SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXI_A_CAMA423_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1col | COLICIN A (Escherichiacoli) |
PF01024(Colicin) | 5 | TYR A 125LEU A 178LEU A 179GLY A 176VAL A 167 | None | 1.24A | 3lxiA-1colA:0.1 | 3lxiA-1colA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2k | CHITINASE 1 (Coccidioidesimmitis) |
PF00704(Glyco_hydro_18) | 5 | TRP A 377THR A 65LEU A 404LEU A 398VAL A 287 | None | 1.33A | 3lxiA-1d2kA:0.0 | 3lxiA-1d2kA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ek6 | UDP-GALACTOSE4-EPIMERASE (Homo sapiens) |
PF16363(GDP_Man_Dehyd) | 5 | LEU A 247LEU A 269GLY A 250VAL A 128VAL A 181 | None | 1.31A | 3lxiA-1ek6A:undetectable | 3lxiA-1ek6A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fsu | N-ACETYLGALACTOSAMINE-4-SULFATASE (Homo sapiens) |
PF00884(Sulfatase) | 5 | THR A 368THR A 107LEU A 371GLY A 101VAL A 122 | None | 1.28A | 3lxiA-1fsuA:undetectable | 3lxiA-1fsuA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gso | PROTEIN (GLYCINAMIDERIBONUCLEOTIDESYNTHETASE) (Escherichiacoli) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | THR A 296THR A 37GLY A 9VAL A 5VAL A 30 | None | 1.33A | 3lxiA-1gsoA:0.0 | 3lxiA-1gsoA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxi | PEROXISOME TARGETINGSIGNAL 1 RECEPTORPEX5 (Trypanosomabrucei) |
no annotation | 5 | THR A 392LEU A 360LEU A 357GLY A 356VAL A 375 | None | 1.29A | 3lxiA-1hxiA:undetectable | 3lxiA-1hxiA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 5 | TYR A 164THR A 215LEU A 121GLY A 122THR A 138 | None | 1.05A | 3lxiA-1ibqA:undetectable | 3lxiA-1ibqA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | TYR A 165THR A 215LEU A 122GLY A 123THR A 139 | None | 1.06A | 3lxiA-1izeA:undetectable | 3lxiA-1izeA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n0w | DNA REPAIR PROTEINRAD51 HOMOLOG 1 (Homo sapiens) |
PF08423(Rad51) | 5 | THR A 298LEU A 109LEU A 113GLY A 116VAL A 264 | NoneNone MG A 401 (-4.2A) MG A 401 (-3.8A)None | 1.17A | 3lxiA-1n0wA:undetectable | 3lxiA-1n0wA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4d | UROPORPHYRIN-IIIC-METHYLTRANSFERASE (Pseudomonasdenitrificans(nomenrejiciendum)) |
PF00590(TP_methylase) | 5 | TYR A 183THR A 130LEU A 136VAL A 152VAL A 179 | SAH A1501 (-4.8A)SAH A1501 ( 3.6A)NoneNoneNone | 1.21A | 3lxiA-1s4dA:undetectable | 3lxiA-1s4dA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umg | 385AA LONG CONSERVEDHYPOTHETICAL PROTEIN (Sulfurisphaeratokodaii) |
PF01950(FBPase_3) | 5 | THR A 49LEU A 292LEU A 293GLY A 294VAL A 8 | None | 1.20A | 3lxiA-1umgA:undetectable | 3lxiA-1umgA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | IRON-SULFUR PROTEINLARGE SUBUNIT OFCUMENE DIOXYGENASE (Pseudomonasfluorescens) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | LEU A 172GLY A 171THR A 206VAL A 208VAL A 357 | None | 1.31A | 3lxiA-1wqlA:undetectable | 3lxiA-1wqlA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 398LEU A 401GLY A 402VAL A 369VAL A 366 | None | 1.16A | 3lxiA-1xb7A:undetectable | 3lxiA-1xb7A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 5 | THR A 312LEU A 316LEU A 319GLY A 326VAL A 248 | None | 1.27A | 3lxiA-1y1pA:undetectable | 3lxiA-1y1pA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z54 | PROBABLETHIOESTERASE (Thermusthermophilus) |
PF03061(4HBT) | 5 | THR A 105LEU A 59LEU A 61VAL A 75VAL A 93 | None | 1.19A | 3lxiA-1z54A:undetectable | 3lxiA-1z54A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7d | ORNITHINEAMINOTRANSFERASE (Plasmodiumyoelii) |
