SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_D_PZID800
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kae | HISTIDINOLDEHYDROGENASE (Escherichiacoli) |
PF00815(Histidinol_dh) | 4 | ASN A 37LEU A 40ASP A 41LYS A 44 | None | 1.23A | 3lslA-1kaeA:undetectable3lslD-1kaeA:undetectable | 3lslA-1kaeA:20.273lslD-1kaeA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ljy | MGP-40 (Capra hircus) |
PF00704(Glyco_hydro_18) | 4 | TYR A 7ASN A 51LEU A 55ASP A 52 | None | 1.16A | 3lslA-1ljyA:undetectable3lslD-1ljyA:undetectable | 3lslA-1ljyA:22.163lslD-1ljyA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nst | HEPARAN SULFATEN-DEACETYLASE/N-SULFOTRANSFERASE (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | SER A 632TYR A 804MET A 626LEU A 624 | None | 1.43A | 3lslA-1nstA:undetectable3lslD-1nstA:undetectable | 3lslA-1nstA:21.353lslD-1nstA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ohe | CDC14B2 PHOSPHATASE (Homo sapiens) |
PF00782(DSPc)PF14671(DSPn) | 4 | TYR A 248ASN A 217LEU A 216ASP A 215 | None | 1.40A | 3lslA-1oheA:undetectable3lslD-1oheA:undetectable | 3lslA-1oheA:22.193lslD-1oheA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szh | HER-1 PROTEIN (Caenorhabditiselegans) |
PF09232(Caenor_Her-1) | 4 | TYR A 137LEU A 123ASP A 124LYS A 127 | None | 0.94A | 3lslA-1szhA:undetectable3lslD-1szhA:undetectable | 3lslA-1szhA:20.963lslD-1szhA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tzq | EQUINATOXIN II (Actinia equina) |
PF06369(Anemone_cytotox) | 4 | SER A 141TYR A 122ASN A 118LEU A 136 | None | 1.44A | 3lslA-1tzqA:undetectable3lslD-1tzqA:undetectable | 3lslA-1tzqA:20.163lslD-1tzqA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1um8 | ATP-DEPENDENT CLPPROTEASE ATP-BINDINGSUBUNIT CLPX (Helicobacterpylori) |
PF07724(AAA_2)PF10431(ClpB_D2-small) | 4 | TYR A 111ASN A 144LEU A 274LYS A 208 | None | 1.22A | 3lslA-1um8A:undetectable3lslD-1um8A:undetectable | 3lslA-1um8A:20.203lslD-1um8A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | TYR A 198ASN A 265LEU A 262ASP A 252 | None | 1.43A | 3lslA-1v5vA:undetectable3lslD-1v5vA:undetectable | 3lslA-1v5vA:21.963lslD-1v5vA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdt | ELONGATION FACTOR GHOMOLOG (Thermusthermophilus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 4 | SER A 254TYR A 164LEU A 136ASP A 137 | GTP A 700 (-2.5A)NoneNoneGTP A 700 (-2.8A) | 1.34A | 3lslA-1wdtA:undetectable3lslD-1wdtA:undetectable | 3lslA-1wdtA:16.523lslD-1wdtA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp4 | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Streptococcuspneumoniae) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 4 | SER A 175TYR A 86ASN A 164LEU A 167 | None | 1.11A | 3lslA-1xp4A:undetectable3lslD-1xp4A:undetectable | 3lslA-1xp4A:21.763lslD-1xp4A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5z | HYPOTHETICAL PROTEINSO2946 (Shewanellaoneidensis) |
no annotation | 4 | SER A 83TYR A 53MET A 56ASP A 247 | NoneNoneNone MG A 701 (-3.2A) | 1.08A | 3lslA-2a5zA:undetectable3lslD-2a5zA:undetectable | 3lslA-2a5zA:23.673lslD-2a5zA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2awa | DNA POLYMERASE III,BETA CHAIN (Streptococcuspneumoniae) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | SER A 23TYR A 123ASN A 26LEU A 31 | None | 1.41A | 3lslA-2awaA:undetectable3lslD-2awaA:undetectable | 3lslA-2awaA:20.903lslD-2awaA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw9 | TRANSLOCASE OF INNERMITOCHONDRIALMEMBRANE (Homo sapiens) |
