SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_G_PZIG800_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 ASN A 184
LEU A 187
ASP A 188
LYS A 191
 None
 1.08A 3lslG-1chkA:
undetectable		 3lslG-1chkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TYR A  28
ASN A  72
LEU A  76
ASP A  73
 None
 1.24A 3lslG-1hjvA:
undetectable		 3lslG-1hjvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		4 TYR A   7
ASN A  51
LEU A  55
ASP A  52
 None
 1.19A 3lslG-1ljyA:
undetectable		 3lslG-1ljyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A 354
MET A 294
ASN A 300
LEU A 299
 None
None
MTL  A5600 (-3.2A)
MTL  A5600 ( 4.7A)
 1.50A 3lslG-1m2wA:
undetectable		 3lslG-1m2wA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 TYR A 248
ASN A 217
LEU A 216
ASP A 215
 None
 1.35A 3lslG-1oheA:
undetectable		 3lslG-1oheA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 TYR B  26
ASN B  52
LEU B  51
ASP B  50
 None
 1.06A 3lslG-1qlbB:
undetectable		 3lslG-1qlbB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 TYR A 111
ASN A 144
LEU A 274
LYS A 208
 None
 1.20A 3lslG-1um8A:
undetectable		 3lslG-1um8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 TYR A 191
ASN A 250
LEU A 247
LYS A 243
 None
 1.34A 3lslG-2azkA:
undetectable		 3lslG-2azkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4s GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 4 TYR A 239
MET A 275
ASN A 273
ASP A 271
 None
 1.31A 3lslG-2i4sA:
undetectable		 3lslG-2i4sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 4 TYR B 312
ASN B 401
LEU B 380
ASP B 400
 None
 1.00A 3lslG-2j04B:
undetectable		 3lslG-2j04B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 TYR B1159
ASN B 789
LEU B 792
ASP B 793
 None
 1.34A 3lslG-2o8eB:
undetectable		 3lslG-2o8eB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 0.97A 3lslG-2ra1A:
undetectable		 3lslG-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 TYR A 426
ASN A 438
LEU A 435
LYS A 431
 None
 1.45A 3lslG-2xu0A:
undetectable		 3lslG-2xu0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 TYR A 281
ASN A 305
LEU A 308
ASP A 309
 None
 1.25A 3lslG-2yp1A:
undetectable		 3lslG-2yp1A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 448
MET A 519
LEU A 776
LYS A 780
 None
 0.40A 3lslG-2znsA:
36.9		 3lslG-2znsA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A 873
ASN A 886
LEU A 840
ASP A 839
 None
 1.26A 3lslG-2zxqA:
undetectable		 3lslG-2zxqA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0d PUTATIVE NITRITE
REDUCTASE NADPH
(SMALL SUBUNIT)
OXIDOREDUCTASE
PROTEIN

(Vibrio
parahaemolyticus) 		PF13806
(Rieske_2) 		4 TYR A  34
ASN A 103
LEU A  12
ASP A  13
 None
 1.43A 3lslG-3c0dA:
undetectable		 3lslG-3c0dA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ASN A  70
LEU A 300
ASP A 301
LYS A 304
 None
 1.12A 3lslG-3ed4A:
undetectable		 3lslG-3ed4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 TYR A  45
ASN A 245
LEU A 248
LYS A 252
 None
 1.09A 3lslG-3f0hA:
undetectable		 3lslG-3f0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		4 TYR A  94
ASN A 379
LEU A 350
ASP A 354
 None
 1.50A 3lslG-3f4bA:
undetectable		 3lslG-3f4bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		no annotation 4 ASN A  58
LEU A  61
ASP A  62
LYS A  65
 None
 1.22A 3lslG-3fbzA:
undetectable		 3lslG-3fbzA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 TYR A 402
MET A 431
ASN A 535
ASP A 490
 None
None
SO4  A  48 ( 4.8A)
None
 1.49A 3lslG-3floA:
undetectable		 3lslG-3floA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 TYR A 194
ASN A 244
LEU A 241
ASP A 231
 None
 1.36A 3lslG-3girA:
undetectable		 3lslG-3girA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  35
MET A 107
ASP A 248
LYS A 251
 None
None
None
CYZ  A 265 ( 4.4A)
 1.03A 3lslG-3h6tA:
42.1		 3lslG-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  35
MET A 107
LEU A 247
LYS A 251
 None
None
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.45A 3lslG-3h6tA:
42.1		 3lslG-3h6tA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 ASN A 278
LEU A 274
ASP A 275
LYS A 220
 None
None
None
P6G  A 362 (-3.0A)
 1.44A 3lslG-3hbzA:
undetectable		 3lslG-3hbzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		4 TYR A 288
ASN A 122
LEU A 125
LYS A 129
 None
 1.45A 3lslG-3hjbA:
undetectable		 3lslG-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 TYR A 234
MET A 353
ASN A 301
ASP A 337
 None
 1.03A 3lslG-3i5gA:
undetectable		 3lslG-3i5gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE

(Homo sapiens) 		PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 TYR G  74
ASN G  10
LEU G   9
LYS G  73
 None
 1.43A 3lslG-3j0kG:
undetectable		 3lslG-3j0kG:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 TYR A 635
ASN A 608
LEU A 605
ASP A 604
 None
 1.49A 3lslG-3o8lA:
undetectable		 3lslG-3o8lA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING

(Vibrio cholerae) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 MET A 241
ASN A 248
LEU A 254
ASP A 274
 None
 1.41A 3lslG-3pajA:
undetectable		 3lslG-3pajA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 TYR A 567
ASN A 519
ASP A 546
LYS A 536
 None
UDP  A 621 ( 4.9A)
None
None
 1.26A 3lslG-3q3hA:
undetectable		 3lslG-3q3hA:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 431
MET A 503
LEU A 760
LYS A 764
 None
 0.39A 3lslG-3qxmA:
13.2		 3lslG-3qxmA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		4 TYR A 176
ASN A 148
LEU A 147
ASP A 146
 None
 1.34A 3lslG-3t0oA:
undetectable		 3lslG-3t0oA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 TYR B 912
ASN B 582
LEU B 585
ASP B 586
 None
 1.31A 3lslG-3thwB:
undetectable		 3lslG-3thwB:
14.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  35
MET A 106
LEU A 242
LYS A 246
 None
None
None
ZN  A 259 (-3.5A)
 0.48A 3lslG-3u92A:
36.6		 3lslG-3u92A:
51.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn5 RIBONUCLEASE HIII

(Aquifex
aeolicus) 		PF01351
(RNase_HII) 		4 TYR A 142
MET A 155
ASN A 153
LEU A 152
 None
 1.47A 3lslG-3vn5A:
undetectable		 3lslG-3vn5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.19A 3lslG-3w1gA:
undetectable		 3lslG-3w1gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		4 TYR A 323
ASN A 258
LEU A 257
ASP A 284
 None
 1.47A 3lslG-3wx7A:
undetectable		 3lslG-3wx7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 TYR A 139
ASN A 484
LEU A 487
ASP A 488
 None
 1.32A 3lslG-4cj0A:
undetectable		 3lslG-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ASN A 109
LEU A 105
ASP A 100
LYS A 157
 None
 1.49A 3lslG-4da9A:
undetectable		 3lslG-4da9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3m BH0337 PROTEIN

(Bacillus
halodurans) 		PF09704
(Cas_Cas5d) 		4 TYR A  46
ASN A 113
ASP A 111
LYS A  48
 None
 1.42A 3lslG-4f3mA:
undetectable		 3lslG-4f3mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		4 MET A 358
ASN A 397
LEU A 395
ASP A 162
 None
 1.48A 3lslG-4fmcA:
undetectable		 3lslG-4fmcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.93A 3lslG-4fyeA:
undetectable		 3lslG-4fyeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		4 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.14A 3lslG-4htpA:
undetectable		 3lslG-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A 347
MET A 288
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.43A 3lslG-4im7A:
undetectable		 3lslG-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A 347
MET A 292
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.41A 3lslG-4im7A:
undetectable		 3lslG-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN

(Escherichia
virus T5) 		no annotation 4 TYR A  54
ASN A   9
LEU A  15
ASP A   5
 None
 1.18A 3lslG-4jmqA:
undetectable		 3lslG-4jmqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnp LIPOPROTEIN

(Staphylococcus
aureus) 		PF01297
(ZnuA) 		4 TYR A 293
ASN A 185
LEU A 145
ASP A 146
 None
 1.44A 3lslG-4nnpA:
undetectable		 3lslG-4nnpA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 TYR A 196
MET A  36
ASN A 220
LEU A 221
 X1X  A 401 (-3.7A)
None
None
None
 1.49A 3lslG-4nx1A:
5.4		 3lslG-4nx1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		4 TYR A 327
ASN A 262
LEU A 261
ASP A 288
 None
 1.47A 3lslG-4nz5A:
undetectable		 3lslG-4nz5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		4 TYR C 322
ASN C 334
LEU C 326
ASP C 329
 None
 1.19A 3lslG-4oogC:
undetectable		 3lslG-4oogC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 TYR H 132
MET H 192
ASN H 197
LEU H 194
 None
 1.48A 3lslG-4qfkH:
2.3		 3lslG-4qfkH:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16

(Homo sapiens) 		PF02760
(HIN) 		4 TYR A 218
ASN A 274
LEU A 245
LYS A 226
 None
 1.23A 3lslG-4qguA:
undetectable		 3lslG-4qguA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		4 TYR A  25
ASN A 455
LEU A 271
LYS A   1
 None
 1.46A 3lslG-4repA:
undetectable		 3lslG-4repA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASN A 204
LEU A 168
ASP A 171
LYS A 170
 None
 0.87A 3lslG-4uxvA:
undetectable		 3lslG-4uxvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 MET A 843
ASN A 703
ASP A 850
LYS A 854
 None
 1.06A 3lslG-4xgtA:
undetectable		 3lslG-4xgtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		4 ASN B 246
LEU B 249
ASP B 250
LYS B 253
 None
 1.16A 3lslG-5aa4B:
22.6		 3lslG-5aa4B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 TYR A 291
ASN A 150
ASP A 154
LYS A 157
 None
 1.27A 3lslG-5c3oA:
undetectable		 3lslG-5c3oA:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  39
MET A 111
LEU A 250
LYS A 254
 None
 0.47A 3lslG-5dtbA:
37.8		 3lslG-5dtbA:
54.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5d CELLULOSOMAL-SCAFFOL
DING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1)
PF13620
(CarboxypepD_reg) 		4 TYR B 161
MET B  98
LEU B  74
ASP B  75
 None
 1.41A 3lslG-5g5dB:
undetectable		 3lslG-5g5dB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 TYR A 507
ASN A 451
LEU A 464
ASP A 463
 None
None
PPI  A 808 ( 4.7A)
None
 1.40A 3lslG-5gsmA:
undetectable		 3lslG-5gsmA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 TYR A 101
ASN A 233
LEU A 212
ASP A 213
 None
None
None
TLA  A 403 (-3.2A)
 1.20A 3lslG-5hyhA:
undetectable		 3lslG-5hyhA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 406
LEU A 209
ASP A 210
LYS A 207
 None
 1.32A 3lslG-5i8iA:
2.1		 3lslG-5i8iA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 431
MET A 503
LEU A 760
LYS A 764
 None
 0.88A 3lslG-5kufA:
33.8		 3lslG-5kufA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
LEU A 759
ASP A 760
LYS A 763
 None
 0.63A 3lslG-5l1bA:
22.2		 3lslG-5l1bA:
70.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 TYR A  62
ASN A 123
LEU A 141
ASP A 142
 None
 1.15A 3lslG-5l56A:
undetectable		 3lslG-5l56A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 ASN A 491
LEU A 566
ASP A 565
LYS A 570
 None
 1.38A 3lslG-5m41A:
undetectable		 3lslG-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TYR A 185
LEU A 148
ASP A 149
LYS A 152
 None
 1.34A 3lslG-5m8tA:
undetectable		 3lslG-5m8tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5

(Plasmodium
falciparum) 		no annotation 4 TYR A 184
LEU A 460
ASP A 461
LYS A 464
 None
 1.01A 3lslG-5mi0A:
undetectable		 3lslG-5mi0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 ASN A  60
LEU A  63
ASP A  64
LYS A  67
 None
 0.93A 3lslG-5ns8A:
undetectable		 3lslG-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 TYR A 383
ASN A 140
LEU A 268
ASP A 165
 None
 1.27A 3lslG-5um6A:
undetectable		 3lslG-5um6A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 4 ASN A 320
LEU A 323
ASP A 324
LYS A 327
 None
 1.10A 3lslG-5ur0A:
undetectable		 3lslG-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 TYR A 261
LEU A 252
ASP A 253
LYS A 258
 None
 1.32A 3lslG-5veoA:
undetectable		 3lslG-5veoA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
ASP A 760
 None
 0.48A 3lslG-5welA:
32.2		 3lslG-5welA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
LYS A 763
 None
 0.85A 3lslG-5welA:
32.2		 3lslG-5welA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
ASP A 760
 None
CYZ  A1302 (-4.3A)
None
CYZ  A1302 (-3.8A)
 0.57A 3lslG-5weoA:
24.8		 3lslG-5weoA:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		4 TYR A 521
ASN A 668
LEU A 680
ASP A 681
 None
 1.30A 3lslG-5xblA:
undetectable		 3lslG-5xblA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 4 TYR A 203
ASN A 178
LEU A 179
ASP A 180
 None
 1.43A 3lslG-5xwqA:
undetectable		 3lslG-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3AE, PUTATIVE

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		4 ASN B 175
LEU B 180
ASP B 183
LYS B 182
 None
 1.38A 3lslG-5xyiB:
undetectable		 3lslG-5xyiB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01) 		no annotation 4 TYR A 115
ASN A 193
LEU A 192
ASP A 106
 None
 1.36A 3lslG-5y33A:
undetectable		 3lslG-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 4 TYR A 252
ASN A 163
LEU A 166
ASP A 167
 None
 1.05A 3lslG-5yeuA:
undetectable		 3lslG-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN

(Trypanosoma
brucei) 		no annotation 4 MET A  13
LEU A  10
ASP A   6
LYS A   5
 None
 1.31A 3lslG-6bm7A:
undetectable		 3lslG-6bm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS

(Homo sapiens) 		no annotation 4 TYR C  24
LEU C  66
ASP C  67
LYS C  71
 None
 1.46A 3lslG-6bnlC:
undetectable		 3lslG-6bnlC:
undetectable