SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_G_PZIG801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 PRO A 152
SER A 133
ASN A  94
 None
 0.94A 3lslG-1a6aA:
0.0		 3lslG-1a6aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 PRO A 218
SER A 202
ASN A  85
 None
 0.83A 3lslG-1bjwA:
0.0		 3lslG-1bjwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 PRO A 148
SER A 252
ASN A 156
 None
F3S  A 267 ( 4.1A)
None
 0.88A 3lslG-1e3dA:
0.2		 3lslG-1e3dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehl ANTI-(6-4)
PHOTOPRODUCT
ANTIBODY 64M-2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H  14
SER H 113
ASN H  84
 None
 0.90A 3lslG-1ehlH:
undetectable		 3lslG-1ehlH:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gp1 GLUTATHIONE
PEROXIDASE

(Bos taurus) 		PF00255
(GSHPx) 		3 PRO A  73
SER A  43
ASN A  75
 None
 0.88A 3lslG-1gp1A:
0.0		 3lslG-1gp1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		3 PRO A  30
SER A  33
ASN A   8
 None
 0.83A 3lslG-1gq8A:
0.0		 3lslG-1gq8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 PRO A 147
SER A 279
ASN A 149
 None
None
PLP  A1202 (-4.1A)
 0.85A 3lslG-1h1cA:
0.0		 3lslG-1h1cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli) 		PF01278
(Omptin) 		3 PRO A  62
SER A   6
ASN A  11
 None
 0.73A 3lslG-1i78A:
0.0		 3lslG-1i78A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icf PROTEIN (INVARIANT
CHAIN)

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		3 PRO I 239
SER I 258
ASN I 221
 None
 0.90A 3lslG-1icfI:
undetectable		 3lslG-1icfI:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE

(Candida
albicans) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 PRO A 229
SER A 241
ASN A 231
 None
 0.93A 3lslG-1iylA:
0.0		 3lslG-1iylA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 3 PRO 1 232
SER 1  50
ASN 1  62
 None
 0.90A 3lslG-1mec1:
undetectable		 3lslG-1mec1:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 PRO A 533
SER A 535
ASN A 571
 None
 0.85A 3lslG-1mz5A:
undetectable		 3lslG-1mz5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 PRO A 519
SER A 375
ASN A 515
 None
 0.93A 3lslG-1n76A:
7.4		 3lslG-1n76A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 PRO A  28
SER A  30
ASN A  59
 None
 0.80A 3lslG-1n8pA:
0.9		 3lslG-1n8pA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 PRO A 379
SER A 341
ASN A 361
 None
 0.91A 3lslG-1p49A:
undetectable		 3lslG-1p49A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 PRO A 106
SER A 202
ASN A 102
 None
None
CA  A 905 (-3.5A)
 0.88A 3lslG-1q5aA:
undetectable		 3lslG-1q5aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpg T-PLASMINOGEN
ACTIVATOR F1-G

(Homo sapiens) 		PF00008
(EGF)
PF00039
(fn1) 		3 PRO A  47
SER A  45
ASN A  29
 None
 0.90A 3lslG-1tpgA:
undetectable		 3lslG-1tpgA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 PRO A  76
SER A 221
ASN A  19
 None
 0.86A 3lslG-1u0kA:
undetectable		 3lslG-1u0kA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 PRO A 122
SER A 112
ASN A 124
 None
CO  A 301 (-4.1A)
None
 0.91A 3lslG-1ugsA:
undetectable		 3lslG-1ugsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 PRO A 112
SER A 110
ASN A 169
 None
 0.83A 3lslG-1vcjA:
undetectable		 3lslG-1vcjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wen INHIBITOR OF GROWTH
FAMILY, MEMBER 4
ING1-LIKE PROTEIN

(Mus musculus) 		PF00628
(PHD) 		3 PRO A  16
SER A  25
ASN A  14
 None
 0.72A 3lslG-1wenA:
undetectable		 3lslG-1wenA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		3 PRO A 111
SER A  78
ASN A 113
 None
 0.89A 3lslG-1yp4A:
undetectable		 3lslG-1yp4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 PRO A 260
SER A 296
ASN A 265
 None
 0.73A 3lslG-1yq2A:
undetectable		 3lslG-1yq2A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 PRO A 266
SER A 142
ASN A 268
 None
 0.84A 3lslG-2c5aA:
undetectable		 3lslG-2c5aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		3 PRO A 164
SER A 200
ASN A 104
 None
 0.86A 3lslG-2d3rA:
undetectable		 3lslG-2d3rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 PRO A 563
SER A 565
ASN A 570
 None
 0.83A 3lslG-2erqA:
undetectable		 3lslG-2erqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 PRO A 151
SER A 594
ASN A 157
 None
 0.84A 3lslG-2et6A:
undetectable		 3lslG-2et6A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8a GLUTATHIONE
PEROXIDASE 1

(Homo sapiens) 		PF00255
(GSHPx) 		3 PRO A  75
SER A  45
ASN A  77
 None
 0.87A 3lslG-2f8aA:
undetectable		 3lslG-2f8aA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		3 PRO A  67
SER A  38
ASN A  69
 None
 0.82A 3lslG-2he3A:
undetectable		 3lslG-2he3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09637
(Med18)
no annotation 		3 PRO I 195
SER B  10
ASN I 197
 None
 0.90A 3lslG-2hzsI:
undetectable		 3lslG-2hzsI:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		3 PRO A  21
SER A  75
ASN A  13
 None
 0.71A 3lslG-2idcA:
undetectable		 3lslG-2idcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpi HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09981
(DUF2218) 		3 PRO A  62
SER A  66
ASN A  60
 None
 0.94A 3lslG-2jpiA:
undetectable		 3lslG-2jpiA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0r THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Neisseria
meningitidis) 		PF11412
(DsbC) 		3 PRO A  84
SER A  57
ASN A  27
 None
 0.90A 3lslG-2k0rA:
undetectable		 3lslG-2k0rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx2 HYPOTHETICAL PROTEIN
YPSA

(Bacillus
subtilis) 		PF06908
(DUF1273) 		3 PRO A  79
SER A  49
ASN A 123
 None
 0.94A 3lslG-2nx2A:
undetectable		 3lslG-2nx2A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		3 PRO A 165
SER A 201
ASN A 104
 None
 0.79A 3lslG-2ow4A:
undetectable		 3lslG-2ow4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		3 PRO A 134
SER A 186
ASN A 107
 None
 0.85A 3lslG-2pziA:
undetectable		 3lslG-2pziA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3n AGGLUTININ-1 B CHAIN

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		3 PRO B  38
SER B  29
ASN B  34
 None
 0.83A 3lslG-2q3nB:
undetectable		 3lslG-2q3nB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		3 PRO A 232
SER A 230
ASN A 206
 None
PHE  A 304 (-3.4A)
PHE  A 304 (-3.0A)
 0.78A 3lslG-2qmxA:
5.7		 3lslG-2qmxA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		3 PRO A  76
SER A  80
ASN A  73
 None
None
CTO  A 165 (-4.1A)
 0.93A 3lslG-2r0hA:
undetectable		 3lslG-2r0hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A 393
SER A 118
ASN A 390
 None
 0.90A 3lslG-2v55A:
undetectable		 3lslG-2v55A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbd XYLANASE D

(Cellulomonas
fimi) 		PF00553
(CBM_2) 		3 PRO A 306
SER A 273
ASN A 292
 None
 0.85A 3lslG-2xbdA:
undetectable		 3lslG-2xbdA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 PRO A 250
SER A 331
ASN A 326
 None
 0.90A 3lslG-2xdqA:
undetectable		 3lslG-2xdqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc4 PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03793
(PASTA) 		3 PRO C 682
SER C 634
ASN C 656
 None
 0.92A 3lslG-2zc4C:
undetectable		 3lslG-2zc4C:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 PRO A 157
SER A 122
ASN A 148
 None
 0.80A 3lslG-3ak5A:
undetectable		 3lslG-3ak5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		3 PRO A 326
SER A 371
ASN A 174
 None
 0.70A 3lslG-3asaA:
undetectable		 3lslG-3asaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 PRO A 167
SER A 169
ASN A 269
 None
None
MG  A 601 (-3.2A)
 0.85A 3lslG-3b5iA:
undetectable		 3lslG-3b5iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		3 PRO A 201
SER A 320
ASN A 315
 None
 0.84A 3lslG-3bwnA:
undetectable		 3lslG-3bwnA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE

(Methanosarcina
mazei) 		PF01933
(UPF0052) 		3 PRO A 128
SER A 174
ASN A 125
 None
 0.79A 3lslG-3cgwA:
undetectable		 3lslG-3cgwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		3 PRO A 170
SER A 305
ASN A 172
 None
None
SO4  A 402 ( 3.4A)
 0.83A 3lslG-3cq5A:
undetectable		 3lslG-3cq5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 PRO A 363
SER A 406
ASN A 209
 None
None
PLP  A 433 (-3.6A)
 0.65A 3lslG-3ei8A:
0.8		 3lslG-3ei8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euc HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE 2

(Cupriavidus
pinatubonensis) 		PF00155
(Aminotran_1_2) 		3 PRO A 165
SER A 303
ASN A 167
 None
None
SO4  A 368 (-3.4A)
 0.73A 3lslG-3eucA:
0.5		 3lslG-3eucA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		3 PRO A 161
SER A 303
ASN A 163
 None
None
LLP  A 226 ( 3.6A)
 0.85A 3lslG-3getA:
undetectable		 3lslG-3getA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PRO A 442
SER A 382
ASN A 445
 None
 0.94A 3lslG-3l8kA:
undetectable		 3lslG-3l8kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		3 PRO A 171
SER A 135
ASN A 287
 None
SO4  A 343 ( 4.9A)
None
 0.86A 3lslG-3ld8A:
undetectable		 3lslG-3ld8A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 PRO A 615
SER A 611
ASN A 660
 None
 0.77A 3lslG-3opyA:
undetectable		 3lslG-3opyA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		3 PRO A 143
SER A 274
ASN A 145
 None
None
TLA  A 343 (-3.3A)
 0.81A 3lslG-3p1tA:
undetectable		 3lslG-3p1tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		3 PRO A 375
SER A 418
ASN A 220
 None
 0.75A 3lslG-3qguA:
undetectable		 3lslG-3qguA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5e TRANSALDOLASE

(Corynebacterium
glutamicum) 		PF00923
(TAL_FSA) 		3 PRO A 290
SER A 263
ASN A  44
 None
SO4  A 401 (-2.5A)
None
 0.86A 3lslG-3r5eA:
undetectable		 3lslG-3r5eA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 PRO A 144
SER A  95
ASN A 128
 None
 0.78A 3lslG-3syjA:
undetectable		 3lslG-3syjA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Deinococcus
radiodurans) 		PF01063
(Aminotran_4) 		3 PRO A 182
SER A 325
ASN A 184
 None
 0.94A 3lslG-3uzbA:
0.8		 3lslG-3uzbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		3 PRO A 161
SER A 195
ASN A 266
 None
 0.77A 3lslG-3vo2A:
undetectable		 3lslG-3vo2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 PRO A 304
SER A 277
ASN A 298
 None
 0.92A 3lslG-3wv4A:
undetectable		 3lslG-3wv4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		3 PRO A 337
SER A 339
ASN A 330
 None
 0.93A 3lslG-4ce7A:
undetectable		 3lslG-4ce7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 PRO A 111
SER A 109
ASN A 168
 None
 0.89A 3lslG-4cpnA:
undetectable		 3lslG-4cpnA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		3 PRO A 163
SER A 306
ASN A 165
 None
 0.90A 3lslG-4dqnA:
undetectable		 3lslG-4dqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		3 PRO A  50
SER A 170
ASN A  55
 None
 0.63A 3lslG-4ei0A:
undetectable		 3lslG-4ei0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 PRO A 321
SER A 287
ASN A 303
 None
 0.92A 3lslG-4fdjA:
undetectable		 3lslG-4fdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 PRO A 377
SER A 420
ASN A 223
 None
None
PLP  A 501 (-3.9A)
 0.67A 3lslG-4fl0A:
undetectable		 3lslG-4fl0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Mus musculus) 		PF00106
(adh_short) 		3 PRO A 182
SER A 135
ASN A 143
 None
 0.83A 3lslG-4k26A:
undetectable		 3lslG-4k26A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		3 PRO A 350
SER A 279
ASN A 356
 None
 0.84A 3lslG-4k68A:
undetectable		 3lslG-4k68A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 PRO A 619
SER A 621
ASN A 626
 None
CME  A 642 ( 2.7A)
None
 0.87A 3lslG-4lglA:
undetectable		 3lslG-4lglA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		3 PRO A  84
SER A 165
ASN A  82
 None
 0.75A 3lslG-4lhsA:
undetectable		 3lslG-4lhsA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mah AA11 LYTIC
POLYSACCHARIDE
MONOOXYGENASE

(Aspergillus
oryzae) 		no annotation 3 PRO A  51
SER A  53
ASN A  42
 None
 0.81A 3lslG-4mahA:
undetectable		 3lslG-4mahA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		3 PRO A  45
SER A 104
ASN A  47
 None
 0.89A 3lslG-4p5iA:
undetectable		 3lslG-4p5iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		3 PRO A 159
SER A 241
ASN A 167
 None
 0.85A 3lslG-4qwwA:
undetectable		 3lslG-4qwwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		3 PRO A 174
SER A 309
ASN A 176
 None
 0.66A 3lslG-4raeA:
undetectable		 3lslG-4raeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		3 PRO A 188
SER A 186
ASN A 244
 None
 0.81A 3lslG-4uacA:
5.9		 3lslG-4uacA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		3 PRO A 104
SER A 102
ASN A  52
 None
 0.86A 3lslG-4v33A:
undetectable		 3lslG-4v33A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		3 PRO A 165
SER A 303
ASN A 167
 None
None
PLP  A 401 (-4.0A)
 0.88A 3lslG-4wbtA:
undetectable		 3lslG-4wbtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		3 PRO A 289
SER A 292
ASN A 255
 None
 0.86A 3lslG-4xe3A:
undetectable		 3lslG-4xe3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		3 PRO A 119
SER A  92
ASN A 117
 None
 0.90A 3lslG-5cvcA:
undetectable		 3lslG-5cvcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		3 PRO A  46
SER A  41
ASN A  10
 None
 0.91A 3lslG-5d95A:
undetectable		 3lslG-5d95A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 PRO A  70
SER A 124
ASN A  72
 None
None
FES  A3002 ( 3.8A)
 0.69A 3lslG-5epgA:
undetectable		 3lslG-5epgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		3 PRO A 251
SER A  22
ASN A 105
 None
 0.93A 3lslG-5feuA:
0.5		 3lslG-5feuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PRO B 615
SER A  76
ASN B 748
 None
 0.85A 3lslG-5fq6B:
undetectable		 3lslG-5fq6B:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mra SORCIN

(Homo sapiens) 		no annotation 3 PRO A 122
SER A 149
ASN A 142
 None
 0.92A 3lslG-5mraA:
undetectable		 3lslG-5mraA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 PRO A 290
SER A 332
ASN A 311
 None
GOL  A 604 (-1.9A)
None
 0.93A 3lslG-5mx9A:
0.5		 3lslG-5mx9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 PRO A3568
SER A3707
ASN A3576
 None
 0.89A 3lslG-5nugA:
undetectable		 3lslG-5nugA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PRO A 309
SER A 206
ASN A 259
 None
 0.90A 3lslG-5oljA:
undetectable		 3lslG-5oljA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 PRO A 572
SER A 404
ASN A 401
 None
 0.82A 3lslG-5tf0A:
undetectable		 3lslG-5tf0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 3 PRO D 240
SER D 214
ASN D 245
 None
 0.87A 3lslG-5ui3D:
undetectable		 3lslG-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy 8ANC195 G52K5 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO K  14
SER K  84
ASN K  82
 None
 0.89A 3lslG-5viyK:
undetectable		 3lslG-5viyK:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2l CST COMPLEX SUBUNIT
CTC1

(Homo sapiens) 		no annotation 3 PRO A 842
SER A 762
ASN A 745
 None
 0.90A 3lslG-5w2lA:
undetectable		 3lslG-5w2lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US19

(Toxoplasma
gondii) 		PF00203
(Ribosomal_S19) 		3 PRO P  78
SER P  97
ASN P  71
 None
 0.94A 3lslG-5xxuP:
undetectable		 3lslG-5xxuP:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7l -

(-) 		no annotation 3 PRO A 145
SER A  58
ASN A  90
 None
 0.90A 3lslG-5y7lA:
undetectable		 3lslG-5y7lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd0 SCHLAFEN 8

(Rattus
norvegicus) 		no annotation 3 PRO A 325
SER A 327
ASN A 340
 None
 0.80A 3lslG-5yd0A:
undetectable		 3lslG-5yd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 3 PRO A 530
SER A 435
ASN A 527
 None
 0.91A 3lslG-5yimA:
undetectable		 3lslG-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN

(Homo sapiens) 		no annotation 3 PRO A 152
SER A 133
ASN A  94
 None
 0.84A 3lslG-6cplA:
undetectable		 3lslG-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 3 PRO A 199
SER A 264
ASN A 206
 None
 0.75A 3lslG-6d2vA:
undetectable		 3lslG-6d2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 PRO B 398
SER B 351
ASN B 396
 None
 0.90A 3lslG-6reqB:
undetectable		 3lslG-6reqB:
19.89