PF04280(Tim44) | 4 | TYR A 348LEU A 336ASP A 337LYS A 340 | None | 0.91A | 3lslA-2cw9A:undetectable3lslD-2cw9A:undetectable | 3lslA-2cw9A:21.833lslD-2cw9A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyb | TYROSYL-TRNASYNTHETASE (Archaeoglobusfulgidus) |
PF00579(tRNA-synt_1b) | 4 | ASN A 249LEU A 252ASP A 253LYS A 256 | None | 1.37A | 3lslA-2cybA:undetectable3lslD-2cybA:undetectable | 3lslA-2cybA:23.783lslD-2cybA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elj | TRANSCRIPTIONALADAPTER 2 (Saccharomycescerevisiae) |
PF04433(SWIRM) | 4 | SER A 84TYR A 41LEU A 30ASP A 26 | None | 1.43A | 3lslA-2eljA:undetectable3lslD-2eljA:undetectable | 3lslA-2eljA:15.083lslD-2eljA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0o | SER/THR PHOSPHATASE (Anophelesgambiae) |
PF00481(PP2C) | 4 | SER A 426ASN A 422ASP A 442LYS A 444 | None | 1.39A | 3lslA-2i0oA:undetectable3lslD-2i0oA:undetectable | 3lslA-2i0oA:22.073lslD-2i0oA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijr | HYPOTHETICAL PROTEINAPI92 (Yersiniapseudotuberculosis) |
PF06924(DUF1281) | 4 | SER A 192TYR A 60ASN A 182LEU A 188 | None | 1.21A | 3lslA-2ijrA:undetectable3lslD-2ijrA:undetectable | 3lslA-2ijrA:22.123lslD-2ijrA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lll | LAMIN-B2 (Homo sapiens) |
PF00932(LTD) | 4 | SER A 453TYR A 501ASN A 470LEU A 503 | None | 1.44A | 3lslA-2lllA:undetectable3lslD-2lllA:undetectable | 3lslA-2lllA:22.083lslD-2lllA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ls6 | HYALURONOGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 4 | SER A 164ASN A 82LEU A 80ASP A 132 | None | 1.42A | 3lslA-2ls6A:undetectable3lslD-2ls6A:undetectable | 3lslA-2ls6A:22.593lslD-2ls6A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q86 | VALPHA14 TCR (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 4 | TYR A 24LEU A 65ASP A 66LYS A 70 | None | 1.32A | 3lslA-2q86A:undetectable3lslD-2q86A:undetectable | 3lslA-2q86A:23.813lslD-2q86A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ra1 | SURFACE LAYERPROTEIN (Geobacillusstearothermophilus) |
PF13205(Big_5) | 4 | TYR A 256LEU A 220ASP A 221LYS A 224 | None | 0.98A | 3lslA-2ra1A:undetectable3lslD-2ra1A:undetectable | 3lslA-2ra1A:21.143lslD-2ra1A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8p | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE (Aquifexaeolicus) |
PF00288(GHMP_kinases_N) | 4 | SER A 236TYR A 175ASN A 206LEU A 208 | NoneCDP A1269 (-3.6A)NoneNone | 1.35A | 3lslA-2v8pA:undetectable3lslD-2v8pA:undetectable | 3lslA-2v8pA:22.623lslD-2v8pA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc7 | ALPHA AMYLASE,CATALYTIC REGION (Nostocpunctiforme) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | SER A 436TYR A 410ASN A 432LEU A 415 | None | 1.26A | 3lslA-2wc7A:undetectable3lslD-2wc7A:undetectable | 3lslA-2wc7A:19.173lslD-2wc7A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wc7 | ALPHA AMYLASE,CATALYTIC REGION (Nostocpunctiforme) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | SER A 437TYR A 410ASN A 432LEU A 415 | None | 1.39A | 3lslA-2wc7A:undetectable3lslD-2wc7A:undetectable | 3lslA-2wc7A:19.173lslD-2wc7A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtk | STE20-RELATED KINASEADAPTER PROTEINALPHA (Homo sapiens) |
