SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_A_PZIA802_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A  29
ASN A  30
SER A   2
 None
 0.71A 3lslA-1biiA:
undetectable
3lslD-1biiA:
undetectable		 3lslA-1biiA:
19.84
3lslD-1biiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		3 ASP A 152
ASN A 212
SER A  94
 None
 0.99A 3lslA-1cemA:
0.0
3lslD-1cemA:
0.0		 3lslA-1cemA:
22.70
3lslD-1cemA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP A 273
ASN A  93
SER A 334
 None
 0.82A 3lslA-1ethA:
0.1
3lslD-1ethA:
0.0		 3lslA-1ethA:
18.94
3lslD-1ethA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 ASP A 658
ASN A 661
SER A 674
 None
 0.98A 3lslA-1h54A:
0.0
3lslD-1h54A:
0.0		 3lslA-1h54A:
16.51
3lslD-1h54A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 ASP A 504
ASN A 499
SER A 457
 ATP  A 606 (-2.8A)
None
None
 0.89A 3lslA-1hp1A:
undetectable
3lslD-1hp1A:
undetectable		 3lslA-1hp1A:
22.22
3lslD-1hp1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j83 ENDO-1,4-BETA
GLUCANASE ENGF

(Clostridium
cellulovorans) 		PF03424
(CBM_17_28) 		3 ASP A1040
ASN A1067
SER A1035
 None
 0.92A 3lslA-1j83A:
undetectable
3lslD-1j83A:
undetectable		 3lslA-1j83A:
18.60
3lslD-1j83A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 ASP A  68
ASN A 161
SER A 385
 None
 0.87A 3lslA-1lf9A:
0.0
3lslD-1lf9A:
undetectable		 3lslA-1lf9A:
16.49
3lslD-1lf9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 ASP A 442
ASN A 544
SER A 444
 None
 0.93A 3lslA-1mu2A:
0.0
3lslD-1mu2A:
0.0		 3lslA-1mu2A:
18.10
3lslD-1mu2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		3 ASP A 255
ASN A 316
SER A  86
 None
 0.89A 3lslA-1nw1A:
0.0
3lslD-1nw1A:
0.0		 3lslA-1nw1A:
19.59
3lslD-1nw1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 ASP A  55
ASN A  52
SER A   5
 None
 0.87A 3lslA-1qjmA:
5.3
3lslD-1qjmA:
5.6		 3lslA-1qjmA:
17.85
3lslD-1qjmA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		3 ASP A  27
ASN A  43
SER A  49
 None
 0.82A 3lslA-1tp8A:
undetectable
3lslD-1tp8A:
undetectable		 3lslA-1tp8A:
21.65
3lslD-1tp8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ASP A 317
ASN A 316
SER A 325
 None
None
SO4  A 964 ( 4.9A)
 0.98A 3lslA-1uagA:
undetectable
3lslD-1uagA:
1.4		 3lslA-1uagA:
21.36
3lslD-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		3 ASP A 689
ASN A 646
SER A 691
 None
XYP  A   2 (-3.4A)
None
 0.97A 3lslA-1vbrA:
undetectable
3lslD-1vbrA:
undetectable		 3lslA-1vbrA:
20.57
3lslD-1vbrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfd LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 ASP A  55
ASN A  52
SER A   5
 None
 0.90A 3lslA-1vfdA:
5.3
3lslD-1vfdA:
5.9		 3lslA-1vfdA:
21.30
3lslD-1vfdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc2 ENDOGLUCANASE