PF00202(Aminotran_3) | 5 | THR A 385THR A 381LEU A 348GLY A 203VAL A 377 | None | 1.21A | 3lxiA-1z7dA:undetectable | 3lxiA-1z7dA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | TYR A 117GLY A 162THR A 45VAL A 51VAL A 49 | None | 1.15A | 3lxiA-1zjrA:undetectable | 3lxiA-1zjrA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ci6 | NG,NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1 (Bos taurus) |
PF02274(Amidinotransf) | 5 | THR A 156GLY A 149THR A 145VAL A 130VAL A 139 | None | 1.31A | 3lxiA-2ci6A:undetectable | 3lxiA-2ci6A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7u | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 5 | TRP A 394LEU A 417LEU A 420VAL A 350VAL A 359 | None | 1.31A | 3lxiA-2e7uA:undetectable | 3lxiA-2e7uA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ego | GENERAL RECEPTOR FORPHOSPHOINOSITIDES1-ASSOCIATEDSCAFFOLD PROTEIN (Rattusnorvegicus) |
PF00595(PDZ) | 5 | THR A 185LEU A 101GLY A 147THR A 149VAL A 134 | None | 1.31A | 3lxiA-2egoA:undetectable | 3lxiA-2egoA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ify | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Bacillusanthracis) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | THR A 462GLY A 405THR A 413VAL A 24VAL A 417 | None | 1.33A | 3lxiA-2ifyA:undetectable | 3lxiA-2ifyA:22.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 5 | THR A 181LEU A 244GLY A 248THR A 252VAL A 396 | NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)None | 1.31A | 3lxiA-2m56A:57.8 | 3lxiA-2m56A:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 6 | TYR A 96THR A 101LEU A 244GLY A 248THR A 252VAL A 295 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A) | 1.26A | 3lxiA-2m56A:57.8 | 3lxiA-2m56A:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 8 | TYR A 96THR A 101THR A 185LEU A 244GLY A 248THR A 252VAL A 295VAL A 396 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)None | 0.54A | 3lxiA-2m56A:57.8 | 3lxiA-2m56A:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oga | TRANSAMINASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 5 | THR A 206LEU A 218GLY A 77VAL A 162VAL A 184 | None | 1.20A | 3lxiA-2ogaA:undetectable | 3lxiA-2ogaA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3j | VP4 (Rotavirus A) |
PF00426(VP4_haemagglut) | 5 | THR A 191THR A 176LEU A 103GLY A 95VAL A 167 | None | 1.19A | 3lxiA-2p3jA:undetectable | 3lxiA-2p3jA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rq6 | ATP SYNTHASE EPSILONCHAIN (Thermosynechococcuselongatus) |
PF00401(ATP-synt_DE)PF02823(ATP-synt_DE_N) | 5 | THR A 42LEU A 24LEU A 31GLY A 32VAL A 69 | None | 1.21A | 3lxiA-2rq6A:undetectable | 3lxiA-2rq6A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | TYR A 165THR A 214LEU A 122GLY A 123THR A 139 | None | 1.14A | 3lxiA-2wedA:undetectable | 3lxiA-2wedA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | LEU A 226GLY A 230THR A 234VAL A 277VAL A 381 | HEM A1400 (-4.4A)PG4 A1399 ( 3.2A)HEM A1400 (-3.7A)HEM A1400 (-4.5A)None | 0.70A | 3lxiA-2xkrA:44.2 | 3lxiA-2xkrA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 5 | TRP A 247THR A 207LEU A 292LEU A 289GLY A 288 | None | 0.88A | 3lxiA-3asaA:undetectable | 3lxiA-3asaA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3d | PUTATIVE MORPHINEDEHYDROGENASE (Bacillussubtilis) |
PF00248(Aldo_ket_red) | 5 | THR A 50LEU A 107LEU A 105GLY A 61VAL A 24 | None | 1.09A | 3lxiA-3b3dA:undetectable | 3lxiA-3b3dA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn3 | INTERCELLULARADHESION MOLECULE 5 (Homo sapiens) |