PF00069(Pkinase) | 4 | SER B 195TYR B 133ASN B 217LEU B 214 | None | 1.43A | 3lslA-2wtkB:undetectable3lslD-2wtkB:undetectable | 3lslA-2wtkB:21.113lslD-2wtkB:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yp1 | AROMATICPEROXYGENASE (Agrocybeaegerita) |
PF01328(Peroxidase_2) | 4 | TYR A 281ASN A 305LEU A 308ASP A 309 | None | 1.25A | 3lslA-2yp1A:undetectable3lslD-2yp1A:undetectable | 3lslA-2yp1A:22.423lslD-2yp1A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2f | LYSOZYME C-2 (Bos taurus) |
PF00062(Lys) | 4 | SER A 122TYR A 38LEU A 29LYS A 33 | None | 1.11A | 3lslA-2z2fA:undetectable3lslD-2z2fA:undetectable | 3lslA-2z2fA:18.783lslD-2z2fA:18.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zns | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 1 (Homo sapiens) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 448MET A 519LEU A 776LYS A 780 | None | 0.43A | 3lslA-2znsA:37.33lslD-2znsA:36.9 | 3lslA-2znsA:51.923lslD-2znsA:51.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumlongum) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | TYR A 873ASN A 886LEU A 840ASP A 839 | None | 1.21A | 3lslA-2zxqA:undetectable3lslD-2zxqA:undetectable | 3lslA-2zxqA:12.393lslD-2zxqA:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | SER A 470TYR A 291ASN A 285ASP A 455 | None | 1.19A | 3lslA-3ai7A:undetectable3lslD-3ai7A:undetectable | 3lslA-3ai7A:14.753lslD-3ai7A:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bz5 | INTERNALIN-J (Listeriamonocytogenes) |
PF12799(LRR_4) | 4 | SER A 239ASN A 262LEU A 259ASP A 258 | None | 1.38A | 3lslA-3bz5A:undetectable3lslD-3bz5A:undetectable | 3lslA-3bz5A:18.323lslD-3bz5A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e15 | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Plasmodiumvivax) |
PF01182(Glucosamine_iso) | 4 | SER A 59TYR A 137ASN A 102ASP A 90 | None | 1.41A | 3lslA-3e15A:undetectable3lslD-3e15A:undetectable | 3lslA-3e15A:23.813lslD-3e15A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoj | BACTERIOCHLOROPHYLLA PROTEIN (Prosthecochlorisaestuarii) |
PF02327(BChl_A) | 4 | SER A 111LEU A 153ASP A 154LYS A 215 | EDO A 383 ( 4.3A)None NA A1232 ( 4.9A)None | 1.28A | 3lslA-3eojA:undetectable3lslD-3eojA:undetectable | 3lslA-3eojA:20.973lslD-3eojA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f0h | AMINOTRANSFERASE ([Eubacterium]rectale) |
PF00266(Aminotran_5) | 4 | TYR A 45ASN A 245LEU A 248LYS A 252 | None | 1.10A | 3lslA-3f0hA:undetectable3lslD-3f0hA:undetectable | 3lslA-3f0hA:22.283lslD-3f0hA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fav | 6 KDA EARLYSECRETORY ANTIGENICTARGET (Mycobacteriumtuberculosis) |
PF06013(WXG100) | 4 | ASN B 66LEU B 29ASP B 30LYS B 33 | NoneNone ZN B 1 (-2.4A)None | 1.07A | 3lslA-3favB:undetectable3lslD-3favB:undetectable | 3lslA-3favB:15.773lslD-3favB:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gir | AMINOMETHYLTRANSFERASE (Bartonellahenselae) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | TYR A 194ASN A 244LEU A 241ASP A 231 | None | 1.37A | 3lslA-3girA:undetectable3lslD-3girA:undetectable | 3lslA-3girA:20.713lslD-3girA:20.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h6t | GLUTAMATE RECEPTOR 2 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 35MET A 107ASP A 248LYS A 251 | NoneNoneNoneCYZ A 265 ( 4.4A) | 1.08A | 3lslA-3h6tA:42.63lslD-3h6tA:42.7 | 3lslA-3h6tA:99.613lslD-3h6tA:99.