:
undetectable
3lxiB-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 THR A 483
LEU A 509
GLY A 508
THR A 477
VAL A 504
None
1.27A 3lxiB-4ypjA:
undetectable
3lxiB-4ypjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6


(Dictyostelium
discoideum)
PF01912
(eIF-6)
5 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.29A 3lxiB-5anbI:
undetectable
3lxiB-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.12A 3lxiB-5b04A:
undetectable
3lxiB-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
ASP A  43
VAL A 107
None
None
None
SAH  A 301 ( 4.5A)
None
1.15A 3lxiB-5bp7A:
undetectable
3lxiB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
None
0.77A 3lxiB-5bp7A:
undetectable
3lxiB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 THR A 365
GLY A 344
THR A 351
VAL A 384
VAL A 353
None
1.16A 3lxiB-5bs5A:
undetectable
3lxiB-5bs5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NANOBODY NB15

(Camelus
dromedarius)
PF07686
(V-set)
5 LEU D  79
LEU D  81
VAL D  47
ASP D  50
VAL D  48
None
1.28A 3lxiB-5c3lD:
undetectable
3lxiB-5c3lD:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156


(uncultured
organism)
no annotation 5 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
None
1.25A 3lxiB-5d8mA:
undetectable
3lxiB-5d8mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
None
1.13A 3lxiB-5dfaA:
undetectable
3lxiB-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
None
None
None
SAH  A 301 ( 4.5A)
None
1.18A 3lxiB-5epeA:
undetectable
3lxiB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
None
0.76A 3lxiB-5epeA:
undetectable
3lxiB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
None
0.84A 3lxiB-5jxmA:
undetectable
3lxiB-5jxmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Legionella
pneumophila)
PF00290
(Trp_syntA)
5 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
None
1.07A 3lxiB-5k9xA:
undetectable
3lxiB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
5 LEU A 279
LEU A 366
GLY A 367
VAL A 402
VAL A 414
None
1.25A 3lxiB-5kjuA:
undetectable
3lxiB-5kjuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE


(Mus musculus)
PF01593
(Amino_oxidase)
5 THR A 222
THR A 279
GLY A  19
VAL A  35
VAL A  10
None
1.14A 3lxiB-5laeA:
undetectable
3lxiB-5laeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C


(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii)
PF00384
(Molybdopterin)
PF01493
(GXGXG)
5 TYR B 207
THR B 268
LEU C 219
GLY C 221
VAL B 227
None
1.30A 3lxiB-5t5iB:
undetectable
3lxiB-5t5iB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis)
PF00291
(PALP)
5 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
None
1.27A 3lxiB-5xw3A:
undetectable
3lxiB-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2


(Homo sapiens)
no annotation 5 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
None
1.30A 3lxiB-6cetN:
undetectable
3lxiB-6cetN:
undetectable