(Mytilus edulis) 		no annotation 3 ASP A 158
ASN A 162
SER A 171
 None
 0.93A 3lslA-1wc2A:
undetectable
3lslD-1wc2A:
undetectable		 3lslA-1wc2A:
21.49
3lslD-1wc2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		3 ASP B  49
ASN B  50
SER B  31
 None
 0.85A 3lslA-1y75B:
undetectable
3lslD-1y75B:
undetectable		 3lslA-1y75B:
16.67
3lslD-1y75B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 ASP A 191
ASN A 193
SER A 156
 None
 0.88A 3lslA-1yd9A:
undetectable
3lslD-1yd9A:
undetectable		 3lslA-1yd9A:
20.69
3lslD-1yd9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		3 ASP B 243
ASN B 327
SER B 409
 None
 0.95A 3lslA-1zunB:
undetectable
3lslD-1zunB:
undetectable		 3lslA-1zunB:
22.80
3lslD-1zunB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A 448
ASN A 541
SER A 477
 MG  A 601 ( 2.4A)
None
TPP  A 602 ( 4.6A)
 0.97A 3lslA-2ag1A:
2.4
3lslD-2ag1A:
2.5		 3lslA-2ag1A:
18.36
3lslD-2ag1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		3 ASP A  81
ASN A 101
SER A 287
 None
 0.83A 3lslA-2au1A:
undetectable
3lslD-2au1A:
undetectable		 3lslA-2au1A:
21.29
3lslD-2au1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		3 ASP A 381
ASN A 382
SER A 388
 None
 0.90A 3lslA-2exaA:
undetectable
3lslD-2exaA:
undetectable		 3lslA-2exaA:
20.04
3lslD-2exaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		3 ASP A 136
ASN A 159
SER A 207
 None
AI2  A 501 (-3.3A)
None
 0.94A 3lslA-2hj9A:
undetectable
3lslD-2hj9A:
2.8		 3lslA-2hj9A:
20.40
3lslD-2hj9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ASP A 379
ASN A 391
SER A 385
 None
 0.96A 3lslA-2htvA:
undetectable
3lslD-2htvA:
undetectable		 3lslA-2htvA:
16.97
3lslD-2htvA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASP B 192
ASN B 180
SER B 194
 None
None
G  A   3 ( 2.3A)
 0.98A 3lslA-2kxnB:
undetectable
3lslD-2kxnB:
undetectable		 3lslA-2kxnB:
19.29
3lslD-2kxnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsn RNASE H

(Simian foamy
virus) 		PF00075
(RNase_H) 		3 ASP A  13
ASN A 150
SER A  15
 None
 0.92A 3lslA-2lsnA:
undetectable
3lslD-2lsnA:
undetectable		 3lslA-2lsnA:
22.05
3lslD-2lsnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		3 ASP A 521
ASN A 525
SER A 464
 None
 0.78A 3lslA-2pfvA:
undetectable
3lslD-2pfvA:
undetectable		 3lslA-2pfvA:
18.82
3lslD-2pfvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 ASP A 253
ASN A 334
SER A 301
 TLA  A 528 (-4.1A)
TLA  A 528 (-4.1A)
None
 0.95A 3lslA-2pyxA:
undetectable
3lslD-2pyxA:
undetectable		 3lslA-2pyxA:
19.48
3lslD-2pyxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 ASP F 235
ASN F 225
SER F 239
 CA  F1298 (-2.6A)
None
None
 0.83A 3lslA-2wnpF:
undetectable
3lslD-2wnpF:
undetectable		 3lslA-2wnpF:
21.85
3lslD-2wnpF:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		3 ASP A 214
ASN A 215
SER A 208
 None
 0.98A 3lslA-2xwgA:
undetectable
3lslD-2xwgA:
undetectable		 3lslA-2xwgA:
21.54
3lslD-2xwgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE
ASPARTOKINASE

(Corynebacterium
glutamicum;
Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
PF01842
(ACT)
PF13840
(ACT_7) 		3 ASP B  45
ASN B  43
SER A 381
 LYS  A 601 (-4.4A)
LYS  A 601 (-3.3A)
None
 0.91A 3lslA-3ab4B:
undetectable
3lslD-3ab4B:
undetectable		 3lslA-3ab4B:
21.67
3lslD-3ab4B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		3 ASP A 247
ASN A  74
SER A 288
 None
 0.82A 3lslA-3clkA:
undetectable
3lslD-3clkA:
undetectable		 3lslA-3clkA:
23.17
3lslD-3clkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens;
Homo sapiens) 		PF04157
(EAP30)
PF05871
(ESCRT-II) 		3 ASP C  24
ASN C  22
SER B 339
 None
 0.89A 3lslA-3cuqC:
undetectable
3lslD-3cuqC:
undetectable		 3lslA-3cuqC:
20.83
3lslD-3cuqC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		3 ASP A 192
ASN A 167
SER A 245
 None
 0.98A 3lslA-3daqA:
undetectable
3lslD-3daqA:
undetectable		 3lslA-3daqA:
21.96
3lslD-3daqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 317
ASN A 263
SER A 320
 None
 0.91A 3lslA-3dfyA:
undetectable
3lslD-3dfyA:
undetectable		 3lslA-3dfyA:
25.58
3lslD-3dfyA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 ASP A 466
ASN A 465
SER A 461
 None
 0.94A 3lslA-3dmkA:
undetectable
3lslD-3dmkA:
undetectable		 3lslA-3dmkA:
15.98
3lslD-3dmkA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 ASP A 220
ASN A 145
SER A 256
 LLP  A 259 ( 2.8A)
None
LLP  A 259 ( 2.5A)
 0.88A 3lslA-3g0tA:
undetectable
3lslD-3g0tA:
0.7		 3lslA-3g0tA:
20.50
3lslD-3g0tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnu 25 KDA PROTEIN
ELICITOR

(Pythium
aphanidermatum) 		PF05630
(NPP1) 		3 ASP P  93
ASN P 194
SER P 153
 None
GAI  P 214 (-3.3A)
None
 0.68A 3lslA-3gnuP:
undetectable
3lslD-3gnuP:
undetectable		 3lslA-3gnuP:
21.92
3lslD-3gnuP:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		3 ASP A 480
ASN A 481
SER A 474
 None
 0.85A 3lslA-3hv0A:
0.6
3lslD-3hv0A:
undetectable		 3lslA-3hv0A:
20.74
3lslD-3hv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 ASP D 457
ASN D 462
SER D 365
 None
 0.77A 3lslA-3j70D:
undetectable
3lslD-3j70D:
undetectable		 3lslA-3j70D:
19.70
3lslD-3j70D:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		3 ASP D 472
ASN D 476
SER D 305
 None
 0.90A 3lslA-3j9eD:
undetectable
3lslD-3j9eD:
undetectable		 3lslA-3j9eD:
18.75
3lslD-3j9eD:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		3 ASP A 457
ASN A 462
SER A 365
 None
 0.73A 3lslA-3jwoA:
undetectable
3lslD-3jwoA:
undetectable		 3lslA-3jwoA:
20.38
3lslD-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		3 ASP A 147
ASN A  78
SER A 172
 CA  A 240 (-2.9A)
CA  A 240 ( 2.8A)
None
 0.60A 3lslA-3kzpA:
undetectable
3lslD-3kzpA:
undetectable		 3lslA-3kzpA:
21.27
3lslD-3kzpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE

(Shigella
flexneri) 		PF00294
(PfkB) 		3 ASP A 102
ASN A 105
SER A 210
 None
 0.85A 3lslA-3lhxA:
1.5
3lslD-3lhxA:
undetectable		 3lslA-3lhxA:
22.01
3lslD-3lhxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ASP A  55
ASN A  95
SER A 351
 None
 0.85A 3lslA-3lk6A:
undetectable
3lslD-3lk6A:
1.4		 3lslA-3lk6A:
18.94
3lslD-3lk6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmz PUTATIVE HAD FAMILY
HYDROLASE

(Streptomyces
avermitilis) 		PF08282
(Hydrolase_3) 		3 ASP A  18
ASN A 110
SER A  62
 CA  A 500 (-2.6A)
CA  A 500 (-2.9A)
None
 0.93A 3lslA-3mmzA:
undetectable
3lslD-3mmzA:
undetectable		 3lslA-3mmzA:
17.37
3lslD-3mmzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 ASP B  81
ASN B 206
SER B  77
 None
 0.94A 3lslA-3n3bB:
undetectable
3lslD-3n3bB:
undetectable		 3lslA-3n3bB:
19.75
3lslD-3n3bB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		3 ASP A 368
ASN A 360
SER A 145
 None
 0.97A 3lslA-3njxA:
undetectable
3lslD-3njxA:
undetectable		 3lslA-3njxA:
17.52
3lslD-3njxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 ASP B 491
ASN B 515
SER B 232
 None
 0.89A 3lslA-3ojyB:
undetectable
3lslD-3ojyB:
undetectable		 3lslA-3ojyB:
19.53
3lslD-3ojyB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 321
ASN A 267
SER A 137
 None
 0.98A 3lslA-3r11A:
undetectable
3lslD-3r11A:
undetectable		 3lslA-3r11A:
20.16
3lslD-3r11A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skq MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
38

(Saccharomyces
cerevisiae) 		PF07766
(LETM1) 		3 ASP A 332
ASN A 333
SER A 382
 None
 0.92A 3lslA-3skqA:
undetectable
3lslD-3skqA:
undetectable		 3lslA-3skqA:
22.41
3lslD-3skqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		3 ASP A 380
ASN A 406
SER A 329
 None
 0.87A 3lslA-3t6qA:
undetectable
3lslD-3t6qA:
undetectable		 3lslA-3t6qA:
17.83
3lslD-3t6qA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		3 ASP A 270
ASN A 269
SER A 254
 COD  A 289 ( 3.8A)
COD  A 289 ( 4.4A)
COD  A 289 (-3.5A)
 0.96A 3lslA-3uf6A:
2.2
3lslD-3uf6A:
undetectable		 3lslA-3uf6A:
21.22
3lslD-3uf6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 ASP D 259
ASN D 262
SER D 156
 None
 0.65A 3lslA-3w3aD:
undetectable
3lslD-3w3aD:
undetectable		 3lslA-3w3aD:
20.52
3lslD-3w3aD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		3 ASP A 429
ASN A 430
SER A 680
 None
PLP  A1644 (-3.6A)
None
 0.86A 3lslA-4a0hA:
undetectable
3lslD-4a0hA:
0.7		 3lslA-4a0hA:
16.94
3lslD-4a0hA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		3 ASP A 239
ASN A  59
SER A 219
 None
 0.98A 3lslA-4ainA:
undetectable
3lslD-4ainA:
undetectable		 3lslA-4ainA:
19.67
3lslD-4ainA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASP A 170
ASN A 180
SER A 173
 None
 0.80A 3lslA-4bziA:
undetectable
3lslD-4bziA:
undetectable		 3lslA-4bziA:
16.80
3lslD-4bziA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7w HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 ASP A 100
ASN A  36
SER A 297
 None
 0.99A 3lslA-4c7wA:
undetectable
3lslD-4c7wA:
undetectable		 3lslA-4c7wA:
20.48
3lslD-4c7wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		3 ASP A 197
ASN A 200
SER A 188
 None
 0.95A 3lslA-4ecmA:
1.1
3lslD-4ecmA:
undetectable		 3lslA-4ecmA:
22.82
3lslD-4ecmA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus;
Eleginops
maclovinus) 		PF00042
(Globin)
PF00042
(Globin) 		3 ASP A  27
ASN A  26
SER B 120
 None
 0.82A 3lslA-4esaA:
undetectable
3lslD-4esaA:
undetectable		 3lslA-4esaA:
20.62
3lslD-4esaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		3 ASP A1101
ASN A1113
SER A1170
 None
 0.98A 3lslA-4fbqA:
undetectable
3lslD-4fbqA:
undetectable		 3lslA-4fbqA:
19.42
3lslD-4fbqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3;
Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT)
no annotation 		3 ASP A  25
ASN B  83
SER B  66
 None
 0.99A 3lslA-4g6tA:
undetectable
3lslD-4g6tA:
undetectable		 3lslA-4g6tA:
18.22
3lslD-4g6tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 144
ASN A 142
SER A  17
 None
 0.78A 3lslA-4h19A:
undetectable
3lslD-4h19A:
undetectable		 3lslA-4h19A:
23.06
3lslD-4h19A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		3 ASP A  22
ASN A 155
SER A  24
 None
 0.83A 3lslA-4ibnA:
undetectable
3lslD-4ibnA:
undetectable		 3lslA-4ibnA:
21.74
3lslD-4ibnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		3 ASP A  64
ASN A  67
SER A 105
 None
 0.94A 3lslA-4icqA:
undetectable
3lslD-4icqA:
undetectable		 3lslA-4icqA:
20.50
3lslD-4icqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		3 ASP A 102
ASN A  95
SER A 195
 None
 0.94A 3lslA-4k8yA:
undetectable
3lslD-4k8yA:
undetectable		 3lslA-4k8yA:
22.56
3lslD-4k8yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  33
ASN H 100
SER H  53
 None
 0.98A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  33
ASN H 100
SER H  54
 None
 0.89A 3lslA-4ktdH:
undetectable
3lslD-4ktdH:
undetectable		 3lslA-4ktdH:
21.58
3lslD-4ktdH:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 204
ASN A 201
SER A 194
 None
 0.98A 3lslA-4l37A:
undetectable
3lslD-4l37A:
undetectable		 3lslA-4l37A:
17.40
3lslD-4l37A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		3 ASP A1513
ASN A1516
SER A1564
 None
 0.84A 3lslA-4lnzA:
undetectable
3lslD-4lnzA:
undetectable		 3lslA-4lnzA:
20.60
3lslD-4lnzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
NANOBODY 9-8

(Homo sapiens;
Lama glama) 		PF00001
(7tm_1)
PF07686
(V-set) 		3 ASP B  33
ASN B  77
SER A 380
 None
 0.81A 3lslA-4mqtB:
undetectable
3lslD-4mqtB:
undetectable		 3lslA-4mqtB:
18.35
3lslD-4mqtB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 3 ASP A  18
ASN A  63
SER A  22
 None
CIT  A 501 (-4.6A)
None
 0.86A 3lslA-4o87A:
undetectable
3lslD-4o87A:
undetectable		 3lslA-4o87A:
22.42
3lslD-4o87A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		3 ASP A 277
ASN A 280
SER A 297
 None
 0.94A 3lslA-4pvcA:
undetectable
3lslD-4pvcA:
undetectable		 3lslA-4pvcA:
24.51
3lslD-4pvcA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		3 ASP A 116
ASN A 179
SER A  54
 TRS  A 402 (-2.8A)
None
TRS  A 402 ( 4.9A)
 0.96A 3lslA-4q2bA:
undetectable
3lslD-4q2bA:
undetectable		 3lslA-4q2bA:
22.07
3lslD-4q2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  99
ASN H  35
SER H 103
 CA  H 301 (-3.7A)
CA  H 301 (-2.9A)
None
 0.91A 3lslA-4r90H:
undetectable
3lslD-4r90H:
undetectable		 3lslA-4r90H:
22.18
3lslD-4r90H:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		3 ASP A  75
ASN A 103
SER A 228
 None
 0.93A 3lslA-4rk1A:
3.0
3lslD-4rk1A:
2.9		 3lslA-4rk1A:
24.29
3lslD-4rk1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASP A  18
ASN A  12
SER A 137
 None
 0.80A 3lslA-4rpfA:
undetectable
3lslD-4rpfA:
undetectable		 3lslA-4rpfA:
20.29
3lslD-4rpfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		3 ASP A 382
ASN A  21
SER A 331
 None
 0.63A 3lslA-4tx8A:
undetectable
3lslD-4tx8A:
undetectable		 3lslA-4tx8A:
18.84
3lslD-4tx8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		3 ASP A  62
ASN A  64
SER A 112
 None
 0.85A 3lslA-4zdlA:
undetectable
3lslD-4zdlA:
undetectable		 3lslA-4zdlA:
20.99
3lslD-4zdlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ASP A 326
ASN A 323
SER A  11
 None
 0.92A 3lslA-4zo6A:
undetectable
3lslD-4zo6A:
undetectable		 3lslA-4zo6A:
17.31
3lslD-4zo6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		3 ASP A 366
ASN A 362
SER A 126
 None
 0.90A 3lslA-5b3jA:
1.2
3lslD-5b3jA:
1.4		 3lslA-5b3jA:
20.87
3lslD-5b3jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		3 ASP A 324
ASN A 327
SER A  62
 None
 0.91A 3lslA-5d8gA:
undetectable
3lslD-5d8gA:
undetectable		 3lslA-5d8gA:
20.97
3lslD-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H) 		3 ASP A 524
ASN A 649
SER A 526
 None
 0.91A 3lslA-5dmrA:
undetectable
3lslD-5dmrA:
undetectable		 3lslA-5dmrA:
25.00
3lslD-5dmrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C

(Pseudomonas sp.) 		PF16670
(PI-PLC-C1) 		3 ASP A 119
ASN A  27
SER A 191
 INS  A 301 ( 3.1A)
CA  A 401 ( 3.0A)
None
 0.84A 3lslA-5fyrA:
undetectable
3lslD-5fyrA:
undetectable		 3lslA-5fyrA:
19.69
3lslD-5fyrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		3 ASP A 372
ASN A 409
SER A 180
 None
 0.71A 3lslA-5g4iA:
undetectable
3lslD-5g4iA:
undetectable		 3lslA-5g4iA:
19.52
3lslD-5g4iA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		3 ASP A 348
ASN A 282
SER A 377
 None
 0.68A 3lslA-5gvvA:
1.4
3lslD-5gvvA:
1.5		 3lslA-5gvvA:
19.55
3lslD-5gvvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 ASP A 480
ASN A 478
SER A 380
 None
 0.62A 3lslA-5ivaA:
undetectable
3lslD-5ivaA:
undetectable		 3lslA-5ivaA:
18.73
3lslD-5ivaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		3 ASP A 393
ASN A 394
SER A 313
 CAC  A 501 (-3.6A)
None
None
 0.85A 3lslA-5j39A:
undetectable
3lslD-5j39A:
undetectable		 3lslA-5j39A:
23.35
3lslD-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		3 ASP A  51
ASN A  52
SER A  73
 None
 0.98A 3lslA-5j6qA:
undetectable
3lslD-5j6qA:
undetectable		 3lslA-5j6qA:
18.98
3lslD-5j6qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 ASP A 353
ASN A 424
SER A 398
 None
 0.98A 3lslA-5kd5A:
undetectable
3lslD-5kd5A:
undetectable		 3lslA-5kd5A:
19.43
3lslD-5kd5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		3 ASP A 249
ASN A 252
SER A 317
 None
 0.99A 3lslA-5kxqA:
undetectable
3lslD-5kxqA:
undetectable		 3lslA-5kxqA:
19.70
3lslD-5kxqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 3 ASP A 634
ASN A 637
SER A 847
 None
NAG  A1108 (-1.8A)
None
 0.89A 3lslA-5nbsA:
undetectable
3lslD-5nbsA:
undetectable		 3lslA-5nbsA:
undetectable
3lslD-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 ASP B 127
ASN B 130
SER B 124
 None
 0.95A 3lslA-5nemB:
undetectable
3lslD-5nemB:
undetectable		 3lslA-5nemB:
18.88
3lslD-5nemB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ASP A 322
ASN A  52
SER A 297
 None
 0.75A 3lslA-5tf0A:
undetectable
3lslD-5tf0A:
undetectable		 3lslA-5tf0A:
17.03
3lslD-5tf0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47

(Homo sapiens;
Homo sapiens;
Human
alphaherpesvirus
1) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF05363
(Herpes_US12) 		3 ASP X   9
ASN B 269
SER A 412
 None
 0.96A 3lslA-5u1dX:
undetectable
3lslD-5u1dX:
undetectable		 3lslA-5u1dX:
18.91
3lslD-5u1dX:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 ASP C 217
ASN C 214
SER C 254
 None
 0.99A 3lslA-5v8fC:
undetectable
3lslD-5v8fC:
undetectable		 3lslA-5v8fC:
18.79
3lslD-5v8fC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgm DIHYDROOROTASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		3 ASP A  11
ASN A  33
SER A 247
 None
 0.96A 3lslA-5vgmA:
undetectable
3lslD-5vgmA:
undetectable		 3lslA-5vgmA:
20.56
3lslD-5vgmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 3 ASP A 241
ASN A 170
SER A 209
 None
 0.97A 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable		 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ASP A 316
ASN A  50
SER A 291
 None
 0.78A 3lslA-5xxoA:
undetectable
3lslD-5xxoA:
undetectable		 3lslA-5xxoA:
undetectable
3lslD-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 3 ASP A 277
ASN A 212
SER A 148
 None
 0.87A 3lslA-6bi4A:
undetectable
3lslD-6bi4A:
undetectable		 3lslA-6bi4A:
20.83
3lslD-6bi4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 3 ASP A 201
ASN A 220
SER A 243
 None
 0.94A 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable		 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable