SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_D_PZID802_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 SER A   2
ASP A  29
ASN A  30
 None
 0.80A 3lslA-1biiA:
0.0
3lslD-1biiA:
0.0		 3lslA-1biiA:
19.84
3lslD-1biiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		3 SER A 148
ASP A 155
ASN A 156
 None
 0.96A 3lslA-1c7jA:
0.0
3lslD-1c7jA:
0.0		 3lslA-1c7jA:
21.46
3lslD-1c7jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 SER A 334
ASP A 273
ASN A  93
 None
 0.93A 3lslA-1ethA:
0.0
3lslD-1ethA:
0.0		 3lslA-1ethA:
18.94
3lslD-1ethA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 SER A 202
ASP A 208
ASN A 265
 None
CA  A1346 (-3.0A)
None
 0.94A 3lslA-1h3jA:
0.0
3lslD-1h3jA:
undetectable		 3lslA-1h3jA:
21.89
3lslD-1h3jA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 SER A 457
ASP A 504
ASN A 499
 None
ATP  A 606 (-2.8A)
None
 0.89A 3lslA-1hp1A:
undetectable
3lslD-1hp1A:
0.0		 3lslA-1hp1A:
22.22
3lslD-1hp1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j83 ENDO-1,4-BETA
GLUCANASE ENGF

(Clostridium
cellulovorans) 		PF03424
(CBM_17_28) 		3 SER A1035
ASP A1040
ASN A1067
 None
 0.99A 3lslA-1j83A:
0.0
3lslD-1j83A:
0.0		 3lslA-1j83A:
18.60
3lslD-1j83A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 SER A 385
ASP A  68
ASN A 161
 None
 0.96A 3lslA-1lf9A:
0.0
3lslD-1lf9A:
0.0		 3lslA-1lf9A:
16.49
3lslD-1lf9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		3 SER A 193
ASP A   5
ASN A 221
 None
 0.95A 3lslA-1m68A:
undetectable
3lslD-1m68A:
undetectable		 3lslA-1m68A:
22.86
3lslD-1m68A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 SER A 444
ASP A 442
ASN A 544
 None
 0.85A 3lslA-1mu2A:
0.0
3lslD-1mu2A:
0.0		 3lslA-1mu2A:
18.10
3lslD-1mu2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 SER C 366
ASP C 338
ASN C 339
 None
 1.00A 3lslA-1n8yC:
undetectable
3lslD-1n8yC:
undetectable		 3lslA-1n8yC:
17.88
3lslD-1n8yC:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		3 SER A  86
ASP A 255
ASN A 316
 None
 0.90A 3lslA-1nw1A:
undetectable
3lslD-1nw1A:
undetectable		 3lslA-1nw1A:
19.59
3lslD-1nw1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA

(Bacillus
subtilis) 		PF01522
(Polysacc_deac_1) 		3 SER A 115
ASP A 158
ASN A 159
 None
 0.95A 3lslA-1ny1A:
undetectable
3lslD-1ny1A:
undetectable		 3lslA-1ny1A:
22.54
3lslD-1ny1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		3 SER A 159
ASP A 288
ASN A 223
 None
None
TDX  A1349 (-4.6A)
 0.86A 3lslA-1oc2A:
undetectable
3lslD-1oc2A:
undetectable		 3lslA-1oc2A:
21.58
3lslD-1oc2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE

(Streptomyces
venezuelae) 		PF16363
(GDP_Man_Dehyd) 		3 SER A 149
ASP A 278
ASN A 213
 None
None
TYD  A 901 ( 4.8A)
 0.83A 3lslA-1r66A:
undetectable
3lslD-1r66A:
undetectable		 3lslA-1r66A:
21.01
3lslD-1r66A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 390
ASP A 380
ASN A 378
 None
 0.98A 3lslA-1s5jA:
undetectable
3lslD-1s5jA:
undetectable		 3lslA-1s5jA:
15.90
3lslD-1s5jA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		3 SER A  49
ASP A  27
ASN A  43
 None
 0.95A 3lslA-1tp8A:
undetectable
3lslD-1tp8A:
undetectable		 3lslA-1tp8A:
21.65
3lslD-1tp8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 SER A 325
ASP A 317
ASN A 316
 SO4  A 964 ( 4.9A)
None
None
 0.90A 3lslA-1uagA:
undetectable
3lslD-1uagA:
1.4		 3lslA-1uagA:
21.36
3lslD-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		3 SER A 691
ASP A 689
ASN A 646
 None
None
XYP  A   2 (-3.4A)
 1.00A 3lslA-1vbrA:
undetectable
3lslD-1vbrA:
undetectable		 3lslA-1vbrA:
20.57
3lslD-1vbrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		3 SER B  31
ASP B  49
ASN B  50
 None
 0.79A 3lslA-1y75B:
undetectable
3lslD-1y75B:
undetectable		 3lslA-1y75B:
16.67
3lslD-1y75B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 SER A 156
ASP A 191
ASN A 193
 None
 0.90A 3lslA-1yd9A:
undetectable
3lslD-1yd9A:
undetectable		 3lslA-1yd9A:
20.69
3lslD-1yd9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A 477
ASP A 448
ASN A 541
 TPP  A 602 ( 4.6A)
MG  A 601 ( 2.4A)
None
 0.85A 3lslA-2ag1A:
undetectable
3lslD-2ag1A:
2.5		 3lslA-2ag1A:
18.36
3lslD-2ag1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		3 SER A 287
ASP A  81
ASN A 101
 None
 0.90A 3lslA-2au1A:
undetectable
3lslD-2au1A:
undetectable		 3lslA-2au1A:
21.29
3lslD-2au1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		3 SER A 388
ASP A 381
ASN A 382
 None
 0.97A 3lslA-2exaA:
undetectable
3lslD-2exaA:
undetectable		 3lslA-2exaA:
20.04
3lslD-2exaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		3 SER A 223
ASP A 126
ASN A 125
 None
None
EDO  A 317 (-3.0A)
 0.73A 3lslA-2ghsA:
undetectable
3lslD-2ghsA:
undetectable		 3lslA-2ghsA:
21.86
3lslD-2ghsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		3 SER A 207
ASP A 136
ASN A 159
 None
None
AI2  A 501 (-3.3A)
 0.93A 3lslA-2hj9A:
1.6
3lslD-2hj9A:
2.7		 3lslA-2hj9A:
20.40
3lslD-2hj9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA

(Homo sapiens) 		PF00076
(RRM_1) 		3 SER B 194
ASP B 192
ASN B 180
 G  A   3 ( 2.3A)
None
None
 0.98A 3lslA-2kxnB:
undetectable
3lslD-2kxnB:
undetectable		 3lslA-2kxnB:
19.29
3lslD-2kxnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsn RNASE H

(Simian foamy
virus) 		PF00075
(RNase_H) 		3 SER A  15
ASP A  13
ASN A 150
 None
 0.90A 3lslA-2lsnA:
1.2
3lslD-2lsnA:
undetectable		 3lslA-2lsnA:
22.05
3lslD-2lsnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 301
ASP A 253
ASN A 334
 None
TLA  A 528 (-4.1A)
TLA  A 528 (-4.1A)
 0.96A 3lslA-2pyxA:
undetectable
3lslD-2pyxA:
undetectable		 3lslA-2pyxA:
19.48
3lslD-2pyxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 SER F 239
ASP F 235
ASN F 225
 None
CA  F1298 (-2.6A)
None
 0.69A 3lslA-2wnpF:
undetectable
3lslD-2wnpF:
undetectable		 3lslA-2wnpF:
21.85
3lslD-2wnpF:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 SER A 208
ASP A 214
ASN A 215
 None
 0.95A 3lslA-2xwgA:
undetectable
3lslD-2xwgA:
undetectable		 3lslA-2xwgA:
21.54
3lslD-2xwgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE
ASPARTOKINASE

(Corynebacterium
glutamicum;
Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
PF01842
(ACT)
PF13840
(ACT_7) 		3 SER A 381
ASP B  45
ASN B  43
 None
LYS  A 601 (-4.4A)
LYS  A 601 (-3.3A)
 0.96A 3lslA-3ab4A:
undetectable
3lslD-3ab4A:
undetectable		 3lslA-3ab4A:
21.13
3lslD-3ab4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		3 SER A 288
ASP A 247
ASN A  74
 None
 0.83A 3lslA-3clkA:
1.4
3lslD-3clkA:
undetectable		 3lslA-3clkA:
23.17
3lslD-3clkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		3 SER A 178
ASP A 180
ASN A  70
 SO4  A 247 ( 3.7A)
None
None
 0.99A 3lslA-3f9rA:
undetectable
3lslD-3f9rA:
undetectable		 3lslA-3f9rA:
22.66
3lslD-3f9rA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnu 25 KDA PROTEIN
ELICITOR

