SIMILAR PATTERNS OF AMINO ACIDS FOR 3LXI_A_CAMA423

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli)
PF01024
(Colicin)
5 TYR A 125
LEU A 178
LEU A 179
GLY A 176
VAL A 167
None
1.24A 3lxiA-1colA:
0.1
3lxiA-1colA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis)
PF00704
(Glyco_hydro_18)
5 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.33A 3lxiA-1d2kA:
0.0
3lxiA-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE


(Homo sapiens)
PF16363
(GDP_Man_Dehyd)
5 LEU A 247
LEU A 269
GLY A 250
VAL A 128
VAL A 181
None
1.31A 3lxiA-1ek6A:
undetectable
3lxiA-1ek6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
5 THR A 368
THR A 107
LEU A 371
GLY A 101
VAL A 122
None
1.28A 3lxiA-1fsuA:
undetectable
3lxiA-1fsuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)


(Escherichia
coli)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
None
1.33A 3lxiA-1gsoA:
0.0
3lxiA-1gsoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxi PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5


(Trypanosoma
brucei)
no annotation 5 THR A 392
LEU A 360
LEU A 357
GLY A 356
VAL A 375
None
1.29A 3lxiA-1hxiA:
undetectable
3lxiA-1hxiA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
5 TYR A 164
THR A 215
LEU A 121
GLY A 122
THR A 138
None
1.05A 3lxiA-1ibqA:
undetectable
3lxiA-1ibqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
None
1.06A 3lxiA-1izeA:
undetectable
3lxiA-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.17A 3lxiA-1n0wA:
undetectable
3lxiA-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE


(Pseudomonas
denitrificans
(nomen
rejiciendum))
PF00590
(TP_methylase)
5 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
1.21A 3lxiA-1s4dA:
undetectable
3lxiA-1s4dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN


(Sulfurisphaera
tokodaii)
PF01950
(FBPase_3)
5 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
None
1.20A 3lxiA-1umgA:
undetectable
3lxiA-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE


(Pseudomonas
fluorescens)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
5 LEU A 172
GLY A 171
THR A 206
VAL A 208
VAL A 357
None
1.31A 3lxiA-1wqlA:
undetectable
3lxiA-1wqlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 398
LEU A 401
GLY A 402
VAL A 369
VAL A 366
None
1.16A 3lxiA-1xb7A:
undetectable
3lxiA-1xb7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
None
1.27A 3lxiA-1y1pA:
undetectable
3lxiA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z54 PROBABLE
THIOESTERASE


(Thermus
thermophilus)
PF03061
(4HBT)
5 THR A 105
LEU A  59
LEU A  61
VAL A  75
VAL A  93
None
1.19A 3lxiA-1z54A:
undetectable
3lxiA-1z54A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE


(Plasmodium
yoelii)
PF00202
(Aminotran_3)
5 THR A 385
THR A 381
LEU A 348
GLY A 203
VAL A 377
None
1.21A 3lxiA-1z7dA:
undetectable
3lxiA-1z7dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
5 TYR A 117
GLY A 162
THR A  45
VAL A  51
VAL A  49
None
1.15A 3lxiA-1zjrA:
undetectable
3lxiA-1zjrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1


(Bos taurus)
PF02274
(Amidinotransf)
5 THR A 156
GLY A 149
THR A 145
VAL A 130
VAL A 139
None
1.31A 3lxiA-2ci6A:
undetectable
3lxiA-2ci6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
None
1.31A 3lxiA-2e7uA:
undetectable
3lxiA-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN


(Rattus
norvegicus)
PF00595
(PDZ)
5 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
None
1.31A 3lxiA-2egoA:
undetectable
3lxiA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Bacillus
anthracis)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 THR A 462
GLY A 405
THR A 413
VAL A  24
VAL A 417
None
1.33A 3lxiA-2ifyA:
undetectable
3lxiA-2ifyA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 THR A 181
LEU A 244
GLY A 248
THR A 252
VAL A 396
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
1.31A 3lxiA-2m56A:
57.8
3lxiA-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
6 TYR A  96
THR A 101
LEU A 244
GLY A 248
THR A 252
VAL A 295
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
1.26A 3lxiA-2m56A:
57.8
3lxiA-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
8 TYR A  96
THR A 101
THR A 185
LEU A 244
GLY A 248
THR A 252
VAL A 295
VAL A 396
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
None
0.54A 3lxiA-2m56A:
57.8
3lxiA-2m56A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
None
1.20A 3lxiA-2ogaA:
undetectable
3lxiA-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A)
PF00426
(VP4_haemagglut)
5 THR A 191
THR A 176
LEU A 103
GLY A  95
VAL A 167
None
1.19A 3lxiA-2p3jA:
undetectable
3lxiA-2p3jA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
None
1.21A 3lxiA-2rq6A:
undetectable
3lxiA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
5 TYR A 165
THR A 214
LEU A 122
GLY A 123
THR A 139
None
1.14A 3lxiA-2wedA:
undetectable
3lxiA-2wedA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 226
GLY A 230
THR A 234
VAL A 277
VAL A 381
HEM  A1400 (-4.4A)
PG4  A1399 ( 3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.70A 3lxiA-2xkrA:
44.2
3lxiA-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
None
0.88A 3lxiA-3asaA:
undetectable
3lxiA-3asaA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 THR A  50
LEU A 107
LEU A 105
GLY A  61
VAL A  24
None
1.09A 3lxiA-3b3dA:
undetectable
3lxiA-3b3dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5


(Homo sapiens)
PF03921
(ICAM_N)
5 THR B  45
THR B  38
LEU B  52
LEU B  36
GLY B  35
None
1.30A 3lxiA-3bn3B:
undetectable
3lxiA-3bn3B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 211
THR A 130
LEU A 323
LEU A 324
GLY A 321
NAD  A 400 (-3.5A)
None
None
None
None
1.18A 3lxiA-3cinA:
undetectable
3lxiA-3cinA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 211
THR A 130
LEU A 324
GLY A 321
THR A  15
NAD  A 400 (-3.5A)
None
None
None
None
1.04A 3lxiA-3cinA:
undetectable
3lxiA-3cinA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Mycobacterium
tuberculosis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
None
1.25A 3lxiA-3dlaA:
undetectable
3lxiA-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE


(Cytophaga
hutchinsonii)
PF00682
(HMGL-like)
5 THR A 211
LEU A 215
LEU A 218
THR A 259
VAL A   7
None
1.21A 3lxiA-3eegA:
undetectable
3lxiA-3eegA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE


(Bacteroides
fragilis)
PF00881
(Nitroreductase)
5 THR A  48
LEU A 144
THR A 155
VAL A  67
VAL A  73
None
1.17A 3lxiA-3eofA:
undetectable
3lxiA-3eofA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Glutamicibacter
protophormiae)
PF03644
(Glyco_hydro_85)
5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
None
1.23A 3lxiA-3fhaA:
undetectable
3lxiA-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
None
1.29A 3lxiA-3g1uA:
undetectable
3lxiA-3g1uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 TRP A 278
LEU A 400
GLY A 384
VAL A 282
VAL A 306
None
1.33A 3lxiA-3gwjA:
undetectable
3lxiA-3gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
1.30A 3lxiA-3i4kA:
undetectable
3lxiA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Leishmania
mexicana)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 THR B 497
GLY B 428
THR B 436
VAL B  36
VAL B 440
None
1.31A 3lxiA-3igzB:
undetectable
3lxiA-3igzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
None
1.29A 3lxiA-3jb9X:
undetectable
3lxiA-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 THR A 120
LEU A 244
LEU A  98
GLY A 241
VAL A 337
None
1.29A 3lxiA-3jq3A:
undetectable
3lxiA-3jq3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica)
PF00923
(TAL_FSA)
5 THR A 179
LEU A 162
GLY A 146
THR A 112
VAL A 116
None
1.30A 3lxiA-3m16A:
undetectable
3lxiA-3m16A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue)
PF00502
(Phycobilisome)
5 THR A1134
LEU A1159
LEU A1156
VAL A1052
VAL A1051
None
None
None
None
CYC  A3002 ( 4.5A)
1.25A 3lxiA-3mwnA:
undetectable
3lxiA-3mwnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus)
PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.26A 3lxiA-3mwtA:
undetectable
3lxiA-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN


(Pseudomonas
fluorescens)
PF01965
(DJ-1_PfpI)
5 THR A 120
LEU A 128
LEU A 131
GLY A 108
VAL A  74
None
1.23A 3lxiA-3noqA:
undetectable
3lxiA-3noqA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A  87
GLY A 234
THR A 238
VAL A 281
VAL A 384
HEM  A 417 (-4.1A)
HEM  A 417 (-4.0A)
HEM  A 417 (-3.6A)
HEM  A 417 ( 4.8A)
None
1.14A 3lxiA-3oftA:
50.0
3lxiA-3oftA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 324
LEU A 241
GLY A 276
VAL A 290
VAL A 267
None
1.31A 3lxiA-3oneA:
undetectable
3lxiA-3oneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
5 THR A  56
GLY A  35
THR A  42
VAL A  44
VAL A 231
None
1.19A 3lxiA-3rmtA:
undetectable
3lxiA-3rmtA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
halodurans)
PF00275
(EPSP_synthase)
5 THR A  56
GLY A  35
THR A  42
VAL A  74
VAL A  44
None
1.24A 3lxiA-3rmtA:
undetectable
3lxiA-3rmtA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
None
1.13A 3lxiA-3sh5A:
undetectable
3lxiA-3sh5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1


(Burkholderia
ambifaria)
PF00793
(DAHP_synth_1)
5 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
None
0.97A 3lxiA-3t4cA:
undetectable
3lxiA-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29)
PF00843
(Arena_nucleocap)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.28A 3lxiA-3t5qA:
undetectable
3lxiA-3t5qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT


(Porphyridium
purpureum)
PF00502
(Phycobilisome)
5 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
None
None
None
None
PEB  A 202 (-4.7A)
1.26A 3lxiA-3v57A:
undetectable
3lxiA-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Coprinopsis
cinerea)
no annotation 5 TYR A 179
LEU A 144
GLY A 156
VAL A 202
VAL A 203
None
1.12A 3lxiA-3w9aA:
undetectable
3lxiA-3w9aA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.75A 3lxiA-3zbyA:
41.6
3lxiA-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 THR A 172
THR A 142
LEU A 167
GLY A 163
THR A  76
None
1.11A 3lxiA-4ad9A:
undetectable
3lxiA-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
None
1.07A 3lxiA-4ad9A:
undetectable
3lxiA-4ad9A:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
10 TRP A  89
TYR A  98
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
VAL A 404
None
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
GOL  A1419 (-3.5A)
0.23A 3lxiA-4c9mA:
72.2
3lxiA-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 THR A 101
LEU A 250
GLY A 254
THR A 258
VAL A 301
VAL A 402
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
0.77A 3lxiA-4dxyA:
55.4
3lxiA-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
LEU A 250
LEU A 253
GLY A 254
THR A 258
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
0.79A 3lxiA-4dxyA:
55.4
3lxiA-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 185
LEU A 250
LEU A 253
GLY A 254
THR A 258
None
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
0.97A 3lxiA-4dxyA:
55.4
3lxiA-4dxyA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glr ANTI-PTAU HEAVY
CHAIN
ANTI-PTAU LIGHT
CHAIN


(Gallus gallus;
Gallus gallus)
PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR H  91
THR H  89
LEU H  45
GLY H  44
VAL I  85
None
1.29A 3lxiA-4glrH:
undetectable
3lxiA-4glrH:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN


(Escherichia
coli;
Candida
albicans)
PF00225
(Kinesin)
PF13416
(SBP_bac_8)
5 THR A 654
THR A 641
LEU A 618
GLY A 619
VAL A 633
None
1.32A 3lxiA-4h1gA:
undetectable
3lxiA-4h1gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
None
1.25A 3lxiA-4hacA:
undetectable
3lxiA-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgn 2-KETO-3-DEOXY-D-MAN
NO-OCTULOSONATE
8-PHOSPHATE
PHOSPHOHYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
5 THR A  61
THR A  38
GLY A  20
THR A  25
VAL A  27
None
None
MG  A 200 ( 4.3A)
None
None
1.17A 3lxiA-4hgnA:
undetectable
3lxiA-4hgnA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
None
SO4  A 904 (-4.5A)
None
None
None
1.29A 3lxiA-4i3gA:
undetectable
3lxiA-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE


(Polynucleobacter
necessarius)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.24A 3lxiA-4k9qA:
undetectable
3lxiA-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 THR A 329
THR A 435
LEU A 404
LEU A 396
VAL A 436
None
1.28A 3lxiA-4lk2A:
undetectable
3lxiA-4lk2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM


(Caldanaerobacter
subterraneus)
PF01891
(CbiM)
5 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
HEZ  A 312 (-4.0A)
None
None
None
None
1.32A 3lxiA-4m5bA:
undetectable
3lxiA-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
None
1.04A 3lxiA-4mfiA:
undetectable
3lxiA-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58


(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
5 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
None
1.02A 3lxiA-4oh0A:
undetectable
3lxiA-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
5 THR A 521
THR A 530
LEU A 512
LEU A 509
THR A 497
None
1.17A 3lxiA-4q7kA:
undetectable
3lxiA-4q7kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus)
no annotation 5 THR A  94
GLY A 206
THR A 190
VAL A 192
VAL A 171
None
1.32A 3lxiA-4qanA:
undetectable
3lxiA-4qanA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 THR A 708
THR A 564
LEU A 580
LEU A 577
GLY A 576
None
1.17A 3lxiA-4rbnA:
undetectable
3lxiA-4rbnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE


(Oryza sativa)
PF00168
(C2)
5 THR A  48
THR A  42
GLY A  16
VAL A  72
VAL A  31
None
1.17A 3lxiA-4rj9A:
undetectable
3lxiA-4rj9A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
5 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
None
1.31A 3lxiA-4rnzA:
undetectable
3lxiA-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN


(Burkholderia
pseudomallei)
PF06429
(Flg_bbr_C)
5 THR A 166
LEU A 278
LEU A 283
GLY A 284
VAL A 159
EDO  A1639 (-3.2A)
None
None
None
None
1.28A 3lxiA-4ut1A:
undetectable
3lxiA-4ut1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
None
1.21A 3lxiA-4wrnA:
undetectable
3lxiA-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 THR A 483
LEU A 509
GLY A 508
THR A 477
VAL A 504
None
1.31A 3lxiA-4ypjA:
undetectable
3lxiA-4ypjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6


(Dictyostelium
discoideum)
PF01912
(eIF-6)
5 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.32A 3lxiA-5anbI:
undetectable
3lxiA-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.14A 3lxiA-5b04A:
undetectable
3lxiA-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
None
0.76A 3lxiA-5bp7A:
undetectable
3lxiA-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 THR A 365
GLY A 344
THR A 351
VAL A 384
VAL A 353
None
1.19A 3lxiA-5bs5A:
undetectable
3lxiA-5bs5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
None
1.11A 3lxiA-5dfaA:
undetectable
3lxiA-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
None
0.73A 3lxiA-5epeA:
undetectable
3lxiA-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2


(Arabidopsis
thaliana)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 TRP A  89
LEU A  72
GLY A  76
VAL A  84
VAL A  87
None
1.21A 3lxiA-5gjaA:
undetectable
3lxiA-5gjaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
None
0.84A 3lxiA-5jxmA:
undetectable
3lxiA-5jxmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B


(Mus musculus)
PF00149
(Metallophos)
5 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
None
1.33A 3lxiA-5karA:
undetectable
3lxiA-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
5 LEU A 279
LEU A 366
GLY A 367
VAL A 402
VAL A 414
None
1.26A 3lxiA-5kjuA:
undetectable
3lxiA-5kjuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE


(Mus musculus)
PF01593
(Amino_oxidase)
5 THR A 222
THR A 279
GLY A  19
VAL A  35
VAL A  10
None
1.19A 3lxiA-5laeA:
undetectable
3lxiA-5laeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
None
1.10A 3lxiA-5nfhA:
undetectable
3lxiA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
THR A 702
LEU A 610
LEU A 613
THR A 618
None
1.17A 3lxiA-5nfhA:
undetectable
3lxiA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C


(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii)
PF00384
(Molybdopterin)
PF01493
(GXGXG)
5 TYR B 207
THR B 268
LEU C 219
GLY C 221
VAL B 227
None
1.30A 3lxiA-5t5iB:
undetectable
3lxiA-5t5iB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Neisseria
gonorrhoeae)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
None
1.32A 3lxiA-5vevA:
undetectable
3lxiA-5vevA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
5 THR A 739
THR A 726
LEU A 704
GLY A 705
VAL A 718
None
1.24A 3lxiA-5wdeA:
undetectable
3lxiA-5wdeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis)
PF00291
(PALP)
5 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
None
1.25A 3lxiA-5xw3A:
undetectable
3lxiA-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 LEU A  81
LEU A  80
GLY A  79
THR A   4
VAL A  22
None
1.31A 3lxiA-6bogA:
undetectable
3lxiA-6bogA:
undetectable