PF03921(ICAM_N) | 5 | THR B 45THR B 38LEU B 52LEU B 36GLY B 35 | None | 1.30A | 3lxiA-3bn3B:undetectable | 3lxiA-3bn3B:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 211THR A 130LEU A 323LEU A 324GLY A 321 | NAD A 400 (-3.5A)NoneNoneNoneNone | 1.18A | 3lxiA-3cinA:undetectable | 3lxiA-3cinA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 211THR A 130LEU A 324GLY A 321THR A 15 | NAD A 400 (-3.5A)NoneNoneNoneNone | 1.04A | 3lxiA-3cinA:undetectable | 3lxiA-3cinA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | TYR A 7THR A 276LEU A 310LEU A 166VAL A 196 | None | 1.25A | 3lxiA-3dlaA:undetectable | 3lxiA-3dlaA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeg | 2-ISOPROPYLMALATESYNTHASE (Cytophagahutchinsonii) |
PF00682(HMGL-like) | 5 | THR A 211LEU A 215LEU A 218THR A 259VAL A 7 | None | 1.21A | 3lxiA-3eegA:undetectable | 3lxiA-3eegA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eof | PUTATIVEOXIDOREDUCTASE (Bacteroidesfragilis) |
PF00881(Nitroreductase) | 5 | THR A 48LEU A 144THR A 155VAL A 67VAL A 73 | None | 1.17A | 3lxiA-3eofA:undetectable | 3lxiA-3eofA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 5 | TRP A 282LEU A 55LEU A 296GLY A 297VAL A 271 | None | 1.23A | 3lxiA-3fhaA:undetectable | 3lxiA-3fhaA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 274LEU A 191GLY A 226VAL A 240VAL A 217 | None | 1.29A | 3lxiA-3g1uA:undetectable | 3lxiA-3g1uA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwj | ARYLPHORIN (Antheraeapernyi) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | TRP A 278LEU A 400GLY A 384VAL A 282VAL A 306 | None | 1.33A | 3lxiA-3gwjA:undetectable | 3lxiA-3gwjA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 340LEU A 336GLY A 332THR A 303VAL A 54 | TYR A 340 ( 1.3A)LEU A 336 ( 0.6A)GLY A 332 ( 0.0A)THR A 303 (-0.8A)VAL A 54 ( 0.6A) | 1.30A | 3lxiA-3i4kA:undetectable | 3lxiA-3i4kA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igz | COFACTOR-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Leishmaniamexicana) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | THR B 497GLY B 428THR B 436VAL B 36VAL B 440 | None | 1.31A | 3lxiA-3igzB:undetectable | 3lxiA-3igzB:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 5 | THR X 774LEU X 765LEU X 761GLY X 738THR X 744 | None | 1.29A | 3lxiA-3jb9X:undetectable | 3lxiA-3jb9X:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jq3 | LOMBRICINE KINASE (Urechis caupo) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | THR A 120LEU A 244LEU A 98GLY A 241VAL A 337 | None | 1.29A | 3lxiA-3jq3A:undetectable | 3lxiA-3jq3A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m16 | TRANSALDOLASE (Oleispiraantarctica) |
PF00923(TAL_FSA) | 5 | THR A 179LEU A 162GLY A 146THR A 112VAL A 116 | None | 1.30A | 3lxiA-3m16A:undetectable | 3lxiA-3m16A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwn | PHYCOERYTHRIN (Phormidiumtenue) |
PF00502(Phycobilisome) | 5 | THR A1134LEU A1159LEU A1156VAL A1052VAL A1051 | NoneNoneNoneNoneCYC A3002 ( 4.5A) | 1.25A | 3lxiA-3mwnA:undetectable | 3lxiA-3mwnA:13.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 5 | THR A 324LEU A 182GLY A 243VAL A 50VAL A 47 | None | 1.26A | 3lxiA-3mwtA:undetectable | 3lxiA-3mwtA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noq | THIJ/PFPI FAMILYPROTEIN (Pseudomonasfluorescens) |
PF01965(DJ-1_PfpI) | 5 | THR A 120LEU A 128LEU A 131GLY A 108VAL A 74 | None | 1.23A | 3lxiA-3noqA:undetectable | 3lxiA-3noqA:20.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3oft | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | LEU A 87GLY A 234THR A 238VAL A 281VAL A 384 | HEM A 417 (-4.1A)HEM A 417 (-4.0A)HEM A 417 (-3.6A)HEM A 417 ( 4.8A)None | 1.14A | 3lxiA-3oftA:50.0 | 3lxiA-3oftA:35.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 324LEU A 241GLY A 276VAL A 290VAL A 267 | None | 1.31A | 3lxiA-3oneA:undetectable | 3lxiA-3oneA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | THR A 56GLY A 35THR A 42VAL A 44VAL A 231 | None | 1.19A | 3lxiA-3rmtA:undetectable | 3lxiA-3rmtA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | THR A 56GLY A 35THR A 42VAL A 74VAL A 44 | None | 1.24A | 3lxiA-3rmtA:undetectable | 3lxiA-3rmtA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sh5 | LG3 PEPTIDE (Homo sapiens) |
PF00054(Laminin_G_1) | 5 | THR A 40LEU A 73LEU A 68GLY A 67VAL A 160 | None | 1.13A | 3lxiA-3sh5A:undetectable | 3lxiA-3sh5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4c | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE 1 (Burkholderiaambifaria) |
PF00793(DAHP_synth_1) | 5 | TYR A 49THR A 29THR A 89LEU A 76GLY A 72 | None | 0.97A | 3lxiA-3t4cA:undetectable | 3lxiA-3t4cA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t5q | NUCLEOPROTEIN (Mopeia Lassavirusreassortant 29) |
PF00843(Arena_nucleocap) | 5 | THR A 324LEU A 182GLY A 243VAL A 50VAL A 47 | None | 1.28A | 3lxiA-3t5qA:undetectable | 3lxiA-3t5qA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v57 | PHYCOERYTHRIN ALPHASUBUNIT (Porphyridiumpurpureum) |
PF00502(Phycobilisome) | 5 | THR A 134LEU A 159LEU A 156VAL A 52VAL A 51 | NoneNoneNoneNonePEB A 202 (-4.7A) | 1.26A | 3lxiA-3v57A:undetectable | 3lxiA-3v57A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9a | PUTATIVEUNCHARACTERIZEDPROTEIN (Coprinopsiscinerea) |
no annotation | 5 | TYR A 179LEU A 144GLY A 156VAL A 202VAL A 203 | None | 1.12A | 3lxiA-3w9aA:undetectable | 3lxiA-3w9aA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | LEU A 229GLY A 233THR A 237VAL A 280VAL A 383 | HEM A1402 ( 4.6A)EDO A1406 ( 3.4A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 0.75A | 3lxiA-3zbyA:41.6 | 3lxiA-3zbyA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | THR A 172THR A 142LEU A 167GLY A 163THR A 76 | None | 1.11A | 3lxiA-4ad9A:undetectable | 3lxiA-4ad9A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | TYR A 180THR A 172THR A 142GLY A 163THR A 76 | None | 1.07A | 3lxiA-4ad9A:undetectable | 3lxiA-4ad9A:22.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 10 | TRP A 89TYR A 98THR A 103THR A 187LEU A 252LEU A 255GLY A 256THR A 260VAL A 303VAL A 404 | NoneNoneGOL A1419 (-3.8A)NoneHEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)GOL A1419 (-3.5A) | 0.23A | 3lxiA-4c9mA:72.2 | 3lxiA-4c9mA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | THR A 101LEU A 250GLY A 254THR A 258VAL A 301VAL A 402 | HEM A 501 ( 4.8A)HEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)None | 0.77A | 3lxiA-4dxyA:55.4 | 3lxiA-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101LEU A 250LEU A 253GLY A 254THR A 258 | HEM A 501 ( 4.8A)HEM A 501 (-4.3A)NonePEG A 502 (-3.8A)HEM A 501 (-3.7A) | 0.79A | 3lxiA-4dxyA:55.4 | 3lxiA-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 185LEU A 250LEU A 253GLY A 254THR A 258 | NoneHEM A 501 (-4.3A)NonePEG A 502 (-3.8A)HEM A 501 (-3.7A) | 0.97A | 3lxiA-4dxyA:55.4 | 3lxiA-4dxyA:61.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glr | ANTI-PTAU HEAVYCHAINANTI-PTAU LIGHTCHAIN (Gallus gallus;Gallus gallus) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 5 | TYR H 91THR H 89LEU H 45GLY H 44VAL I 85 | None | 1.29A | 3lxiA-4glrH:undetectable | 3lxiA-4glrH:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Escherichiacoli;Candidaalbicans) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 5 | THR A 654THR A 641LEU A 618GLY A 619VAL A 633 | None | 1.32A | 3lxiA-4h1gA:undetectable | 3lxiA-4h1gA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hac | MEVALONATE KINASE (Methanosarcinamazei) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | THR A 291THR A 257LEU A 31LEU A 92GLY A 8 | None | 1.25A | 3lxiA-4hacA:undetectable | 3lxiA-4hacA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hgn | 2-KETO-3-DEOXY-D-MANNO-OCTULOSONATE8-PHOSPHATEPHOSPHOHYDROLASE (Bacteroidesthetaiotaomicron) |
PF08282(Hydrolase_3) | 5 | THR A 61THR A 38GLY A 20THR A 25VAL A 27 | NoneNone MG A 200 ( 4.3A)NoneNone | 1.17A | 3lxiA-4hgnA:undetectable | 3lxiA-4hgnA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | TYR A 573THR A 590GLY A 440THR A 554VAL A 546 | NoneSO4 A 904 (-4.5A)NoneNoneNone | 1.29A | 3lxiA-4i3gA:undetectable | 3lxiA-4i3gA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k9q | BENZOYLFORMATEDECARBOXYLASE (Polynucleobacternecessarius) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 441THR A 19LEU A 412GLY A 409VAL A 65 | None | 1.24A | 3lxiA-4k9qA:undetectable | 3lxiA-4k9qA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lk2 | PRE-MRNA-PROCESSINGATP-DEPENDENT RNAHELICASE PRP5 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | THR A 329THR A 435LEU A 404LEU A 396VAL A 436 | None | 1.28A | 3lxiA-4lk2A:undetectable | 3lxiA-4lk2A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m5b | COBALAMINBIOSYNTHESIS PROTEINCBIM (Caldanaerobactersubterraneus) |
PF01891(CbiM) | 5 | THR A 77LEU A 87LEU A 74GLY A 70THR A 202 | HEZ A 312 (-4.0A)NoneNoneNoneNone | 1.32A | 3lxiA-4m5bA:undetectable | 3lxiA-4m5bA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfi | SN-GLYCEROL-3-PHOSPHATE ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN USPB (Mycobacteriumtuberculosis) |
PF13416(SBP_bac_8) | 5 | THR A 331LEU A 99LEU A 309GLY A 308VAL A 348 | None | 1.04A | 3lxiA-4mfiA:undetectable | 3lxiA-4mfiA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh0 | BETA-LACTAMASEOXA-58 (Acinetobacterbaumannii) |
PF00905(Transpeptidase) | 5 | THR A 59LEU A 274GLY A 275VAL A 238VAL A 246 | None | 1.02A | 3lxiA-4oh0A:undetectable | 3lxiA-4oh0A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7k | ABC TRANSPORTER (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | THR A 521THR A 530LEU A 512LEU A 509THR A 497 | None | 1.17A | 3lxiA-4q7kA:undetectable | 3lxiA-4q7kA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qan | HYPOTHETICAL PROTEIN ([Ruminococcus]gnavus) |
no annotation | 5 | THR A 94GLY A 206THR A 190VAL A 192VAL A 171 | None | 1.32A | 3lxiA-4qanA:undetectable | 3lxiA-4qanA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | THR A 708THR A 564LEU A 580LEU A 577GLY A 576 | None | 1.17A | 3lxiA-4rbnA:undetectable | 3lxiA-4rbnA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rj9 | C2 DOMAIN-CONTAININGPROTEIN-LIKE (Oryza sativa) |
PF00168(C2) | 5 | THR A 48THR A 42GLY A 16VAL A 72VAL A 31 | None | 1.17A | 3lxiA-4rj9A:undetectable | 3lxiA-4rj9A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | TYR A 264THR A 233LEU A 354GLY A 355VAL A 344 | None | 1.31A | 3lxiA-4rnzA:undetectable | 3lxiA-4rnzA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ut1 | FLAGELLARHOOK-ASSOCIATEDPROTEIN (Burkholderiapseudomallei) |
PF06429(Flg_bbr_C) | 5 | THR A 166LEU A 278LEU A 283GLY A 284VAL A 159 | EDO A1639 (-3.2A)NoneNoneNoneNone | 1.28A | 3lxiA-4ut1A:undetectable | 3lxiA-4ut1A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrn | MALTOSE-BINDINGPERIPLASMICPROTEIN,UROMODULIN (Escherichiacoli;Homo sapiens) |
PF00100(Zona_pellucida)PF13416(SBP_bac_8) | 5 | THR A 589LEU A 601LEU A 602GLY A 641VAL A 637 | None | 1.21A | 3lxiA-4wrnA:undetectable | 3lxiA-4wrnA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | THR A 483LEU A 509GLY A 508THR A 477VAL A 504 | None | 1.31A | 3lxiA-4ypjA:undetectable | 3lxiA-4ypjA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anb | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Dictyosteliumdiscoideum) |
PF01912(eIF-6) | 5 | LEU I 70LEU I 71GLY I 65THR I 110VAL I 135 | None | 1.32A | 3lxiA-5anbI:undetectable | 3lxiA-5anbI:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | THR A 141LEU A 153LEU A 152THR A 189VAL A 166 | None | 1.14A | 3lxiA-5b04A:undetectable | 3lxiA-5b04A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | LEU A 26LEU A 29GLY A 30VAL A 41VAL A 107 | None | 0.76A | 3lxiA-5bp7A:undetectable | 3lxiA-5bp7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | THR A 365GLY A 344THR A 351VAL A 384VAL A 353 | None | 1.19A | 3lxiA-5bs5A:undetectable | 3lxiA-5bs5A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfa | BETA-GALACTOSIDASE (Geobacillusstearothermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | THR A 48THR A 10LEU A 359LEU A 320VAL A 406 | None | 1.11A | 3lxiA-5dfaA:undetectable | 3lxiA-5dfaA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | LEU A 25LEU A 28GLY A 29VAL A 40VAL A 106 | None | 0.73A | 3lxiA-5epeA:undetectable | 3lxiA-5epeA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gja | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEOXIDASE 2 (Arabidopsisthaliana) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | TRP A 89LEU A 72GLY A 76VAL A 84VAL A 87 | None | 1.21A | 3lxiA-5gjaA:undetectable | 3lxiA-5gjaA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxm | PRIB (Streptomycessp. RM-5-8) |
PF11991(Trp_DMAT) | 5 | THR A 91LEU A 35GLY A 36VAL A 111VAL A 93 | None | 0.84A | 3lxiA-5jxmA:undetectable | 3lxiA-5jxmA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kar | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3B (Mus musculus) |
PF00149(Metallophos) | 5 | TYR A 151LEU A 132GLY A 133VAL A 108VAL A 112 | None | 1.33A | 3lxiA-5karA:undetectable | 3lxiA-5karA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kju | SHIKIMATEO-HYDROXYCINNAMOYLTRANSFERASE (Arabidopsisthaliana) |
PF02458(Transferase) | 5 | LEU A 279LEU A 366GLY A 367VAL A 402VAL A 414 | None | 1.26A | 3lxiA-5kjuA:undetectable | 3lxiA-5kjuA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 5 | THR A 222THR A 279GLY A 19VAL A 35VAL A 10 | None | 1.19A | 3lxiA-5laeA:undetectable | 3lxiA-5laeA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | THR A 710LEU A 606LEU A 610GLY A 611VAL A 723 | None | 1.10A | 3lxiA-5nfhA:undetectable | 3lxiA-5nfhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | THR A 710THR A 702LEU A 610LEU A 613THR A 618 | None | 1.17A | 3lxiA-5nfhA:undetectable | 3lxiA-5nfhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT BTUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT C (Methanothermobactersp. CaT2;Methanothermobacterwolfeii) |
PF00384(Molybdopterin)PF01493(GXGXG) | 5 | TYR B 207THR B 268LEU C 219GLY C 221VAL B 227 | None | 1.30A | 3lxiA-5t5iB:undetectable | 3lxiA-5t5iB:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vev | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Neisseriagonorrhoeae) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | THR A 294THR A 37GLY A 9VAL A 5VAL A 30 | None | 1.32A | 3lxiA-5vevA:undetectable | 3lxiA-5vevA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wde | KINESIN-LIKE PROTEINKIFC3 (Homo sapiens) |
PF00225(Kinesin) | 5 | THR A 739THR A 726LEU A 704GLY A 705VAL A 718 | None | 1.24A | 3lxiA-5wdeA:undetectable | 3lxiA-5wdeA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xw3 | O-ACETYLSERINE LYASE (Bacillusanthracis) |
PF00291(PALP) | 5 | THR A 284THR A 288LEU A 30VAL A 200VAL A 174 | None | 1.25A | 3lxiA-5xw3A:undetectable | 3lxiA-5xw3A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bog | RNAPOLYMERASE-ASSOCIATED PROTEIN RAPA (Escherichiacoli) |
no annotation | 5 | LEU A 81LEU A 80GLY A 79THR A 4VAL A 22 | None | 1.31A | 3lxiA-6bogA:undetectable | 3lxiA-6bogA:undetectable |