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h6t | GLUTAMATE RECEPTOR 2 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 35MET A 107LEU A 247LYS A 251 | NoneNoneCYZ A 265 (-4.3A)CYZ A 265 ( 4.4A) | 0.49A | 3lslA-3h6tA:42.63lslD-3h6tA:42.7 | 3lslA-3h6tA:99.613lslD-3h6tA:99.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 4 | TYR A 288ASN A 122LEU A 125LYS A 129 | None | 1.43A | 3lslA-3hjbA:undetectable3lslD-3hjbA:undetectable | 3lslA-3hjbA:17.743lslD-3hjbA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl9 | GLUTAMYLAMINOPEPTIDASE (Streptococcuspneumoniae) |
PF05343(Peptidase_M42) | 4 | SER A 307TYR A 354LEU A 266LYS A 352 | None | 0.92A | 3lslA-3kl9A:undetectable3lslD-3kl9A:undetectable | 3lslA-3kl9A:21.823lslD-3kl9A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lez | BETA-LACTAMASE (Oceanobacillusiheyensis) |
PF13354(Beta-lactamase2) | 4 | SER A 194TYR A 206LEU A 165ASP A 170 | None | 1.34A | 3lslA-3lezA:undetectable3lslD-3lezA:undetectable | 3lslA-3lezA:22.183lslD-3lezA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgx | PUTATIVE P450MONOOXYGENASE (Amycolatopsisbalhimycina) |
PF00067(p450) | 4 | SER A 41TYR A 15LEU A 9ASP A 8 | None | 1.35A | 3lslA-3mgxA:undetectable3lslD-3mgxA:undetectable | 3lslA-3mgxA:20.673lslD-3mgxA:20.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qxm | GLUTAMATE RECEPTORIONOTROPIC, KAINATE2 (Homo sapiens) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 431MET A 503LEU A 760LYS A 764 | None | 0.48A | 3lslA-3qxmA:13.33lslD-3qxmA:37.1 | 3lslA-3qxmA:51.923lslD-3qxmA:51.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sze | SERINE PROTEASE ESPP (Escherichiacoli) |
PF02395(Peptidase_S6) | 4 | SER A 505ASN A 503LEU A 482ASP A 481 | None | 1.07A | 3lslA-3szeA:undetectable3lslD-3szeA:undetectable | 3lslA-3szeA:16.073lslD-3szeA:16.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u92 | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 3 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 35MET A 106LEU A 242LYS A 246 | NoneNoneNone ZN A 259 (-3.5A) | 0.43A | 3lslA-3u92A:36.93lslD-3u92A:36.8 | 3lslA-3u92A:51.343lslD-3u92A:51.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1g | DNA LIGASE 4 (Homo sapiens) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 4 | TYR A 82ASN A 149LEU A 152ASP A 153 | None | 1.21A | 3lslA-3w1gA:undetectable3lslD-3w1gA:undetectable | 3lslA-3w1gA:17.513lslD-3w1gA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4buo | NEUROTENSIN RECEPTORTYPE 1 (Rattusnorvegicus) |
PF00001(7tm_1) | 4 | SER A 361ASN A 365LEU A 109ASP A 113 | None | 1.06A | 3lslA-4buoA:undetectable3lslD-4buoA:undetectable | 3lslA-4buoA:21.703lslD-4buoA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cj0 | ENDOGLUCANASE D (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | SER A 240LEU A 245ASP A 246LYS A 249 | NoneNone CA A1577 (-3.0A)None | 0.85A | 3lslA-4cj0A:undetectable3lslD-4cj0A:undetectable | 3lslA-4cj0A:18.023lslD-4cj0A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cj0 | ENDOGLUCANASE D (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | TYR A 139ASN A 484LEU A 487ASP A 488 | None | 1.31A | 3lslA-4cj0A:undetectable3lslD-4cj0A:undetectable | 3lslA-4cj0A:18.023lslD-4cj0A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4erv | RYANODINE RECEPTOR 3 (Homo sapiens) |
PF02026(RyR) | 4 | SER A2625TYR A2743LEU A2787ASP A2786 | None | 1.41A | 3lslA-4ervA:undetectable3lslD-4ervA:undetectable | 3lslA-4ervA:21.923lslD-4ervA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3m | BH0337 PROTEIN (Bacillushalodurans) |