(Pythium
aphanidermatum) 		PF05630
(NPP1) 		3 SER P 153
ASP P  93
ASN P 194
 None
None
GAI  P 214 (-3.3A)
 0.68A 3lslA-3gnuP:
undetectable
3lslD-3gnuP:
undetectable		 3lslA-3gnuP:
21.92
3lslD-3gnuP:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 3 SER A  59
ASP A  28
ASN A   2
 None
 1.00A 3lslA-3gozA:
undetectable
3lslD-3gozA:
undetectable		 3lslA-3gozA:
21.92
3lslD-3gozA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		3 SER A 474
ASP A 480
ASN A 481
 None
 0.92A 3lslA-3hv0A:
0.7
3lslD-3hv0A:
undetectable		 3lslA-3hv0A:
20.74
3lslD-3hv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 SER D 365
ASP D 457
ASN D 462
 None
 0.73A 3lslA-3j70D:
undetectable
3lslD-3j70D:
undetectable		 3lslA-3j70D:
19.70
3lslD-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		3 SER D 305
ASP D 472
ASN D 476
 None
 0.89A 3lslA-3j9eD:
undetectable
3lslD-3j9eD:
undetectable		 3lslA-3j9eD:
18.75
3lslD-3j9eD:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		3 SER A 365
ASP A 457
ASN A 462
 None
 0.61A 3lslA-3jwoA:
undetectable
3lslD-3jwoA:
undetectable		 3lslA-3jwoA:
20.38
3lslD-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		3 SER A 172
ASP A 147
ASN A  78
 None
CA  A 240 (-2.9A)
CA  A 240 ( 2.8A)
 0.72A 3lslA-3kzpA:
undetectable
3lslD-3kzpA:
undetectable		 3lslA-3kzpA:
21.27
3lslD-3kzpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE

(Shigella
flexneri) 		PF00294
(PfkB) 		3 SER A 210
ASP A 102
ASN A 105
 None
 0.79A 3lslA-3lhxA:
1.5
3lslD-3lhxA:
undetectable		 3lslA-3lhxA:
22.01
3lslD-3lhxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 SER A 351
ASP A  55
ASN A  95
 None
 0.82A 3lslA-3lk6A:
undetectable
3lslD-3lk6A:
1.5		 3lslA-3lk6A:
18.94
3lslD-3lk6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 SER B  77
ASP B  81
ASN B 206
 None
 0.92A 3lslA-3n3bB:
undetectable
3lslD-3n3bB:
undetectable		 3lslA-3n3bB:
19.75
3lslD-3n3bB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		3 SER A 145
ASP A 368
ASN A 360
 None
 0.97A 3lslA-3njxA:
undetectable
3lslD-3njxA:
undetectable		 3lslA-3njxA:
17.52
3lslD-3njxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 SER B 232
ASP B 491
ASN B 515
 None
 0.80A 3lslA-3ojyB:
undetectable
3lslD-3ojyB:
undetectable		 3lslA-3ojyB:
19.53
3lslD-3ojyB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 137
ASP A 321
ASN A 267
 None
 0.95A 3lslA-3r11A:
undetectable
3lslD-3r11A:
undetectable		 3lslA-3r11A:
20.16
3lslD-3r11A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skq MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
38

