SIMILAR PATTERNS OF AMINO ACIDS FOR 3LTW_A_HLZA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		4 LEU A 142
GLU A 139
PRO A 140
ARG A  29
 None
 1.17A 3ltwA-1cfzA:
undetectable		 3ltwA-1cfzA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 LEU A 431
GLU A 399
ARG A 433
HIS A 337
 None
None
GOL  A 900 ( 3.9A)
None
 1.35A 3ltwA-1dl2A:
0.0		 3ltwA-1dl2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		4 LEU A 199
GLU A 193
PRO A 192
ARG A 248
 None
 1.42A 3ltwA-1dp2A:
undetectable		 3ltwA-1dp2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 LEU A 303
PRO A 305
ARG A 265
HIS A 269
 None
 1.46A 3ltwA-1gveA:
0.0		 3ltwA-1gveA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 LEU A 377
GLU A 363
PRO A 360
ARG A 373
 None
None
None
G  B  47 ( 3.6A)
 1.45A 3ltwA-1h3eA:
undetectable		 3ltwA-1h3eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		4 LEU A 193
GLU A 162
PRO A 161
ARG A 195
 None
 1.16A 3ltwA-1iooA:
undetectable		 3ltwA-1iooA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 LEU A  70
GLU A  74
PRO A  72
ARG A 113
 None
 1.12A 3ltwA-1jmzA:
1.6		 3ltwA-1jmzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE

(Clarkia breweri) 		PF03492
(Methyltransf_7) 		4 LEU X 134
GLU X 198
PRO X 136
ARG X 195
 None
 1.30A 3ltwA-1m6eX:
0.0		 3ltwA-1m6eX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjl METHIONINE REPRESSOR
PROTEIN METJ

(Escherichia
coli) 		PF01340
(MetJ) 		4 LEU A  56
GLU A  59
ARG A  43
HIS A  50
 None
 1.39A 3ltwA-1mjlA:
undetectable		 3ltwA-1mjlA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 521
GLU A 522
PRO A 523
ARG A 375
 None
 1.36A 3ltwA-1ozhA:
undetectable		 3ltwA-1ozhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 GLU A 246
PRO A 300
ARG A 249
HIS A 307
 None
 1.11A 3ltwA-1ue8A:
undetectable		 3ltwA-1ue8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 LEU A 219
GLU A 181
PRO A 182
ARG A 177
 None
 1.21A 3ltwA-1v9aA:
undetectable		 3ltwA-1v9aA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 LEU A 368
PRO A 370
ARG A 269
HIS A 272
 None
 1.36A 3ltwA-1vljA:
undetectable		 3ltwA-1vljA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.36A 3ltwA-1w6fA:
43.4		 3ltwA-1w6fA:
61.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		4 LEU A 595
GLU A 570
ARG A 597
HIS A 524
 None
None
SMD  A1003 (-3.8A)
None
 1.37A 3ltwA-1x9dA:
undetectable		 3ltwA-1x9dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 305
GLU A 306
PRO A 304
ARG A   9
 None
 1.19A 3ltwA-1yb5A:
undetectable		 3ltwA-1yb5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 239
GLU A 243
PRO A 238
HIS A 298
 None
 1.41A 3ltwA-1yx2A:
undetectable		 3ltwA-1yx2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A 293
GLU A 298
PRO A 295
ARG A 301
 None
 0.96A 3ltwA-1zswA:
undetectable		 3ltwA-1zswA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LEU A  91
GLU A  88
PRO A  85
ARG A 172
 None
 1.40A 3ltwA-2be4A:
undetectable		 3ltwA-2be4A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		4 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.32A 3ltwA-2bszA:
38.8		 3ltwA-2bszA:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A  63
GLU A  67
PRO A 147
HIS A 414
 None
None
None
CU  A1743 (-3.3A)
 1.48A 3ltwA-2c11A:
undetectable		 3ltwA-2c11A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 GLU A  43
PRO A  44
ARG A  98
HIS A  94
 None
 1.41A 3ltwA-2c7bA:
undetectable		 3ltwA-2c7bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgg HYPOTHETICAL PROTEIN
RV2632C/MT2708

(Mycobacterium
tuberculosis) 		PF08962
(DUF1876) 		4 GLU A  22
PRO A  47
ARG A  23
HIS A  20
 None
 1.36A 3ltwA-2fggA:
undetectable		 3ltwA-2fggA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1l KINESIN-LIKE PROTEIN
KIF1C

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		4 LEU A 545
GLU A 561
PRO A 562
ARG A 547
 None
 1.40A 3ltwA-2g1lA:
undetectable		 3ltwA-2g1lA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 LEU A 245
GLU A 241
PRO A 242
ARG A 328
 None
 1.41A 3ltwA-2g29A:
undetectable		 3ltwA-2g29A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 514
PRO A 516
ARG A 493
HIS A 512
 None
 1.05A 3ltwA-2iutA:
undetectable		 3ltwA-2iutA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 LEU A 514
PRO A 516
ARG A 493
HIS A 512
 None
 1.08A 3ltwA-2iuuA:
undetectable		 3ltwA-2iuuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 LEU A  78
GLU A  82
PRO A  83
ARG A 157
 None
 1.47A 3ltwA-2iyfA:
undetectable		 3ltwA-2iyfA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxy HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
C1/C2

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  84
GLU A  87
PRO A  88
ARG A  64
 None
None
U  B   4 ( 3.4A)
None
 1.47A 3ltwA-2mxyA:
undetectable		 3ltwA-2mxyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		4 LEU A 137
GLU A 141
PRO A 142
ARG A  26
 None
 1.42A 3ltwA-2p0nA:
undetectable		 3ltwA-2p0nA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 LEU A 181
PRO A 165
ARG A 230
HIS A 233
 None
 1.43A 3ltwA-2rdlA:
undetectable		 3ltwA-2rdlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 LEU A 606
GLU A 603
PRO A 604
ARG A 568
 None
 1.31A 3ltwA-2xsgA:
0.9		 3ltwA-2xsgA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvp MUTT/NUDIX FAMILY
PROTEIN

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 LEU A 102
GLU A  84
PRO A 104
ARG A  88
 None
 1.50A 3ltwA-2yvpA:
undetectable		 3ltwA-2yvpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU B 144
GLU B 145
PRO B 142
ARG B 148
 None
 1.19A 3ltwA-3amjB:
undetectable		 3ltwA-3amjB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		4 LEU A 145
GLU A 214
PRO A 147
ARG A 211
 None
 1.40A 3ltwA-3b5iA:
undetectable		 3ltwA-3b5iA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		4 LEU A 187
GLU A 233
ARG A 104
HIS A 165
 None
 1.43A 3ltwA-3cq0A:
undetectable		 3ltwA-3cq0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy7 CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 3

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LEU A 156
GLU A 153
PRO A 154
ARG A 160
 None
 1.34A 3ltwA-3fy7A:
undetectable		 3ltwA-3fy7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 LEU A 179
GLU A 247
PRO A 209
ARG A  89
 SAM  A 300 (-4.0A)
None
None
SAM  A 300 (-2.9A)
 1.32A 3ltwA-3fzgA:
undetectable		 3ltwA-3fzgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 LEU A 126
GLU A 231
PRO A 232
ARG A 156
 None
None
None
MET  A 296 (-3.2A)
 1.13A 3ltwA-3gxaA:
undetectable		 3ltwA-3gxaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 LEU A 126
GLU A 231
PRO A 232
ARG A 156
 None
None
None
MET  A 600 (-3.2A)
 1.13A 3ltwA-3ir1A:
undetectable		 3ltwA-3ir1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 LEU B 198
GLU B 267
PRO B 229
ARG B 108
 SAM  B 301 (-4.1A)
None
None
SAM  B 301 (-3.0A)
 1.31A 3ltwA-3lcvB:
undetectable		 3ltwA-3lcvB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 GLU A 274
PRO A 328
ARG A 277
HIS A 335
 None
 1.04A 3ltwA-3mgxA:
undetectable		 3ltwA-3mgxA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		4 LEU A 162
GLU A 165
PRO A 166
ARG A  93
 None
 1.27A 3ltwA-3mtvA:
undetectable		 3ltwA-3mtvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLU A 295
PRO A 349
ARG A 298
HIS A 356
 None
 1.33A 3ltwA-3r9bA:
undetectable		 3ltwA-3r9bA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 LEU X 189
GLU X 193
ARG X 303
HIS X 207
 None
 1.46A 3ltwA-3utnX:
undetectable		 3ltwA-3utnX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 LEU A 219
GLU A 109
PRO A 108
HIS A 217
 None
 1.38A 3ltwA-3vayA:
undetectable		 3ltwA-3vayA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		4 LEU A 273
PRO A 271
ARG A 266
HIS A 263
 None
 1.46A 3ltwA-3wvsA:
undetectable		 3ltwA-3wvsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A  41
GLU A  38
PRO A  39
HIS A  51
 None
 1.50A 3ltwA-4a14A:
undetectable		 3ltwA-4a14A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE

(Methanosarcina
acetivorans) 		PF04140
(ICMT) 		4 LEU B 107
GLU B  42
PRO B  39
ARG B 163
 None
None
None
PLM  B1194 ( 4.6A)
 1.25A 3ltwA-4a2nB:
undetectable		 3ltwA-4a2nB:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		4 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 None
 0.81A 3ltwA-4bgfA:
44.2		 3ltwA-4bgfA:
74.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbp NEURAL/ECTODERMAL
DEVELOPMENT FACTOR
IMP-L2

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 LEU A 106
GLU A 140
PRO A 139
ARG A 110
 None
 1.39A 3ltwA-4cbpA:
0.5		 3ltwA-4cbpA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 396
GLU A 252
PRO A 251
HIS A 260
 None
 1.21A 3ltwA-4cokA:
undetectable		 3ltwA-4cokA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 GLU B 311
PRO B 328
ARG B 288
HIS B 289
 None
 1.46A 3ltwA-4e54B:
undetectable		 3ltwA-4e54B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A1064
GLU A1149
PRO A1148
ARG A 295
 None
 1.29A 3ltwA-4f4cA:
undetectable		 3ltwA-4f4cA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		4 LEU A 200
GLU A 197
PRO A 198
ARG A 208
 None
 1.49A 3ltwA-4ffcA:
undetectable		 3ltwA-4ffcA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 GLU A 348
PRO A 402
ARG A 351
HIS A 388
 None
 1.44A 3ltwA-4g3jA:
undetectable		 3ltwA-4g3jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		4 LEU A 275
GLU A 280
PRO A 277
ARG A 265
 None
 1.49A 3ltwA-4i7uA:
undetectable		 3ltwA-4i7uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 LEU A 514
GLU A 508
PRO A 512
ARG A 516
 None
 1.41A 3ltwA-4jncA:
undetectable		 3ltwA-4jncA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nv7 ARYLAMINE
N-ACETYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF00797
(Acetyltransf_2) 		4 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 COA  A 301 (-3.7A)
None
None
COA  A 301 (-3.4A)
 0.27A 3ltwA-4nv7A:
39.3		 3ltwA-4nv7A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLU A4589
PRO A4618
ARG A4249
HIS A4587
 None
 1.28A 3ltwA-4opeA:
undetectable		 3ltwA-4opeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 LEU A 288
GLU A 292
ARG A 337
HIS A 335
 None
None
None
CSO  A 336 ( 3.4A)
 0.91A 3ltwA-4q3rA:
undetectable		 3ltwA-4q3rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 GLU A 267
PRO A 268
ARG A 173
HIS A 238
 None
 1.27A 3ltwA-4qvgA:
undetectable		 3ltwA-4qvgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h HOMEOBOX PROTEIN
NKX-2.5

(Homo sapiens) 		PF00046
(Homeobox) 		4 LEU B 163
GLU B 167
PRO B 166
ARG B 156
 None
 1.39A 3ltwA-4s0hB:
undetectable		 3ltwA-4s0hB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0q BASIGIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 LEU B  90
GLU B  92
PRO B  93
ARG B  54
 None
 1.43A 3ltwA-4u0qB:
undetectable		 3ltwA-4u0qB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU L 515
PRO L 517
ARG L 509
HIS L 341
 None
 1.28A 3ltwA-4u9iL:
undetectable		 3ltwA-4u9iL:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 372
GLU A 367
ARG A 414
HIS A 411
 None
 1.47A 3ltwA-4woeA:
0.9		 3ltwA-4woeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 LEU A 162
GLU A 166
PRO A 167
ARG A 200
 None
 1.48A 3ltwA-4zrqA:
undetectable		 3ltwA-4zrqA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 LEU J 120
GLU J  93
PRO J 122
ARG J 102
 None
 1.43A 3ltwA-5afuJ:
undetectable		 3ltwA-5afuJ:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 346
GLU A 342
PRO A 341
ARG A   8
 None
 1.33A 3ltwA-5ajzA:
undetectable		 3ltwA-5ajzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 LEU A 514
GLU A 508
PRO A 512
ARG A 516
 None
 1.42A 3ltwA-5allA:
undetectable		 3ltwA-5allA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv5 CYTOCHROME P450 119

(Sulfolobus
solfataricus) 		PF00067
(p450) 		4 GLU A 246
PRO A 300
ARG A 249
HIS A 307
 None
 1.08A 3ltwA-5bv5A:
undetectable		 3ltwA-5bv5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 LEU E 518
GLU E 520
PRO E 521
ARG E 528
 None
 1.37A 3ltwA-5c4gE:
undetectable		 3ltwA-5c4gE:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LEU A 108
GLU A 106
PRO A  62
ARG A  98
 None
 1.49A 3ltwA-5cvvA:
undetectable		 3ltwA-5cvvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57

(Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
PF13874
(Nup54) 		4 LEU C 541
GLU C 545
ARG E 198
HIS E 201
 None
 1.28A 3ltwA-5cwsC:
undetectable		 3ltwA-5cwsC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		4 LEU A 165
GLU A 168
ARG A 164
HIS A 174
 None
 1.31A 3ltwA-5dn5A:
undetectable		 3ltwA-5dn5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 LEU A 132
GLU A 191
PRO A 519
ARG A 189
 None
 1.34A 3ltwA-5gwnA:
undetectable		 3ltwA-5gwnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 LEU A 264
GLU A 267
PRO A 300
HIS A 266
 None
 1.32A 3ltwA-5h6sA:
undetectable		 3ltwA-5h6sA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 LEU A 136
GLU A  44
PRO A 141
ARG A 207
 None
 1.47A 3ltwA-5j49A:
undetectable		 3ltwA-5j49A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		4 LEU A 275
GLU A 272
PRO A 273
ARG A 244
 None
 1.27A 3ltwA-5jjpA:
undetectable		 3ltwA-5jjpA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 474
PRO A 358
ARG A 404
HIS A 415
 None
 1.48A 3ltwA-5jtaA:
undetectable		 3ltwA-5jtaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 LEU A  77
GLU A 704
PRO A  74
HIS A 700
 None
 1.05A 3ltwA-5jxfA:
undetectable		 3ltwA-5jxfA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		4 LEU A 156
GLU A 153
ARG A 157
HIS A 154
 None
 1.48A 3ltwA-5logA:
undetectable		 3ltwA-5logA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 LEU A 279
GLU A  87
PRO A  88
HIS A 287
 None
NAD  A 503 (-2.2A)
None
NAD  A 503 (-3.1A)
 1.39A 3ltwA-5tprA:
undetectable		 3ltwA-5tprA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME

(Homo sapiens) 		PF06859
(Bin3)
PF13847
(Methyltransf_31) 		4 LEU A 581
GLU A 616
PRO A 617
ARG A 433
 SAH  A 701 (-4.4A)
SAH  A 701 ( 4.9A)
None
SAH  A 701 (-3.1A)
 1.15A 3ltwA-5unaA:
undetectable		 3ltwA-5unaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 LEU A 972
PRO A 971
ARG A1013
HIS A1052
 None
 1.46A 3ltwA-5ux5A:
undetectable		 3ltwA-5ux5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 4 LEU A 416
GLU A 415
PRO A 414
ARG A 383
 None
 1.13A 3ltwA-5uyrA:
undetectable		 3ltwA-5uyrA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 359
GLU A 410
PRO A 355
HIS A 403
 None
 1.17A 3ltwA-5wugA:
undetectable		 3ltwA-5wugA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 4 LEU A 719
PRO A 256
ARG A 709
HIS A 846
 None
MGD  A 902 (-4.5A)
None
None
 1.49A 3ltwA-6czaA:
undetectable		 3ltwA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 LEU B 132
GLU B 134
PRO B 150
ARG B 113
 None
 1.49A 3ltwA-6fd2B:
undetectable		 3ltwA-6fd2B:
14.70