PF09704(Cas_Cas5d) | 4 | TYR A 46ASN A 113ASP A 111LYS A 48 | None | 1.42A | 3lslA-4f3mA:undetectable3lslD-4f3mA:undetectable | 3lslA-4f3mA:21.583lslD-4f3mA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fye | SIDF, INHIBITOR OFGROWTH FAMILY,MEMBER 3 (Legionellapneumophila) |
no annotation | 4 | TYR A 508LEU A 524ASP A 525LYS A 528 | None | 0.97A | 3lslA-4fyeA:undetectable3lslD-4fyeA:undetectable | 3lslA-4fyeA:16.163lslD-4fyeA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htp | DNA LIGASE 4 (Homo sapiens) |
PF04675(DNA_ligase_A_N) | 4 | TYR A 82ASN A 149LEU A 152ASP A 153 | None | 1.15A | 3lslA-4htpA:undetectable3lslD-4htpA:undetectable | 3lslA-4htpA:20.383lslD-4htpA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i97 | DELTA CLASS 1GLUTATHIONES-TRANSFERASE (Scaptomyzanigrita) |
PF00043(GST_C)PF02798(GST_N) | 4 | SER A 11MET A 164ASN A 197LEU A 161 | None | 1.12A | 3lslA-4i97A:undetectable3lslD-4i97A:undetectable | 3lslA-4i97A:22.013lslD-4i97A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4im7 | HYPOTHETICALOXIDOREDUCTASE YDFI (Escherichiacoli) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 4 | TYR A 347MET A 288ASN A 294LEU A 293 | NoneNoneCS2 A 501 (-3.0A)CS2 A 501 ( 4.5A) | 1.45A | 3lslA-4im7A:undetectable3lslD-4im7A:undetectable | 3lslA-4im7A:19.013lslD-4im7A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4im7 | HYPOTHETICALOXIDOREDUCTASE YDFI (Escherichiacoli) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 4 | TYR A 347MET A 292ASN A 294LEU A 293 | NoneNoneCS2 A 501 (-3.0A)CS2 A 501 ( 4.5A) | 1.43A | 3lslA-4im7A:undetectable3lslD-4im7A:undetectable | 3lslA-4im7A:19.013lslD-4im7A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgu | GAMMA-INTERFERON-INDUCIBLE PROTEIN 16 (Homo sapiens) |
PF02760(HIN) | 4 | TYR A 218ASN A 274LEU A 245LYS A 226 | None | 1.27A | 3lslA-4qguA:undetectable3lslD-4qguA:undetectable | 3lslA-4qguA:19.413lslD-4qguA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ufc | GH95 (Bacteroidesovatus) |
PF14498(Glyco_hyd_65N_2) | 4 | SER A 737TYR A 456ASN A 762LEU A 764 | None | 1.38A | 3lslA-4ufcA:undetectable3lslD-4ufcA:undetectable | 3lslA-4ufcA:15.043lslD-4ufcA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uxv | SEPTATION RINGFORMATION REGULATOREZRA (Bacillussubtilis) |
PF06160(EzrA) | 4 | ASN A 204LEU A 168ASP A 171LYS A 170 | None | 0.88A | 3lslA-4uxvA:undetectable3lslD-4uxvA:undetectable | 3lslA-4uxvA:18.853lslD-4uxvA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzs | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | SER A 668TYR A 357LEU A 391ASP A 387 | None | 1.41A | 3lslA-4uzsA:undetectable3lslD-4uzsA:undetectable | 3lslA-4uzsA:17.573lslD-4uzsA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 4 | SER A 165LEU A 131ASP A 128LYS A 129 | None | 1.16A | 3lslA-4wzbA:undetectable3lslD-4wzbA:undetectable | 3lslA-4wzbA:19.013lslD-4wzbA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgt | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 4 | MET A 843ASN A 703ASP A 850LYS A 854 | None | 1.08A | 3lslA-4xgtA:undetectable3lslD-4xgtA:undetectable | 3lslA-4xgtA:15.123lslD-4xgtA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a21 | PORTAL PROTEIN (Bacillus phageSPP1) |
PF05133(Phage_prot_Gp6) | 4 | SER A 312TYR A 286ASN A 290LEU A 288 | None | 1.45A | 3lslA-5a21A:undetectable3lslD-5a21A:undetectable | 3lslA-5a21A:21.373lslD-5a21A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3o | THYMINE DIOXYGENASE (Neurosporacrassa) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 4 | TYR A 291ASN A 150ASP A 154LYS A 157 | None | 1.32A | 3lslA-5c3oA:undetectable3lslD-5c3oA:undetectable | 3lslA-5c3oA:23.323lslD-5c3oA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6n | ACYL-COA SYNTHASE (Mycolicibacteriumsmegmatis) |
PF00501(AMP-binding) | 4 | SER A 188TYR A 343LEU A 345ASP A 232 | None | 1.06A | 3lslA-5d6nA:undetectable3lslD-5d6nA:undetectable | 3lslA-5d6nA:19.093lslD-5d6nA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE ACIDICPROTEIN (Influenza Cvirus) |
PF00603(Flu_PA) | 4 | SER A 54TYR A 83ASP A 96LYS A 100 | None | 1.39A | 3lslA-5d9aA:undetectable3lslD-5d9aA:undetectable | 3lslA-5d9aA:17.233lslD-5d9aA:17.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dtb | CG3822 (Drosophilamelanogaster) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 39MET A 111LEU A 250LYS A 254 | None | 0.53A | 3lslA-5dtbA:38.03lslD-5dtbA:37.8 | 3lslA-5dtbA:54.793lslD-5dtbA:54.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fei | DISTAL TUBE PROTEIN (Bacillus virusphi29) |
PF16838(Caud_tail_N) | 4 | SER A 247TYR A 210ASN A 194ASP A 251 | None | 1.28A | 3lslA-5feiA:undetectable3lslD-5feiA:undetectable | 3lslA-5feiA:17.283lslD-5feiA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fww | KREMEN PROTEIN 1DICKKOPF-RELATEDPROTEIN 1 (Homo sapiens;Homo sapiens) |
PF00051(Kringle)PF00431(CUB)PF01822(WSC)no annotation | 4 | SER C 193TYR B 165LEU C 190LYS C 208 | None | 1.32A | 3lslA-5fwwC:undetectable3lslD-5fwwC:undetectable | 3lslA-5fwwC:13.953lslD-5fwwC:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5d | CELLULOSOMAL-SCAFFOLDING PROTEIN A (Ruminiclostridiumthermocellum) |
PF00404(Dockerin_1)PF13620(CarboxypepD_reg) | 4 | TYR B 161MET B 98LEU B 74ASP B 75 | None | 1.38A | 3lslA-5g5dB:undetectable3lslD-5g5dB:undetectable | 3lslA-5g5dB:21.883lslD-5g5dB:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hoe | HYDROLASE (Sinorhizobiummeliloti) |
PF13472(Lipase_GDSL_2) | 4 | SER A 61TYR A 170MET A 113ASP A 97 | None | 1.43A | 3lslA-5hoeA:undetectable3lslD-5hoeA:undetectable | 3lslA-5hoeA:21.793lslD-5hoeA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyh | UNCHARACTERIZEDPROTEIN (Streptomycesvenezuelae) |
PF11583(AurF) | 4 | TYR A 101ASN A 233LEU A 212ASP A 213 | NoneNoneNoneTLA A 403 (-3.2A) | 1.19A | 3lslA-5hyhA:undetectable3lslD-5hyhA:undetectable | 3lslA-5hyhA:23.443lslD-5hyhA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5il7 | RAB FAMILY PROTEIN (Chlorobaculumtepidum) |
PF12799(LRR_4)PF13516(LRR_6) | 4 | SER A 72ASN A 95LEU A 92ASP A 93 | None | 1.32A | 3lslA-5il7A:undetectable3lslD-5il7A:undetectable | 3lslA-5il7A:19.953lslD-5il7A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm6 | AMINOPEPTIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF02127(Peptidase_M18) | 4 | SER A 390TYR A 58LEU A 309ASP A 307 | NoneNoneNone ZN A 602 ( 4.3A) | 1.29A | 3lslA-5jm6A:undetectable3lslD-5jm6A:undetectable | 3lslA-5jm6A:18.523lslD-5jm6A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kuf | GLUTAMATE RECEPTORIONOTROPIC, KAINATE2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 4 | TYR A 431MET A 503LEU A 760LYS A 764 | None | 0.86A | 3lslA-5kufA:34.43lslD-5kufA:33.9 | 3lslA-5kufA:18.463lslD-5kufA:18.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l1b | GLUTAMATE RECEPTOR2,GLUTAMATE RECEPTOR2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | TYR A 424MET A 496LEU A 759ASP A 760LYS A 763 | None | 0.64A | 3lslA-5l1bA:22.23lslD-5l1bA:22.4 | 3lslA-5l1bA:70.173lslD-5l1bA:70.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l56 | PLEXIN-A1 (Mus musculus) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 4 | TYR A 62ASN A 123LEU A 141ASP A 142 | None | 1.15A | 3lslA-5l56A:undetectable3lslD-5l56A:undetectable | 3lslA-5l56A:12.113lslD-5l56A:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5low | RABPHILIN-3A (Rattusnorvegicus) |
PF00168(C2) | 4 | SER A 628TYR A 613LEU A 625ASP A 626 | None | 1.43A | 3lslA-5lowA:undetectable3lslD-5lowA:undetectable | 3lslA-5lowA:20.853lslD-5lowA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lt1 | KINESIN-LIKE PROTEIN (Homo sapiens) |
PF00225(Kinesin) | 4 | TYR A 118ASN A 216LEU A 126ASP A 123 | None | 1.11A | 3lslA-5lt1A:undetectable3lslD-5lt1A:undetectable | 3lslA-5lt1A:22.263lslD-5lt1A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | TYR A 185LEU A 148ASP A 149LYS A 152 | None | 1.34A | 3lslA-5m8tA:undetectable3lslD-5m8tA:undetectable | 3lslA-5m8tA:20.803lslD-5m8tA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mi0 | RETICULOCYTEBINDING-LIKE PROTEIN5,RETICULOCYTEBINDING PROTEIN 5 (Plasmodiumfalciparum) |
no annotation | 4 | TYR A 184LEU A 460ASP A 461LYS A 464 | None | 1.06A | 3lslA-5mi0A:undetectable3lslD-5mi0A:undetectable | 3lslA-5mi0A:21.643lslD-5mi0A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5my0 | FATTY ACID SYNTHASE (Mus musculus) |
no annotation | 4 | SER B 114MET B 139LEU B 79ASP B 76 | None | 1.45A | 3lslA-5my0B:undetectable3lslD-5my0B:undetectable | 3lslA-5my0B:undetectable3lslD-5my0B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nkz | PEROXIN 22 (Ogataea angusta) |
no annotation | 4 | SER D 121ASN D 124LEU D 143ASP D 144 | None | 1.34A | 3lslA-5nkzD:2.73lslD-5nkzD:2.8 | 3lslA-5nkzD:undetectable3lslD-5nkzD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5no8 | BACCELL_00875 (Bacteroidescellulosilyticus) |
no annotation | 4 | SER A 41MET A 31ASN A 53LEU A 43 | None | 1.44A | 3lslA-5no8A:undetectable3lslD-5no8A:undetectable | 3lslA-5no8A:18.843lslD-5no8A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ns8 | - (-) |
no annotation | 4 | ASN A 60LEU A 63ASP A 64LYS A 67 | None | 0.97A | 3lslA-5ns8A:undetectable3lslD-5ns8A:undetectable | 3lslA-5ns8A:undetectable3lslD-5ns8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u70 | POTASSIUM CHANNELSUBFAMILY T MEMBER 1 (Gallus gallus) |
PF03493(BK_channel_a)PF07885(Ion_trans_2) | 4 | SER A 779MET A 832LEU A 811ASP A 812 | None | 1.41A | 3lslA-5u70A:undetectable3lslD-5u70A:undetectable | 3lslA-5u70A:13.213lslD-5u70A:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 4 | TYR A 383ASN A 140LEU A 268ASP A 165 | None | 1.27A | 3lslA-5um6A:undetectable3lslD-5um6A:undetectable | 3lslA-5um6A:14.193lslD-5um6A:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vxl | INVASIN IPAD (Shigellaflexneri) |
PF06511(IpaD) | 4 | SER A 86TYR A 301ASN A 146LEU A 150 | None | 1.43A | 3lslA-5vxlA:undetectable3lslD-5vxlA:undetectable | 3lslA-5vxlA:21.363lslD-5vxlA:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wel | CHIMERA OF GLUTAMATERECEPTOR 2, GERMCELL-SPECIFIC GENE1-LIKE PROTEIN (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF07803(GSG-1)PF10613(Lig_chan-Glu_bd) | 4 | TYR A 424MET A 496LEU A 759ASP A 760 | None | 0.50A | 3lslA-5welA:32.23lslD-5welA:32.5 | 3lslA-5welA:66.673lslD-5welA:66.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wel | CHIMERA OF GLUTAMATERECEPTOR 2, GERMCELL-SPECIFIC GENE1-LIKE PROTEIN (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF07803(GSG-1)PF10613(Lig_chan-Glu_bd) | 4 | TYR A 424MET A 496LEU A 759LYS A 763 | None | 0.92A | 3lslA-5welA:32.23lslD-5welA:32.5 | 3lslA-5welA:66.673lslD-5welA:66.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 4 | TYR A 424MET A 496LEU A 759ASP A 760 | NoneCYZ A1302 (-4.3A)NoneCYZ A1302 (-3.8A) | 0.50A | 3lslA-5weoA:25.43lslD-5weoA:25.3 | 3lslA-5weoA:66.673lslD-5weoA:66.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5weo | GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNITCHIMERA (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF00822(PMP22_Claudin)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 4 | TYR A 424MET A 496LEU A 759LYS A 763 | NoneCYZ A1302 (-4.3A)NoneCYZ A1302 (-2.9A) | 1.20A | 3lslA-5weoA:25.43lslD-5weoA:25.3 | 3lslA-5weoA:66.673lslD-5weoA:66.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbl | CRISPR-ASSOCIATEDENDONUCLEASECAS9/CSN1 (Streptococcuspyogenes) |
PF13395(HNH_4)PF16592(Cas9_REC)PF16593(Cas9-BH)PF16595(Cas9_PI) | 4 | TYR A 521ASN A 668LEU A 680ASP A 681 | None | 1.27A | 3lslA-5xblA:undetectable3lslD-5xblA:undetectable | 3lslA-5xblA:11.933lslD-5xblA:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y33 | ALGINATE LYASE (Flavobacteriumsp. UMI-01) |
no annotation | 4 | TYR A 115ASN A 193LEU A 192ASP A 106 | None | 1.40A | 3lslA-5y33A:undetectable3lslD-5y33A:undetectable | 3lslA-5y33A:undetectable3lslD-5y33A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yeu | - (-) |
no annotation | 4 | TYR A 252ASN A 163LEU A 166ASP A 167 | None | 1.09A | 3lslA-5yeuA:undetectable3lslD-5yeuA:undetectable | 3lslA-5yeuA:undetectable3lslD-5yeuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9x | SMALL RNA DEGRADINGNUCLEASE 1 (Arabidopsisthaliana) |
no annotation | 4 | SER A 125TYR A 109ASN A 78ASP A 235 | None | 1.21A | 3lslA-5z9xA:undetectable3lslD-5z9xA:undetectable | 3lslA-5z9xA:undetectable3lslD-5z9xA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bm7 | S-ADENOSYLMETHIONINEDECARBOXYLASE BETACHAIN (Trypanosomabrucei) |
no annotation | 4 | MET A 13LEU A 10ASP A 6LYS A 5 | None | 1.30A | 3lslA-6bm7A:undetectable3lslD-6bm7A:undetectable | 3lslA-6bm7A:undetectable3lslD-6bm7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bnl | NKT VALPHA14 (MOUSE)- 2C12 TCR - HYBRIDMOUSE VARIABLE ANDHUMAN CONSTANTDOMAINS (Homo sapiens) |
no annotation | 4 | TYR C 24LEU C 66ASP C 67LYS C 71 | None | 1.45A | 3lslA-6bnlC:undetectable3lslD-6bnlC:undetectable | 3lslA-6bnlC:undetectable3lslD-6bnlC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC2 (Saccharomycescerevisiae) |
no annotation | 4 | SER B 222TYR B 348ASN B 203LEU B 335 | None | 1.45A | 3lslA-6f42B:undetectable3lslD-6f42B:undetectable | 3lslA-6f42B:undetectable3lslD-6f42B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC2 (Saccharomycescerevisiae) |
no annotation | 4 | SER B 223TYR B 348ASN B 203LEU B 335 | None | 1.39A | 3lslA-6f42B:undetectable3lslD-6f42B:undetectable | 3lslA-6f42B:undetectable3lslD-6f42B:undetectable |