(Saccharomyces
cerevisiae) 		PF07766
(LETM1) 		3 SER A 382
ASP A 332
ASN A 333
 None
 0.84A 3lslA-3skqA:
undetectable
3lslD-3skqA:
undetectable		 3lslA-3skqA:
22.41
3lslD-3skqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		3 SER A 329
ASP A 380
ASN A 406
 None
 0.88A 3lslA-3t6qA:
undetectable
3lslD-3t6qA:
undetectable		 3lslA-3t6qA:
17.83
3lslD-3t6qA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		3 SER A  17
ASP A  38
ASN A  59
 None
 0.97A 3lslA-3tpcA:
undetectable
3lslD-3tpcA:
undetectable		 3lslA-3tpcA:
23.84
3lslD-3tpcA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		3 SER A 254
ASP A 270
ASN A 269
 COD  A 289 (-3.5A)
COD  A 289 ( 3.8A)
COD  A 289 ( 4.4A)
 0.98A 3lslA-3uf6A:
2.2
3lslD-3uf6A:
undetectable		 3lslA-3uf6A:
21.22
3lslD-3uf6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 SER D 156
ASP D 259
ASN D 262
 None
 0.75A 3lslA-3w3aD:
undetectable
3lslD-3w3aD:
undetectable		 3lslA-3w3aD:
20.52
3lslD-3w3aD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		3 SER A 680
ASP A 429
ASN A 430
 None
None
PLP  A1644 (-3.6A)
 0.78A 3lslA-4a0hA:
undetectable
3lslD-4a0hA:
0.7		 3lslA-4a0hA:
16.94
3lslD-4a0hA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		3 SER A 186
ASP A 226
ASN A 228
 None
 0.90A 3lslA-4b0tA:
undetectable
3lslD-4b0tA:
undetectable		 3lslA-4b0tA:
19.60
3lslD-4b0tA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 SER A 173
ASP A 170
ASN A 180
 None
 0.76A 3lslA-4bziA:
undetectable
3lslD-4bziA:
undetectable		 3lslA-4bziA:
16.80
3lslD-4bziA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		3 SER A 188
ASP A 197
ASN A 200
 None
 0.91A 3lslA-4ecmA:
1.1
3lslD-4ecmA:
undetectable		 3lslA-4ecmA:
22.82
3lslD-4ecmA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus;
Eleginops
maclovinus) 		PF00042
(Globin)
PF00042
(Globin) 		3 SER B 120
ASP A  27
ASN A  26
 None
 0.88A 3lslA-4esaB:
undetectable
3lslD-4esaB:
undetectable		 3lslA-4esaB:
21.43
3lslD-4esaB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3;
Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT)
no annotation 		3 SER B  66
ASP A  25
ASN B  83
 None
 0.95A 3lslA-4g6tB:
undetectable
3lslD-4g6tB:
undetectable		 3lslA-4g6tB:
20.98
3lslD-4g6tB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		3 SER A 220
ASP A 254
ASN A 258
 None
 0.95A 3lslA-4h18A:
undetectable
3lslD-4h18A:
undetectable		 3lslA-4h18A:
20.42
3lslD-4h18A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  17
ASP A 144
ASN A 142
 None
 0.70A 3lslA-4h19A:
undetectable
3lslD-4h19A:
undetectable		 3lslA-4h19A:
23.06
3lslD-4h19A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		3 SER A  24
ASP A  22
ASN A 155
 None
 0.83A 3lslA-4ibnA:
undetectable
3lslD-4ibnA:
undetectable		 3lslA-4ibnA:
21.74
3lslD-4ibnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		3 SER A 105
ASP A  64
ASN A  67
 None
 0.95A 3lslA-4icqA:
undetectable
3lslD-4icqA:
undetectable		 3lslA-4icqA:
20.50
3lslD-4icqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  53
ASP H  33
ASN H 100
 None
 0.98A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  54
ASP H  33
ASN H 100
 None
 0.94A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		3 SER A1564
ASP A1513
ASN A1516
 None
 0.85A 3lslA-4lnzA:
undetectable
3lslD-4lnzA:
undetectable		 3lslA-4lnzA:
20.60
3lslD-4lnzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
NANOBODY 9-8

(Homo sapiens;
Lama glama) 		PF00001
(7tm_1)
PF07686
(V-set) 		3 SER A 380
ASP B  33
ASN B  77
 None
 0.83A 3lslA-4mqtA:
undetectable
3lslD-4mqtA:
undetectable		 3lslA-4mqtA:
23.12
3lslD-4mqtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8c HEAVY CHAIN OF
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  44
ASP H  46
ASN H  61
 None
 0.97A 3lslA-4n8cH:
undetectable
3lslD-4n8cH:
undetectable		 3lslA-4n8cH:
21.38
3lslD-4n8cH:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 3 SER A  22
ASP A  18
ASN A  63
 None
None
CIT  A 501 (-4.6A)
 0.91A 3lslA-4o87A:
undetectable
3lslD-4o87A:
undetectable		 3lslA-4o87A:
22.42
3lslD-4o87A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		3 SER A 297
ASP A 277
ASN A 280
 None
 0.97A 3lslA-4pvcA:
undetectable
3lslD-4pvcA:
undetectable		 3lslA-4pvcA:
24.51
3lslD-4pvcA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		3 SER A  54
ASP A 116
ASN A 179
 TRS  A 402 ( 4.9A)
TRS  A 402 (-2.8A)
None
 0.94A 3lslA-4q2bA:
undetectable
3lslD-4q2bA:
undetectable		 3lslA-4q2bA:
22.07
3lslD-4q2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 103
ASP H  99
ASN H  35
 None
CA  H 301 (-3.7A)
CA  H 301 (-2.9A)
 0.96A 3lslA-4r90H:
undetectable
3lslD-4r90H:
undetectable		 3lslA-4r90H:
22.18
3lslD-4r90H:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		3 SER A 228
ASP A  75
ASN A 103
 None
 0.95A 3lslA-4rk1A:
3.0
3lslD-4rk1A:
2.9		 3lslA-4rk1A:
24.29
3lslD-4rk1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 SER A 137
ASP A  18
ASN A  12
 None
 0.88A 3lslA-4rpfA:
undetectable
3lslD-4rpfA:
undetectable		 3lslA-4rpfA:
20.29
3lslD-4rpfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		3 SER A 331
ASP A 382
ASN A  21
 None
 0.58A 3lslA-4tx8A:
undetectable
3lslD-4tx8A:
undetectable		 3lslA-4tx8A:
18.84
3lslD-4tx8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ums CELLULOSOMAL
ANCHORING SCAFFOLDIN
B

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		3 SER A1124
ASP A1119
ASN A1118
 None
 0.88A 3lslA-4umsA:
undetectable
3lslD-4umsA:
undetectable		 3lslA-4umsA:
21.37
3lslD-4umsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0m ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 SER A  23
ASP A  65
ASN A  75
 None
 0.96A 3lslA-4z0mA:
undetectable
3lslD-4z0mA:
undetectable		 3lslA-4z0mA:
22.84
3lslD-4z0mA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		3 SER A 112
ASP A  62
ASN A  64
 None
 0.81A 3lslA-4zdlA:
undetectable
3lslD-4zdlA:
undetectable		 3lslA-4zdlA:
20.99
3lslD-4zdlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 SER A  11
ASP A 326
ASN A 323
 None
 0.99A 3lslA-4zo6A:
undetectable
3lslD-4zo6A:
undetectable		 3lslA-4zo6A:
17.31
3lslD-4zo6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		3 SER A  74
ASP A 136
ASN A 200
 None
GOL  A 402 (-2.9A)
None
 0.98A 3lslA-5cd2A:
undetectable
3lslD-5cd2A:
undetectable		 3lslA-5cd2A:
22.02
3lslD-5cd2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		3 SER A  62
ASP A 324
ASN A 327
 None
 0.91A 3lslA-5d8gA:
undetectable
3lslD-5d8gA:
0.7		 3lslA-5d8gA:
20.97
3lslD-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H) 		3 SER A 526
ASP A 524
ASN A 649
 None
 0.84A 3lslA-5dmrA:
undetectable
3lslD-5dmrA:
undetectable		 3lslA-5dmrA:
25.00
3lslD-5dmrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C

(Pseudomonas sp.) 		PF16670
(PI-PLC-C1) 		3 SER A 191
ASP A 119
ASN A  27
 None
INS  A 301 ( 3.1A)
CA  A 401 ( 3.0A)
 0.92A 3lslA-5fyrA:
undetectable
3lslD-5fyrA:
undetectable		 3lslA-5fyrA:
19.69
3lslD-5fyrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		3 SER A 180
ASP A 372
ASN A 409
 None
 0.66A 3lslA-5g4iA:
undetectable
3lslD-5g4iA:
undetectable		 3lslA-5g4iA:
19.52
3lslD-5g4iA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		3 SER A 377
ASP A 348
ASN A 282
 None
 0.60A 3lslA-5gvvA:
1.7
3lslD-5gvvA:
1.8		 3lslA-5gvvA:
19.55
3lslD-5gvvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 SER A 380
ASP A 480
ASN A 478
 None
 0.64A 3lslA-5ivaA:
undetectable
3lslD-5ivaA:
undetectable		 3lslA-5ivaA:
18.73
3lslD-5ivaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		3 SER A 313
ASP A 393
ASN A 394
 None
CAC  A 501 (-3.6A)
None
 0.84A 3lslA-5j39A:
undetectable
3lslD-5j39A:
undetectable		 3lslA-5j39A:
23.35
3lslD-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 SER A 398
ASP A 353
ASN A 424
 None
 0.95A 3lslA-5kd5A:
undetectable
3lslD-5kd5A:
undetectable		 3lslA-5kd5A:
19.43
3lslD-5kd5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq6 VIRULENCE PROTEIN
VSDE

(Salmonella
enterica) 		PF05563
(SpvD) 		3 SER A 105
ASP A 163
ASN A 165
 None
 0.97A 3lslA-5lq6A:
undetectable
3lslD-5lq6A:
undetectable		 3lslA-5lq6A:
19.64
3lslD-5lq6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI)
PF01833
(TIG) 		3 SER A 525
ASP A 587
ASN A 642
 None
 0.95A 3lslA-5lspA:
undetectable
3lslD-5lspA:
undetectable		 3lslA-5lspA:
20.93
3lslD-5lspA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 SER A1401
ASP A1475
ASN A1513
 None
 0.94A 3lslA-5m5pA:
undetectable
3lslD-5m5pA:
1.5		 3lslA-5m5pA:
9.10
3lslD-5m5pA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 3 SER A 847
ASP A 634
ASN A 637
 None
None
NAG  A1108 (-1.8A)
 0.85A 3lslA-5nbsA:
undetectable
3lslD-5nbsA:
undetectable		 3lslA-5nbsA:
undetectable
3lslD-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 SER B 124
ASP B 127
ASN B 130
 None
 0.91A 3lslA-5nemB:
undetectable
3lslD-5nemB:
undetectable		 3lslA-5nemB:
18.88
3lslD-5nemB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nrm ENDOGLUCANASE

(Acetivibrio
cellulolyticus) 		no annotation 3 SER A  85
ASP A  81
ASN A  64
 None
 0.98A 3lslA-5nrmA:
undetectable
3lslD-5nrmA:
undetectable		 3lslA-5nrmA:
undetectable
3lslD-5nrmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 SER A 297
ASP A 322
ASN A  52
 None
 0.84A 3lslA-5tf0A:
undetectable
3lslD-5tf0A:
undetectable		 3lslA-5tf0A:
17.03
3lslD-5tf0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 SER 6 791
ASP 2 544
ASN 2 651
 None
None
AGS  22001 (-3.0A)
 0.77A 3lslA-5udb6:
undetectable
3lslD-5udb6:
undetectable		 3lslA-5udb6:
14.63
3lslD-5udb6:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 SER C 254
ASP C 217
ASN C 214
 None
 0.97A 3lslA-5v8fC:
undetectable
3lslD-5v8fC:
undetectable		 3lslA-5v8fC:
18.79
3lslD-5v8fC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 3 SER A 209
ASP A 241
ASN A 170
 None
 0.99A 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable		 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 SER A 291
ASP A 316
ASN A  50
 None
 0.86A 3lslA-5xxoA:
undetectable
3lslD-5xxoA:
undetectable		 3lslA-5xxoA:
undetectable
3lslD-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 3 SER A 148
ASP A 277
ASN A 212
 None
 0.84A 3lslA-6bi4A:
undetectable
3lslD-6bi4A:
undetectable		 3lslA-6bi4A:
20.83
3lslD-6bi4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 3 SER A 246
ASP A 121
ASN A 119
 None
 0.96A 3lslA-6czmA:
8.8
3lslD-6czmA:
6.4		 3lslA-6czmA:
23.46
3lslD-6czmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 3 SER A 243
ASP A 201
ASN A 220
 None
 0.99A 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable		 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable